Medicine and Health Sciences Commons^™

Acute Effects Of Neuromuscular Electrical Stimulation On Blood Glucose And Energy Metabolism In Overweight/Obese Population, Ali Mossayebi

Open Access Theses & Dissertations

Background: In the perspective of preventing cardiovascular disease and promoting health, weight control and physical activity are the main concerns. Electrical stimulation (ES) is an alternate strategy to induce muscle contraction, using electrical impulses. However, effectiveness of ES induced muscle contraction to improve energy expenditure and glucose metabolism is not well examined.Purpose: To determine the acute effect of ES on whole body energy expenditure and body glucose metabolism in sedentary overweight or obese population Methods: Sedentary overweight/obese participants (n=8; age: 37.25 ± 6.09 years; BMI= 37.57 ± 2.43 kg/m2) were included in this study. All participants received bilateral quadriceps ES …

Autoantibody Against Tumor-Associated Antigens As Diagnostic Biomarkers In Hispanic Patients With Hepatocellular Carcinoma, Yangcheng Ma

Open Access Theses & Dissertations

Liver cancer is one of the most prevalent malignancies, in which hepatocellular carcinoma (HCC) takes up more than 80% of liver cancer cases. Early diagnosis and treatment are practical approaches to impede HCC progression. Identifying and classifying autoantibodies against tumor-associated antigens (TAAs) have long been interested in cancer diagnosis, especially for HCC. Circulating anti-TAA autoantibodies amplify the antigen expression and are more stable in blood, guaranteeing anti-TAA autoantibodies as valid diagnostic biomarkers in clinical application. Nonetheless, very few studies had focused on the Hispanic HCC group, which might retain distinct etiological risk factors compared to other ethnicities. The high incidence …

Examining Social Determinants Of Health And Cervical Cancer Risk And Outcomes In Ecuadorian Women, Pooja Tewari

Open Access Theses & Dissertations

Background and Significance: The burden of cervical cancer in the Latin American region is high. The crude incidence rate and the crude mortality rate in Ecuador are significantly higher than that of South America and the World. Riobamba, Ecuador, where the Fundación Internacional Buen Samaritano Paul Martel (FIBUSPAM) hospital is located, has been found to be one of the cities most affected with cervical cancer in the country. Risk factors for cervical cancer that have been identified in Latin American women include chronological age, age of first sexual intercourse, number of sexual partners, number of pregnancies, use of oral contraceptives, …

Trauma And Resilience Among Migrant Children From Mexico And The Northern Triangle Eroute To The United States, Georgina Sanchez-Garcia

Open Access Theses & Dissertations

Children who experience the phenomenon of migration from the Northern Triangle region and Mexico en route to the United States face pressing problems with psychosocial consequences that ostensibly affect them and are reflected in the violation of their human rights. We studied trauma and resilience among migrant children from Mexico and the Northern Triangle nations â??Guatemala, El Salvador, and Hondurasâ?? who are uprooted from their communities to undertake the dangerous overland journey to the United States (Lusk & Sanchez-Garcia, 2021; Rodriguez, 2020; UNICEF, 2018). The experience of such migration for children can be fraught with hardship, and it may have …

Twitter Posts, Gist, And The Perceived Harmfulness Of The Human Papillomavirus Vaccine, Candice Fawn Coffman

Open Access Theses & Dissertations

Individuals frequently encounter two types of information when evaluating the risk of a vaccination: statistical evidence describing the frequency of positive and negative outcomes, and anecdotal evidence describing positive and negative personal experiences. The present study evaluated the relative importance of both types of evidence when considered simultaneously. We predicted that the presentation of even one negative anecdote would have an effect on the key risk information (the â??gistâ??) that subjects extracted from the statistical and anecdotal data. Self-generated twitter posts (tweets) and standard measures of perceived risk were used to test the latter prediction. The current findings partially supported …

The Use Of Person-First Language In Diabetes Care & Research. How Far Have We Come Since Ada & Adces Recommendations?: A Systematic Review, Denise Nicole Portillo

Open Access Theses & Dissertations

Background: Diabetes is a chronic medical condition that affects more than 34 million people across the United States (Centers for Disease Control and Prevention (CDC), 2020). Diabetes is characterized as the inability to create or regulate insulin adequately (Costabile et al., 2020). There are three main types of diabetes, type 1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), and gestational diabetes (CDC, 2020). Of the more than 34 million people with diabetes, 5 to 10% have T1D, while the remaining 90-95% have T2D (CDC, 2020). In 2017, the Association of Diabetes Care & Education Specialists (ADCES) and the American …

