Medicine and Health Sciences Commons^™

Meiotic And Mitotic Phenotypes Conferred By The Blm1-1 Mutation In Saccharomyces Cerevisiae And Msh4 Suppression Of The Bleomycin Hypersusceptibility, Georgia Anyatonwu, Ediberto Garcia, Ajay Pramanik, Marie Powell, Carol Wood Moore

Publications and Research

Oxidative damage can lead to a number of diseases, and can be fatal. The blm1-1 mutation of Saccharomyces cerevisiae confers hypersusceptibility to lethal effects of the oxidative, anticancer and antifungal agent, bleomycin. For the current report, additional defects conferred by the mutation in meiosis and mitosis were investigated. The viability of spores produced during meiosis by homozygous normal BLM1/BLM1, heterozygous BLM1/blm1-1, and homozygous mutant blm1-1/blm1-1 diploid strains was studied and compared. Approximately 88% of the tetrads derived from homozygous blm1-1/blm1-1 mutant diploid cells only produced one or two viable spores. In contrast, just one tetrad among all BLM1/BLM1 and BLM1/blm1-1 …

Up-Regulation Of Neuronal Calcium Sensor-1 (Ncs-1) In The Prefrontal Cortex Of Schizophrenic And Bipolar Patients, Phil Ok Koh, Ashiwel S. Undieh, Robert Levenson, Patricia S. Goldman-Rakic, Michael S. Lidow

Publications and Research

The delineation of dopamine dysfunction in the mentally ill has been a long-standing quest of biological psychiatry. The present study focuses on a recently recognized group of dopamine receptor- interacting proteins as possible novel sites of dysfunction in schizophrenic and bipolar patients. We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1. These levels of neuronal calcium sensor-1 were not influenced by age, gender, hemisphere, cause of death, postmortem period, alcohol consumption, or antipsychotic and mood stabilizing …

Laboratory Response To Anthrax Bioterrorism, New York City, 2001, Michael B. Heller, Michel L. Bunning, Martin E.B. France, Debra M. Niemeyer, Leonard Peruski, Tim Naimi, Phillip M. Talboy, Patrick H. Murray, Harald W. Pietz, John Kornblum, William Oleszko, Sara T. Beatrice, Joint Microbiological Rapid Response Team, New York City Anthrax Investigation Working Group, Denis Nash

Publications and Research

In October 2001, the greater New York City Metropolitan Area was the scene of a bioterrorism attack. The scale of the public response to this attack was not foreseen and threatened to overwhelm the Bioterrorism Response Laboratory’s (BTRL) ability to process and test environmental samples. In a joint effort with the Centers for Disease Control and Prevention and the cooperation of the Department of Defense, a massive effort was launched to maintain and sustain the laboratory response and return test results in a timely fashion. This effort was largely successful. The development and expansion of the facility are described, as …

Relationship Between Low Quality-Of-Care Scores And Hmos' Subsequent Public Disclosure Of Quality-Of-Care Scores, Danny Mccormick, David U. Himmelstein, Steffie Woolhandler, Sidney M. Wolfe, David H. Bor

Publications and Research

Context Public disclosure of quality data on health maintenance organizations (HMOs) might improve public accountability, inform consumer decision making, and promote quality improvement. But, because disclosure is voluntary, some HMOs could subvert these objectives by refusing to release unfavorable data.

Objective To determine the association between HMO quality of care and withdrawal from public disclosure of quality-of-care data the subsequent year.

Design and Setting Retrospective cohort study of administrative and quality-of-care data on HMOs from the National Committee for Quality Assurance (NCQA) annual Quality Compass databases for 1997, 1998, and 1999, including Health Plan Employer Data and Information Set (HEDIS) …

Timing Of New Black Box Warnings And Withdrawals For Prescription Medications, Karen Lasser, Paul D. Allen, Steffie Woolhandler, David U. Himmelstein, Sidney M. Wolfe, David H. Bor

Publications and Research

Context Recently approved drugs may be more likely to have unrecognized adverse drug reactions (ADRs) than established drugs, but no recent studies have examined how frequently postmarketing surveillance identifies important ADRs.

Objective To determine the frequency and timing of discovery of new ADRs described in black box warnings or necessitating withdrawal of the drug from the market.

