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Full-Text Articles in Medicine and Health Sciences
Determining The Health Beliefs And Breast Cancer Fear Levels Ofwomen Regarding Mammography, Fatma Ersi̇n, Fatma Gözükara, Peri̇han Polat, Gözde Erçeti̇n, Mehmet Ekrem Bozkurt
Determining The Health Beliefs And Breast Cancer Fear Levels Ofwomen Regarding Mammography, Fatma Ersi̇n, Fatma Gözükara, Peri̇han Polat, Gözde Erçeti̇n, Mehmet Ekrem Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Women's fears and health beliefs impact their participation in early breast cancer diagnosis approaches. This study was conducted to determine the health beliefs and fear levels of women older than 50 regarding mammography. Materials and methods: A cross-sectional study was conducted in Turkey. The study cohort consisted of 300 women selected by cluster sampling who agreed to participate in the study. A health belief model scale and breast cancer fear scale were used in data collection. Descriptive statistics, t-test, chi-square test, and correlation analysis were used in the data analysis. Results: Participants had an age average of 59.88 ± …
The Relationship Between Hla-G Levels And Oxidative Stress Parameters In Patients With Breast Cancer, Sema Bozali̇oğlu, Nedret Kiliç, Zuhal Yildirim, Bi̇lkay Baştürk, Osman Kurukahveci̇oğlu
The Relationship Between Hla-G Levels And Oxidative Stress Parameters In Patients With Breast Cancer, Sema Bozali̇oğlu, Nedret Kiliç, Zuhal Yildirim, Bi̇lkay Baştürk, Osman Kurukahveci̇oğlu
Turkish Journal of Medical Sciences
To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P < 0.001). While vitamin C levels were significantly lower in the patient group (P < 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P > 0.05). Serum …
A Potential Association Between The Number Of Ca Repeats In The Promoter Region Of The Adamts9 Gene With Lymphatic Metastasis Of Breast Cancer, Mi̇kdat Bozer, Fatma Aşik, Muradi̇ye Acar, Hacer Haltaş, Si̇bel Yeni̇dünya, Meti̇n Canbal, Vehap Topçu, Muhammet Ramazan Yi̇ği̇toğlu, Mehmet Gündüz, Esra Gündüz, Satoshi Hirohata, Kadi̇r Demi̇rcan
A Potential Association Between The Number Of Ca Repeats In The Promoter Region Of The Adamts9 Gene With Lymphatic Metastasis Of Breast Cancer, Mi̇kdat Bozer, Fatma Aşik, Muradi̇ye Acar, Hacer Haltaş, Si̇bel Yeni̇dünya, Meti̇n Canbal, Vehap Topçu, Muhammet Ramazan Yi̇ği̇toğlu, Mehmet Gündüz, Esra Gündüz, Satoshi Hirohata, Kadi̇r Demi̇rcan
Turkish Journal of Medical Sciences
We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in …
Analysis Of Promoter Methylation Of Dickkopf1 (Dkk1) Gene In Breast Cancer, Muradi̇ye Acar, Tülün Çora, Hati̇ce Toy, Hasan Acar
Analysis Of Promoter Methylation Of Dickkopf1 (Dkk1) Gene In Breast Cancer, Muradi̇ye Acar, Tülün Çora, Hati̇ce Toy, Hasan Acar
Turkish Journal of Medical Sciences
Breast cancer is the most common malignancy in women worldwide. The Dickkopf1 (DKK1) gene product is a potent inhibitor of the Wnt pathway. DKK1 methylation status and its protein expression were examined in normal and cancer tissues of breast cancer patients. Materials and methods: We examined methylation changes in 83 tumor and adjacent normal tissues, and also in 9 normal breast tissues from unaffected women (no breast cancer history) as controls. DKK1 promoter methylation was assessed by methylation-specific polymerase chain reaction. Immunohistochemical staining was used to investigate DKK1 protein expression in the 9 controls and in 70 out of the …
2-[18f]-Fluoro–2-Deoxy-D-Glucose Positron Emission Tomography In The Evaluation Of Breast Lesions And Axillary Involvement: A Comparison With Mammography And Histopathological Diagnosis, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Semi̇h Görgülü, Mehmet Fati̇h Can, Hani̇fe Asli Ayan Eke, Semra İnce, Erkan Öztürk, Ramazan Yildiz, Mehmet Ali̇ Özgüven