Understanding Mental Health Related Factors And High-Risk Behaviors Among Emerging Adults Through The Lens Of The Social-Ecological Model, Sheralyn Sanchez

Open Access Theses & Dissertations

Emerging adulthood is a transitional period where young adults are faced with new challenges while exploring their identity and experimenting with life choices. However, during this time, young adults are more at risk of engaging in risky behaviors. The focus on emerging adults is important since the health and development of young adults can influence their health and life outcomes. The social-ecological model was used to understand the relationship between mental health and high-risk behaviors, in addition to the influence from different ecological factors (individual, relationship, and community). This study examined the relationship between the presence of mental health issues …

Covid Synergy: A Machine Learning Approach Uncovering Potential Treatment Combinations For Sars-Cov-2, Jason Eden Sanchez

Open Access Theses & Dissertations

For more than two years, the COVID-19 pandemic has upended the lives of billions of individualsworldwide leading to disruptions in healthcare, the economy and society at large. As the pandemic enters its third year, the human impact cannot be overstated and the need to develop effective pharmaceuticals remains. Though there currently exits FDA-approved medications for COVID-19, the emergence of novel variants, such as Omicron, highlights the importance of discovering new therapies which will continue to be effective regardless of the pandemicâ??s progression. Because discovering new medications is a costly and timeintensive endeavor, my approach entails drug repurposing to test medications …

Family Disruptions And Maternal Health In Covid Times, Donna Maldonado

Open Access Theses & Dissertations

AbstractPrenatal and postpartum women of the border region of El Paso-Ciudad Juarez have been experiencing multiple forms of family disruption due to the twenty-month border closure in an attempt to contain the COVID pandemic, partners having to find jobs far away from home because of economic concerns, and fear of familial disruption due to the threat of deportation of partners or family members. The purpose of the study is to explore the perceived effects of these types of family disruptions and how they are shaping maternal health in COVID times. This project included the analysis of fifteen interviews with pregnant …

Regulation Of C-C Chemokine Receptor 7 (Ccr7) Ligand-Mediated Internalization And Chemotaxis By G Protein-Coupled Receptor Kinase Family 4 (Grk-4, 5, 6) In Human Pediatric T-Cell Acute Lymphoblastic Leukemia (T-All), Eduardo Elias Chaib

Open Access Theses & Dissertations

Background and Significance: The Hispanic population is disproportionally affected by T-ALL (T-cell acute lymphoblastic leukemia) when compared to other races in the US. C-C Chemokine Receptor 7 (CCR7) in T-ALL is used during disease progression, and may lead to migration of cancerous cells into the Central Nervous System (CNS) of patients. Goals and Objectives: This project aims to find relevant rates and risk factors for T-ALL for the Hispanic population in the US/Mexico border region. The other aim is to assess the effect of the G protein-coupled Receptor Kinase 4 (GRK-4) family proteins on migration and receptor internalization through CCR7 …

The Role Of Map Kinase Phosphatase-5 In Cardiac Adaptations To Endurance Exercise, Jaime Alfredo Perales

Open Access Theses & Dissertations

Endurance Exercise is a form of exercise that provides many benefits to the human body. Primarily, the cardiac muscle endures many cardiac adaptations in response to Endurance Exercise. But the mechanisms that are involved within these adaptations remains to be fully understood. MAPK or mitogen-activated protein kinase is a well know signaling pathway that promotes many cardiac benefits such as cell proliferation, protein synthesis and cell differentiation. Although this pathway is activated due to its upstream kinase (MKKs), the research presented focuses on the relationship and mechanisms involved in mitogen kinase phosphatase (MKPs) specifically (MKP-5). The research presented hopes to …

The Influence Of Violence, Policing, And Substance Use Stigma On Sexual And Substance Use Risk Engagement In Substance Using Men Along The U.S.-Mexico Border, William Campillo Terrazas

Open Access Theses & Dissertations

Background: Cities along the U.S.-Mexico border are unique environments where structural level variables place residents at risk for increased substance use subsequently impacting HIV rates and acquisition. Growing evidence emphasizes the importance of understanding how structural drivers of infectious diseases impact community and social networks to develop interventions to reduce HIV transmission among hard-to-reach populations.

