Medicine and Health Sciences Commons^™

Investigating Vital Neutrophil Extracellular Trap Pathogen Response In Neutropenic Individuals, Ryan Illig

Thinking Matters Symposium

Neutrophils, also called polymorphonuclear leukocytes (PMNs), constitute the majority of innate immune cells. These cells possess a complex arsenal of functions that allow them to detect and eliminate a broad spectrum of pathogens. Neutropenia is characterized by decreased levels of neutrophils in the bloodstream, typically falling below the normal range. Moderate to severe neutropenia can increase the risk of pathogenic infections and without treatment can be life-threatening. Although the concentration of neutrophils in neutropenic individuals is decreased, upon activation, neutrophils still release neutrophil extracellular traps (NETs). NETs are pivotal in combating a spectrum of pathogens through their non-selective nature. Overreactive …

Increased Risk Of Mental Illness Due To Epigenetic Alteration Of The Nr3c1 Gene After Early Life Adversity., Erin Mccue

Thinking Matters Symposium

Early life adversity (ELA), such as malnutrition, abuse, and economic disparity, is an issue commonly seen in adolescents, a group already facing increased risk for stress-related disorders. This review of current literature reveals that gestational stress exposure, as well as variations in maternal care during postnatal development, cause latent effects on the epigenome, specifically impacting the glucocorticoid receptors (GRs) encoded by the NR3C1 gene. GRs bind to glucocorticoids to regulate the body’s neuroendocrine stress response. However, in those with a history of ELA, the number of GRs is reduced, generating dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis. Rodent studies are utilized …

Covid Susceptibility And Severity Correlation With The Ace2 Gene, Natalie Taylor

Thinking Matters Symposium

A wide spectrum of susceptibility and severity of infection has been observed among COVID-19 patients. While some individuals remain unaffected by the Sars-Cov-2 virus, others have contracted the virus multiple times with varying levels of severity. This poster reviews some of the research demonstrating a link between the susceptibility of the Sars-Cov- 2 virus and the severity of infection, and a specific gene called ACE2. The ACE2 gene encodes an angiotensin-converting enzyme that acts as a functional receptor for the spike glycoprotein receptor binding domain of the coronavirus and severe acute respiratory syndrome coronaviruses. ACE2 presents numerous amino acid variants …

The Effect Of Contingency Management On The Recovery Of Patients With Substance Use Disorder: A Systematic Review Of The Literature, Emily A. Gilman, Alexis Mccrossin, John R. Massey

Thinking Matters Symposium

Substance use disorder (SUD) is traditionally managed with behavioral therapy and medication. Contingency management (CM), a therapeutic method that reinforces positive behaviors with incentives, may be a useful adjuvant to enhance treatment engagement and efficacy for those who struggle with SUD. This systematic review of literature was conducted using databases CINAHL, Cochrane, and PubMed from January 2010 to July 2021. The search yielded 132 initial records. Studies were included if they were written in English, peer reviewed, and randomized control trials. Six final studies rendered results for 650 patients with varying substance use disorders including cannabis, tobacco, and opioids. Studies …

Evaluation Of Current Post-Graduate Family Nurse Practitioner Training Programs: A Qualitative Analysis, John R. Massey

Thinking Matters Symposium

Introduction: Family nurse practitioners (FNPs) are master or doctoral-level trained registered nurses that manage the care of patients in the primary care setting. FNP post-graduate training programs further prepare FNPs and ease the transition from education to practice. While FNP post-graduate training programs are emerging and remain relatively new, they are becoming more commonplace as graduates and employers alike seek further preparation to practice in the primary care setting.

Methods: Interview questions were developed using Consolidated Framework for Implementation Research (CFIR) guidelines. Participants were selected using convenience sampling. 14 semi-structured interviews with 19 key informants were conducted between …

The Effects Of Paclitaxel On Cellular Migration And The Cytoskeleton, Ashley Salguero-Gonzalez

Thinking Matters Symposium

In a clinical setting, some patients are exposed to an anti-cancer chemotherapy agent, paclitaxel. Cancerous cells undergo rapid, continuous cell division without control. Chemotherapy treatments try to slow and stop the uncontrollable cell division cycles and eliminate cancerous cells in the process. Paclitaxel serves as a treatment for some types of cancers, including lung, melanoma, bladder, and esophageal. Because it targets the cytoskeleton, paclitaxel can also influence cell migration. This project utilizes a cellular migration assay and an immunohistochemistry assay to analyze the effects of paclitaxel on the movement of cells and on the cytoskeleton of neuroglia rat cells with …

A Path For Evidenced-Based Evaluation: The Case For Restorative Justice, Raúl D. Gierbolini-Rivera, Atc,Cscs

Thinking Matters Symposium

No abstract provided.