2-[18f]-Fluoro–2-Deoxy-D-Glucose Positron Emission Tomography In The Evaluation Of Breast Lesions And Axillary Involvement: A Comparison With Mammography And Histopathological Diagnosis, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Semi̇h Görgülü, Mehmet Fati̇h Can, Hani̇fe Asli Ayan Eke, Semra İnce, Erkan Öztürk, Ramazan Yildiz, Mehmet Ali̇ Özgüven
Turkish Journal of Medical Sciences
The objective of this prospective study was to evaluate the potential role of 2-[18f]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the differentiation of malignant and benign breast masses and the evaluation of axillary lymph node involvement. The secondary objective of this study was to assess the value of FDG PET in the initial staging of patients with breast cancer. Materials and methods: We evaluated 82 lesions in 79 consecutive patients (mean age of 54.4 ± 13.0; age range: 25-82 years) with FDG PET. While ultrasounds were performed in all cases, of the 79 patients, 72 had mammography and 58 had …
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Radioimmunotherapy Of Mice Bearing Breast Tumors With ^{177}Lu-Labeled Trastuzumab, Samira Rasaneh, Hossein Rajabi, Shahram Akhlaghpoor, Shahab Sheybani
Turkish Journal of Medical Sciences
In the present study, we investigated the therapeutic efficacy of trastuzumab labeled with lutetium-177 (^{177}Lu) in mice bearing breast tumors. Materials and methods: Trastuzumab was labeled with ^{177}Lu via DOTA as a chelator. In vitro and in vivo quality control tests of incorporated activity, immunoreactivity, stability of ^{177}Lu-trastuzumab, biodistribution, and imaging studies were performed. Therapeutic efficacy and dosimetry studies were carried out in mice with breast tumors. Results: The good in vitro and in vivo quality control results suggested that ^{177}Lu-trastuzumab could be used as a radioimmunotherapy agent. Reductions of 81% and 98% in the mean tumor volume for the …
Developing And Comparing Two Different Prognostic Indexes For Predicting Disease-Free Survival Of Nonmetastatic Breast Cancer Patients, Zehra Füsun Tokatli, Mevlüt Türe, İmran Kurt Ömürlü, Ruşen Çoşar Alas, Mustafa Cem Uzal
Developing And Comparing Two Different Prognostic Indexes For Predicting Disease-Free Survival Of Nonmetastatic Breast Cancer Patients, Zehra Füsun Tokatli, Mevlüt Türe, İmran Kurt Ömürlü, Ruşen Çoşar Alas, Mustafa Cem Uzal
Turkish Journal of Medical Sciences
To determine 2 different prognostic indexes (PI) for the differentiation of subgroups of nonmetastatic breast cancer patients with the Cox regression analysis and survival tree (ST) methods and the additional usage of the Kaplan-Meier estimates to investigate the predictive power of these methods. Materials and methods: Prognostic factors data were collected for 410 patients. The Cox regression analysis examines the relationship of the survival distribution and covariates. The ST method is a tree-structured survival analysis based on a recursive partitioning algorithm. In this study, Harrell's concordance indexes of models for training and test sets were computed. Furthermore, survival curves were …
Effect Of Mechanical Closure Of Dead Space On Seroma Formation In Modified Radical Mastectomy, Ci̇hangi̇r Özaslan, Keri̇m Bora Yilmaz, Lütfi̇ Doğan, Can Atalay, Mehmet Altinok
Effect Of Mechanical Closure Of Dead Space On Seroma Formation In Modified Radical Mastectomy, Ci̇hangi̇r Özaslan, Keri̇m Bora Yilmaz, Lütfi̇ Doğan, Can Atalay, Mehmet Altinok
Turkish Journal of Medical Sciences
Seroma is an important complication of breast surgery. This study investigated the effects of fixation of the flaps and obliterating the dead space on seroma formation. Materials and methods: Patients undergoing modified radical mastectomy were separated into 2 random groups of 50 according to wound closure methods: either flap fixation/mechanical obliteration or standard wound closure group. The fluid that collected under the flaps assessed at the physical examination after the drains were removed was accepted as seroma. The patients' characteristics, duration of the operation, drainage amount, removal time of the drains, flap necroses, and infection were recorded. The groups were …
