Open Access. Powered by Scholars. Published by Universities.®
Articles 31 - 55 of 55
Full-Text Articles in Medicine and Health Sciences
Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman
Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman
Turkish Journal of Medical Sciences
Background/aim:Malassezia colonization, sebaceous gland activity, hormones, immune system defects, environmental factors, and the interactions between these factors are thought to contribute to the pathogenesis of seborrheic dermatitis (SD). Zinc, an essential element, is involved in many biological processes including the ones that contribute to the development of SD. The aim of this study is to evaluate serum zinc levels in patients with SD.Materials and methods: Forty-three patients with SD and 41 healthy controls were enrolled in the study. Disease activity was assessed by the Seborrheic Dermatitis Area and Severity Index by a single dermatologist. Serum zinc levels of all subjects …
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Materials and methods: Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured …
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
Turkish Journal of Medical Sciences
Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental …
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
Turkish Journal of Medical Sciences
Background/aim: e aim of this study was to combine some easy and economical de ned methods and constitute a comprehensive cell culture model to use in the bowel diseases characterized by in ammation. Materials and methods: Induction of inflammation was performed using lipopolysaccharide (LPS) or a cytokine mixture (TNF-?: 10 ng/mL; IFN-?: 100 ng/mL; IL-1ß: 1 ng/mL). IEC-6 cells were grown to con uence and serum-starved, wounds were constituted, and progress of cell migration into the wounds was photographed at 0, 2, 4, 6, 8, 10, 12, and 24 h in the presence or absence of an in ammatory environment. …
Evaluation Of Platelet Parameters And Neutrophil/Lymphocyte Ratio During Omalizumab Treatment In Patients With Severe Chronic Spontaneous Urticaria, Ragip Ertaş, Kemal Özyurt, Çi̇ğdem Karakükcü, Muhammet Reşat Akkuş, Emi̇n Özlü, Atil Avci, Mustafa Atasoy
Evaluation Of Platelet Parameters And Neutrophil/Lymphocyte Ratio During Omalizumab Treatment In Patients With Severe Chronic Spontaneous Urticaria, Ragip Ertaş, Kemal Özyurt, Çi̇ğdem Karakükcü, Muhammet Reşat Akkuş, Emi̇n Özlü, Atil Avci, Mustafa Atasoy
Turkish Journal of Medical Sciences
Background/aim: Spontaneous wheals and/or angioedema lasting longer than six weeks are described as chronic spontaneous urticaria (CSU). Omalizumab is used for the treatment of antihistamine-resistant CSU. The neutrophil-lymphocyte ratio (NLR), platelet- lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are considered important indicators of inflammation and platelet activation in chronic diseases. We aimed to determine the NLR, PLR, MPV, and PDW levels in patients with CSU compared with healthy controls. We also aimed to investigate the effects of omalizumab therapy on these parameters in CSU patients. Materials and methods: This hospital-based, retrospective study included 143 patients …
The Relationship Between Vitamin D Deficiency And Erythrocyte Sedimentation Rate In Patients With Diabetes, Tezcan Kaya, Emi̇ne Ülkü Akçay, Zeynep Ertürk, Hasan Ergenç, Ali̇ Tamer
The Relationship Between Vitamin D Deficiency And Erythrocyte Sedimentation Rate In Patients With Diabetes, Tezcan Kaya, Emi̇ne Ülkü Akçay, Zeynep Ertürk, Hasan Ergenç, Ali̇ Tamer
Turkish Journal of Medical Sciences
Background/aim: Vitamin D deficiency in diabetic patients has been shown to be associated with some in ammatory markers. However, its relationship with erythrocyte sedimentation rate (ESR) is still unknown. The aim of this study was to investigate the relationship between vitamin D deficiency and ESR in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This cross-sectional study was conducted with 294 consecutive patients with T2DM. Serum levels of 25-hydroxyvitamin D, glycemic parameters, lipids, ESR, and C-reactive protein were measured. Patients were evaluated according to 25-hydroxyvitamin D levels as having vitamin D deficiency, vitamin D insuficiency, and vitamin D …
Ginger (Zingiber Officinale) Prevents Severe Damage To The Lungs Due To Hyperoxia Andinflammation, Ati̇lla Çi̇fci̇, Cüneyt Tayman, Hali̇l İbrahi̇m Yakut, Hali̇t Hali̇l, Esra Çakir, Ufuk Çakir, Sali̇h Aydemi̇r
Ginger (Zingiber Officinale) Prevents Severe Damage To The Lungs Due To Hyperoxia Andinflammation, Ati̇lla Çi̇fci̇, Cüneyt Tayman, Hali̇l İbrahi̇m Yakut, Hali̇t Hali̇l, Esra Çakir, Ufuk Çakir, Sali̇h Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed to hyperoxia and inflammation. Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O2) + lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O2). Pups in the hyperoxia + LPS + ginger group were administered oral ginger at a dose of 1000 mg/kg daily during the study period. Histopathologic, …
