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Full-Text Articles in Medicine and Health Sciences
Serum Leptin Levels And Their Proportional Relationship With Pro- And Antiinflammatory Mediators In Aggressive Periodontitis: Preliminary Report, Zuhal Yetki̇n Ay, Recep Sütcü, Havva Koçak, Fatma Yeşi̇m Kirzioğlu
Serum Leptin Levels And Their Proportional Relationship With Pro- And Antiinflammatory Mediators In Aggressive Periodontitis: Preliminary Report, Zuhal Yetki̇n Ay, Recep Sütcü, Havva Koçak, Fatma Yeşi̇m Kirzioğlu
Turkish Journal of Medical Sciences
To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients. Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC). The fasting venous serum samples were used to determine the OB and the cytokines/mediators belonging to the Th1/Th2/Th17 cells. The correlations among the OB and cytokines/mediators in the serum and clinical periodontal parameters were also investigated. Results: The AP group presented significantly higher serum TGF-\beta1 and IL-2 concentrations (pg/mL) and lower IL-4, IL-5, IL-12, IL-13, and IL-17A concentrations than the …
Leptin Regulation Of Pubertal Maturation In Intact And Pinealectomized Female Rats, Emi̇ne Kaçar, Si̇ğnem Eyuboğlu Di̇nç, Bayram Yilmaz, Haluk Keleşti̇mur
Leptin Regulation Of Pubertal Maturation In Intact And Pinealectomized Female Rats, Emi̇ne Kaçar, Si̇ğnem Eyuboğlu Di̇nç, Bayram Yilmaz, Haluk Keleşti̇mur
Turkish Journal of Medical Sciences
To explore the roles of leptin and melatonin in early pubertal maturation. Materials and methods: Wistar female rats were used as experimental animals. Leptin was subcutaneously infused for 28 days through osmotic minipumps starting from postnatal day 15 (preweaning). Pinealectomy was performed on postnatal day 21 (weaning), and the animals were decapitated when estrus was detected by vaginal smearing. Results: Chronic preweaning, by peripheral infusion of leptin through subcutaneous routes, advanced the onset of puberty in leptin-treated sham and pinealectomized groups as determined by vaginal opening, while causing no significant change in serum estradiol levels and uterus weight. Mean body …