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Taking A Closer Look On The Coronavirus, Alisha Barday, Janina Duran, Lisa Agranov May 2020

Taking A Closer Look On The Coronavirus, Alisha Barday, Janina Duran, Lisa Agranov

Publications and Research

No abstract provided.


The Time Course Of Moral Perception: An Erp Investigation Of The Moral Pop-Out Effect, Ana Gantman, Sayeed Devraj-Kizuk, Peter Mende-Siedlecki, Jay J. Van Bavel, Kyle E. Mathewson May 2020

The Time Course Of Moral Perception: An Erp Investigation Of The Moral Pop-Out Effect, Ana Gantman, Sayeed Devraj-Kizuk, Peter Mende-Siedlecki, Jay J. Van Bavel, Kyle E. Mathewson

Publications and Research

Humans are highly attuned to perceptual cues about their values. A growing body of evidence suggests that people selectively attend to moral stimuli. However, it is unknown whether morality is prioritized early in perception or much later in cognitive processing. We use a combination of behavioral methods and electroencephalography to investigate how early in perception moral words are prioritized relative to non-moral words. The behavioral data replicate previous research indicating that people are more likely to correctly identify moral than non-moral words in a modified lexical decision task. The electroencephalography data reveal that words are distinguished from non-words as early …


A National Prospective Cohort Study Of Sars/Cov2 Pandemic Outcomes In The U.S.: The Chasing Covid Cohort, Mckaylee Robertson, Sarah Kulkarni, Amanda Berry, Chloe Mirzayi, Andrew Maroko, Rebecca Zimba, Drew Westmoreland, Christina Grov, Angela Parcesepe, Levi Waldron, Denis Nash May 2020

A National Prospective Cohort Study Of Sars/Cov2 Pandemic Outcomes In The U.S.: The Chasing Covid Cohort, Mckaylee Robertson, Sarah Kulkarni, Amanda Berry, Chloe Mirzayi, Andrew Maroko, Rebecca Zimba, Drew Westmoreland, Christina Grov, Angela Parcesepe, Levi Waldron, Denis Nash

Publications and Research

Introduction: The Chasing COVID Cohort (C 3 ) study is a US-based, geographically and socio-demographically diverse sample of adults (18 and older) enrolled into a prospective cohort study during the upswing of the U.S. COVID-19 pandemic.

Methods: We used internet-based strategies to enroll C 3 participants beginning March 28th, 2020. Following baseline questionnaire completion, study participants will be contacted monthly (for 6 months) to complete assessments of engagement in non-pharmaceutical interventions (e.g., use of cloth masks, avoiding large gatherings); COVID-19 symptoms; SARS/COV2 testing and diagnosis; hospitalizations; healthcare access; and uptake of health messaging. Dried blood spot (DBS) specimens will be …


Replacing A Single Tooth: Single Implant Vs. Three Unit Bridge, Ibeth Erazo, Aneeza Hussain May 2020

Replacing A Single Tooth: Single Implant Vs. Three Unit Bridge, Ibeth Erazo, Aneeza Hussain

Publications and Research

There are more than two options for restoring a single tooth but our research includes a three-unit bridge and a single-tooth implant as the main options. In this paper, we discuss the advantages and disadvantages of these methods and the factors that must be considered when choosing between them for the replacement of a single tooth. Although in some cases a three-unit bridge is the most appropriate choice, implants have the advantage of allowing preservation of the integrity of sound teeth adjacent to the edentulous area. Many factors must be considered when choosing between a three-unit bridge and an implant …


Twenty-Seven Questions For Writers & Journalists To Consider When Writing About Covid-19 & Hiv/Aids, Alexandra Juhasz, Pato Hebert, Theodore Kerr, Diana Cage May 2020

Twenty-Seven Questions For Writers & Journalists To Consider When Writing About Covid-19 & Hiv/Aids, Alexandra Juhasz, Pato Hebert, Theodore Kerr, Diana Cage

