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Research outputs 2022 to 2026

Articles 211 - 240 of 2205

Full-Text Articles in Medicine and Health Sciences

The Gut Microbiome Mediates The Association Between A Flavonoid-Rich Diet And Masld In A Population-Level Analysis, William Bell, Amy Jennings, Nicola P. Bondonno, Andre Franke, Corinna Bang, Marcus Both, Jan Kassubek, Hans Peter Müller, Jan Borggrefe, Wolfgang Lieb, Tilman Kühn, Aedín Cassidy Jan 2026

The Gut Microbiome Mediates The Association Between A Flavonoid-Rich Diet And Masld In A Population-Level Analysis, William Bell, Amy Jennings, Nicola P. Bondonno, Andre Franke, Corinna Bang, Marcus Both, Jan Kassubek, Hans Peter Müller, Jan Borggrefe, Wolfgang Lieb, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Purpose: A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome. Methods: In a cross-sectional analysis (n = 531), using the FlavoDiet score …

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Alcohol Advertising At The Beach: Insights From Young People In Western Australia, Renee N. Carey, Gemma Crawford, Nicola D'Orazio, Gina S.A. Trapp, Lauren Nimmo, Tina Lam, Jonine Jancey, Justine E. Leavy Jan 2026

Alcohol Advertising At The Beach: Insights From Young People In Western Australia, Renee N. Carey, Gemma Crawford, Nicola D'Orazio, Gina S.A. Trapp, Lauren Nimmo, Tina Lam, Jonine Jancey, Justine E. Leavy

Research outputs 2022 to 2026

Background: Advertising and marketing by the alcohol industry serve to normalise alcohol use, with exposure to alcohol advertising linked to earlier and riskier drinking among young people. Advertising that portrays alcohol use in and around waterways is of particular concern, with one in five fatal drownings being associated with alcohol. Objective: This study aimed to explore the types of alcohol advertising that young people were exposed to, and to determine whether exposure to alcohol advertising was related to their alcohol use in aquatic environments. Methods: We surveyed 102 young people aged 18 to 25 years attending a free event at …

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Under-Five Mortality Estimation Methods: A Methodological Systematic Review, Bereket Kefale, Jonine Jancey, Amanuel T. Gebremedhin, Daniel Gashaneh Belay, Gavin Pereira, Gizachew A. Tessema Jan 2026

Under-Five Mortality Estimation Methods: A Methodological Systematic Review, Bereket Kefale, Jonine Jancey, Amanuel T. Gebremedhin, Daniel Gashaneh Belay, Gavin Pereira, Gizachew A. Tessema

Research outputs 2022 to 2026

Purpose This methodological systematic review aimed to identify and synthesise the existing under-five mortality (U5M) estimation methods globally. Methods We searched seven databases including Medline, Embase, Scopus, Web of Science, CINAHL, Global Health, and ProQuest Central, as well as grey literature sources from inception to September 25, 2025. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023465476). Results Fifty-six studies were included in this review. The most frequently employed child mortality estimation method was the indirect method (n = 16), followed by the Global Burden of Disease (GBD) study method (n = 12) …

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Tea And Coffee Intakes, Copd, Adult Asthma, And Lung Function In The Uk Biobank, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Alysha S. Thompson, Amy Jennings, Kevin Murray, Howraman Meteran, Jonathan Hodgson, Tilman Kühn, Aedín Cassidy Jan 2026

Tea And Coffee Intakes, Copd, Adult Asthma, And Lung Function In The Uk Biobank, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Alysha S. Thompson, Amy Jennings, Kevin Murray, Howraman Meteran, Jonathan Hodgson, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Introduction: Previous studies suggest non-linear associations between tea and coffee intake and respiratory health, with lower risks at low-to-moderate intakes but higher, unexplored risks at high intakes. This study aims to investigate associations between tea and coffee intake and the risk of chronic obstructive pulmonary disease (COPD) and adult-onset asthma. Methods: Among 366 869 participants of the UK Biobank, intakes of tea and coffee were derived from both a food frequency questionnaire and from repeated 24 hour diet assessments. Cross-sectional associations with measures of lung function [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC] and …

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Association Of Sarcopenic Obesity With Dementia Risk In A Cohort Of Older Women, Zhongyang Guan, Blossom C.M. Stephan, Lorenzo M. Donini, Joshua R. Lewis, Carla M. Prado, Richard L. Prince, David Scott, Kun Zhu, Marc Sim, Mario Siervo Jan 2026