Changes In Gene Sequence That Cause Discordances Involving Disease In Monozygotic Twins, Kacie Jacques

Thinking Matters Symposium

Identical twins or, monozygotic twins, occur when the egg in a mother is fertilized, but one zygote divides into two separate embryos. Monozygotic twins are considered to be genetically identical, but most twins often display discordances, some involving diseases or disorders. Some of these differences are due to environmental factors. For example, one twin may have diabetes due to diet. Recent literature has shown that some differences in monozygotic twins may be due to changes in gene sequence, as opposed to random, environmental or epigenetic factors. Identical twins from pedigrees with familial disease often show discordances. When looking at schizophrenia …

Importance Of Understanding Genetic Predisposition, Andrew Carter

Thinking Matters Symposium

Hypersensitivity reactions can be sudden and are often fatal. Many of these reactions occur as a result of allergies to prescribed medication. Adverse drug reactions or (ADR’s) were show in a recent study to affect over 6% of hospitalized patients and resulted in over 100,000 deaths a year in the US alone. This poster will review the importance of understanding genetic predisposition, through articles about possible genetic causes of allergies to penicillin and other beta-lactams. Changes in a specific HLA gene located on chromosome 6 showed a correlation to penicillin reactions in over 600,000 participants. Another study found a conclusive …

App Development For Wearable Sensors, Connor Pittman, Christopher Chappie, Patrick A. Tetreault

Thinking Matters Symposium

The objective of this research project was to create a wearable device that monitors bodily functions for the user to view on their smartphone. Sensor data is processed using the Arduino Nano 33 BLE microcontroller. The sensors used in this project include: proximity, temperature, humidity, heart rate, pressure, and skin impedance. This project takes advantage of the Arduino's Bluetooth low energy (BLE) capabilities so that all the data can be transmitted to a smartphone. This presentation shows the challenges faced during the project and how they were overcome. Some of these challenges include: programming, how heart rate sensors work, and …

Empowering Action Against Femicide: A Case Study Of Turkey An Integrated Literature Review, Ashley Simon

Thinking Matters Symposium

The primary purpose of this integrative literature review is to explore the relationship between culture and femicide within Turkey to empower action against femicide. Femicides within Turkey are on the rise, as a study done by Sage Journals in 2009 reported that 42% of Turkish women between the ages of 15 and 60 experienced some form of physical or sexual abuse from their husband or partner. Currently, there has been an onslaught of articles released that more and more women are being abused throughout the country during the COVID-19 pandemic. The research will explore cultural aspects that allow for women’s …

Examining The Effect Of Provider Bias On Pain Management In Black Patients: A Systematic Literature Review, John Massey, Monica Gambilado

Thinking Matters Symposium

Black Americans face unequal treatment for pain management when seeking care. The aim of this systematic literature review is to examine the impact of provider bias on Black patients receiving appropriate pain management interventions in the clinical setting. This review followed the Preferred Reporting Items for Systematic Literature Reviews and Meta-Analysis guidelines. CINAHL and PubMed were searched with the following key search terms: Black/African American, bias, prejudice, discrimination, unconscious bias, pain management, pain reduction, pain control and analgesic. A self-developed Critical Appraisal Tool was used for quality assessment of the studies included in the review. A total of 101 probable …

Clinicians Use Of Mindfulness-Based Practices During The Covid-19 Pandemic, Leah Ridley, Samuel J. Giese, Shelby Cogan, Chelsea Hughes

Thinking Matters Symposium

Alternative mental health treatments like mindfulness hold a great deal of promise, but limited research exists on their success and application with the adolescent population. This study investigates the primary research question, “What are the experiences of clinicians providing mindfulness-based treatment to school-aged children in Maine during the COVID-19 pandemic?” This explanatory mixed methods study involves a quantitative survey of clinicians, and will be followed by a virtual focus group to further unpack the value of mindfulness-based practices when working with school-aged children. Survey data will be analyzed using descriptive statistics and qualitative content analysis; focus group data will be …

Perivascular Adipose Tissue In Relation To Diet, Thermogenesis And Cardiovascular Health, Ginger Paquette, Caitlin Stieber, Ashely Soucy, Benjamin Tero, Lucy Liaw