Design and Setting Examination of the Physicians' Desk Reference for all new chemical entities approved by the US Food and Drug Administration between 1975 and 1999, and all drugs withdrawn from the market between 1975 and 2000 (with or without a prior black …

Mercury Exposure And Malaria Prevalence Among Gold Miners In Pará, Brazil, Ellen K. Silbergeld, Denis Nash, Circey Trevant, G. Thomas Strickland, Jose Maria De Souza, Rui S.U. Da Silva

Publications and Research

No abstract provided.

Ipsilesional Biases In Saccades But Not Perception After Lesions Of The Human Inferior Parietal Lobule, Tony Ro, Chris Rorden, Jon Driver, Robert Rafal

Publications and Research

We examined the effects of chronic unilateral lesions to either the inferior parietal lobe, or to the dorsolateral prefrontal cortex including the frontal eye fields (FEFs), upon human visual perception and saccades in temporal-order-judgment (TOJ) tasks. Two visual events were presented on each trial, one in each hemifield at various stimulus onset asynchronies (SOAs). In the saccade task, patients moved their eyes to whichever stimulus attracted gaze first. In the perceptual-manual task, they pressed a button to indicate which stimulus was perceived first. Frontal patients showed appropriate TOJs for visual targets in both tasks. Parietal patients showed appropriate TOJs in …

The Outbreak Of West Nile Virus Infection In The New York City Area In 1999, Denis Nash, Farzad Mostashari, Annie Fine, James Miller, Daniel O'Leary, Kristy Murray, Ada Huang, Amy Rosenberg, Abby Greenberg, Margaret Sherman, Susan Wong, Marcelle Layton

Publications and Research

Background In late August 1999, an unusual cluster of cases of meningoencephalitis associated with muscle weakness was reported to the New York City Department of Health. The initial epidemiologic and environmental investigations suggested an arboviral cause.

Methods Active surveillance was implemented to identify patients hospitalized with viral encephalitis and meningitis. Cerebrospinal fluid, serum, and tissue specimens from patients with suspected cases underwent serologic and viral testing for evidence of arboviral infection.

Results Outbreak surveillance identified 59 patients who were hospitalized with West Nile virus infection in the New York City area during August and September of 1999. The median age …

Stress In 1st-Year Women Teachers: The Context Of Social Support And Coping, Irvin Sam Schonfeld

Publications and Research

The effects of adverse work environments were examined in the context of other risk/protective factors in this extension of a short-term longitudinal study involving 184 newly appointed women teachers. Regression analyses revealed that, adjusting for preemployment levels of the outcomes and negative affectivity, social support and adversity in the fall work environment were among the factors that affected spring depressive symptoms, self-esteem, job satisfaction, and motivation to teach. Support from nonwork sources was directly related to future improved symptom levels and self-esteem; supervisor and colleague support were directly related to future job satisfaction. Effects of occupational coping, professional …

The Role Of Pathology In An Investigation Of An Outbreak Of West Nile Encephalitis In New York, 1999, Wun-Ju Shieh, Jeannette Guarner, Marci Layton, Annie Fine, James Miller, Denis Nash, Grant L. Campbell, John T. Roehrig, Duane J. Gubler, Sherif R. Zaki

Publications and Research

An outbreak of encephalitis occurred in New York City in late August 1999, the first caused by West Nile virus in North America. Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent.

An Updated Look At Depressive Symptoms And Job Satisfaction In First-Year Women Teachers, Irvin Sam Schonfeld

Publications and Research

This report updates a longitudinal study (I. S. Schonfeld, 1992) of the effects of working conditions on newly appointed womenteachers. The update included a later graduating cohort and additional outcome measures. Moreover, women who were not fully exposed to work stressors (e.g. part-time work, change of schools) were now excluded from the analyses. Among the 184 teachers (average age 27 yrs), work environment measures were more highly correlated with future depressive symptoms, self-esteem, job satisfaction, and motivation to teach than with pre-employment counterparts of the outcomes. Regression analyses underlined the effects of the work environment on …

Nutritional Therapies For Ulcerative Colitis: Literature Review, Chart Review Study, And Future Research, Joel S. Edman, William (Bill) H. Williams, Robert C. Atkins

Publications and Research

Few clinical studies suggest a significant influence of diet or nutritional supplementation on ulcerative colitis. One reason is that ulcerative colitis, like many chronic diseases, is multifactorial. This article reviews the relevant literature and presents the results of a retrospective chart review study that was done at a complimentary medicine office.