Association Of Sarcopenic Obesity With Dementia Risk In A Cohort Of Older Women, Zhongyang Guan, Blossom C.M. Stephan, Lorenzo M. Donini, Joshua R. Lewis, Carla M. Prado, Richard L. Prince, David Scott, Kun Zhu, Marc Sim, Mario Siervo

Research outputs 2022 to 2026

Background and aims: Longitudinal studies have explored the association between sarcopenic obesity (SO) and the risk of cognitive impairment, yet findings remain mixed. This study aimed to investigate the associations of SO with risk of incident dementia in older women, using two diagnostic models: the Sarcopenic Obesity Global Leadership Initiative (SOGLI) and the load-capacity model. Methods: We analysed data from 900 community-dwelling women (aged ≥70 years). SO was defined using two models: (1) the SOGLI criteria, based on low handgrip strength (HGS), low appendicular lean soft tissue to body weight (ALST/W) ratio, and high fat mass percentage (%FM); and (2) …

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Addressing Professional Tensions Through Intellectual Candour And Stewardship, Thoughtful Dialoguing As A Duoethnographic Collaborative Exploration, Sarah Barradell, Narelle Lemon Jan 2026

Addressing Professional Tensions Through Intellectual Candour And Stewardship, Thoughtful Dialoguing As A Duoethnographic Collaborative Exploration, Sarah Barradell, Narelle Lemon

Research outputs 2022 to 2026

Using duoethnography, we explore our experiences of physiotherapy practice and education and argue that the profession’s desire for credibility is at the expense of vulnerability, risk and intellectual candour–of imagining the profession and education of its graduates differently. We identified key themes around: alignment/misalignment, reflection/reflexivity and professional scope. This methodology models risk and questioning through the juxtaposition of different perspectives. Through our contrasting narratives, we remain open to new forms of learning, modelling what intellectual candour demands from us: facing the problems of the past so that we might learn from our history and change our future. This can be …

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Effect Of Caffeine Ingestion On Cycling Performance: A Systematic Review And Meta-Analysis, Jinyan Wu, Kai Xu, Mingyue Yin, Xianming Ding, Tong Wang, Qiubo Zhang, Xiaowei Wu, Ningkun Xiao Jan 2026

Effect Of Caffeine Ingestion On Cycling Performance: A Systematic Review And Meta-Analysis, Jinyan Wu, Kai Xu, Mingyue Yin, Xianming Ding, Tong Wang, Qiubo Zhang, Xiaowei Wu, Ningkun Xiao

Research outputs 2022 to 2026

This study aimed to determine the effects of acute caffeine ingestion on cycling performance through a systematic review and meta-analysis, while also exploring the moderating roles of caffeine dosage, training status, and athlete age. A comprehensive search was conducted across five databases, yielding 20 eligible studies with a total of 226 participants. A three-level mixed-effects model was applied to pool main effects on cycling time trial performance, mean power output, mean heart rate, and ratings of perceived exertion (RPE). Subgroup analyses and meta-regression were performed to examine potential moderators. Caffeine intake significantly reduced cycling completion time (SMD = −0.36, 95% …

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Effects Of Recreational Football On Body Composition, Cardiometabolic Health, And Functional Performance In Children And Adolescents: A Systematic Review And Meta-Analysis, Yanzhao Lei, Yanmei Ding, Bo Wang, Hengzhi Deng, Mingyue Yin, Kai Xu, Hengxian Liu, Meiling Tao, Yanfeng Li, Yilin Zhang, Yuhang Liu, Fanhao Meng, Hansen Li, Xing Zhang, Bitai Wu Jan 2026

Effects Of Recreational Football On Body Composition, Cardiometabolic Health, And Functional Performance In Children And Adolescents: A Systematic Review And Meta-Analysis, Yanzhao Lei, Yanmei Ding, Bo Wang, Hengzhi Deng, Mingyue Yin, Kai Xu, Hengxian Liu, Meiling Tao, Yanfeng Li, Yilin Zhang, Yuhang Liu, Fanhao Meng, Hansen Li, Xing Zhang, Bitai Wu

Research outputs 2022 to 2026

Purpose: The systematic review and meta-analysis aimed to evaluate the effects of recreational football on body composition, cardiometabolic health, and functional performance in children and adolescents. Additionally, it explored potential moderators through subgroup analyses. Methods: A systematic search was conducted in six databases in May 2025. A random-effects model was employed for the meta-analysis, and effect sizes were reported as standardized mean differences (SMD, Hedges’ g). Subgroup and sensitivity analyses were conducted to examine sources of heterogeneity. Results: A total of 20 studies (N = 2,906; age range: 8–17 years) were included. Of the participants, 1,524 (52.44%) were male, 1,174 …

