Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

Research outputs 2022 to 2026

Articles 1951 - 1980 of 2400

Full-Text Articles in Medicine and Health Sciences

Theory-Based Behaviour Change Intervention To Promote Mental Health Help-Seeking Among Older Adults In Australia: Initial Dissemination And Acceptability, Claire Adams, Eyal Gringart, Natalie Strobel Jan 2023

Theory-Based Behaviour Change Intervention To Promote Mental Health Help-Seeking Among Older Adults In Australia: Initial Dissemination And Acceptability, Claire Adams, Eyal Gringart, Natalie Strobel

Research outputs 2022 to 2026

Objective: Rates of help-seeking for mental health problems among older adults are low and initiatives to increase help-seeking in older populations are limited. To our knowledge, no interventions have aimed to promote help-seeking among older adults by tapping internal motivations to seek help. In this paper, we describe the development of a theory-based intervention designed to promote mental health help-seeking among older adults in Australia, using an internal motivation paradigm. Methods: The intervention was co-designed through a consultative process with nine key stakeholders who represented five main groups: primary health-care providers, mental health professionals, health-care executives, community organisations and consumers. …


A Feasibility, Safety, And Efficacy Evaluation Of Supervised Aerobic And Resistance Exercise For Patients With Glioblastoma Undertaking Adjuvant Chemoradiotherapy, Anna K. Nowak, Robert U. Newton, Travis Cruickshank, Prue Cormie, Georgia K. Halkett, Daphne Tsoi, Daniel A. Galvao Jan 2023

A Feasibility, Safety, And Efficacy Evaluation Of Supervised Aerobic And Resistance Exercise For Patients With Glioblastoma Undertaking Adjuvant Chemoradiotherapy, Anna K. Nowak, Robert U. Newton, Travis Cruickshank, Prue Cormie, Georgia K. Halkett, Daphne Tsoi, Daniel A. Galvao

Research outputs 2022 to 2026

Background: While therapeutically effective, chemoradiotherapy treatment for high-grade glioma (glioblastoma) is often accompanied by side effects. Exercise has been demonstrated to alleviate the adverse effects of such treatments in other cancers. We aimed to evaluate the feasibility and preliminary efficacy of supervised exercise incorporating autoregulation. Methods: Thirty glioblastoma patients were recruited, five declined exercise and 25 were provided with a multimodal exercise intervention for the duration of their chemoradiotherapy treatment. Patient recruitment, retention, adherence to training sessions and safety were evaluated throughout the study. Physical function, body composition, fatigue, sleep quality, and quality of life were evaluated before and after …


Summary Of Gynaecological Cancer Among Aboriginal And/Or Torres Strait Islander People In Australia, Australian Indigenous Healthinfonet Jan 2023

Summary Of Gynaecological Cancer Among Aboriginal And/Or Torres Strait Islander People In Australia, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This publication, in plain language, is based on information presented in the Review of gynaecological cancer among Aboriginal and/or Torres Strait Islander people in Australia (2023). This short, visual report summarises the key findings and concepts from the review to provide a holistic picture of gynaecological cancer among Aboriginal and/or Torres Strait Islander women. It is a quick source of information covering:

  • the social, cultural and historical contexts that contribute to inequitable gynaecological cancer rates among Aboriginal and/or Torres Strait Islander women
  • the extent of gynaecological cancer, specifically cervical cancer, ovarian cancer and uterine cancer, including the incidence, mortality, …


Clinical Practice Recommendations For Management Of Lateropulsion After Stroke Determined By A Delphi Expert Panel, Jessica Nolan, Angela Jacques, Erin Godecke, Hiroaki Abe, Suzanne Babyar, Jeannine Bergmann, Melissa Birnbaum, Shenhao Dai, Cynthia Danells, Taiza G. S. Edwards, Marialuisa Gandolfi, Klaus Jahn, Ryan Koter, Avril Mansfield, Junji Nakamura, Vicky Pardo, Dominic Perennou, Celine Piscicelli, David Punt, Devra Romick-Sheldon, Wim Saeys, Nicola Smania, Nathalie Vaes, Abigail L. Whitt, Barbara Singer Jan 2023

Clinical Practice Recommendations For Management Of Lateropulsion After Stroke Determined By A Delphi Expert Panel, Jessica Nolan, Angela Jacques, Erin Godecke, Hiroaki Abe, Suzanne Babyar, Jeannine Bergmann, Melissa Birnbaum, Shenhao Dai, Cynthia Danells, Taiza G. S. Edwards, Marialuisa Gandolfi, Klaus Jahn, Ryan Koter, Avril Mansfield, Junji Nakamura, Vicky Pardo, Dominic Perennou, Celine Piscicelli, David Punt, Devra Romick-Sheldon, Wim Saeys, Nicola Smania, Nathalie Vaes, Abigail L. Whitt, Barbara Singer

