Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- 8 hydroxydeoxyguanosine (1)
- Adult (1)
- Airborne particle (1)
- Article (1)
- Biological marker (1)
-
- Blood analysis (1)
- Body mass (1)
- C reactive protein (1)
- Carbon monoxide (1)
- Controlled study (1)
- Cybersecurity (1)
- ETP (1)
- Electronic Transfer of Prescription (1)
- Endothelin 1 (1)
- Endotoxin (1)
- Female (1)
- Glucan (1)
- HL7 (1)
- Human (1)
- Implementing eTP (1)
- Interleukin 6 (1)
- Lipid oxidation (1)
- Lipid peroxidation (1)
- Male (1)
- Malonaldehyde (1)
- Medical devices (1)
- Nitrogen dioxide (1)
- Normal human (1)
- Oxidative stress (1)
- Ozone (1)
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
The Hare And The Hortoise [Sic]: The Potential Versus The Reality Of Etp Implementation, Kyaw Kyaw Htat, Patricia A. H Williams, Vincent Mccauley
The Hare And The Hortoise [Sic]: The Potential Versus The Reality Of Etp Implementation, Kyaw Kyaw Htat, Patricia A. H Williams, Vincent Mccauley
Research outputs 2014 to 2021
In a health system increasingly driven by cost constraints, there is a focus on improved electronic transfer of information to support healthcare delivery. One area of healthcare that has moved more quickly than others to achieve this is prescribing in the primary care environment. Whilst the move to electronic transfer of prescriptions has reduced transcription errors, the regulatory environment persists with handwritten signatures. This constraint, whilst addressed slowly with technology solutions, needs support from legislative change. The ultimate step is to have a secure mobile model, which would support the move to a fully-electronic, paperless transaction model.
Cybersecurity Vulnerabilities In Medical Devices: A Complex Environment And Multifaceted Problem, Patricia A.H. Williams, Andrew J. Woodward
Cybersecurity Vulnerabilities In Medical Devices: A Complex Environment And Multifaceted Problem, Patricia A.H. Williams, Andrew J. Woodward
Research outputs 2014 to 2021
The increased connectivity to existing computer networks has exposed medical devices to cybersecurity vulnerabilities from which they were previously shielded. For the prevention of cybersecurity incidents, it is important to recognize the complexity of the operational environment as well as to catalog the technical vulnerabilities. Cybersecurity protection is not just a technical issue; it is a richer and more intricate problem to solve. A review of the factors that contribute to such a potentially insecure environment, together with the identification of the vulnerabilities, is important for understanding why these vulnerabilities persist and what the solution space should look like. This …
Effects Of Ambient Coarse, Fine, And Ultrafine Particles And Their Biological Constituents On Systemic Biomarkers: A Controlled Human Exposure Study, Ling Liu, Bruce Urch, Raymond Poon, Mieczyslaw Szyszkowicz, Mary Speck, Diane R. Gold, Amanda J. Wheeler, James A. Scott, Jeffrey R. Brook, Peter S. Thorne, Frances S. Silverman
Effects Of Ambient Coarse, Fine, And Ultrafine Particles And Their Biological Constituents On Systemic Biomarkers: A Controlled Human Exposure Study, Ling Liu, Bruce Urch, Raymond Poon, Mieczyslaw Szyszkowicz, Mary Speck, Diane R. Gold, Amanda J. Wheeler, James A. Scott, Jeffrey R. Brook, Peter S. Thorne, Frances S. Silverman
Research outputs 2014 to 2021
Background: Ambient coarse, fine, and ultrafine particles have been associated with mortality and morbidity. Few studies have compared how various particle size fractions affect systemic biomarkers. Objectives: We examined changes of blood and urinary biomarkers following exposures to three particle sizes. Methods: Fifty healthy nonsmoking volunteers, mean age of 28 years, were exposed to coarse (2.5–10 μm; mean, 213 μg/m3) and fine (0.15–2.5 μm; mean, 238 μg/m3) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP (< 0.3 μm; mean, 136 μg/m3) and filtered medical air. Exposures lasted 130 min, separated by ≥ 2 weeks. Blood/urine samples were collected preexposure and 1 hr and 21 hr postexposure to determine blood interleukin-6 and C-reactive protein (inflammation), endothelin-1 and vascular endothelial growth factor (VEGF; vascular mediators), and malondialdehyde (lipid peroxidation); as well as urinary VEGF, 8-hydroxy-deoxy-guanosine (DNA oxidation), and malondialdehyde. Mixed-model regressions assessed pre- and postexposure differences. results: One hour postexposure, for every 100-μg/m3 increase, coarse CAP was associated with increased blood VEGF (2.41 pg/mL; 95% CI: 0.41, 4.40) in models adjusted for O3, fine CAP with increased urinary malondialdehyde in single- (0.31 nmol/mg creatinine; 95% CI: 0.02, 0.60) and two-pollutant models, and ultrafine CAP with increased urinary 8-hydroxydeoxyguanosine in single- (0.69 ng/mg creatinine; 95% CI: 0.09, 1.29) and two-pollutant models, lasting < 21 hr. Endotoxin was significantly associated with biomarker changes similar to those found with CAPs. conclusions: Ambient particles with various sizes/constituents may influence systemic biomarkers differently. Endotoxin in ambient particles may contribute to vascular mediator changes and oxidative stress.