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Full-Text Articles in Medicine and Health Sciences
The Effect Of Chloroquine Treatment In Malignant Astrocytomas On Prognosis, Turgay Bulut, Mehmet Ali̇ Eki̇ci̇, Bülent Tucer, Seyi̇t Kağan Başarslan, Kağan Kamaşak, Ali̇ Kurtsoy
The Effect Of Chloroquine Treatment In Malignant Astrocytomas On Prognosis, Turgay Bulut, Mehmet Ali̇ Eki̇ci̇, Bülent Tucer, Seyi̇t Kağan Başarslan, Kağan Kamaşak, Ali̇ Kurtsoy
Turkish Journal of Medical Sciences
To investigate the adjuvant role of the antimutagenic agent chloroquine in the treatment of patients with malignant astrocytomas (MAs). Materials and methods: Clinical research was conducted at the Neurosurgery Clinic of the Erciyes University School of Medicine, from September 2003 to April 2007, on 37 patients diagnosed with MA after tumor resection subsequent to craniotomy. Chloroquine treatment was started on a daily dose of 150 mg, additional to the patients' radiotherapy and chemotherapy protocol, and was continued throughout the 43-month surveillance period. A control group was formed of 81 patients with MA after the craniotomy. Results: While the mean survival …
Renal Bcl-2/Bax Expression In Childhood Henoch-Schönlein Nephritis: Prognostic Importance?, Kenan Bek, Ayşegül Oksal, Gülay Demi̇rci̇n, Mehmet Bülbül, Özlem Aydoğ, Ali̇ Deli̇baş, Ayşe Öner
Renal Bcl-2/Bax Expression In Childhood Henoch-Schönlein Nephritis: Prognostic Importance?, Kenan Bek, Ayşegül Oksal, Gülay Demi̇rci̇n, Mehmet Bülbül, Özlem Aydoğ, Ali̇ Deli̇baş, Ayşe Öner
Turkish Journal of Medical Sciences
To investigate the renal expression of apoptosis regulatory proteins b-cell lymphoma 2 (bcl-2) and bcl-2 associated X (bax) in children with Henoch–Schönlein nephritis (HSN) Materials and methods: Renal expression of antiapoptotic bcl-2 and proapoptotic bax proteins were studied immunohistochemically in 22 children with HSN. The kidneys of 5 children who died due to nonrenal reasons were used as the control. The patients were compared according to their renal histopathology and prognosis. Results: Nephrotic or nephrotic-nephritic renal involvement was the most common presentation. Histopathological findings were Class I in 1, Class II in 5, Class III in 10, Class IV in …
Prognostic Factors In Patients With Glioblastoma Multiforme (Clinical Research), Mehmet Ali̇ Eki̇ci̇, Turgay Bulut, Bülent Tucer, Seyi̇t Kağan Başarslan, Ali̇ Kurtsoy
Prognostic Factors In Patients With Glioblastoma Multiforme (Clinical Research), Mehmet Ali̇ Eki̇ci̇, Turgay Bulut, Bülent Tucer, Seyi̇t Kağan Başarslan, Ali̇ Kurtsoy
Turkish Journal of Medical Sciences
To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM). Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006. A total of 98 patients were diagnosed with GBM after tumor resections. Patients' demographic, neurological, radiological, surgical, and clinical features and adjunct therapies were analyzed retrospectively. Results: Of the 98 patients, 36 (36.7%) were female and 62 (65.4%) were male. There were 15 patients (15.3%) still alive. The median survival time (MST) of the gross total resection and subtotal resection …