Research outputs 2022 to 2026

Objective: People exhibiting post-stroke lateropulsion actively push their body across the midline to the more affected side and/or resist weight shift toward the less affected side. Despite its prevalence and associated negative rehabilitation outcomes, no clinical practice guidelines exist for the rehabilitation of post-stroke lateropulsion. We aimed to develop consensus-based clinical practice recommendations for managing post-stroke lateropulsion using an international expert panel. Design: This Delphi panel process conformed with Guidance on Conducting and Reporting Delphi Studies recommendations. Participants: Panel members had demonstrated clinical and/or scientific background in the rehabilitation of people with post-stroke lateropulsion. Main Measures: The process consisted of …


Ctla4 Mrna Is Downregulated By Mir-155 In Regulatory T Cells, And Reduced Blood Ctla4 Levels Are Associated With Poor Prognosis In Metastatic Melanoma Patients, Prasanna Kumar Vaddi, Douglas Grant Osborne, Andrew Nicklawsky, Nazanin K. Williams, Dinoop Ravindran Menon, Derek Smith, Jonathan Mayer, Anna Reid, Joanne Domenico, Giang Huong Nguyen, William A. Robinson, Melanie Ziman, Dexiang Gao, Zili Zhai, Mayumi Fujita Jan 2023

Ctla4 Mrna Is Downregulated By Mir-155 In Regulatory T Cells, And Reduced Blood Ctla4 Levels Are Associated With Poor Prognosis In Metastatic Melanoma Patients, Prasanna Kumar Vaddi, Douglas Grant Osborne, Andrew Nicklawsky, Nazanin K. Williams, Dinoop Ravindran Menon, Derek Smith, Jonathan Mayer, Anna Reid, Joanne Domenico, Giang Huong Nguyen, William A. Robinson, Melanie Ziman, Dexiang Gao, Zili Zhai, Mayumi Fujita

Research outputs 2022 to 2026

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immune checkpoint expressed in regulatory T (Treg) cells and activated T lymphocytes. Despite its potential as a treatment strategy for melanoma, CTLA-4 inhibition has limited efficacy. Using data from The Cancer Genome Atlas (TCGA) melanoma database and another dataset, we found that decreased CTLA4 mRNA was associated with a poorer prognosis in metastatic melanoma. To investigate further, we measured blood CTLA4 mRNA in 273 whole-blood samples from an Australian cohort and found that it was lower in metastatic melanoma than in healthy controls and associated with worse patient survival. We confirmed these findings …


Development Of A Standardised System To Classify Injury-Inciting Circumstances In Football: The Football Injury Inciting Circumstances Classification System (Fiiccs), Francesco Aiello, Alan Mccall, Susan J. Brown, Andreas Serner, Lauren V. Fortington, Suzanne A. E. Huurman, Colin Lewin, Masashi Nagao, James O’Brien, Anastasia Panossian, Ricard Pruna, Guilherme P. Ramos, Matthew Whalan, Franco M. Impellizzeri Jan 2023

Development Of A Standardised System To Classify Injury-Inciting Circumstances In Football: The Football Injury Inciting Circumstances Classification System (Fiiccs), Francesco Aiello, Alan Mccall, Susan J. Brown, Andreas Serner, Lauren V. Fortington, Suzanne A. E. Huurman, Colin Lewin, Masashi Nagao, James O’Brien, Anastasia Panossian, Ricard Pruna, Guilherme P. Ramos, Matthew Whalan, Franco M. Impellizzeri

Research outputs 2022 to 2026

Background: A comprehensive examination of the sport-specific activities and circumstances being performed at the time of injury is important to hypothesise mechanisms, develop prevention strategies and inform future investigations. Results reported in the literature are inconsistent because inciting activities are reported using different classifications. Hence the aim was to develop a standardised system for the reporting of inciting circumstances. Methods: The system was developed using a modified Nominal Group Technique. The initial panel included 12 sports practitioners and researchers from four continents with respectively ≥ 5 years of experience working in professional football and/or conducting injury research. The process consisted …


Considerations For The Consumption Of Vitamin And Mineral Supplements In Athlete Populations, Peter Peeling, Marc Sim, Alannah K. A. Mckay Jan 2023