Can [F-18] Fluorodeoxyglucose Positron Emission Tomography Replace Sentinel Lymph Node Biopsy For The Detection Of Axillary Metastases In Patients With Early-Stage Breast Cancer?*, Semi̇h Görgülü, Mehmet Fati̇h Can, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Erkan Öztürk, Emel Öztürk, Müjdat Balkan, Turgut Tufan
Can [F-18] Fluorodeoxyglucose Positron Emission Tomography Replace Sentinel Lymph Node Biopsy For The Detection Of Axillary Metastases In Patients With Early-Stage Breast Cancer?*, Semi̇h Görgülü, Mehmet Fati̇h Can, Oğuz Hançerli̇oğullari, Nuri̇ Arslan, Erkan Öztürk, Emel Öztürk, Müjdat Balkan, Turgut Tufan
Turkish Journal of Medical Sciences
To investigate the value of fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting axillary involvement, and to compare its accuracy with sentinel lymph node biopsy (SLNB) in patients with clinically early-stage breast cancer. Materials and methods: Twenty-eight female patients with histologically-confirmed T1-2 breast cancer who were scheduled to have SLNB were included in the study. FDG-PET images were obtained 1-7 days prior to surgery with an intravenous injection of 370 MBq of FDG, while plasma glucose levels were maintained below 120 mg/dL. All the images were interpreted by 2 independent nuclear medicine specialists, who were blinded to the histological diagnoses. SLNB …
General Anesthesia For Cesarean Delivery Followed By Anterior And Posterior Spinal Cord Decompression Of A Parturient With Symptomatic Spinemetastasis Due To Breast Cancer, Berri̇n Günaydin, Sema Öncül, Mehmet Erdem, Memduh Kaymaz, Hakan Emmez, Zerri̇n Özköse
General Anesthesia For Cesarean Delivery Followed By Anterior And Posterior Spinal Cord Decompression Of A Parturient With Symptomatic Spinemetastasis Due To Breast Cancer, Berri̇n Günaydin, Sema Öncül, Mehmet Erdem, Memduh Kaymaz, Hakan Emmez, Zerri̇n Özköse
Turkish Journal of Medical Sciences
Cesarean delivery of a parturient suffering from paraplegia followed by anterior corpectomy and posterior spinal cord decompression because of spine metastasis at T1 due to breast cancer was presented. General anesthesia was uneventfully completed after rapid sequence anesthesia induction with propofol, ketamine, and succinylcholine, which was maintained by isoflurane inhalation in 50% oxygen-air mixture until delivery of the newborn. After delivery, remifentanil infusion was added to isoflurane inhalation in approximately 33%/66% oxygen:air until skin closure of the latter operation. Consequently, satisfactory recovery of paraplegia resulting from spine metastasis and delivery of a healthy baby were provided by successful and uneventful …
Effects Of Peer And Group Education On Knowledge, Beliefs And Breast Self-Examination Practice Among University Students In Turkey, Özgül Karayurt, Akli̇me Di̇cle, Arzu Tuna Malak
Effects Of Peer And Group Education On Knowledge, Beliefs And Breast Self-Examination Practice Among University Students In Turkey, Özgül Karayurt, Akli̇me Di̇cle, Arzu Tuna Malak
Turkish Journal of Medical Sciences
Aims: To determine the effects of peer and group education on knowledge and beliefs about breast cancer and performance of breast self–examination (BSE). Materials and Methods: The study included a total of 193 female university students, of whom 59 were assigned to peer education and 134 to group education. Data collected at baseline and after six months included sociodemographic characteristics, knowledge of breast cancer and BSE and performance of BSE forms, and Champion´s Health Belief Model Scale. Data were analyzed using the chi-square, McNemar chi-square, independent Student´s t, and paired Student´s t tests. Results: Mean knowledge scores increased from 42.08 …