Update: West Nile Virus Encephalitis — New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

The West Nile virus (WNV) encephalitis outbreak continues to wane in the Northeast with the onset of cooler temperatures and continued vector-control operations. This report updates the progress of the ongoing investigation. Since the last published update (1), five additional domestic human cases and one international case have been identified. As of October 19, 56 (31 confirmed and 25 probable) cases of WNV infection have been identified, including seven deaths (Figure 1). The date of onset of the latest cases was September 22. The international case was a Canadian citizen who had visited the New York City (NYC) area in …

Update: West Nile-Like Viral Encephalitis — New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

The outbreak of human arboviral encephalitis attributable to a mosquito-transmitted West Nile-like virus (WNLV) continues to wane in the Northeast (Figure 1). As of October 5, the number of laboratory-positive cases had increased to 50 (27 confirmed and 23 probable), including five deaths. The increase in cases is mainly a result of completed retesting with West Nile virus antigen of specimens previously tested with the related St. Louis encephalitis virus antigen and to intensive retrospective case finding in the ongoing epidemiologic investigations (1,2).

Outbreak Of West Nile-Like Viral Encephalitis -- New York, 1999, Centers For Disease Control And Prevention, Denis Nash

Publications and Research

An outbreak of arboviral encephalitis was first recognized in New York City in late August and has since been identified in neighboring counties in New York state. Although initially attributed to St. Louis encephalitis (SLE) virus based on positive serologic findings in cerebrospinal fluid (CSF) and serum samples using a virus-specific IgM-capture enzyme-linked immunosorbent assay (ELISA), the cause of the outbreak has been confirmed as a West Nile-like virus based on the identification of virus in human, avian, and mosquito.

Quality Of Care In Investor-Owned Vs Not-For-Profit Hmos, David U. Himmelstein, Steffie Woolhandler, Ida Hellander, Sidney M. Wolfe

Publications and Research

Context The proportion of health maintenance organization (HMO) members enrolled in investor-owned plans has increased sharply, yet little is known about the quality of these plans compared with not-for-profit HMOs.

Objective To compare quality-of-care measures for investor-owned and not-for-profit HMOs.

Design, Setting, and Participants Analysis of the Health Plan Employer Data and Information Set (HEDIS) Version 3.0 from the National Committee for Quality Assurance's Quality Compass 1997, which included 1996 quality-of-care data for 329 HMO plans (248 investor-owned and 81 not-for-profit), representing 56% of the total HMO enrollment in the United States.

Main Outcome Measures Rates for 14 HEDIS quality-of-care …

The Guillain-Barre Syndrome And The 1992-1993 And 1993-1994 Influenza Vaccines, Tamar Lasky, Gina J. Terracciano, Laurence Magder, Carol Lee Koski, Michael Ballesteros, Denis Nash, Shelley Clarke, Penina Haber, Paul D. Stolley, Lawrence B. Schonberger, Robert T. Chen

Publications and Research

Background
The number of reports of influenza-vaccine-associated Guillain-Barré syndrome to the national Vaccine Adverse Event Reporting System increased from 37 in 1992-1993 to 74 in 1993-1994, arousing concern about a possible increase in vaccine-associated risk.

Methods
Patients given a diagnosis of the Guillain-Barré syndrome in the 1992-1993 and 1993-1994 influenza-vaccination seasons were identified in the hospital-discharge data bases of four states. Vaccination histories were obtained by telephone interviews during 1995-1996 and were confirmed by the vaccine providers. Disease with an onset within six weeks after vaccination was defined as vaccine-associated. Vaccine coverage in the population was measured through a random-digit-dialing …

Mechanism Of Triazolo-Benzodiazepine And Benzodiazepine Action In Anxiety And Depression: Behavioral Studies With Concomitant In Vivo Ca1 Hippocampal Norepinephrine And Serotonin Release Detection In The Behaving Animal, Patricia A. Broderick, Omotola Hope, Pierrot Jeannot

Publications and Research

1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA₁ region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat.

2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection.