Considerations For The Consumption Of Vitamin And Mineral Supplements In Athlete Populations, Peter Peeling, Marc Sim, Alannah K. A. Mckay

Research outputs 2022 to 2026

Vitamins and minerals are of fundamental importance to numerous human functions that are essential to optimise athlete performance. Athletes incur a high turnover of key vitamins and minerals and are therefore dependent on sufficient energy intake to replenish nutrient stores. However, many athletes are poor at servicing their energy replenishment needs, especially female athletes, and although a ‘food first approach’ to meeting nutrient requirements is the primary goal, it may be important for some athletes to consider a vitamin and/or mineral supplement to meet their daily needs. When working to determine if an athlete requires vitamin or mineral supplements, practitioners …


Economic Evaluation Of The Very Early Rehabilitation In Speech (Verse) Intervention, J. Kim, G. Sookram, Erin Godecke, Emily Louise Brogan, Elizabeth Armstrong, F. Ellery, T. Rai, M. L. Rose, Natalie Ciccone, S. Middleton, A. Holland, G. J. Hankey, J. Bernhardt, D. A. Cadilhac Jan 2023

Economic Evaluation Of The Very Early Rehabilitation In Speech (Verse) Intervention, J. Kim, G. Sookram, Erin Godecke, Emily Louise Brogan, Elizabeth Armstrong, F. Ellery, T. Rai, M. L. Rose, Natalie Ciccone, S. Middleton, A. Holland, G. J. Hankey, J. Bernhardt, D. A. Cadilhac

Research outputs 2022 to 2026

Introduction: There is limited evidence on the costs and outcomes of patients with aphasia after stroke. The aim of this study was to estimate costs in patients with aphasia after stroke according to the aphasia therapies provided.

Methods: A three-arm, prospective, randomized, parallel group, open-label, blinded endpoint assessment trial conducted in Australia and New Zealand. Usual ward-based care (Usual Care) was compared to additional usual ward-based therapy (Usual Care Plus) and a prescribed and structured aphasia therapy program in addition to Usual Care (the VERSE intervention). Information about healthcare utilization and productivity were collected to estimate costs in Australian dollars …


Effects Of Submaximal And Supramaximal Accentuated Eccentric Loading On Mass And Function, Sergio Maroto-Izquierdo, Fernando Martín-Rivera, Kazunori Nosaka, Marco Beato, Javier González-Gallego, José A. De Paz Jan 2023

Effects Of Submaximal And Supramaximal Accentuated Eccentric Loading On Mass And Function, Sergio Maroto-Izquierdo, Fernando Martín-Rivera, Kazunori Nosaka, Marco Beato, Javier González-Gallego, José A. De Paz

Research outputs 2022 to 2026

Introduction: Eccentric-overload (EO) resistance training emerges as an alternative to more optimally prescribe intensity relative to the force generation capabilities of the eccentric muscle contraction. Given the difficulties to individually prescribe absolute eccentric loads relative to each person’s eccentric ability, setting the load relative to the concentric one-repetition maximum (1-RM) is the most used EO training approach. Therefore, we investigated the effects of submaximal and supramaximal (i.e., eccentric loads above 100% of 1-RM) accentuated eccentric training on changes in lean mass, anabolic hormonal responses and muscle function. Methods: Physically active university students (n = 27) were randomly assigned to two …


It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith Jan 2023

It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith

Research outputs 2022 to 2026

Background: : Group singing for people with Parkinson's disease (PD) is an established intervention not only to improve voice and speech difficulties but also for emotional and social benefit. Less is known about the experiences of group singing on the couple—the person with PD and their spouse or partner together—and studies have not specifically tracked impact through time or in combination with songwriting. Aims: : To understand the impact of group singing/songwriting on couples (participants with PD and their spouses) to unpack whether this broader view might help explain why such interventions are reported as beneficial. Using a trajectory approach, …


Neuromuscular Fatigue And Muscle Damage Following A Simulated Singles Badminton Match, Zengyuan Lin, Anthony J. Blazevich, Chris R. Abbiss, Jodie Cochrane Wilkie, Kazunori Nosaka Jan 2023

Neuromuscular Fatigue And Muscle Damage Following A Simulated Singles Badminton Match, Zengyuan Lin, Anthony J. Blazevich, Chris R. Abbiss, Jodie Cochrane Wilkie, Kazunori Nosaka

Research outputs 2022 to 2026

Purpose:

To understand muscle damage in badminton, changes in neuromuscular function were investigated after simulated badminton singles matches performed by ten state-level male players.