A Novel Method Of Reporting C-Erbb-2 Overexpression; Correlation With Grade But Not With Other Prognostic Parameters In Breast Cancer, Mustafa Samur, Şeyda Karaveli̇, Hakan Bozcuk, Eli̇f Pestereli̇, Mustafa Özdoğan, Mustafa Yildiz, Mehmet Artaç, Burhan Savaş
A Novel Method Of Reporting C-Erbb-2 Overexpression; Correlation With Grade But Not With Other Prognostic Parameters In Breast Cancer, Mustafa Samur, Şeyda Karaveli̇, Hakan Bozcuk, Eli̇f Pestereli̇, Mustafa Özdoğan, Mustafa Yildiz, Mehmet Artaç, Burhan Savaş
Turkish Journal of Medical Sciences
Overexpression of erbB-2 protein is a marker of clinically aggressive behavior in breast cancer patients. In general erbB-2 status is reported on a scale from negative to 3+, depending on staining intensity, if more than 10% of the tumor cells are stained. However, the original definition does not take into account the percentage of stained cells in detail, since all samples score in the same way if they are above the cut-off, established at 10%. In this study, we evaluated the erB-B2 overexpression by immunohistochemistry in 169 patients and evaluated any correlation with the other well known prognostic parameters. We …
Arsenic Trioxide Has Additive Cytotoxic Effects On Mcf-7 Breast Cancer Cell Line With Taxanes, Canfeza Sezgi̇n, Ulus Ali̇ Şanli, Rüçhan Uslu, Erdem Göker
Arsenic Trioxide Has Additive Cytotoxic Effects On Mcf-7 Breast Cancer Cell Line With Taxanes, Canfeza Sezgi̇n, Ulus Ali̇ Şanli, Rüçhan Uslu, Erdem Göker
Turkish Journal of Medical Sciences
Breast cancer is the most prevalent cancer in women and an important cause of both morbidity and mortality. Although long-term disease-free survival is offered to women with early stage disease by current treatment modality, some, 30-40% of patients will have metastatic disease. Treatment of patients with metastatic disease is a great challenge for oncologists. Therefore, new drugs and therapeutic options for women with metastatic breast cancer are urgently required. Arsenical compounds have cytotoxic effects on several cancer cell lines including promyelocytic leukemia, esophageal carcinoma, megakaryocytic leukemia, and malignant lymphocytic cell lines. In addition, recent studies showed that arsenic trioxide (As_2O_3) …
Gene Therapy In Human Breast Cancer, Ogan D. Abaan, Wayne E. Criss
Gene Therapy In Human Breast Cancer, Ogan D. Abaan, Wayne E. Criss
Turkish Journal of Medical Sciences
Gene therapy, being a novel treatment for many diseases, is readily applicable for the treatment of cancer patients. Breast cancer is the most common cancer among women. There are many clinical protocols for the treatment of breast cancer, and gene therapy is now being considered within current protocols. This review will focus on the basic concepts of cancer gene therapy strategies (suicide gene, tumor suppressor gene, anti-angiogenesis, immunotherapy, oncolytic viruses and ribozyme/antisense targeting) and current approaches for breast cancer gene therapies.
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Genetic Polymorphisms In Steroid Hormone Metabolizing Enzymes In Human Breast Cancer, Nesli̇han Aygün Kocabaş
Turkish Journal of Medical Sciences
Epidemiologic studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. The evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved in hormone metabolism may be a cost effective manner in which to determine individual breast cancer susceptibility. A number of molecular epidemiologic studies have been conducted to evaluate associations between polymorphic genes involved in steroid hormone metabolism (i.e., CYP17, CYP19, CYP1A1, CYP1B1, MnSOD, COMT, and GST) that may account for a proportion of enzymatic variability. An evaluation of associations between breast cancer risk and genetic polymorphisms in enzymes involved …