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly …
Hyperbolic Relation Between Beta-Cell Function And Insulin Sensitivity For Type 2 Diabetes Mellitus, Malaria, Influenza, Helicobacter Pylori, Chlamydia Pneumoniae, And Hepatitis C Virus Infection-Induced Inflammation/Oxidative Stress And Temporary Insulin Resistance In Central Africans, Jean Bosco Kasiam Lasi On'kin, Benjamin Longo-Mbenza, Venant Tchokonte-Nana, Augustin Nge Okwe, Nelly Kangola Kabangu
Hyperbolic Relation Between Beta-Cell Function And Insulin Sensitivity For Type 2 Diabetes Mellitus, Malaria, Influenza, Helicobacter Pylori, Chlamydia Pneumoniae, And Hepatitis C Virus Infection-Induced Inflammation/Oxidative Stress And Temporary Insulin Resistance In Central Africans, Jean Bosco Kasiam Lasi On'kin, Benjamin Longo-Mbenza, Venant Tchokonte-Nana, Augustin Nge Okwe, Nelly Kangola Kabangu
Turkish Journal of Medical Sciences
Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo. Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.Results: In total, 219 patients and 110 healthy controls were matched for sex and age. The hyperbolic product for 85 infected patients occupied an intermediate position between the hyperbolic product for 110 controls and that of …
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Turkish Journal of Medical Sciences
Background/aim: We investigated the role of body flora and chronic inflammatory infections in the etiology of allergic disorders in Turkish children. Materials and methods: Forty pediatric asthma patients with positive skin prick tests and 40 age-matched healthy subjects with negative skin prick tests were enrolled in this cross-sectional study. Serum H. pylori IgG, viral hepatitis serology, IL-10, and TGF-beta levels were measured. Stool and throat cultures were taken and tested for occurrence of microorganisms. Results: A significantly higher percentage of nonatopic subjects tested positive for anti-H. pylori antibodies compared to atopic subjects (60% vs. 20%). Serum IL-10 levels were also …
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Turkish Journal of Medical Sciences
Background/aim: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients. Materials and methods: Fifty-nine patients with systemic sclerosis (SSc) were enrolled in the study. We used high-resolution computed tomography for diagnosis and used …
Host Immune Responses And Peritumoral Stromal Reactions In Different Basal Cell Carcinoma Subtypes: Histopathological Comparison Of Basosquamous Carcinoma And High-Risk And Low-Risk Basal Cell Carcinoma Subtypes, Ni̇lay Duman, Ni̇lay Şen Korkmaz, Zafer Erol
Host Immune Responses And Peritumoral Stromal Reactions In Different Basal Cell Carcinoma Subtypes: Histopathological Comparison Of Basosquamous Carcinoma And High-Risk And Low-Risk Basal Cell Carcinoma Subtypes, Ni̇lay Duman, Ni̇lay Şen Korkmaz, Zafer Erol
Turkish Journal of Medical Sciences
Background/aim: The literature does not include sufficient data on the associations between host immune responses and stromal reactions in different basal cell carcinoma (BCC) subtypes. The aim of the study was to compare host immune responses and stromal reactions between basosquamous carcinoma (BSC) and high-risk (HR) and low-risk (LR) BCC subtypes. Materials and methods: The study included 35 BSC, 40 HR-BCC, and 40 LR-BCC patients. Age, sex, lesion location, density of peritumoral/adjacent perivascular inflammation, presence of lymphoid follicle formation, and stromal reaction type were compared between groups. Results: In all 3 groups, age, sex distribution, and lesion location were similar. …
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to scrutinize the effects of crocin on obesity and type-2 diabetes, with an approach that takes oxidative stress and inflammatory parameters into account. Materials and methods: The experimental obesity model was created by utilizing a 10-week-long high-fat diet (HFD). An experimental type-2 diabetes model was created by injecting multiple low-dose streptozocin (STZ) injections into rats that were fed with the HFD. The treatment groups were administered a daily crocin dose of 150 mg/kg for 6 weeks via gavage. Results: Findings of the study demonstrated that crocin could be effective in relieving the symptoms …
Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan
Caffeic Acid Phenethyl Ester Protects Lung Alveolar Epithelial Cellsfrom Cigarette Smoke-Induced Damage, Firat Bariş Barlas, Suat Erdogan
Turkish Journal of Medical Sciences