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Fall Prevention Strategies And Fall-Related Outcome Measures Used For Inpatients In Mental Health Settings: A Scoping Review, Min Zhang, Gideon Di Ji, Irene Ngune, Khairul Dzakirin Bin Rusli, Maggie Zgambo, Rosemary Saunders, Seng Giap Marcus Ang Jan 2026

Fall Prevention Strategies And Fall-Related Outcome Measures Used For Inpatients In Mental Health Settings: A Scoping Review, Min Zhang, Gideon Di Ji, Irene Ngune, Khairul Dzakirin Bin Rusli, Maggie Zgambo, Rosemary Saunders, Seng Giap Marcus Ang

Research outputs 2022 to 2026

Introduction Patients in mental health settings are at risk of falling and sustaining injury due to the unique risk factors related to their mental illness and its accompanied treatment. Objective To examine the literature on the fall prevention strategies used, and fall-related outcome measures reported for inpatients in mental health settings. Methods A literature search was conducted using Medline, CINAHL, PsycINFO, Web of Science, Scopus and sources from the Grey Literatures. Peer-reviewed research studies that examined fall prevention strategies for inpatients in mental health settings were included. The fall prevention strategies and fall-related outcome measures were extracted and grouped using …

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Can Dual-Task High-Velocity Exercise Training Improve Cognitive Function In Older Adults? Secondary Analysis Of An 18-Month Cluster Randomized Controlled Trial, Jamie L. Tait, Rachel L. Duckham, Timo Rantalainen, Catherine M. Milte, Luana C. Main, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Gavin Abbott, Robin M. Daly Jan 2026

Can Dual-Task High-Velocity Exercise Training Improve Cognitive Function In Older Adults? Secondary Analysis Of An 18-Month Cluster Randomized Controlled Trial, Jamie L. Tait, Rachel L. Duckham, Timo Rantalainen, Catherine M. Milte, Luana C. Main, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Gavin Abbott, Robin M. Daly

Research outputs 2022 to 2026

Background Identifying strategies to mitigate age-associated cognitive decline is crucial. High-velocity power training enhances physical function in older adults and cognitive training has mixed cognitive benefits, however the combined effects of these interventions remain uncertain. Objective This 18-month cluster randomized controlled trial investigated whether dual-task functional power training (DT-FPT) enhances cognition in older adults and assessed if responses differ by apolipoprotein-E and brain-derived neurotrophic factor (BDNF) polymorphisms. Subjects and Methods Twenty-two independent-living retirement communities (300 residents, ≥65y at increased falls risk) were randomized to 12-months of group-based DT-FPT (6-months supervised +6-months maintenance, 45–60 minutes, 2/week) performed simultaneously with cognitive and/or …

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Exploring The Mechanisms Of Tanshinone Iia In The Treatment Of Intracranial Aneurysm Based On Network Pharmacology And Machine Learning, Wanqi Wang, Lois Balmer, Shaotao Weng Jan 2026

Exploring The Mechanisms Of Tanshinone Iia In The Treatment Of Intracranial Aneurysm Based On Network Pharmacology And Machine Learning, Wanqi Wang, Lois Balmer, Shaotao Weng

Research outputs 2022 to 2026

Background Intracranial aneurysm (IA) is a cerebrovascular disease with high mortality and limited treatment options. Tanshinone IIA (Tan IIA), a bioactive compound from Salvia miltiorrhiza , has shown vascular protective effects, but its mechanism in the treatment of IA remains unclear. Methods The GSE75436 dataset was used to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was performed to identify disease-related modules. IA targets were obtained from GeneCards and the Comparative Toxicogenomics Database (CTD). Potential targets of Tan IIA were predicted using TCMSP, SwissTargetPrediction, and SymMap. KEGG enrichment analysis was conducted for DEGs, WGCNA modules, disease-related genes, …

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Functional Data Analysis Of Vertical Barbell Acceleration During The Pull Of The Power Clean, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, G. Gregory Haff Jan 2026

Functional Data Analysis Of Vertical Barbell Acceleration During The Pull Of The Power Clean, Tsuyoshi Nagatani, Shayne Vial, Kristina L. Kendall, Paul Comfort, G. Gregory Haff