Aims and Objectives: The goal of this study was to investigate the influence of structural factors such as neighborhood disruption, harsh policing, and substance use stigma on engagement of HIV risk behaviors among social networks of people who use drugs and who reside in El …

Informing The Parent Component Of An Acceptance-Based Behavioral Weight Loss Treatment Program Tailored For Hispanic Adolescents In The El Paso Region, Patrick Vaughn Hopkins

Open Access Theses & Dissertations

ABSTRACT

Regarding the clinical efficacy of adolescent weight loss interventions, no agreed-upon definitions or standards for weight loss success exist among pediatric populations, nor do they exist for weight regain or weight maintenance. There are currently no safe, efficacious, long-term treatment options for Hispanic adolescents with overweight or obesity (OW/OB). The purpose of this study was to gather data to inform development of an acceptance-based behavior therapy (ABT) intervention for adolescents with OW/OB in the Paso del Norte region. The primary goal of this research study was to inform the parent component of this adapted intervention. A secondary goal was …

Understanding Depressive Symptoms Among Emerging Adults, Salvador Dominguez

Open Access Theses & Dissertations

As societies have progressed following the industrial revolution, the transitioning into adulthood has undergone constant changes. This shift has resulted in young adults delaying traditional roles such as marriage and parenthood to pursue tertiary education and other opportunities. Emerging adulthood (ages 18-25) is a phase during an individual's life where they undergo constant changes because of newfound independence, new relationships, and other life-changing events. Currently, it has transitioned into a period where symptoms of depression are commonly experienced more than any other time in life. Given the negative impacts that depressive symptoms can have on individuals' well-being, two studies were …

Validity And Reliability Of The Apple Series 6 And 7 Smartwatches And Polar H-10 Monitor On Heart Rate, Armando Martinez Ruiz

Open Access Theses & Dissertations

A persistent problem with field devices lies in the quality of the data that is obtained through the device. Given that data accuracy, validity, and reliability is currently unknown, errors in the estimation of these variables are often prevalent. Wrist-based monitors may show convenience and comfort in comparison to chest-strap monitors and enable them to be largely used. The purpose of this project is to monitor and compare heart rate data through the use of the Apple Watch Series 6, Apple Watch Series 7, and Polar H-10 chest-strap monitor, in comparison with the gold-standard 12-lead ECG in collegiate level athletes …

Targeting Delivery Of Bcl-2 Family Protein Inhibitor Has The Potential To Treat Cancer And Fibrosis, Mohammad Nurul Huda

Open Access Theses & Dissertations

Apoptosis is a naturally occurring cell death mechanism to remove the selective cell population. B-cell leukemia/lymphoma-2 (BCL-2) family protein plays a critical role in activating the upstream apoptosis signaling pathway, primarily the intrinsic apoptosis pathway. The BCL-2 family consists of both pro-and anti-apoptotic proteins, which are structurally and functionally similar, containing up to four BCL-2 homologies (BH) motifs (BH1-4). Defecting apoptosis along this signaling pathway can lead to various events, including malignant cell transformation, tumor metastasis, tissue fibrosis, and drug resistance. In fibrosis, the aberrant apoptosis signaling also activates multiple effector proteins and growth factors, such as TGF-β, CTGF, and …

The Physiological Factors Of Diabetes And Their Effect On The Cognitive And Emotional Functioning In Older Populations: A Secondary Data Analysis, Celeste Anahi Alvidrez

Open Access Theses & Dissertations

Background: The rates of Type 2 Diabetes (T2D) have increased over the past 20 years in all age groups. The physiological factors that underlie T2D could have impact on specific brain pathways that support cognitive and emotional functioning. Aims and Objective: The goal of this study was to examine whether older Mexican American individuals with a history of T2D were more likely to develop later cognitive impairment and/or depression. Hypotheses: It was predicted that elderly participants (mean age at time of interview = 87.87 years) with a history of T2D onset prior to age 65, are more likely to have …

Associations Between Living On The Texas-Mexico Border, Drug Use, And Sexual Behaviors Among Sexual Minority Men During The First Shelter-In-Place Order Of The Coronavirus Pandemic, Nqobile Nzama

Open Access Theses & Dissertations

Background: There have been changes in drug use and sexual behaviors among sexual minority men since the coronavirus pandemic. At this time, there is not adequate literature focusing on the state of Texas. Aims and Objective: The aims of this secondary data analysis and exploratory study are to determine associations between sociodemographic characteristics and living on the Texas-Mexico border, drug use, sexual behaviors, and use of dating/hook-up apps among sexual minority men who completed the COVID-19 & You Survey conducted between May 1, 2020 to July 31, 2020, during the first shelter-in-place order of the Coronavirus pandemic. Hypotheses: The hypotheses …