Publications and Research

The desire to compare COVID-19 and HIV/AIDS is understandable. The response to HIV provides an inspiring road map for how to save lives. For over four decades, starting in the early 1980s, activists, scientists, politicians and cultural producers have been working alongside one another resulting in life saving developments—and goals not yet achieved. Since the late 1990s, HIV has become a manageable chronic illness for those with access to life saving medicine, housing, food, and social support. Meanwhile, stigma, discrimination, and criminalization directed at people living with HIV continue, based on social difference, access to resources and community, and an …


Case Presentation On Periampullary Cancer And Ampullectomy, Tetiana Soloviova May 2020

Case Presentation On Periampullary Cancer And Ampullectomy, Tetiana Soloviova

Publications and Research

Periampullary cancer is a complex disease of heterogenous origin. This is cancer arising within 2 cm of the papilla of Vater and includes pancreatic, ampullary, biliary and duodenal cancers. Duodenal cancer has the highest estimated 5-year survival (49%), followed by ampullary cancer (45%), distal bile duct cancer (27%), and pancreatic cancer (18%). (Ray-Offor, 2019, ¶ 1)


Covid-19 In Prisons And Jails In The United States, Laura Hawks, Steffie Woolhander, Danny Mccormick Apr 2020

Covid-19 In Prisons And Jails In The United States, Laura Hawks, Steffie Woolhander, Danny Mccormick

Publications and Research

In mid-March 2020, the first case of novel coronavirus 2019 (COVID-19) was diagnosed at Riker’s Island, the main jail complex in New York City. Within 2 weeks,more than 200 cases were diagnosed within the facility, despite efforts to curb the spread.The situation at the Cook County jail in Chicago is similar, with about 350 incarcerated persons and staff members testing positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as of early April 2020. Many other jails and prisons have reported outbreaks of COVID-19 and related deaths.

Prior viral epidemics have wrought havoc in carceral settings. An account …


Covid-19 And Inequity: A Comparative Spatial Analysis Of New York City And Chicago Hot Spots, Andrew Maroko, Denis Nash, Brian Pavilonis Apr 2020

Covid-19 And Inequity: A Comparative Spatial Analysis Of New York City And Chicago Hot Spots, Andrew Maroko, Denis Nash, Brian Pavilonis

Publications and Research

There have been numerous reports that the impact of the ongoing COVID-19 epidemic has disproportionately impacted traditionally vulnerable communities, including well-researched social determinants of health, such as racial and ethnic minorities, migrants, and the economically challenged. The goal of this ecological cross-sectional study is to examine the demographic and economic nature of spatial hot and cold spots of SARS-CoV-2 rates in New York City and Chicago as of April 13, 2020.

In both cities, cold spots (clusters of low SARS-CoV-2 rate ZIP code tabulation areas) demonstrated typical protective factors associated with the social determinants of health and the ability to …


Estimating Population Immunity Without Serological Testing, Andrew Lesniewski Apr 2020

Estimating Population Immunity Without Serological Testing, Andrew Lesniewski

Publications and Research

We propose an approximate methodology for estimating the overall level of immunity against COVID-19 in a population that has been affected by the recent epidemic. The methodology relies on the currently available mortality data and utilizes the properties of the SIR model. We illustrate the application of the method by estimating the recent levels of immunity in 10 US states with highest case numbers of COVID-19.


Inequities Faced By Female Doctors Serving Communities Of Need, Ana Motta-Moss, Zainab Hussain Apr 2020

Inequities Faced By Female Doctors Serving Communities Of Need, Ana Motta-Moss, Zainab Hussain

Publications and Research

The reasons for sex inequity in medicine are complex and partly interface ethnic background, specialty choice, and practice location. Multiple factors influence career choices including cultural values, balancing family responsibilities with professional growth, and career mentoring and support. Over the last 40 years, the Sophie Davis/CUNY School of Medicine (CSOM) has pursued a mission to increase diversity in medicine at the same time in which it has fostered the importance of primary care and service in underserved areas of New York State. Data from 1524 CSOM graduates show an increase in the number of women and underrepresented groups, with about …


In Vivo Data: Treatment With The F11r/Jam-A Peptide 4d Decreases Mortality And Reduces The Generation Of Atherosclerotic Plaques In Apoe-Deficient Mice, Anna Babinska, Cristina C. Clement, Yan Li, Joanna Wzorek, Tomasz Przygodzki, Marcin Talar, Marcin Braun, Maria Swiatkowska, Yigal H. Ehrlich, Elizabeth Kornecki, Cezary Watala, Moro O. Salifu Apr 2020