Methods:

Each participant played eight matches and measurements were taken before, immediately after, and 1 and 24 h after each match. Maximal voluntary isometric contraction (MVC) torque of the knee extensors and flexors, voluntary activation (VA) during MVC and torques generated by doublet (TDoublet), 20 (T20) and 80 Hz (T80) electrical stimulations of the knee extensors were measured from the dominant leg (the racket-hold arm side). Muscle soreness was assessed …


Overview Of Aboriginal And Torres Strait Islander Health Status 2022, Australian Indigenous Healthinfonet Jan 2023

Overview Of Aboriginal And Torres Strait Islander Health Status 2022, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The main purpose of the Overview of Aboriginal and Torres Strait Islander health status (Overview) is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The Overview has been prepared by HealthInfoNet staff as part of our contribution to supporting those who work in the Aboriginal and Torres Strait Islander health sector. The Overview is a key indicator of the HealthInfoNet’s commitment to authentic and engaged knowledge development and exchange. The initial sections of this Overview provide information about the context of Aboriginal and …


Development Of A Tool To Identify Barriers And Enablers To Practice Innovation In Midwifery: A Participatory Action Research Study, Sara D. Davis, Sara Bayes, Sadie Geraghty Jan 2023

Development Of A Tool To Identify Barriers And Enablers To Practice Innovation In Midwifery: A Participatory Action Research Study, Sara D. Davis, Sara Bayes, Sadie Geraghty

Research outputs 2022 to 2026

Introduction: Transferring research evidence into midwifery practice is fraught with challenges and obstacles. Implementation tools can streamline the process and are most effective when they are discipline-specific; however, there are currently no midwifery specific implementation tools. The aim of this study was to develop a midwifery specific tool to identify barriers and enablers to evidence-informed practice change within the clinical setting. Methods: Participatory action research methodology was employed to ensure potential end-users contributed to content and format of the tool. Purposeful sampling ensured participants were selected from a range of midwifery practice settings in Western Australia and the United Kingdom. …


Genomic Epidemiology And Transmission Dynamics Of Recurrent Clostridioides Difficile Infection In Western Australia, Daniel R. Knight, Korakrit Imwattana, Deirdre A. Collins, Su-Chen Lim, Stacey Hong, Papanin Putsathit, Thomas V. Riley Jan 2023

Genomic Epidemiology And Transmission Dynamics Of Recurrent Clostridioides Difficile Infection In Western Australia, Daniel R. Knight, Korakrit Imwattana, Deirdre A. Collins, Su-Chen Lim, Stacey Hong, Papanin Putsathit, Thomas V. Riley

Research outputs 2022 to 2026

Recurrent cases of Clostridioides difficile infection (rCDI) remain one of the most common and serious challenges faced in the management of CDI. The accurate distinction between a relapse (caused by infection with the same strain) and reinfection (caused by a new strain) has implications for infection control and prevention, and patient therapy. Here, we used whole-genome sequencing to investigate the epidemiology of 94 C. difficile isolates from 38 patients with rCDI in Western Australia. The C. difficile strain population comprised 13 sequence types (STs) led by ST2 (PCR ribotype (RT) 014, 36.2 %), ST8 (RT002, 19.1 %) and ST34 (RT056, …


The Effect Of Regular Consumption Of Reformulated Breads On Glycemic Control: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Alena M. Schadow, Ingrid Revheim, Ulrike Spielau, Jutta Dierkes, Lukas Schwingshackl, Jan Frank, Jonathan M. Hodgson, André Moreira-Rosário, Chris J. Seal, Anette E. Buyken, Hanne Rosendahl-Riise Jan 2023

The Effect Of Regular Consumption Of Reformulated Breads On Glycemic Control: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials, Alena M. Schadow, Ingrid Revheim, Ulrike Spielau, Jutta Dierkes, Lukas Schwingshackl, Jan Frank, Jonathan M. Hodgson, André Moreira-Rosário, Chris J. Seal, Anette E. Buyken, Hanne Rosendahl-Riise

Research outputs 2022 to 2026

Bread is a major source of grain-derived carbohydrates worldwide. High intakes of refined grains, low in dietary fiber and high in glycemic index, are linked with increased risk for type 2 diabetes mellitus (T2DM) and other chronic diseases. Hence, improvements in the composition of bread could influence population health. This systematic review evaluated the effect of regular consumption of reformulated breads on glycemic control among healthy adults, adults at cardiometabolic risk or with manifest T2DM. A literature search was performed using MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies employed a bread intervention …


