Medicine and Health Sciences Commons^™

Could Titin Have A Role In Strain-Induced Injuries?, Craig Perrin, Kazunori Nosaka, James Steele

Research outputs 2014 to 2021

It has been known for some time that strain injuries occur through the excessive lengthening of a muscle. However, the precise mechanism for strain injury remains elusive and has been the subject of recent debate in the Journal of Sport and Health Science, but it seems sensible to consider mechanisms at the level of the muscle fiber. It was previously believed that damage was the result of non-uniform stretching of sarcomeres on the descending limb of the length–tension curve, with the weakest sarcomeres undergoing the greatest deformation and ultimately damaging the myofibril. This non-uniform lengthening was also believed to …