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Antinociceptive, Antiinflammatory, And Antioxidant Activities Of The Ethanol Extract Of Crataegus Orientalis Leaves*, Zeynep Bor, Rana Arslan, Nurcan Bektaş, Sevda Pirildar, Ali̇ Aslan Dönmez
Antinociceptive, Antiinflammatory, And Antioxidant Activities Of The Ethanol Extract Of Crataegus Orientalis Leaves*, Zeynep Bor, Rana Arslan, Nurcan Bektaş, Sevda Pirildar, Ali̇ Aslan Dönmez
Turkish Journal of Medical Sciences
To determine the in vitro antioxidant activity and to investigate the possible antinociceptive and antiinflammatory effects of the ethanol extract of Crataegus orientalis leaves. The medicinal use of extracts prepared from the leaves, flowers, and fruits of Crataegus (hawthorn) dates back to ancient times. It has been proposed that its antioxidant constituents account for these beneficial therapeutic effects. Materials and methods: To evaluate these effects, the hot-plate, tail-immersion, writhing, and carrageenan-induced edema tests were used. Moreover, the antioxidant activity of the extract was determined using the 2,2-diphenyl-1-picrylhydrazyl and \beta-carotene-linoleic acid assay systems. In the tests that were used to determine …
Ovariectomy Decreases Biomechanical Quality Of Skin Via Oxidative Stress In Rat, Ülkü Çömelekoğlu, Serap Yalin, Ebru Balli, Mehmet Berköz
Ovariectomy Decreases Biomechanical Quality Of Skin Via Oxidative Stress In Rat, Ülkü Çömelekoğlu, Serap Yalin, Ebru Balli, Mehmet Berköz
Turkish Journal of Medical Sciences
To investigate the effect of ovariectomy on the skin using biomechanical, biochemical, and histological techniques in the ovariectomized rat model. Ovariectomy causes significant changes in the physical characteristics of the skin. Materials and methods: Twenty female Wistar albino rats were divided into 2 groups, with each group consisting of 10 rats: the control group and the ovariectomized group. The ovariectomized group underwent bilateral ovariectomy via ventral incision and the control group underwent a sham operation. Skin biomechanics were measured 3 months following the ovariectomy with a tensile test using a biomaterial testing machine, and tensile strength, stress, strain, and toughness …