Research outputs 2022 to 2026

The purpose of this study was to examine the relationship between vertical barbell acceleration patterns and power clean performance. Thirty strength-power athletes performed a one repetition maximum (1RM) power clean test, recording vertical barbell acceleration data from their heaviest successful lifts. This data was then analysed using functional principal component (fPC) analysis methods. Three vertical barbell acceleration patterns were extracted, with each primarily reflecting variations in the magnitude of vertical barbell acceleration during the second pull (fPC1), the transition (fPC2), and the first pull (fPC3). Additionally, two fPCs were extracted from displacement fields, which explain timing variations in barbell acceleration …

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Gut Microbial Composition And Short-Chain Fatty Acid Metabolism In Cognitively Unimpaired Adults Stratified By Amyloid-Β Status, D. M.Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, Stephanie R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M.A.D.Binosha Fernando Jan 2026

Gut Microbial Composition And Short-Chain Fatty Acid Metabolism In Cognitively Unimpaired Adults Stratified By Amyloid-Β Status, D. M.Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, Stephanie R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Short-chain fatty acids (SCFAs) produced by gut microbial fermentation influence host metabolism and neuroinflammatory processes implicated in Alzheimer’s disease (AD). However, the relationship between fecal SCFAs, microbial taxa, and cerebral amyloid-β (Aβ) burden in cognitively unimpaired individuals remains unclear. Fecal SCFAs were quantified using GC-MS, and microbial species were profiled by shotgun metagenomics in 87 participants. Associations between SCFAs, demographics, APOE ε4 status, and Aβ burden were tested using nonparametric statistics and multivariable regression. Microbial–SCFA links were evaluated using Spearman correlations and multivariate ordinations, with mediation analysis exploring potential indirect pathways. Acetate was the predominant SCFA and demonstrated the most …

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Paternal Age Is Associated With Offspring Bone Health—But Not Soft Tissue Composition Or Fracture: The Vitamin D In Pregnancy Study, Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Marc Sim, Sarah M. Hosking, John D. Wark, Natalie K. Hyde Jan 2026

Paternal Age Is Associated With Offspring Bone Health—But Not Soft Tissue Composition Or Fracture: The Vitamin D In Pregnancy Study, Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Marc Sim, Sarah M. Hosking, John D. Wark, Natalie K. Hyde

Research outputs 2022 to 2026

Summary: Emerging evidence suggests that paternal health may be associated with offspring later life heath. In this study, advanced paternal age at childbirth was associated with poorer offspring bone mineral density and content at age 11 years. These findings suggest that paternal age may impact childhood musculoskeletal development, warranting further investigation. Introduction: Maternal health during pregnancy is known to impact offspring’s later life health. However, emerging evidence suggests that paternal factors may also be important. Advanced paternal age is associated with poorer offspring outcomes, yet few studies assess musculoskeletal outcomes. This study investigated the association between paternal age at childbirth …

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Glycomedicine: Unveiling The Paracentral Dogma, Wei Wang, Gordan Lauc Jan 2026

Glycomedicine: Unveiling The Paracentral Dogma, Wei Wang, Gordan Lauc

Research outputs 2022 to 2026

No abstract provided.

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Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen Jan 2026

Optimising Vaginal Microbiome Profiling For Clinical Translation: A Comparative Assessment Of Sample Storage Methods And A Vagina-Specific 16s Rrna Gene Database, Alishum Ali, Jeffrey A. Keelan, Blagica Penova-Veselinovic, Morten E. Allentoft, Michael Bunce, Claus T. Christophersen

Research outputs 2022 to 2026

Vaginal microbiome composition has been linked to risk of preterm birth (PTB), a persistent global health challenge. 16S rRNA microbial profiling has identified specific vaginal community state types (CSTs) that have been associated with PTB risk. Diagnostic profiling requires standardised pre-analytical protocols. We evaluated two storage methods and validated a curated, vagina-specific 16S rRNA gene database (VagDB) to enhance annotation. Paired Copan FLOQ swabs from 22 women at high PTB risk were processed for either (a) dry/immediate freezing or (b) Amies-stabilisation/refrigeration. Amplicon sequence variants were generated via 16S rRNA gene (V4) PCR and Illumina sequencing. We assessed diversity, composition, and …

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Prevalence Of Dementia In Selected Middle East And North Africa (Mena) Countries: A Systematic Review And Meta-Analysis, Mohsen Sedighi, Mohammad Hasan Shahabi, Alireza Amanollahi, Khurshid Alam, Soudabeh Shemehsavar, Zahra Shirzadi, Serena Sabatini, Ahmad R. Khatoonabadi, Matthew Prina, Akram A. Hosseini, Claire V. Burley, Jennifer Dunne, Simin Mahinrad, Iman Dajani, Ralph N. Martins, Blossom C.M. Stephan, Ali Chaari, Hamid R. Sohrabi Jan 2026