3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam …

Myelin-Associated Glycoprotein Interacts With Neurons Via A Sialic Acid Binding Site At Arg118 And A Distinct Neurite Inhibition Site, Song Tang, Ying Jing Shen, Maria Elena Debellard, Gitali Mukhopadhyay, James L. Salzer, Paul R. Crocker, Marie T. Filbin

Publications and Research

Inhibitory components in myelin are largely responsible for the lack of regeneration in the mammalian CNS. Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo. Here, we show that MAG’s sialic acid binding site is distinct from its neurite inhibitory activity. Alone, sialic acid–dependent binding of MAG to neurons is insufficient to effect inhibition of axonal growth. Thus, while soluble MAG-Fc (MAG extracellular domain fused to Fc), a truncated form of MAG-Fc missing Ig-domains 4 and 5, MAG(d1-3)-Fc, …

Transcranial Magnetic Stimulation Of The Prefrontal Cortex Delays Contralateral Endogenous Saccades, Tony Ro, Avishai Henik, Liana Machado, Robert D. Rafal

Publications and Research

The contributions of the superior prefrontal cortex (SPFC) and the superior parietal lobule (SPL) in generating voluntary endogenous and reflexive visually guided saccades were investigated using transcranial magnetic stimulation (TMS). Subjects made choice saccades to the left or right visual field in response to a central arrowhead (endogenous go signal) or a peripheral asterisk (exogenous go signal) that were presented along with a single TMS pulse at varying temporal intervals. TMS over the SPFC increased latencies for saccades made in response to an endogenous go signal toward the contralateral hemifield. No effects were observed when the go signal was exogenous …

Effects Of A Sugar-Free Hypoallerdenic Diet And Nutrtional Supplementation On Ulcerative Colitis, William (Bill) H. Williams, Robert C. Atkins Md, Joel S. Edman

Publications and Research

Few clinical studies have found that dietary or nutritional factors significantly influence ulcerative colitis (UC}(l,2}. It is noteworthy, however, that a range of factors have been researched including dietary components such as refined sugars (3,4}, allergenic foods (1,5,6} and fast foods (7), as well as nutritional supplement effects from fish oil (2), zinc (8), glutamine (9), folate (10, 11} and alpha-tocopherolquinone (12}. More recently investigators have also examined the interelationships between bowel flora and UC, including factors such as flora changes (13,14), endotoxemia (15} and supplementation effects with Lactobacillous species (16,17). These studies taken together and a recent review of …

Minor Physical Anomalies: Modifiers Of Environmental Risk For Psychopathology, Daniel S. Pine, David Shaffer, Irvin Sam Schonfeld, Mark Davies

Publications and Research

Tested the hypothesis that minor physical anomalies (MPAs) modify an adolescent's vulnerability to environmental risk factors for psychopathology. 118 male 17-yr-olds who had been evaluated as 7-year-olds received a comprehensive neuropsychiatric evaluation. The evaluation included standardized assessments of environmental risk factors for psychiatric impairment, neurological signs, IQ, MPAs, and psychiatric impairment. The relationship between psychiatric status and environmental risk was examined as a function of the MPA profile. There was a significant interaction between MPAs and environmental risk in predicting psychiatric status. Environmental risk was more predictive of psychiatric impairment at age 17 in Ss with high scores on the …

Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth

Publications and Research

Examined the relation of neonatal cranial ultrasonography abnormalities to later psychiatric disorder in 564 low birth weight children (aged 5.2–8.7 yrs). Psychiatric diagnoses were assessed by means of the Diagnostic Interview Schedule for Children–Parent version, and detailed information was collected on other predictors and outcomes. Results show that 454 Ss had no cranial abnormalities, 78 had germinal matrix hemorrhage (GMH) and/or intraventricular hemorrhage (IVH), and 32 had a parenchymal lesion (PL) or ventricular enlargement (VE). 22% of the Ss had at least 1 psychiatric disorder, the most common being attention deficit hyperactivity disorder (ADHD). Isolated GMH/IVH did not increase …

Neonatal Cranial Ultrasound Abnormalities In Lbw Infants: Relation To Cognitive Outcomes At Age Six, Agnes H. Whitaker, Judy F. Feldman, Ronan Van Rossem, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, Suzannah R. Blumenthal, Nigel S. Paneth