Barry Turner: The Under-Acknowledged Safety Pioneer, Kym Bills, Leesa N. Costello, Marcus Cattani Jan 2023

Barry Turner: The Under-Acknowledged Safety Pioneer, Kym Bills, Leesa N. Costello, Marcus Cattani

Research outputs 2022 to 2026

Barry Turner’s 1978 Man-made Disasters and Charles Perrow’s 1984 Normal Accidents were seminal books but a detailed comparison has yet to be undertaken. Doing so is important to establish content and priority of key ideas underpinning contemporary safety science. Turner’s research found socio-technical and systemic patterns that meant that major organisational disasters could be foreseen and were preventable. Perrow’s macro-structuralist industry focus was on technologically deterministic but unpredictable and unpreventable “system” accidents, particularly rare catastrophes. Andrew Hopkins and Nick Pidgeon respectively suggested that some prominent writers who wrote after Turner may not have been aware of, or did not properly …


Dementia Care For People From Culturally And Linguistically Diverse Backgrounds: Qualitative Secondary Analysis Of The Aged Care Australian Royal Commission Data, Pelden Chejor, Patricia Cain, Bridget Laging, Davina Porock Jan 2023

Dementia Care For People From Culturally And Linguistically Diverse Backgrounds: Qualitative Secondary Analysis Of The Aged Care Australian Royal Commission Data, Pelden Chejor, Patricia Cain, Bridget Laging, Davina Porock

Research outputs 2022 to 2026

Objective:

Understanding the concerns and experiences of people living with dementia from culturally and linguistically diverse backgrounds is critical to ensure culturally appropriate care is delivered. This study aimed to describe the current experiences and concerns of older people from culturally and linguistically diverse backgrounds using the publicly available evidence from the Australian Royal Commission into Aged Care Quality and Safety.

Methods:

This was a qualitative secondary analysis of the Australian Royal Commission into Aged Care Quality and Safety data to explore new and nuanced insights about care for culturally and linguistically diverse people living with dementia. Using the keywords …


Prognostic And Predictive Value Of Metformin In The European Organisation For Research And Treatment Of Cancer 1325/Keynote-054 Phase Iii Trial Of Pembrolizumab Versus Placebo In Resected High-Risk Stage Iii Melanoma, Oliver J. Kennedy, Michal Kicinski, Sara Valpione, Sara Gandini, Stefan Suciu, Christian U. Blank, Georgina V. Long, Victoria G. Atkinson, Stéphane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Marye Boers-Sonderen, Anna M. Di Giacomo, Alfonsus J. M. Van Der Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C. J. Van Akkooi, Caroline Robert, Alexander M. M. Eggermont, Paul Lorigan, Mario Mandala Jan 2023

Prognostic And Predictive Value Of Metformin In The European Organisation For Research And Treatment Of Cancer 1325/Keynote-054 Phase Iii Trial Of Pembrolizumab Versus Placebo In Resected High-Risk Stage Iii Melanoma, Oliver J. Kennedy, Michal Kicinski, Sara Valpione, Sara Gandini, Stefan Suciu, Christian U. Blank, Georgina V. Long, Victoria G. Atkinson, Stéphane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Marye Boers-Sonderen, Anna M. Di Giacomo, Alfonsus J. M. Van Der Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C. J. Van Akkooi, Caroline Robert, Alexander M. M. Eggermont, Paul Lorigan, Mario Mandala

Research outputs 2022 to 2026

Background: Metformin is a commonly prescribed and well-tolerated medication. In laboratory studies, metformin suppresses BRAF wild-type melanoma cells but accelerates the growth of BRAF-mutated cells. This study investigated the prognostic and predictive value of metformin, including with respect to BRAF mutation status, in the European Organisation for Research and Treatment of Cancer 1325/KEYNOTE-054 randomised controlled trial. Methods: Patients with resected high-risk stage IIIA, IIIB, or IIIC melanoma received 200 mg of pembrolizumab (n = 514) or placebo (n = 505) every 3 weeks for twelve months. Pembrolizumab prolonged recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) at approximately 42 months …


Associations Of Physical Activity And Quality Of Life In Parapneumonic Effusion Patients, Pedro Lopez, Deirdre B. Fitzgerald, Joanne A. Mcveigh, Arash Badiei, Sanjeevan Muruganandan, Robert U. Newton, Leon Straker, Yun C. G. Lee, Carolyn J. Peddle-Mcintyre Jan 2023