In Vivo Data: Treatment With The F11r/Jam-A Peptide 4d Decreases Mortality And Reduces The Generation Of Atherosclerotic Plaques In Apoe-Deficient Mice, Anna Babinska, Cristina C. Clement, Yan Li, Joanna Wzorek, Tomasz Przygodzki, Marcin Talar, Marcin Braun, Maria Swiatkowska, Yigal H. Ehrlich, Elizabeth Kornecki, Cezary Watala, Moro O. Salifu

Publications and Research

The data in this article focus on the F11 Receptor (F11R/JAM-A; Junctional Adhesion Molecule-A; JAM-A, F11R), a cell adhesion protein constitutively expressed on the membrane surface of circulating platelets and localized within the tight junctions of healthy endothelial cells (ECs). Previous reports have shown that F11R/JAM-A plays a critical role in the adhesion of platelets to an inflamed endothelium due to its’ pathological expression on the luminal surface of the cytokine-inflamed endothelium. Since platelet adhesion to an inflamed endothelium is an early step in the development of atherosclerotic plaque formation, and with time, resulting in heart attacks and stroke, we …


Greater Social Cohesion Is Associated With Lower Body Mass Index Among African American Adults, Adolfo G. Cuevas, Ichiro Kawachi, Kasim Ortiz, Mariam Pena, Lorraine R. Reitzel, Lorna H. Mcneill Apr 2020

Greater Social Cohesion Is Associated With Lower Body Mass Index Among African American Adults, Adolfo G. Cuevas, Ichiro Kawachi, Kasim Ortiz, Mariam Pena, Lorraine R. Reitzel, Lorna H. Mcneill

Publications and Research

Obesity remains a public health issue, especially for Blacks (or African Americans). Obesity is thought to reflect a complex interaction of socioenvironmental, biological, and cognitive factors. Yet, insufficient attention has been given to psychosocial factors like social cohesion within the African American community. Using multivariable linear regression, we examined the association between social cohesion, measured by the Social Cohesion and Trust scale, and body mass index (BMI) with cross-sectional data (n = 1467) from a cohort study (2008–2009). Greater social cohesion was associated with lower BMI (b = -0.88; 95% CI: −1.45, −0.32) in an unadjusted model. The association was …


Efficacy Of Glutathione Therapy In Relieving Dyspnea Associated With Covid-19 Pneumonia: A Report Of 2 Cases, Richard I. Horowtiz, Phyllis R. Freeeman, James Bruzzese Apr 2020

Efficacy Of Glutathione Therapy In Relieving Dyspnea Associated With Covid-19 Pneumonia: A Report Of 2 Cases, Richard I. Horowtiz, Phyllis R. Freeeman, James Bruzzese

Publications and Research

Purpose: Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.

Methods: Two patients living in New York City …


Combating Sars-Cov-2: Leveraging Microbicidal Experiences With Other Emerging/Re-Emerging Viruses, M. Khalid Ijaz, Syed A. Sattar, Joseph R. Rubino, Raymond W. Nims, Charles P. Gerba Apr 2020

Combating Sars-Cov-2: Leveraging Microbicidal Experiences With Other Emerging/Re-Emerging Viruses, M. Khalid Ijaz, Syed A. Sattar, Joseph R. Rubino, Raymond W. Nims, Charles P. Gerba

Publications and Research

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan City, China, late in December 2019 is another example of an emerging zoonotic virus that threatens public health and international travel and commerce. When such a virus emerges, there is often insufficient specific information available on mechanisms of virus dissemination from animal to human or from person to person, on the level or route of infection transmissibility or of viral release in body secretions/excretions, and on the survival of virus in aerosols or on surfaces. The effectiveness of available virucidal agents and hygiene practices as interventions for disrupting …


Coronavirus Transmission In The Dental Setting, Susan H. Davide, Anty Lam, Christine Macarelli Apr 2020

Coronavirus Transmission In The Dental Setting, Susan H. Davide, Anty Lam, Christine Macarelli

Publications and Research

Oral health professionals should remain up-to-date on the coronavirus, and clinical measures to prevent its transmission in the dental setting.