Development Of A Measure Assessing Perceptions Of E-Cigarettes: A Mixed Methods Approach, Dessaray Monique Gorbett

Open Access Theses & Dissertations

Tobacco use is the leading cause of preventable death in the United States (U.S.), killingmore than 480,000 people each year. In recent years, we have seen a steady decline in cigarette smoking but have seen increased alternative tobacco product use (e.g., electronic cigarettes). Positive perceptions of e-cigarettes are associated with increased e-cigarette use (Amrock, Zakhar, Zhou, & Weitzman, 2015; Chen-Sankey & Kong, Choi, 2019; Pokhrel, Fagan, Kehl, & Herzog, 2015; Simmons et al., 2016). However, studies assessing the perceptions of e-cigarettes vary widely and do not adequately capture perceptions of social norms and the addictiveness of e-cigarettes. The current study …

Examination Of The Association Between C - Reactive Protein(Crp) And Covid-19 Infection Severity And Length Of Hospitalization, Abdulahi Aremu Ayanwale

Open Access Theses & Dissertations

Chronic stress can lead to many systemic complications and low-grade systemic inflammation including increased levels of inflammatory cytokines, such as C-reactive protein (CRP). CRP is a marker of systemic inflammation and is associated with depression and perceived stress. Elevations can result in ineffective immune responses, thereby increasing the risk of complications and mortality from infections. Recent evidence suggests that uncontrolled inflammatory responses associated with COVID 19 are a major determinant of disease severity.  The COVID 19 is transmitted from one person to another through droplets from coughing, sneezing, talking, touching droplets on surfaces and contamination by hand-to-mouth routes. The mechanism …

Impact Of Xenobiotics On Neuronal Outcomes, Gabriela Henriquez

Open Access Theses & Dissertations

Neurodegenerative diseases are a common affliction of the Central Nervous System. They are caused by age, genetics, and environmental factors. Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis are well-known among the host of neurodegenerative disorders, with Alzheimer's disease and Parkinson's disease being the leading pathologies across this canvas. It is known that the pathogenesis of neurodegenerative diseases is multifactorial due to the involvement of genetic mutations, radical-induced protein damage, abnormal aggregation of misfolded proteins, and the formation of amyloid deposits. The amyloid proteins in neurodegenerative disease include Tau and Amyloid (Aβ) in Alzheimer's disease and α-Synuclein in …

Influence Of Political Affiliation, Distrust Of Government And Pharmaceutical Companies On Hpv Vaccination Intentions And Uptake, Alyssa Andrea Martinez

Open Access Theses & Dissertations

Background and Significance: The Human Papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the United States. Currently, approximately 79 million people in the United States are infected with HPV. The CDC estimates that there are nearly 31,500 cases of cancers caused by HPV each year in the United States. Cervical cancer is the most common HPV-related cancer and almost all cervical cancers are caused by a few strains of HPV. Research suggests that Latinx women residing in the U.S.-Mexico border may be at increased risk of contracting HPV types that cause cervical cancer. Although there is no …

Translation And Validation Of The Spanish Version Of The Quality Of Life Inventory For Adolescents (Qolie-Ad-48), Perla Michelle Martinez

Open Access Theses & Dissertations

Background: In 1999, an instrument was developed to assess quality of life (QoL) among adolescences with epilepsy. To our knowledge there is not a validated Spanish version of this questionnaire. There is a gap in the literature about QoL and epilepsy among speaking Spanish populations. Objectives: 1) To conduct an English-Spanish translation of the QOLIE-AD-48; 2) to evaluate the reliability of the Spanish version of the QoLIE-AD-48; and 3) to assess the validity of the Spanish version of the QoLIE-AD-48. Method: Phase 1 translation: Methods followed the published work of Sousa and Rojjanasrirat (2010). Phase 2 Pilot study: the sample …

A Critical Analysis On Mexican Americans Associated With Gangs Living In San Antonio, Texas, Rubi Guadalupe Gonzales

Open Access Theses & Dissertations

The U.S has a major national concern of mass incarceration. Mass incarceration poses a threat to achieve health equity as there are many adverse health effects documented related to incarceration (i.e., posttraumatic stress disorder, depression, anxiety, hypertension, diabetes, asthma, hepatitis, HIV, tuberculosis, etc.,). There is a great need to conduct research on incarceration with a critical lens. The present study examined the incarceration trajectories of Mexican American men who were associated with gangs during their youth and lived in the west side of San Antonio. This cohort of males were followed at three different timepoints in their life using retrospective …

