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Renal Ultrastructural Alterations Followingadministration Of Diethylstilbestrol, Bilge Onarlioğlu, Yasemin Günay, İsmihan Göze, Emel Koptagel
Renal Ultrastructural Alterations Followingadministration Of Diethylstilbestrol, Bilge Onarlioğlu, Yasemin Günay, İsmihan Göze, Emel Koptagel
Turkish Journal of Medical Sciences
Diethylstilbestrol (DES), nonsteroid in structure, is an artificial estrogen derivative and is used as an anabolic agent. It is known that diethylstilbestrol causes genetic disorders and toxic effects leading up to carcinoma even in amounts below its residual levels. For this purpose, a dose of 60µm/kg/day of DES dissolved in 0,1 ml corn oil has been administered to rats by oral gavage for varying periods of 20, 50 and 100 days periods. Rat renal tissue samples, following routine electron microscopical procedure, have been examined by transmission electron microscopy. Following diethylstilbestrol administration, glomerular capilleries seemed dilated along with occasional basement membrane …
Hüseyin Eray Bulut,Erdoğan Gürsoy, An Ultrastructural Study
Hüseyin Eray Bulut,Erdoğan Gürsoy, An Ultrastructural Study
Turkish Journal of Medical Sciences
Cryptorchidism causes a failure in testosterone secretion from the testicles. The metabolism of the adrenocortical steroids is influenced by sex hormones. Therefore testicular failure may cause structural and func-tional alterations in adrenal cortex. It is the aim of the present study to evaluate the effect of experimental caryptorchidism on the ultrastructure of the rat adrenal cortex, especialy on the reticularis region during prepubertal and postpubertal ages. Three groups of animals were used in the present study. The first (prepubertal) group consisted of 5,21-day old rats whereas the second (postpubertal) group was made of 5,3-month old rats. Third group was the …