What Would A Covid 19 Doula Do Zine, Alexandra Juhasz, Theodore Kerr, Pato Hebert, Jih-Fei Cheng Apr 2020

What Would A Covid 19 Doula Do Zine, Alexandra Juhasz, Theodore Kerr, Pato Hebert, Jih-Fei Cheng

Publications and Research

This zine is a snapshot of a time from the WHAT WOULD AN HIV DOULA DO? (WWHIVDD) community, responding in words, actions and images to the unfolding, unprecedented, global crisis of the COVID-19 pandemic. The first half of the zine is rooted in the exhibition, Metanoia: Transformation through AIDS Archives and Activism curated by WWHIVDD for the ONE Archives Foundation (ONE) . The second half are responses from our Metanoia and WWHIVDD communities responding to the prompt: What Does a COVID-19 Doula Do? Many of the entries were submitted the second week of March as people in the US were …


Cyp1a2 Genotype And Acute Effects Of Caffeine On Resistance Exercise, Jumping, And Sprinting Performance, Jozo Grgic, Craig Pickering, David Bishop, Brad J. Schoenfeld, Pavle Mikulic, Zeljko Pedisic Apr 2020

Cyp1a2 Genotype And Acute Effects Of Caffeine On Resistance Exercise, Jumping, And Sprinting Performance, Jozo Grgic, Craig Pickering, David Bishop, Brad J. Schoenfeld, Pavle Mikulic, Zeljko Pedisic

Publications and Research

Background: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.

Methods: Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed …


Effects Of A Ketogenic Diet On Body Compostion And Strength In Trained Women, Salvador Vargas-Molina, Jorge L. Petro, Ramón Romance, Richard B. Kreider, Brad J. Schoenfeld, Diego A. Bonilla, Javier Benítez-Porres Apr 2020

Effects Of A Ketogenic Diet On Body Compostion And Strength In Trained Women, Salvador Vargas-Molina, Jorge L. Petro, Ramón Romance, Richard B. Kreider, Brad J. Schoenfeld, Diego A. Bonilla, Javier Benítez-Porres

Publications and Research

Background: The effect of ketogenic diets (KD) on body composition in different populations has been investigated. More recently, some have recommended that athletes adhere to ketogenic diets in order to optimize changes in body composition during training. However, there is less evidence related to trained women. We aimed to evaluate the effect of a KD on body composition and strength in trained women following an eight-week resistance training (RT) program.

Methods: Twenty-one strength-trained women (27.6 ± 4.0 years; 162.1 ± 6.6 cm; 62.3 ± 7.8 kg; 23.7 ± 2.9 kg·m− 2) were randomly assigned to either a non-KD group (n …


Impact Of Meteorological Factors On The Covid-19 Transmission: A Multicity Study In China, Jiangtao Liu, Ji Zhou, Jinxi Yao, Xiuxia Zhang, Lanyu Li, Xiaocheng Xu, Xiaotao He, Bo Wang, Shihua Fu, Tingting Niu, Jun Yan, Yanjun Shi, Xiaowei Ren, Jingping Niu, Weihao Zhu, Sheng Li, Bin Luo, Kai Zhang Apr 2020

Impact Of Meteorological Factors On The Covid-19 Transmission: A Multicity Study In China, Jiangtao Liu, Ji Zhou, Jinxi Yao, Xiuxia Zhang, Lanyu Li, Xiaocheng Xu, Xiaotao He, Bo Wang, Shihua Fu, Tingting Niu, Jun Yan, Yanjun Shi, Xiaowei Ren, Jingping Niu, Weihao Zhu, Sheng Li, Bin Luo, Kai Zhang

Publications and Research

The purpose of the present study is to explore the associations between novel coronavirus disease 2019 (COVID- 19) case counts and meteorological factors in 30 provincial capital cities of China. We compiled a daily dataset including confirmed case counts, ambient temperature (AT), diurnal temperature range (DTR), absolute humidity (AH) and migration scale index (MSI) for each city during the period of January 20th to March 2nd, 2020. First, we explored the associations between COVID-19 confirmed case counts, meteorological factors, and MSI using non-linear regression. Then, we conducted a two-stage analysis for 17 cities with more than 50 confirmed cases. In …


