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Full-Text Articles in Medicine and Health Sciences
Profiling Igg N-Glycans As Potential Biomarker Of Chronological And Biological Ages: A Community-Based Study In A Han Chinese Population, Xinwei Yu, Youix Wang, Jasminka Krištić, Jing Dong, Xi Chu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Di Lui, Zhongya Zhao, Hongli Peng, Maja P. Baković, Lijuan Wu, Manshu Song, Igor Rudan, Harry Campbell, Gordan Lauc, Wei Wang
Profiling Igg N-Glycans As Potential Biomarker Of Chronological And Biological Ages: A Community-Based Study In A Han Chinese Population, Xinwei Yu, Youix Wang, Jasminka Krištić, Jing Dong, Xi Chu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Di Lui, Zhongya Zhao, Hongli Peng, Maja P. Baković, Lijuan Wu, Manshu Song, Igor Rudan, Harry Campbell, Gordan Lauc, Wei Wang
Research outputs 2014 to 2021
As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a component of predictive biomarkers for chronological age in several European populations, whereas no study has been reported in Chinese. Herein, we report various patterns of changes in IgG glycosylation associated with age by analyzing IgG glycosylation in 701 community-based Han Chinese (244 males, 457 females; 23-68 years old). Eleven IgG glycans, including FA2B, A2G1, FA2[6]G1, FA2[3]G1, FA2[6]BG1, FA2[3]BG1, A2G2, …
Integration Of Suboptimal Health Status And Endothelial Dysfunction As A New Aspect For Risk Evaluation Of Cardiovascular Disease, Vitalli Kupaev, Oleg Borisov, Ekaterina Marutina, Yuxiang Yan, Wei Wang
Integration Of Suboptimal Health Status And Endothelial Dysfunction As A New Aspect For Risk Evaluation Of Cardiovascular Disease, Vitalli Kupaev, Oleg Borisov, Ekaterina Marutina, Yuxiang Yan, Wei Wang
Research outputs 2014 to 2021
Background:
Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction.
Methods:
A community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks. The SHS score was derived from the data collected in …
China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang
China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang
Research outputs 2014 to 2021
Background:
Suboptimal health status (SHS) is a physical state between health and disease, characterized by the perception of health complaints, general weakness, chronic fatigue and low energy levels. SHS is proposed by the ancient concept of traditional Chinese medicine (TCM) from the perspective of preservative, predictive and personalized (precision) medicine. We previously created the suboptimal health status questionnaire 25 (SHSQ-25), a novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords a window of opportunity for early detection and intervention, contributing to the reduction of chronic disease burdens.
Methods/design:
To investigate the causative effect of SHS in non-communicable …