Publications and Research

bjective: To assess the independent relation of neonatal cranial ultrasound (US) abnormalities in low birth weight (LBW) infants to cognitive outcomes at 6 years of age.
Design: Prospective cohort study.
Sample and Methods: Six-year follow-up data were obtained on a regional birth cohort of LBW infants (< 2 kg) systematically screened as neonates with serial US. US abnormalities were dichotomized into isolated germinal matrix/intraventricular hemorrhage (GM/IVH) and parenchymal lesions/ventricular enlargement (PL/VE). Global cognitive outcomes (mental retardation, borderline intelligence, and normal intelligence) and selected specific cognitive abilities were assessed at 6 years of age with standardized instruments. Multivariate techniques were used to assess the effects of US independent of maternal social …

Relation Of Negative Affectivity To Self-Reports Of Job Stressors And Psychological Outcomes, Irvin Sam Schonfeld

Publications and Research

A total of 250 new women teachers participated in a longitudinal study of the influence of negative affectivity (NA) on the relation of self-report work-environment measures to psychological outcomes. Three "neutrally worded" work-environment measures were specially constructed to minimize confounding with NA. The work-environment measures were moderately related to postemployment depressive symptoms, job satisfaction, and, among Whites but not among a principally Black and Hispanic subsample, motivation. Correlation and regression coefficients were largely unchanged when the preemployment psychophysiologic symptoms scale and the Center for Epidemiologic Studies-Depression Scale (L. S. Radloff, 1977), factors that tap NA, were controlled. Findings suggest NA …

A Population-Based Serologic Survey Of Immunity To Tetanus In The United States, Peter J. Gergen, Geraldine M. Mcquillan, Michele Kiely, Trena M. Ezzati-Rice, Roland W. Sutter, Gabriel Virella

Publications and Research

Background. Vaccination rates are frequently considered a surrogate measure of protection. To provide more accurate estimates, serum levels of antibody against tetanus were measured as part of the third National Health and Nutrition Examination Survey (NHANES III), which studied a representative sample of the civilian, noninstitutionalized population of the United States.

Methods. We measured tetanus antitoxin using a solid- phase enzyme immunoassay in serum samples from 10,618 persons six years of age and older who were examined during phase 1 of NHANES III in 1988 to 1991.

Results. Overall, 69.7 percent of Americans six years of age and …

Methodological Issues In Occupational-Stress Research: Research In One Occupational Group And Its Wider Applications, Irvin Sam Schonfeld, Jaesoon Rhee, Fang Xia

Publications and Research

The chapter addresses a number of important methodologic issues that are relevant to occupational-stress researchers. The issues addressed have arisen in the context of an ongoing research program involving cross-sectional and longitudinal studies of stress in teachers; the issues, however, apply to occupational research in general. The first issue involves measurement strategies required in operationalizing the stress process. The focal concern is the reduction of confounding in measures of the work environment. The second issue encompasses the question of whether to sample new or veteran workers. The third issue applies to types of job stressors. The chapter describes a …

A Longitudinal Study Of Occupational Stressors And Depressive Symptoms In First-Year Teachers, Irvin Sam Schonfeld

Publications and Research

Administered the Center for Epidemiologic Studies Depression Scale and episodic stressor and strain scales to 255 female newly appointed teachers. Job conditions were related to postemployment depressive symptoms independently of pre-employment symptoms and other risk factors. Ss who worked in the most adverse school environments showed the most depressive symptoms; Ss in schools with the best conditions tended to show the fewest symptoms. The effects of working conditions on symptoms were relatively immediate. There may be positive mental health effects, in relation to preemployment levels, associated with teaching in benign school environments. Suggestions for future progress in …

Persistent Emotional Disorder In Children With Neurological Soft Signs, Daniel Pine, David Shaffer, Irvin Sam Schonfeld

Publications and Research

Provides clinical details in the form of 11 case vignettes from a prospective epidemiological study that found the combination of childhood 'soft' signs and anxious behavior to be a strong risk factor for adolescent emotional disorders. The original study conducted a neuropsychiatric assessment of 180 African-American adolescents (aged 16–18 yrs) who had been followed through childhood. The at-risk Ss exhibited a persistent and specific pattern of both motor abnormalities and anxiety, obsessional compulsive, or depressive symptoms over time. The form of at-risk Ss' neurological and psychiatric abnormalities is consistent with a link between motor system abnormalities and …

Tabaco, Ambiente Y Salud. La Situación En Venezuela Y El Mundo, Aldemaro Romero Jr.

Publications and Research

No abstract provided.