Prevalence Of Dementia In Selected Middle East And North Africa (Mena) Countries: A Systematic Review And Meta-Analysis, Mohsen Sedighi, Mohammad Hasan Shahabi, Alireza Amanollahi, Khurshid Alam, Soudabeh Shemehsavar, Zahra Shirzadi, Serena Sabatini, Ahmad R. Khatoonabadi, Matthew Prina, Akram A. Hosseini, Claire V. Burley, Jennifer Dunne, Simin Mahinrad, Iman Dajani, Ralph N. Martins, Blossom C.M. Stephan, Ali Chaari, Hamid R. Sohrabi

Research outputs 2022 to 2026

Data on dementia epidemiology in the Middle East and North Africa (MENA) region is limited. This systematic review and meta-analysis examined dementia prevalence across MENA. Databases were searched up to October 2024. Analyses were stratified by country and sex. Pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI). Fifty-two studies on the selected countries met inclusion criteria, covering 87,219 individuals with dementia from a total population of 1,045,908. The pooled prevalence was 12.16% (95% CI: 9.61–14.96) for the region and the Israel had the highest prevalence (17.00%), followed by Iran (13.20%), Turkey (11.40%), Saudi Arabia …

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The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman Jan 2026

The Effectiveness Of Virtual Reality Aggression And Violence De-Escalation Training For Nursing And Midwifery Students: A Quasi-Experimental Study, Joshua Johnson, Brennen Mills, Luke Hopper, Sara Hansen, Kelley Mumford, Renju Joseph, Susan Philip, Gina Kruger, Abdi D. Osman

Research outputs 2022 to 2026

Background: Nursing students experience substantial exposure to aggression and violence while attending clinical placement. De-escalation training can effectively prepare students for aggressive encounters, yet is resource-intensive to deliver. Immersive virtual reality (VR) may improve training accessibility for nursing students. Aim: To evaluate the effectiveness of a VR de-escalation training program to improve nursing students’ confidence in managing patient aggression and its perceived usability. Methods: This study utilized a single-group quasi-experimental pre-/post-test design. Undergraduate Australian nursing students (n = 221) completed a VR de-escalation training program, providing pre-/postintervention self-reported confidence in coping with patient aggression, system usability, and motion sickness data. …

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Rapid Decentralized Prostate Cancer Risk Stratification By Portable Liquid Biopsy Analysis Within A Clinical Biosensor Validation Framework, Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke-Lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau Jan 2026

Rapid Decentralized Prostate Cancer Risk Stratification By Portable Liquid Biopsy Analysis Within A Clinical Biosensor Validation Framework, Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke-Lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau

Research outputs 2022 to 2026

Clinical liquid biopsy (e.g., blood or urine) specimens, as a minimally invasive source of crucial molecular information, continue to grow in importance for efficacious targeted cancer treatment. Yet, current molecular profiling technologies are still confined to centralized laboratory testing, which escalates testing costs, result turnaround time, and patient anxiety. Crucially, there is also a scarcity of purposeful clinical validation studies to rigorously evaluate emerging liquid biopsy technologies from research settings to facilitate clinical translation. Here, we report liquid biopsy biosensor advancements in achieving rapid, accurate, and decentralized molecular profiling of a clinically accredited prostate cancer (PCa) urinary circulating RNA biomarker …

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The Proposed Impact And Anticipated Barriers Of Establishing Food Action Groups In Rural, Regional, And Remote Western Australia, Stephanie L. Godrich, Jess Doe, Sarah Goodwin, Melissa Stoneham, Amanda Devine Jan 2026

The Proposed Impact And Anticipated Barriers Of Establishing Food Action Groups In Rural, Regional, And Remote Western Australia, Stephanie L. Godrich, Jess Doe, Sarah Goodwin, Melissa Stoneham, Amanda Devine

Research outputs 2022 to 2026

Objective: To identify Food Action Groups’ activities that positively impact local food systems, and anticipated barriers to establishing Food Action Groups in rural, regional, and remote Western Australia. Design: This qualitative study employed a phenomenological approach. Nineteen focus groups were conducted. Setting: Rural, regional, and remote Western Australia locations, including 11 towns across 8 regions. Participants: A total of 92 participants (61 interest holders and 31 community members). Analysis: A thematic analysis was undertaken. Results: Priority activities included government advocacy to support local commercial food production, processing, and sales; retain food within its region of origin; and home and community …