Associations Of Physical Activity And Quality Of Life In Parapneumonic Effusion Patients, Pedro Lopez, Deirdre B. Fitzgerald, Joanne A. Mcveigh, Arash Badiei, Sanjeevan Muruganandan, Robert U. Newton, Leon Straker, Yun C. G. Lee, Carolyn J. Peddle-Mcintyre

Research outputs 2022 to 2026

Introduction Little is known about activity behaviours and quality of life (QoL) of patients with parapneumonic pleural effusions (PPE) after hospital discharge. This study is a secondary analysis of a randomised trial (dexamethasone versus placebo) for hospitalised patients with PPE. We: 1) described the patients’ activity behaviour patterns and QoL measured at discharge and at 30 days post-discharge; and 2) examined the association between activity behaviours and QoL scores. Methods Activity behaviour (7-day accelerometry; Actigraph GT3X+) and QoL (Medical Outcomes Study Short-Form 36) were assessed. Repeated measures analysis of covariance controlling for baseline values and a series of linear regression …


Association Between Immunoglobulin G N-Glycosylation And Lupus Nephritis In Female Patients With Systemic Lupus Erythematosus: A Case-Control Study, Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li Jan 2023

Association Between Immunoglobulin G N-Glycosylation And Lupus Nephritis In Female Patients With Systemic Lupus Erythematosus: A Case-Control Study, Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li

Research outputs 2022 to 2026

Background: Lupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE) and has important clinical implications in guiding treatment. N-glycosylation of immunoglobulin G (IgG) plays a key role in the development of SLE by affecting the balance of anti-inflammatory and proinflammatory responses. This study aimed to evaluate the performance of IgG N-glycosylation for diagnosing LN in a sample of female SLE patients. Methods: This case-control study recruited 188 women with SLE, including 94 patients with LN and 94 age-matched patients without LN. The profiles of plasma IgG N-glycans were detected by hydrophilic interaction chromatography with ultra-performance liquid chromatography …


Predicting 1-, 3-, 5-, And 8-Year All-Cause Mortality In A Community-Dwelling Older Adult Cohort: Relevance For Predictive, Preventive, And Personalized Medicine, Yequn Chen, Xiulian Deng, Dong Lin, Peixuan Yang, Shiwan Wu, Xidong Wang, Hui Zhou, Ximin Chen, Xiaochun Wang, Weichai Wu, Kaibing Ke, Wenjia Huang, Xuerui Tan Jan 2023

Predicting 1-, 3-, 5-, And 8-Year All-Cause Mortality In A Community-Dwelling Older Adult Cohort: Relevance For Predictive, Preventive, And Personalized Medicine, Yequn Chen, Xiulian Deng, Dong Lin, Peixuan Yang, Shiwan Wu, Xidong Wang, Hui Zhou, Ximin Chen, Xiaochun Wang, Weichai Wu, Kaibing Ke, Wenjia Huang, Xuerui Tan

Research outputs 2022 to 2026

Background: Population aging is a global public health issue involving increased prevalence of age-related diseases, and concomitant burden on medical resources and the economy. Ninety-two diseases have been identified as age-related, accounting for 51.3% of the global adult disease burden. The economic cost per capita for older people over 60 years is 10 times that of the younger population. From the aspects of predictive, preventive, and personalized medicine (PPPM), developing a risk-prediction model can help identify individuals at high risk for all-cause mortality and provide an opportunity for targeted prevention through personalized intervention at an early stage. However, there is …


Machine-Learning Assessed Abdominal Aortic Calcification Is Associated With Long-Term Fall And Fracture Risk In Community-Dwelling Older Australian Women, Jack Dalla Via, Abadi Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim Jan 2023

Machine-Learning Assessed Abdominal Aortic Calcification Is Associated With Long-Term Fall And Fracture Risk In Community-Dwelling Older Australian Women, Jack Dalla Via, Abadi Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Abdominal aortic calcification (AAC), a recognized measure of advanced vascular disease, is associated with higher cardiovascular risk and poorer long-term prognosis. AAC can be assessed on dual-energy X-ray absorptiometry (DXA)-derived lateral spine images used for vertebral fracture assessment at the time of bone density screening using a validated 24-point scoring method (AAC-24). Previous studies have identified robust associations between AAC-24 score, incident falls, and fractures. However, a major limitation of manual AAC assessment is that it requires a trained expert. Hence, we have developed an automated machine-learning algorithm for assessing AAC-24 scores (ML-AAC24). In this prospective study, we evaluated the …


Musculoskeletal Complaint Epidemiology In Australian Special Operation Forces Trainees, Lisa Wolski, Joanne Stannard, Liam Toohey, Alison Fogarty, Michael Drew Jan 2023

