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Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Investigation Of The Protective Effects Of L-Carnitine And L-Arginine On Cardiovascular Changes Induced By Acth And Dexamethasone In Rabbits, Bi̇rkan Topçu, Metehan Uzun
Turkish Journal of Medical Sciences
To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged …
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
Turkish Journal of Medical Sciences
To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group …