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Adjuvant Pembrolizumab For Stage Iib Or Iic Melanoma: A Secondary Analysis Of A Randomized Clinical Trial, Sancy A. Leachman, Jason J. Luke, Paolo A. Ascierto, Georgina V. Long, Muhammad Khattak, Piotr Rutkowski, Zhi Jin Xu, Mizuho Fukunaga-Kalabis, Clemens Krepler, Alexander M.M. Eggermont, Dirk Schadendorf Jan 2026

Adjuvant Pembrolizumab For Stage Iib Or Iic Melanoma: A Secondary Analysis Of A Randomized Clinical Trial, Sancy A. Leachman, Jason J. Luke, Paolo A. Ascierto, Georgina V. Long, Muhammad Khattak, Piotr Rutkowski, Zhi Jin Xu, Mizuho Fukunaga-Kalabis, Clemens Krepler, Alexander M.M. Eggermont, Dirk Schadendorf

Research outputs 2022 to 2026

Importance Patients with melanoma are at risk of developing subsequent cutaneous malignant neoplasms, and the effect of prior immunotherapy is unknown. Objective To analyze new skin cancers in participants with high-risk stage II melanoma treated with adjuvant pembrolizumab or placebo. Design, Setting, and Participants The multicenter double-blind, phase 3 KEYNOTE-716 randomized clinical trial enrolled 976 participants 12 years or older with completely resected stage IIB or IIC cutaneous melanoma between September 23, 2018, and November 4, 2020. Follow-up was completed on February 16, 2024. This analysis was not prespecified in the trial protocol. Interventions Participants were randomly assigned to receive …

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Aerobic Exercise Increases Brain-Derived Neurotrophic Factor (Bdnf) In Sub-Acute Stroke: A Randomized Controlled Trial, Christopher P. Mackay, Suzanne Kuys, Mia Schaumberg, Li Ann Leow, Sandy Brauer Jan 2026

Aerobic Exercise Increases Brain-Derived Neurotrophic Factor (Bdnf) In Sub-Acute Stroke: A Randomized Controlled Trial, Christopher P. Mackay, Suzanne Kuys, Mia Schaumberg, Li Ann Leow, Sandy Brauer

Research outputs 2022 to 2026

Background: Brain-derived neurotrophic factor (BDNF) is a key neurotrophin due to its role in neuron process outgrowth, plasticity, and neuronal survival. Aerobic exercise can induce BDNF release and may ultimately maximize post-stroke recovery. Objectives: This study aimed to determine if a program of moderate-to-high-intensity aerobic exercise increased concentrations of BDNF in subacute stroke survivors compared to usual care. Methods: A parallel-group, RCT was undertaken in people with subacute stroke undergoing rehabilitation. Participants were randomly allocated to usual care (control group) or usual care plus an 8-week program of moderate-high intensity treadmill walking (3 x 30 min sessions per week) (experimental …

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Developing Consumer Consensus On Remote Assessment And Management Of Physical Function In Older Adults (Ramp): International Modified Delphi Process, Elsa Dent, Christopher Hurst, Jack Dalla Via, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Gary Skinner, Marc Sim, Mylene Aubertin-Leheudre, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Jennifer R.A. Jones, Pauline Kelly, Robert Kob, Suzanne N. Morin, Girish Nandakumar, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Vina P.S. Tan, Rosanna Tran Jan 2026

Developing Consumer Consensus On Remote Assessment And Management Of Physical Function In Older Adults (Ramp): International Modified Delphi Process, Elsa Dent, Christopher Hurst, Jack Dalla Via, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Gary Skinner, Marc Sim, Mylene Aubertin-Leheudre, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Jennifer R.A. Jones, Pauline Kelly, Robert Kob, Suzanne N. Morin, Girish Nandakumar, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Vina P.S. Tan, Rosanna Tran

Research outputs 2022 to 2026

Background: Remote health care delivery, including the use of digital health interventions, is emerging as a tool for assessing and managing physical function, but its design and implementation often overlook the needs and preferences of older adult end users. Objective: The primary aim of this modified Delphi process was to develop consumer consensus on preferences for remote assessment and management of physical function in older adults. Methods: Research and consumer experts of the Remote Assessment and Management of Physical Function in Older Adults (RAMP) Working Group co-developed the Round 1 Delphi survey, which was advertised to consumers (adults aged ≥60 …

