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Full-Text Articles in Medicine and Health Sciences
Investigating The Influence Of Environmental Factors On The Incidence Of Renal Disease With Compositional Data Analysis Using Balances, Jennifer M. Mckinley, Ute Mueller, Peter M. Atkinson, Ulrich Ofterdinger, Chloe Jackson, Siobhan F. Cox, Rory Doherty, Damian Fogarty, J. J. Egozcue, V. Pawlowsky-Glahn
Investigating The Influence Of Environmental Factors On The Incidence Of Renal Disease With Compositional Data Analysis Using Balances, Jennifer M. Mckinley, Ute Mueller, Peter M. Atkinson, Ulrich Ofterdinger, Chloe Jackson, Siobhan F. Cox, Rory Doherty, Damian Fogarty, J. J. Egozcue, V. Pawlowsky-Glahn
Research outputs 2014 to 2021
This research uses an urban soil geochemistry database of elemental concentration to examine the potential relationship between Standardised Incidence Rates (SIRs) of Chronic Kidney Disease (CKD) of uncertain aetiology (CKDu), and cumulative low level geogenic and diffuse anthropogenic contamination of soils with PTEs. A compositional data analysis approach was applied to determine the elemental balance(s) of the geochemical data showing the greatest association with CKDu. The research concludes that both anthropogenic and geogenic factors may be contributing influences to explain high incidences of CKDu, up to 12 times greater in some Super Output Areas (SOAs) than would be expected for …
Chronic Kidney Disease Of Unknown Origin Is Associated With Environmental Urbanisation In Belfast, Uk, Jennifer M. Mckinley, Ute Mueller, Peter M. Atkinson, Ulrich Ofterdinger, Siobhan F. Cox, Rory Doherty, Damian Fogarty, J. J. Egozcue, V. Pawlowsky-Glahn
Chronic Kidney Disease Of Unknown Origin Is Associated With Environmental Urbanisation In Belfast, Uk, Jennifer M. Mckinley, Ute Mueller, Peter M. Atkinson, Ulrich Ofterdinger, Siobhan F. Cox, Rory Doherty, Damian Fogarty, J. J. Egozcue, V. Pawlowsky-Glahn
Research outputs 2014 to 2021
© 2020, The Author(s). Chronic kidney disease (CKD), a collective term for many causes of progressive renal failure, is increasing worldwide due to ageing, obesity and diabetes. However, these factors cannot explain the many environmental clusters of renal disease that are known to occur globally. This study uses data from the UK Renal Registry (UKRR) including CKD of uncertain aetiology (CKDu) to investigate environmental factors in Belfast, UK. Urbanisation has been reported to have an increasing impact on soils. Using an urban soil geochemistry database of elemental concentrations of potentially toxic elements (PTEs), we investigated the association of the standardised …