Background/aim: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells. Materials and methods: A549 alveolar epithelial cells were divided into control, CS exposure, CAPE, and CS+CAPE treatment groups. Undiluted CS-exposed medium (100%) and three dilutions (50%, 25%, and 10%) of CS-exposed media were applied to cultured A549 cells, which were analyzed after 3 h of incubation. Viability was measured by MTT assay, the gene expressions were evaluated by real-time PCR, and spectrophotometric techniques were used for biochemical assessments. Results: While CS exposure markedly reduced …
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Evaluation Of Autoinflammatory Disease Genes In Nasal Polyposis, Sabri̇ Köseoğlu, Kürşat Murat Özcan, Aykut İki̇nci̇oğullari, Mehmet Ali̇ Çeti̇n, Tali̇h Özdaş, Si̇bel Özdaş, Serdar Ensari̇, Haci Hüseyi̇n Dere
Turkish Journal of Medical Sciences
To investigate cold-induced autoinflammatory syndrome 1 (CIAS1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP). Materials and methods: The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group. Results: The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A …
Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan
Beraprost Sodium, A Prostacyclin (Pgi) Analogue, Ameliorateslipopolysaccharide-Induced Cellular Injury In Lung Alveolar Epithelial Cells, Si̇nan Vicil, Suat Erdogan
Turkish Journal of Medical Sciences
Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I_2 (PGI_2) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells. Materials and methods: Human pulmonary alveolar epithelial cells (A549) were pretreated with 10 µM beraprost sodium 30 min before stimulation with 1 µg/mL LPS for 24 h. The cellular viability assessments were evaluated by quantitative MTT test. Catalase activity and glutathione and lipid peroxidation levels were determined using spectrophotometric techniques. mRNA expression analyses were …
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …
Prognostic Value Of Neutrophil/Lymphocyte Ratio In Patients With Pulmonary Embolism, Umut Yücel Çavuş, Si̇nan Yildirim, Ertan Sönmez, Çağatay Ertan, Özcan Özeke
Prognostic Value Of Neutrophil/Lymphocyte Ratio In Patients With Pulmonary Embolism, Umut Yücel Çavuş, Si̇nan Yildirim, Ertan Sönmez, Çağatay Ertan, Özcan Özeke
Turkish Journal of Medical Sciences
Preliminary evidence suggests that inflammation plays a role in the development and prognosis of pulmonary embolism (PE). We used the neutrophil/lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with PE. Materials and methods: A total of 266 patients who were diagnosed with PE and a control group of 124 age- and sex-matched healthy subjects were included in this study. We further classified the PE patients into 2 groups: those who survived and those who died in the first 30 days. Baseline NLR was measured by dividing neutrophil count to lymphocyte count and was compared between …
Investigation Of Serum Macrophage Migration Inhibitor Factor And Monocyte Chemotactic Protein-1 Levels In Irritable Bowel Syndrome, Feti̇ Tülübaş, Mustafa Oran, Rafet Mete, Fi̇li̇z Turan, Ahsen Yilmaz, Zeynep Deni̇z Yildiz, Ahmet Gürel
Investigation Of Serum Macrophage Migration Inhibitor Factor And Monocyte Chemotactic Protein-1 Levels In Irritable Bowel Syndrome, Feti̇ Tülübaş, Mustafa Oran, Rafet Mete, Fi̇li̇z Turan, Ahsen Yilmaz, Zeynep Deni̇z Yildiz, Ahmet Gürel
Turkish Journal of Medical Sciences
Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between …
Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim
Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim
Turkish Journal of Medical Sciences
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung associated with progressive airflow limitation. The aim of this study is to assess the influence of tiotropium treatment on airway inflammation and symptoms in stable COPD patients. Materials and methods: Inflammatory markers were measured in the expired breath condensate fluid (EBC) before starting tiotropium treatment and at the end of the first month. Results: Twenty-two patients (81% men) with a mean age of 65.4 ± 10.1 years completed the study. The mean nitrotyrosine and 8-isoprostane levels for oxidative stress markers in EBC before and after treatment were 4.5 …
Postoperative Atrial Fibrillation, Oxidative Stress, And Inflammation, Mehmet Özaydin
Postoperative Atrial Fibrillation, Oxidative Stress, And Inflammation, Mehmet Özaydin
Turkish Journal of Medical Sciences
Postoperative atrial fibrillation is the most common complication of cardiac surgery. It is associated with increased complication rates. Recent trials have suggested that inflammation and oxidative stress have key roles in the pathophysiology of atrial fibrillation. Current evidence evaluating the use of antiinflammatory and antioxidant agents, including statins, corticosteroids, N-acetylcysteine, vitamin C, and fish oil, to prevent postoperative atrial fibrillation is promising. However, larger randomized, controlled trials comparing different dose regimens are needed.