Biological Sex Influences Susceptibility To Acinetobacter Baumannii Pneumonia In Mice, Sílvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker Apr 2020

Biological Sex Influences Susceptibility To Acinetobacter Baumannii Pneumonia In Mice, Sílvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker

Publications and Research

Acinetobacter baumannii (A. baumannii) is an extremely versatile multidrug-resistant pathogen with a very high mortality rate; therefore, it has become crucial to understand the host response during its infection. Given the importance of mice for modeling infection and their role in preclinical drug development, equal emphasis should be placed on the use of both sexes. Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced …


The Influence Of Education On Health: An Empirical Assessment Of Oecd Countries For The Period 1995–2015, Viju Raghupathi, Wullianallur Raghupathi Apr 2020

The Influence Of Education On Health: An Empirical Assessment Of Oecd Countries For The Period 1995–2015, Viju Raghupathi, Wullianallur Raghupathi

Publications and Research

Background: A clear understanding of the macro-level contexts in which education impacts health is integral to improving national health administration and policy. In this research, we use a visual analytic approach to explore the association between education and health over a 20-year period for countries around the world.

Method: Using empirical data from the OECD and the World Bank for 26 OECD countries for the years 1995–2015, we identify patterns/associations between education and health indicators. By incorporating pre- and post- educational attainment indicators, we highlight the dual role of education as both a driver of opportunity as well as of …


Motivation To Access Laparoscopic Skills Training: Results Of A National Survey Of Obstetric And Gynaecology Residents, Jocelyn Stairs, Bradley W. Bergey, Finlay Maguire, Stephanie Scott Apr 2020

Motivation To Access Laparoscopic Skills Training: Results Of A National Survey Of Obstetric And Gynaecology Residents, Jocelyn Stairs, Bradley W. Bergey, Finlay Maguire, Stephanie Scott

Publications and Research

Objective

Competency based medical education (CBME) requires novel approaches to surgical education. Significant investment has been made in laparoscopic simulation, which has been shown to foster skill development prior to patient encounters. However, research suggests variable voluntary use of these resources by residents, and little is known about the motivational factors that influence their utilization. The purpose of this study was to characterize factors that motivate residents to seek laparoscopic simulation experience outside of the formal curriculum.

Design

We developed a questionnaire grounded in Expectancy Value Theory, an established psychological theory of motivation, by adapting validated measures to fit the …


Understanding Facilitators And Barriers To Dietary Management Of Type 2 Diabetes Among Hispanic Men: Perceptions Of Health Professionals, Leah Galitzdorfer, Melissa Fuster Phd, Pamela Koch Edd, Rd Apr 2020

Understanding Facilitators And Barriers To Dietary Management Of Type 2 Diabetes Among Hispanic Men: Perceptions Of Health Professionals, Leah Galitzdorfer, Melissa Fuster Phd, Pamela Koch Edd, Rd

Publications and Research

Objectives: Hispanic Americans have a higher prevalence of Type 2 Diabetes (T2DM) compared to non-Hispanic whites, and are at greater risk for developing diabetes-related complications. Barriers and facilitators to dietary managment of T2DM among this population may be particularly influenced by culture and gender, where traditional gender roles and values prevent Hispanic men from engaging in healthy dietary self-management behaviors. Despite this, research focusing on dietary management of T2DM among Hispanic men is scant. This study aimed to assess perceived barriers and facilitators, as well as perceived influences of culture and gender on the dietary management of T2DM among Hispanic …


The Public Health Dialogue, 2020 (Editor's Choice), Alfredo Morabia Apr 2020

The Public Health Dialogue, 2020 (Editor's Choice), Alfredo Morabia

Publications and Research

No abstract provided.


Congenital Zika Syndrome - Background And Nutrition Care Of Affected Infants, Ann Gaba, Ghada Soliman Apr 2020

Congenital Zika Syndrome - Background And Nutrition Care Of Affected Infants, Ann Gaba, Ghada Soliman

Publications and Research

This review provides a history and overview of Zika infection, with special attention to resultant birth defects and the nutrition care required by Zika affected infants.