Musculoskeletal Complaint Epidemiology In Australian Special Operation Forces Trainees, Lisa Wolski, Joanne Stannard, Liam Toohey, Alison Fogarty, Michael Drew

Research outputs 2022 to 2026

Intorduction: Elite military trainees are burdened by high numbers of musculoskeletal (MSK) injuries and are a priority military population for injury prevention. This research aims to describe the MSK complaint epidemiology of trainees undertaking special forces (SF) training in the Australian Defence Force (ADF). One barrier to accurate injury surveillance in military populations is that traditional surveillance methods rely on personnel engaging with the military healthcare system to collect injury data. This approach is likely to underestimate the injury burden as it is known that many military personnel, particularly trainees, avoid reporting their injuries because of various motives. Subsequently, the …


Exploring The Underutilized Potential Of Clinical Hypnosis: A Scoping Review Of Healthcare Professionals’ Perceptions, Knowledge, And Attitudes, Malwina Szmaglinska, Lesley Andrew, Debbie Massey, Deborah Kirk Jan 2023

Exploring The Underutilized Potential Of Clinical Hypnosis: A Scoping Review Of Healthcare Professionals’ Perceptions, Knowledge, And Attitudes, Malwina Szmaglinska, Lesley Andrew, Debbie Massey, Deborah Kirk

Research outputs 2022 to 2026

The perceptions, knowledge, and attitudes of healthcare professionals (GPs, oncologists, nurses, midwives and obstetricians, anesthetists, mental health professionals, and other professionals) toward hypnosis are explored in this scoping review. Despite proven effectiveness in various health conditions, the use of hypnosis in healthcare has stagnated, emphasizing a gap between research and practice. Data from 35 studies (1995–2023) were analyzed, revealing predominantly positive attitudes and interest in training. Professionals with more knowledge and experience had favorable attitudes toward hypnosis compared to those with limited exposure or understanding of the practice. The main obstacles were insufficient time and inadequate training. Considering the growing …


Investigating Pre-Professional Dancer Health Status And Preventative Health Knowledge, Joanna Nicholas, Sara Grafenauer Jan 2023

Investigating Pre-Professional Dancer Health Status And Preventative Health Knowledge, Joanna Nicholas, Sara Grafenauer

Research outputs 2022 to 2026

Introduction: Dance is a highly demanding physical pursuit coupled with pressure to conform to aesthetic ideals. Assessment of health status and preventative health knowledge of pre-professional dancers may help inform educational strategies promoting dancers’ health and career longevity. The aim of this research was to establish a baseline understanding of dance students at a single pre-professional institution based on metrics focused on current health, nutrition, lifestyle, and wellbeing while also gauging knowledge of longer-term health implications. Methods: Adopting a cross-sectional study design, the Dance-Specific Energy Availability Questionnaire was tailored for Australian participants and administered online. Results: The response rate was …


Ketone Bodies Mediate Alterations In Brain Energy Metabolism And Biomarkers Of Alzheimer’S Disease, Matin Ramezani, Malika Fernando, Shaun Eslick, Prita R. Asih, Sina Shadfar, Ekanayaka M. S. Bandara, Heidi Hillebrandt, Silochna Meghwar, Maryam Shahriari, Pratishtha Chatterjee, Rohith Thota, Cintia B. Dias, Manohar L. Garg, Ralph N. Martins Jan 2023

Ketone Bodies Mediate Alterations In Brain Energy Metabolism And Biomarkers Of Alzheimer’S Disease, Matin Ramezani, Malika Fernando, Shaun Eslick, Prita R. Asih, Sina Shadfar, Ekanayaka M. S. Bandara, Heidi Hillebrandt, Silochna Meghwar, Maryam Shahriari, Pratishtha Chatterjee, Rohith Thota, Cintia B. Dias, Manohar L. Garg, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is the most common form of dementia. AD is a progressive neurodegenerative disorder characterized by cognitive dysfunction, including learning and memory deficits, and behavioral changes. Neuropathology hallmarks of AD such as amyloid beta () plaques and neurofibrillary tangles containing the neuron-specific protein tau is associated with changes in fluid biomarkers including A , phosphorylated tau (p-tau)-181, p-tau 231, p-tau 217, glial fibrillary acidic protein (GFAP), and neurofilament light (NFL). Another pathological feature of AD is neural damage and hyperactivation of astrocytes, that can cause increased pro-inflammatory mediators and oxidative stress. In addition, reduced brain glucose metabolism and …