The Role Of Calcium Ions In Signaling And Regulation Of Efflux Pump Genes In Staphylococcus Aureus, Amy Rebecca Nava

Open Access Theses & Dissertations

Calcium ions (Ca2+) play an important role in eukaryote cell signaling and regulation of physiological functions. Although evidence of a similar role for Ca2+ in prokaryotes has been difficult to demonstrate, there is mounting evidence that Ca2+ acts as a cell regulator in bacteria. The purpose of this study was to investigate Ca2+ signaling and the effect of Ca2+ on gene expression of various multidrug resistant (MDR) efflux pumps and their regulator MgrA in Staphylococcus aureus and clinically isolated MRSA. We hypothesized that the presence of Ca2+ increased gene expression of multidrug resistance pumps, LmrS, NorA, and the regulator, MgrA. …

Exploring The Relationship Between The Distance Of Parks And Rates Of Adult Obesity In El Paso, Texas, Shawna Payan

Open Access Theses & Dissertations

Background: In El Paso, areas of the city do not have access to parks within walking distance. The rates of people suffering from obesity and the comorbidities that come with obesity are rising annually. Physical activity has been shown to increase lifespan and provide positive health outcomes for the individual. Increasing physical activity in adults by using the parks can decrease their risk for heart disease and diabetes. Objectives: The overall aim of the procedure is to determine a relationship between park density and distance from residence to the nearest park, adult population density, and the obesity rate density within …

Systematic Review Of Alternative Interventions For Construction Workers To Manage Work-Related Musculoskeletal Pain And Discomfort, Isaac Abraham Rodriguez

Open Access Theses & Dissertations

Background: The prevalence of Work-Related Musculoskeletal Pain and Discomfort (WRMSPD) among construction workers in 2017 was almost 20,000 injuries. Close to 60% were overexertion, others included lifting and lowering. The most common form of WRMSPD could originate from the upper back to lower back and neck pain. It was reported that the highest prevalence of WRMSPD were in the upper extremities (nearing 60%) because of the physically demanding factor of the job (heavy lifting and repetitive movement). Over 250,000 cases were reported to be WRMSPD in the private sector of the U.S. Purpose: The purpose of this systematic review was …

Identification Of Leishmania Spp. And T. Cruzi Parasites In Bats Captured In El Paso, Texas Region: Bats As A New Reserviour, Edith Sandoval

Open Access Theses & Dissertations

Background: Recognized by the World Health Organization (WHO) as two of the world’s thirteen most neglected tropical diseases (NTD), both T. cruzi and Leishmania spp. parasites are accountable for Chagas disease and Leishmaniasis, respectively and they continue to rank among the most important public health problems in South America. Together, Leishmaniasis and Chagas affect 300 million people. Wildlife reservoirs play an important role in the maintenance and transmission of parasites in sylvatic transmission cycles. In the last decade studies have been conducted in this region of El Paso, Texas, and other parts of the world to detect both parasites in …

Surveillance Of Ticks And Associated Pathogens In Central Texas, Alexa Mendoza

Open Access Theses & Dissertations

Background: Ticks are the second most common vector of human and veterinary pathogens, after mosquitoes, which results in a number of different diseases around the world. These diseases, referred to as tick-borne diseases (TBDs), are increasing in their prevalence around the world as the geographical distribution of ticks change due to environmental and human factors. Increased testing for pathogens and a better comprehension of their relationship to different tick species will be crucial in deepening our understanding of TBDs and protecting our human and animal populations. Increasing surveillance of ticks and the potential pathogens they may be vectors for and …

Determination Of Perceived Calorie Content Of Common Foods, Sarah Leticia Ruiz

Open Access Theses & Dissertations

Currently, dietary weight-loss interventions focus on recommended caloric intake aimed at creating an energy deficit through the use of calorie-based education. This approach assumes individuals can accurately estimate caloric content of foods and beverages, yet little is known about the validity of such assumptions. This study assessed the accuracy of perceptions of calorie content for individual food items and mixed meals and determined its association with education level, nutrition background, body composition, fruit and vegetable intake, and the domains of eating (emotional eating, uncontrolled eating, and cognitive restraint). A cross-sectional survey assessed calorie perceptions using both visual food displays and …