The Ends Of Medicine And The Experience Of Patients, D. Robert Macdougall Apr 2020

The Ends Of Medicine And The Experience Of Patients, D. Robert Macdougall

Publications and Research

The ends of medicine are sometimes construed simply as promotion of health, treatment and prevention of disease, and alleviation of pain. Practitioners might agree that this simple formulation captures much of what medical practice is about. But while the ends of medicine may seem simple or even obvious, the essays in this issue demonstrate the wide variety of philosophical questions and issues associated with the ends of medicine. They raise questions about how to characterize terms like “health” and “disease”; whether medicine’s goals should be extended to include enhancement beyond normal human function; and whether the ends of medicine are …


Managing The Threat Of Covid-19, Susan H. Davide, Anty Lam, Christine Macarelli Apr 2020

Managing The Threat Of Covid-19, Susan H. Davide, Anty Lam, Christine Macarelli

Publications and Research

Oral health professionals should remain up-to-date on Covid-19 to prevent its transmission in the dental practice.


Feminist Pedagogy In A Time Of Coronavirus Pandemic, Alexandra Juhasz, Laura Wexler, Liz Losh, Sharon Irish Mar 2020

Feminist Pedagogy In A Time Of Coronavirus Pandemic, Alexandra Juhasz, Laura Wexler, Liz Losh, Sharon Irish

Publications and Research

FemTechNet, a network of scholars, artists, and students working on, with, and at the borders of technology, science, and feminism, has a great deal of experience thinking about pedagogy and technology. We have produced real intimacy, vibrant classes, and insurgent pedagogy since 2012. The principles of our signature Distributed Open Collaborative Courses (DOCCs) are crucial (see below). In this time of crisis, we believe we need to think again, drawing the most power possible from the radical knowledges, tactics, and commitments of feminist pedagogies of past experience. We write while schools, colleges, and universities have closed in a cascade of …


Commentary: Can Blood Flow Restricted Exercise Cause Muscle Damage? Commentary On Blood Flow Restriction Exercise: Considerations Of Methodology, Application, And Safety, Mathias Wernbom, Brad J. Schoenfeld, Gøran Paulsen, Thomas Bjørnsen, Kristoffer T. Cumming, Per Aagaard, Brian C. Clark, Truls Raastad Mar 2020

Commentary: Can Blood Flow Restricted Exercise Cause Muscle Damage? Commentary On Blood Flow Restriction Exercise: Considerations Of Methodology, Application, And Safety, Mathias Wernbom, Brad J. Schoenfeld, Gøran Paulsen, Thomas Bjørnsen, Kristoffer T. Cumming, Per Aagaard, Brian C. Clark, Truls Raastad

Publications and Research

Low-load exercise combined with blood flow restriction (BFR) is known to induce significant gains in muscle strength and size, and this mode of training is increasingly used in both healthy and clinical populations, as documented in the recent review of Patterson et al. (2019). However, since the first training studies on BFR exercise appeared about 20 years ago, there have been some concerns about its safety, in particular with regard to the potential risk for muscle damage (Wernbom et al., 2019). In a recent editorial, Wernbom et al. (2019) briefly discussed the accumulating evidence for muscle damage and rhabdomyolysis with …


Metabolic Reprogramming By C-Met Inhibition As A Targetable Vulnerability In Glioblastoma, Trang Thi Thu Nguyen, Enyuan Shang, Georg Karpel-Massler, Markus D. Siegelin Mar 2020

Metabolic Reprogramming By C-Met Inhibition As A Targetable Vulnerability In Glioblastoma, Trang Thi Thu Nguyen, Enyuan Shang, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

The elucidation of better treatments for solid tumors and especially malignant glial tumors is a priority. Better understanding of the molecular underpinnings of treatment response and resistance are critical determinants in the success for this endeavor. Recently, a battery of novel tools have surfaced that allow to interrogate tumor cell metabolism to more precise extent than this was possible in the earlier days. At the forefront of these developments are the extracellular flux and carbon tracing analyses. Through utilization of these techniques our group made the recent observation that acute and chronic c-MET inhibition drives fatty acid oxidation that in …