Evidence-Based Guidelines For Intrapartum Maternal Hydration Assessment And Management: A Scoping Review, Lauren Kearney, Alison Craswell, Nellie Dick, Debbie Massey, Rachael Nugent Jan 2023

Evidence-Based Guidelines For Intrapartum Maternal Hydration Assessment And Management: A Scoping Review, Lauren Kearney, Alison Craswell, Nellie Dick, Debbie Massey, Rachael Nugent

Research outputs 2022 to 2026

Problem: Inconsistent practice relating to intrapartum hydration assessment and management is reported, and potential harm exists for laboring women and birthing persons. Background: Labor and birth are physically demanding, and adequate nutrition and hydration are essential for labor progress. A lack of clear consensus on intrapartum hydration assessment and management during labor and birth currently exists. In addition, there is an inconsistent approach to managing hydration, often including a mixture of intravenous and oral fluids that are poorly monitored. Aim: The aim of this scoping review was to identify and collate evidence-based guidelines for intrapartum hydration assessment and management of …


Development Of A Scoring Tool For Australian Rural Food Retail Environments, Tracy L. Schumacher, Carissa A. Alderton, Leanne J. Brown, Susan Heaney, Laura Alston, Katherine Kent, Stephanie L. Godrich Jan 2023

Development Of A Scoring Tool For Australian Rural Food Retail Environments, Tracy L. Schumacher, Carissa A. Alderton, Leanne J. Brown, Susan Heaney, Laura Alston, Katherine Kent, Stephanie L. Godrich

Research outputs 2022 to 2026

Current tools scoring the healthiness of food retail outlets do not reflect outlets found in rural locations. This study aimed to adapt pre-existing Australian scoring tools to represent non-metropolitan areas. Rural nutrition experts were identified, and a modified Delphi technique was used to adapt two pre-existing, food-scoring tools in five iterative stages. Stages included identifying all relevant outlets, providing a description and score for each, ensuring consistency between outlet scores and pre-existing, metro-centric tools, and providing instructions for correct use. Six rural nutrition experts were identified and engaged in the modified Delphi technique. The final tool consisted of 12 categories …


Changes In Parental Anxiety And Intention To Demand Antibiotics: A Longitudinal Study Among Parents During The Covid-19 Pandemic, Aaron L. Alejandro, Mieghan Bruce, Wei W. C. Leo Jan 2023

Changes In Parental Anxiety And Intention To Demand Antibiotics: A Longitudinal Study Among Parents During The Covid-19 Pandemic, Aaron L. Alejandro, Mieghan Bruce, Wei W. C. Leo

Research outputs 2022 to 2026

Aims: Assessing the effects of the COVID-19 pandemic on parental anxiety and preferences for antibiotic treatment can help inform antibiotic stewardship strategies. Therefore, this study aimed to examine COVID-19 pandemic-related changes in parental anxiety levels, their intentions to demand antibiotics and frequencies of practising preventative behaviours. Design: This longitudinal quantitative study compared two groups of parents, those from Victoria and Western Australia, who experienced high and low COVID-19 risk, respectively. Methods: Participants were recruited through an online panel to complete three waves of surveys between October 2020 and August 2021. Anxiety scores and frequency of preventative behaviours were analysed using …


Clinical Deterioration As A Nurse Sensitive Indicator In The Out-Of-Hospital Context: A Scoping Review, Kylie Mccullough, Melanie Baker, Dianne Bloxsome, Carol Crevacore, Hugh Davies, Gemma Doleman, Michelle Gray, Nilufeur Mckay, Peter Palamara, Gina Richards, Rosemary Saunders, Amanda Towell-Barnard, Linda L. Coventry Jan 2023

Clinical Deterioration As A Nurse Sensitive Indicator In The Out-Of-Hospital Context: A Scoping Review, Kylie Mccullough, Melanie Baker, Dianne Bloxsome, Carol Crevacore, Hugh Davies, Gemma Doleman, Michelle Gray, Nilufeur Mckay, Peter Palamara, Gina Richards, Rosemary Saunders, Amanda Towell-Barnard, Linda L. Coventry

Research outputs 2022 to 2026

Aims: To explore and summarise the literature on the concept of ‘clinical deterioration’ as a nurse-sensitive indicator of quality of care in the out-of-hospital context. Design: The scoping review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review and the JBI best practice guidelines for scoping reviews. Methods: Studies focusing on clinical deterioration, errors of omission, nurse sensitive indicators and the quality of nursing and midwifery care for all categories of registered, enrolled, or licensed practice nurses and midwives in the out-of-hospital context were included regardless of methodology. Text and opinion papers were also …