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Protective Effects Of Vitamin E Selenium And Allopurinol Against Stress-Induced Ulcer Formation In Rats, Nai̇me Canoruç, Ramazan Çi̇çek, Aytaç Atamer, Mehmet Dursun, Cengi̇z Turgut, Ensari̇ Güneli̇, Fi̇kri̇ Canoruç

Turkish Journal of Medical Sciences

This study was carried out in the Health Research Center (DÜSAM) laboratory of Dicle University. Vitamin E, Selenium and Allopurinol were given to counteract gastric damage caused by stress in rats. In the study 64 male Sprague dawley rats were used. They were divided into 8 groups, and protective agents were applied at different doses for 8 weeks. Then, performing cold-restraint stress stomach tissues were taken out and investigated macroscopically to determine mucosal damage. Lipid peroxidation levels in the stomach specimens were determined by identifying Malondialdehyde (MDA) levels by the thiobarbituric acid method. These agents have shown protective effects against …