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Effects Of Dietary Salt On Blood Pressure, Heartrate, Extracellular Fluid Volume And Glomerularfiltration Rate In Diabetic Rats, Besi̇m Özaykan, Ayşe Doğan
Effects Of Dietary Salt On Blood Pressure, Heartrate, Extracellular Fluid Volume And Glomerularfiltration Rate In Diabetic Rats, Besi̇m Özaykan, Ayşe Doğan
Turkish Journal of Medical Sciences
In the present study, we aimed to investigate the effects of dietary salt restriction and loading on extracellular fluid volume (ECFV), blood pressure (BP), heart rate (HR), glomerular filtration rate (GFR) and renal hypertrophy in diabetic rats. Diabetes was induced by injection of streptozotocin (STZ, 65 mg/kg, iv) into male Wistar rats. Four groups were formed: a) the diabetic rats given a standard rat diet (DC), b) the diabetic rats given a high-salt diet (DHS), c) the diabetic rats given a low-salt diet (DLS), d) the nondiabetic rats given a standard rat diet (C). Salt loading and salt restriction were …