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Examining Links Between Somatosensation And Cognition In Children With Hemiplegic Cerebral Palsy, Kassandra M. Hewitt, Donna M. Bayliss, Belinda A. Mclean, Ashleigh L. Thornton, Jonson J. Moyle Jan 2026

Examining Links Between Somatosensation And Cognition In Children With Hemiplegic Cerebral Palsy, Kassandra M. Hewitt, Donna M. Bayliss, Belinda A. Mclean, Ashleigh L. Thornton, Jonson J. Moyle

Research outputs 2022 to 2026

Children with cerebral palsy (CP) are at increased risk of impaired somatosensation and cognition. Among children with hemiplegia, approximately three-quarters have impaired somatosensation and one-third have intellectual impairment. While somatosensation may relate to cognitive functioning in CP, this relationship has not previously been investigated. This cross-sectional study examined the relationship between somatosensation and cognition in children with hemiplegic CP, and whether the pattern of brain injury, classified using an established MRI classification system, moderates this relationship. Forty-seven children (26 females) with hemiplegic CP participated (mean age = 11.0 years; SD = 3.6; range: 6–16 years). Parent questionnaires provided demographic, educational, …

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Do Combined Resistance And Aerobic Exercise Programs Cause An Interference Effect In Women With Breast Cancer? A Systematic Review And Network Meta-Analysis, Pedro Lopez, Anderson Rech, Maria Petropoulou, Caroline B. Silveira, Talita Molinari, Cindranne Torres Muller, Priscila Casara, Francesco Bettariga, Favil Singh, Régis Radaelli Jan 2026

Do Combined Resistance And Aerobic Exercise Programs Cause An Interference Effect In Women With Breast Cancer? A Systematic Review And Network Meta-Analysis, Pedro Lopez, Anderson Rech, Maria Petropoulou, Caroline B. Silveira, Talita Molinari, Cindranne Torres Muller, Priscila Casara, Francesco Bettariga, Favil Singh, Régis Radaelli

Research outputs 2022 to 2026

Background: Exercise medicine has gained significant recognition owing to its demonstrated benefits throughout the breast cancer treatment continuum. While resistance exercise (RE) promotes improvements in lean mass and muscle strength, aerobic exercise (AE) enhances cardiorespiratory fitness, with several studies investigating both exercise modes in patients with breast cancer. However, because of an effect often referred to as interference effect, it is hypothesised that combining resistance and aerobic exercise (COMB) may compromise gains in lean mass and muscle strength and other outcomes in cancer populations. Objective: This study aims to investigate the presence of an interference effect from prescribing COMB compared …

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Intravenous Infusion Of Nicotinamide Adenine Dinucleotide (Nad+) Versus Nicotinamide Riboside (Nr): A Retrospective Tolerability Pilot Study In A Real-World Setting, Kirsten Reyna, Greer Heinzen, Nikita Patel, Marie Ritter, Alexandra Siojo, Henry Legere, Rachele Pojednic Jan 2026

Intravenous Infusion Of Nicotinamide Adenine Dinucleotide (Nad+) Versus Nicotinamide Riboside (Nr): A Retrospective Tolerability Pilot Study In A Real-World Setting, Kirsten Reyna, Greer Heinzen, Nikita Patel, Marie Ritter, Alexandra Siojo, Henry Legere, Rachele Pojednic

Research outputs 2022 to 2026

Background: Nicotinamide adenine dinucleotide (NAD+) is a cofactor for NAD+-dependent enzymes that regulate DNA repair, cellular metabolism, and immune function. Supplementation with NAD+ and its precursors is commonly used to prevent age-related disease and extend healthspan. Commercial clinical and wellness settings increasingly provide intravenous (IV) NAD+ and nicotinamide riboside (NR) despite limited evaluation of safety and effectiveness. These considerations are important, as NAD+ and its precursors differ in reported side effects, cellular uptake, and metabolism. This study sought to compare commercially administered NAD+ IV and NR IV in humans by evaluating infusion …

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Importance Of Strength Training To Prevent Secondary Lower Limb Musculoskeletal Injury In Military Personnel, Peter Ladlow, Russell J. Coppack, Robyn P. Cassidy, Rachel Rodgers, Robert Barker-Davies, Paul Comfort, Nicholas J. Ripley, Christopher Bramah, Colin Suffield, Debra Hayhurst, Marina De Vecchis, Samual R. Higgins, Alexander N. Bennett, Oliver O’Sullivan Jan 2026