The Effects Of 3-Benzoyl-1-Methyl-4-Phenyl-4 Piperidinolhydrochloride (C1), Indomethacin, Nimesulide And Rofecoxib On Cyclooxygenase Activities In Carrageenan-Induced Paw Edema Model, Yaşar Nuri̇ Şahi̇n, Berna Demi̇rcan, Hali̇s Süleyman, Hülya Aksoy, Hali̇se İnci̇ Gül
The Effects Of 3-Benzoyl-1-Methyl-4-Phenyl-4 Piperidinolhydrochloride (C1), Indomethacin, Nimesulide And Rofecoxib On Cyclooxygenase Activities In Carrageenan-Induced Paw Edema Model, Yaşar Nuri̇ Şahi̇n, Berna Demi̇rcan, Hali̇s Süleyman, Hülya Aksoy, Hali̇se İnci̇ Gül
Turkish Journal of Medical Sciences
The aim of this study was to investigate the effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride (C1), which is a structural and also non-classical isomer of bis Mannich base, bis (3-aryl-3-oxo-propyl) methylamine hydrochlorides (B1), on cyclooxygenase (COX) activities in 48 rats with inflammation by using carrageenan-induced paw edema, and to compare its effect with other non-steroidal anti-inflammatory drugs (NSAIDs). Materials and methods: Experimental animals were supplied by the Center of Experimental Research and Practice in Ataturk University. The animals were housed and fed in the laboratory (normal room temparature, food and water) under standard conditions. Rats were randomly assigned to eight groups (n = …
Comparison Of Gliclazide Treatment With Diet Therapy On Acute Phase Protein Levels In Patients With Type 2 Diabetes, Ramazan Memi̇şoğullari, Fati̇h Akçay, Abdurrahman Coşkun, Uğur Korkmaz
Comparison Of Gliclazide Treatment With Diet Therapy On Acute Phase Protein Levels In Patients With Type 2 Diabetes, Ramazan Memi̇şoğullari, Fati̇h Akçay, Abdurrahman Coşkun, Uğur Korkmaz
Turkish Journal of Medical Sciences
Aims: It is known that there is a relationship between diabetic complications and chronic inflammation characterized by alterations in circulating acute phase proteins. It has been emphasized that inflammation contributes to diabetic complications and that gliclazide -an antidiabetic sulfonylurea - decreases the development of such complications. In this study, we aimed to investigate whether gliclazide or diet treatment has an effect on serum levels of acute phase reactants, markers of inflammation. Materials and Methods: Fifty-six newly diagnosed patients with type 2 diabetes and 30 clinically healthy subjects were evaluated prospectively. Twenty-six patients were treated with proper diet and daily gliclazide …
Humoral Immunity And Haemoglobin F (Hbf) Status In Steady State Adult Nigerian Sickle Cell Disease Patients With Asymptomatic Malaria, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola
Humoral Immunity And Haemoglobin F (Hbf) Status In Steady State Adult Nigerian Sickle Cell Disease Patients With Asymptomatic Malaria, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola
Turkish Journal of Medical Sciences
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a malaria endemic zone to reduce mortality. Haematology Department, University College Hospital, Ibadan, Nigeria. Materials and methods: The levels of HbF, IgG, IgA, IgM, transferin (TRF), C-reactive protein (CRP), and haptoglobin (HPT) were determined in 14 Nigerians having HbAA genotype with malaria parasitaemia (HbAA +MP), 17 Nigerians having haemoglobin AA genotype without malaria parasitaemia (HbAA -MP), 15 Nigerians having haemoglobin SS genotype without malaria parasitaemia (HbSS -MP), …
The Role Of Leukotrienes In The Pathogenesis Ofsteroid-Sensitive Nephrotic Syndrome, Sevgi Mi̇r, Afig Hüseyi̇nov, Mehmet Kantar, Caner Kabasakal, Alphan Cura, Işıl Çoker
The Role Of Leukotrienes In The Pathogenesis Ofsteroid-Sensitive Nephrotic Syndrome, Sevgi Mi̇r, Afig Hüseyi̇nov, Mehmet Kantar, Caner Kabasakal, Alphan Cura, Işıl Çoker
Turkish Journal of Medical Sciences
Endogenous leukotrienes (LT) levels in plasma and urine samples, and LT levels released from stimulated leukocytes in vitro were examined in children with steroid sensitive nephrotic syndrome (SSNS). Plasma LT concentrations were found to be higher in the SSNS group than in healthy subjects. Subjects with SSNS were also shown to have high levels of urinary cysteinyl-LTs and LTB 4 , while healthy children had only urinary LTE 4 levels. In the second part of the study, peripheral leukocytes of patients and heatlhy children were stimulated by Ca ionophore, A23187. We detected significantly higher levels of LTs in patients with …