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The Effect Of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole On The Cell Death Induced By Zinc Administration In The Brain Of Rats, M. Fati̇h Gökçe, Faruk Bağirici, Şeri̇f Demi̇r, M. Ömer Bostanci, Aysel Güven
The Effect Of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole On The Cell Death Induced By Zinc Administration In The Brain Of Rats, M. Fati̇h Gökçe, Faruk Bağirici, Şeri̇f Demi̇r, M. Ömer Bostanci, Aysel Güven
Turkish Journal of Medical Sciences
Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4·7H2O) treatment. Materials and Methods: Rats were divided into 3 groups (n = 21; 7 rats in each group): Control, Zinc, and Zinc+7-NI. In the Zinc and Zinc+7-NI (pretreatment) groups, ZnSO4·7H2O was applied intracortically to the left sensory motor cortex. The 7-NI (50 mg/kg) was injected into the third group (Zinc+7-NI) intraperitoneally 20 min prior to zinc application and daily for the next 7 days. Cell loss in the left and right hippocampal hemispheres was quantified …
Etofenamate And Anastomoses Of The Colon In Rats, Aydin İnan, Önder Sürgi̇t, Meral Şen, Ayhan Akpinar, Mi̇kdat Bozer
Etofenamate And Anastomoses Of The Colon In Rats, Aydin İnan, Önder Sürgi̇t, Meral Şen, Ayhan Akpinar, Mi̇kdat Bozer
Turkish Journal of Medical Sciences
Aim: Non-steroidal anti-inflammatory drugs have been used for many years due to their analgesic and anti-inflammatory properties. They have also been used for postoperative analgesia. We aimed to study the effects of etofenamate, a non-steroidal anti-inflammatory drug, on the healing of colonic anastomoses in rats. Materials and methods: Sprague-Dawley rats were used in this study. Resection and anastomosis were performed on the distal colon. The etofenamate group received 30 mg/kg etofenamate and the control group received 0.1 mL of 0.9% NaCl intramuscularly daily. Bursting pressures of anastomoses and hydroxyproline levels of perianastomotic tissues were determined on days 3 and 7. …