Importance Of Strength Training To Prevent Secondary Lower Limb Musculoskeletal Injury In Military Personnel, Peter Ladlow, Russell J. Coppack, Robyn P. Cassidy, Rachel Rodgers, Robert Barker-Davies, Paul Comfort, Nicholas J. Ripley, Christopher Bramah, Colin Suffield, Debra Hayhurst, Marina De Vecchis, Samual R. Higgins, Alexander N. Bennett, Oliver O’Sullivan

Research outputs 2022 to 2026

Considerable operational and financial costs are associated with musculoskeletal injury (MSKI) across military organisations. Following an MSKI, reaching ‘medically fully deployable’ status is often contingent on meeting physical employment standards. Strength training has a critical role to play in military physical preparation, injury mitigation and guiding rehabilitation practice. Low levels of muscle strength are associated with increased MSKI risk, and previous MSKI is a leading risk factor for re-injury. When an MSKI does occur, it is essential that all attempts to mitigate the risk of secondary MSKI are met. Maximal force (muscle strength) and rapid force (rate of force development …

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Influence Of Prior Alkalosis Or Acidosis On Physiological Responses During Passive Hyperthermia, Jacky Soo, Shernise Ng, Chris Abbiss, Olivier Girard, Mohammed Ihsan Jan 2026

Influence Of Prior Alkalosis Or Acidosis On Physiological Responses During Passive Hyperthermia, Jacky Soo, Shernise Ng, Chris Abbiss, Olivier Girard, Mohammed Ihsan

Research outputs 2022 to 2026

This study manipulated the blood pH of participants to be mildly acidic or basic prior to passive hyperthermia to examine its effects on thermoregulatory and chemo-regulatory responses, including ventilatory parameters, rectal temperature (Tre) and thermal perception. Twelve healthy males attended three experimental sessions in a double-blind, randomised, counterbalanced design. Passive hyperthermia was induced by hot water immersion at 40°C following the consumption of corn starch (placebo; PLA), ammonium chloride (AC) or sodium bicarbonate (SB). Compared with PLA, SB consumption increased blood pH and HCO3−, whilst AC decreased both blood pH and HCO3− (all P < 0.001). Specifically, minute ventilation was unchanged following SB (11.0 ± 3.7 L min−1) but …

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International Cardiac Advanced Life Support Course: A Cross-Sectional Descriptive Analysis, Nilufeur Mckay, Jody Ede, Jessica Stokes-Parish, Adrian Levine, Helen Walthall, Debbie Massey Jan 2026

International Cardiac Advanced Life Support Course: A Cross-Sectional Descriptive Analysis, Nilufeur Mckay, Jody Ede, Jessica Stokes-Parish, Adrian Levine, Helen Walthall, Debbie Massey

Research outputs 2022 to 2026

Background: Recognising and responding to cardiac surgical deterioration requires a systematic, structured approach that encompasses monitoring, identifying and managing signs and symptoms of post-surgical complications. Cardiac Advanced Life Support (CALS) was originally developed in recognition of this educational requirement and consists of a series of protocols aimed at supporting clinicians’ recognition and response to the deteriorating cardiac surgical patient. Aim: The aim of this analysis was to evaluate participant perceptions of a CALS course using a descriptive online survey. Design: A cross-sectional analysis of post-course online survey responses assessing participant’ perceptions of the CALS course. Results: 331 surveys were returned …

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Personal Family-Centred Care For Lgbtq+ Individuals In Acute Hospital Settings: A Scoping Review, Gideon U. Johnson, Bianca Ysabelle Esmeralda, Stephen Pearson, Beverley Ewens, Louise Rose Jan 2026

Personal Family-Centred Care For Lgbtq+ Individuals In Acute Hospital Settings: A Scoping Review, Gideon U. Johnson, Bianca Ysabelle Esmeralda, Stephen Pearson, Beverley Ewens, Louise Rose

Research outputs 2022 to 2026

Aim: To identify and synthesise existing evidence on family-centred care for Lesbian, Gay, Bisexual, Transgender, Queer and other diverse identities (LGBTQ+) people in acute hospital settings, including hospital-based palliative care, oncology, general in-patient and intensive care. Design: A scoping review guided by the JBI methodology. Methods: Nine databases and grey literature sources were searched. Inclusion criteria focused on LGBTQ+ adults and family-related care experiences in hospital-based acute settings. After screening, qualitative, quantitative, and narrative data were extracted. Thematic analysis synthesised findings, with quantitative data narratively integrated. Data Sources: Searches were conducted across nine databases and grey literature up to April …

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