Medicine and Health Sciences Commons^™

Investigating The Impact Of Nonlinguistic Cognitive Reserve On Naming Pre- And Post-Treatment, Lillian Jarold

Theses and Dissertations

Background: The relationship between linguistic and nonlinguistic cognition in persons with aphasia is complex and often debated in the literature. Furthermore, the impact of nonlinguistic cognition on aphasia treatment outcomes is unclear. The present study sought 1) to examine the relationship between WAIS scores and performance on a test of naming and 2) to examine the relationship between WAIS scores and change scores on a test of naming between baseline and post-treatment in persons with chronic aphasia.

Method: This retrospective study utilized data from participants (N=102) who were recruited for a multi-center cross-over trial (POLAR: Predicting Outcomes of Language Rehabilitation). …

Feasibility And Preliminary Outcomes Of A 6-Week Mindful Walking Program To Maintain And Improve Cognition In Adults At Risk For Alzheimer’S Disease Or Other Related Dementias, Caroline Mannion Wood

Theses and Dissertations

The present study examined the impact of a 6-week Mindful Walking intervention. Participants completed 30 minute walking sessions twice a week for 6 weeks. Ten older adults attended 100% of the supervised walking sessions. Pre-post comparison of the Montreal Cognitive Assessment and examination of subtests of the Montreal Cognitive Assessment did not reveal a significant change in mean scores (p.05, one-tailed). The number of steps accumulated as a result of Mindful Walking and other activities measured with the ActivPAL and change in MoCA total scores did not reach significance. Generally, the Mindful Walking program was well-liked (4 on a scale …

The Relationship Between Perceptions Of Vocal Quality And Function With Self-Esteem In Older Adults, Victoria Berto

Theses and Dissertations

Alterations to the voice that occur in older adulthood include changes in vocal fold mass, inadequate approximation of the vocal folds, tremor, and air loss (Lundy, Silva, Casiano, Lu, & Xue, 1998). Many of the vocal changes that occur in older adults, those aged 65 and older (Colby & Ortman, 2015), may affect their social and emotional well-being. While some persons are not affected by life span vocal changes, others suffer from co-occuring depression, anxiety, and social withdrawal (Epstein, Hirani, Stygall, & Newman, 2009; Mirza, Ruiz, Baum, & Staab, 2003; Monini, Filippi, Baldini, & Barbara, 2015). There have been numerous …

The Cognitive And Functional Impact Of Open Heart Surgery: A Pilot Study Including Three Common Procedures (Coronary Artery Bypass Graft, Heart Valve Replacement, And Left Ventricular Assist Device), Robert Fix

Theses and Dissertations

This study investigated the impact of open heart surgery (Coronary Artery Bypass Graft, Heart Valve Replacement, or Left Ventricular Assist Device placement) on cognition, functional performance, and mood in the three months following surgery. The Montreal Cognitive Assessment (MoCA), Kettle Test (KT), Physical Self Maintenance Scale (PSMS), and Hospital Anxiety and Depression Scale (HD) measured global cognition, functional cognition, functional performance, and mood states, respectively.

Thirteen male participants (ages 38 – 75) completed assessments at four time points -- when they were scheduled for surgery, within one week prior to surgery, before hospital discharge after surgery, and three months after …

The Impact Of Chemotherapy And Radiotherapy For Breast Cancer On Cognition And Functional Performance: A Comparative Analysis Of Survey Data Taken At Three Time Points Post-Treatment, Ann Marie Potter

Theses and Dissertations

Cognitive impairment related to treatment for breast cancer, affects as many as 75% of patients in study samples (Jansen, Cooper, Dodd & Miaskowski, 2011). Deficits in the cognitive domains of short-term memory, attention, speed of information processing, judgment, reasoning, spatial attention, and verbal memory have been documented. The extent to which these deficits impact functional performance within this population has not yet been quantified. The purpose of this study was to investigate the impact of breast cancer on self-reported cognition and functional performance in the six months post-completion in two groups of breast cancer survivors, a chemotherapy group and chemotherapy …

Age Related Decline In Memory: Examining The Mediation Effect Of Processing, Executive Functioning And Intelligence In Normal Adults, Jada J. Stewart

Theses and Dissertations

Multiple mediation analyses that collectively examine the prominent theories of cognitive aging (i.e., Common Cause, Processing, and Executive Decline Hypotheses) along with other cognitive domains that are sensitive to aging are rare. Moreover, having identified that cognition begins to decline as early as 30 years old, few studies have examined the mechanisms that underlie memory change among younger aging individuals. As a result, it is unclear whether relevant mediating variables have been excluded from early research on age-related memory decline, or to what extent rehabilitative strategies are applicable as early interventions for maintaining cognitive functioning into late life.

The present …

On The Binding Of N1-Substituted Tryptamines At H5-Ht6 Receptors, Abner Nyamwaro Nyandege

Theses and Dissertations

Serotonin was first discovered in the late 1940s as a vasotonic factor and is now considered a principal neurotransmitter in the nervous system. 5-HT6 receptors are one of the most recently identified members of the serotonin receptor family which consists of seven classes (5-HT1-5-HT7). 5-HT6 receptors are G-protein coupled, positively coupled to an adenylate cyclase second messenger system and are primarily found in the central nervous system (CNS). The exact functional role of 5-HT6 receptors has not been determined, but is implicated to have possible involvement in certain neuropsychiatric disorders and cognition. To investigate the functional role of these receptors, …

Factors Influencing Health Status In Community-Dwelling Older Adults, Janet Jestina Byam-Williams

Theses and Dissertations

This descriptive, correlational study was based on Pender's Health Promotion Model (Pender, Murdaugh, & Parsons, 2002). The purpose was to examine factors influencing health status in community-dwelling, older white and black adults. The following research question was addressed by the study: What are the relationships among the individual characteristics (age, gender, race, education, and income); the behavior-specific cognitions and affect (perceived self-efficacy, perceived barriers, and interpersonal influences); and the behavioral outcomes (health-promoting behaviors), and health status in community-dwelling whites and blacks 65 years of age and older? The convenience sample of 113 participants from four congregate meal sites in Central …

Effect Of Repeated Dosing Of Delta 9-Tetrahydrocannabinol, The Major Psychoactive Ingredient Of Marijuana, On Memory In Mice, Floride Niyuhire

Theses and Dissertations

Purpose: Marijuana is the most widely used illicit drug in the United States. However, marijuana and cannabinoid derivatives have potential therapeutic uses. Studies in cannabis users have yielded contradictory results with regard to long-term effects on cognitive functions. There is no prospective study assessing this issue, and such studies may raise ethical issues in humans, whereas mice have been shown to exhibit similar cannabinoid-mediated behaviors as humans. The purpose of this study was to assess the consequences of chronic administration of Δ9-THC, the major psychoactive component of marijuana, in a mouse memory model. Methods: In Experiment 1, the dose-response relationship …