Thinking Matters Symposium

Adipose tissue is a diverse and crucial component to vascular health due to its role in energy storage and heat production. The primary function of white adipose tissue (WAT) is energy storage while the function of mitochondria-rich brown adipose tissue (BAT) is heat production. Perivascular adipose tissue (PVAT), which surrounds blood vessels, contains both WAT and BAT adipocytes. Dietary calorie restriction is associated with increased lifespan with decreased adiposity. Increased prevalence of WAT-like PVAT, due to high-fat diets and obesity, leads to increased metabolic disfunction and cardiovascular-disease. We used a calorie-restriction model in C57BL6/J mice to test the hypothesis that …

Opioid Use And Harm Reduction, Elise Bourassa, David Lee, Jason Rogers, Christian Silverthorne

Thinking Matters Symposium

Calls for various harm reduction approaches to the opioid epidemic are increasing in activist communities (Chapkis, 2020; Kennedy-Hendricks et al., 2019; Sederer & Marino, 2018). Given that harm reduction approaches, if implemented, will be provided by people in various helping professions, the current study investigates the relationship between choice of human service-focused college major and level of support for harm reduction interventions for people who use opioid drugs. A quantitative survey that aims to measure knowledge and perceptions of harm reduction strategies has been disseminated to students in social work, counseling, public health and nursing departments at the University of …

Impact Of Group Prenatal Care On Health Outcomes For Women Of Color In The United States: A Systematic Literature Review, Morgan Brockington, Emily Bauer, Julie Kameisha

Thinking Matters Symposium

Women of color in the United States experience disproportionately higher rates of adverse pregnancy-related outcomes, both in the prenatal and postpartum period. Group prenatal care (GPC) has been gaining popularity in recent years and has demonstrated improved health outcomes. The aim of this systematic literature review was to examine and summarize the impact of group prenatal care on health outcomes for women of color in the United States. Using a systematic approach and PRISMA guidelines, two electronic databases—CINAHL and PubMed—were used to search the literature. Quantitative research studies that were published in peer-reviewed journals between 2010 and 2020, written in …

The Impacts Of Social Media Sites Such As Instagram And Facebook On Emerging Adult’S Perceptions Of Self-Esteem And Body Satisfaction, Wynne Cushing, Samantha Shandorf, Courtney Piccirillo, Abby Frazier

Thinking Matters Symposium

This study investigated the impacts of social media use, specifically Facebook and Instagram, on emerging adults’ perceptions of self-esteem and body satisfaction. Limited research exists regarding the influence of demographic variables, such as gender, race, and geographic location, on the relationship between social media use and negative outcome variables. The researchers utilized a cross-sectional survey design with a target population of University of Southern Maine students. Researchers hypothesize that emerging adults who spend more time on Facebook and Instagram are more likely to have lower self-esteem and body satisfaction than emerging adults who spend little to no time on Facebook …

Inherited Bone-Marrow Failure Syndrome, James Joseph

Thinking Matters Symposium

The inherited bone marrow failure syndromes are heterogeneous group of rare genetic disorders characterized by bone marrow failure, congenital anomalies, and cancer predisposition. This includes disorders associated with pancytopenia, such as fanconi anemia and dyskeratosis congenita, as well as disorders with predominantly, but not exclusively, single lineage cytopenias. These syndromes are associated with mutations in 33 genes, and this has led to further understanding of hematopoiesis and how this is disrupted in patients with bone marrow failure. Other fundamental biological pathways were examined in patients, such as the DNA repair-fa/BRCA pathway. Fanconi anemia/ BRCA is a human tumor suppressor gene …

Educator Wellbeing During Covid-19: Caregivers Vs. Non-Caregivers, Elizabeth Larsen, Judy Gagnon, Yana Davis, Nicole Hudson

Thinking Matters Symposium

The phenomenon of the COVID-19 pandemic has dramatically changed the format of public education, putting stress on the educational system and its teachers. This research study aims to understand the impact of COVID-19 on the role of teachers in Maine, specifically focusing on the added responsibility that parents may experience while simultaneously meeting professional obligations. Researchers posed the question: “What is the relationship between caregiving responsibilities and emotional wellbeing of teachers during the COVID-19 pandemic among public school teachers in Maine?” Participants from K-12 public schools around the state were recruited through direct contact or via building administrators who distributed …

The Impact Of Female Sport Coaches: Role Models For The Next Generatio, Molly Wilkie

Thinking Matters Symposium

Gender equity in higher education settings, such as academic faculty and admission to graduate schools in medical and STEM fields has been well researched (Ceci & Williams, 2011; Cheryan, 2011; Moss & Racusin, 2012). Based on this previous research, there is a pattern of implicit bias towards female applicants for professorships, as well as admissions to graduate and research positions that results in an imbalance of men and women in these positions. However, less research has been conducted on the gender inequities that exist in another area of higher education, collegiate athletics. The purpose of this project is to identify …