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Full-Text Articles in Medicine and Health Sciences
Does Adma Affect The Oxidant/Antioxidant Balance In Rats?, Hasan Alaçam, Bahatti̇n Avci, Osman Şaliş, Ahmet Di̇lek, Ahmet Kozan, Cuma Mertoğlu, Mehmet Şahi̇n, Ali̇ Okuyucu
Does Adma Affect The Oxidant/Antioxidant Balance In Rats?, Hasan Alaçam, Bahatti̇n Avci, Osman Şaliş, Ahmet Di̇lek, Ahmet Kozan, Cuma Mertoğlu, Mehmet Şahi̇n, Ali̇ Okuyucu
Turkish Journal of Medical Sciences
Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ADMA causes oxidative damage. Materials and methods: Thirty rats were divided into 3 equal groups: a control group, a group administered 1 mg/kg ADMA, and a group administered 2 mg/kg ADMA. ADMA was administered intraperitoneally for 7 days. Malondialdehyde (MDA), protein carbonyl (PC) content, and nitrate+nitrite concentrations were measured with serum samples. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) activities were analyzed with plasma samples. Results: A …
Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan
Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan
Turkish Journal of Medical Sciences
Asymmetric dimethylarginine (ADMA) is the major endogenous inhibitor of nitric oxide synthase. We aimed to investigate the ADMA levels in allergic rhinitis (AR) and nasal polyposis (NP). Materials and methods: A total of 29 AR patients, 21 NP patients, and 30 healthy subjects to be used as a control group were enrolled in the study. ADMA was measured in the AR, NP, and control groups with enzyme-linked immunosorbent assay. Any patients or control subjects with coronary artery disease, renal failure, diabetes mellitus, or hypertension were excluded from the study. Results: The mean ADMA serum concentration was 0.52 ± 0.08 µmol/L …