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Reversible Conduction Block In Frog Sciatic Nerve For Three Different Concentrations Of Bupivacaine, Belgi̇n Büyükakilli, Ülkü Çömelekoğlu, Oya Öğenler

Turkish Journal of Medical Sciences

We examined the effects of various concentrations of the bupivacaine commonly used for spinal anaesthesia on the reversibility of conduction block in isolated frog sciatic nerves measured by the extracellular recording technique. Seventy-two isolated nerves were divided into 3 groups (n = 24), each of which was bathed in a different bupivacaine solution in a range of concentrations (10, 20 or 30 mM for 20 min). In each group, the extracellular action potentials were recorded before exposure to the bupivacaine solution to provide the control data. The extracellular action potentials were recorded after 20 min exposure to the drug by …