Medicine and Health Sciences Commons^™

Rutin Exerts Antidepressant Effect In A Rat Model Of Diabetes, Suzan A. Khodir, Eman A. Ali, Heba F. El-Domiaty

Menoufia Medical Journal

Objectives: to evaluate the potential antidepressant effect of rutin in diabetic rats and the assumed underlying mechanisms involved.

Background: Depression is a common behavioral disorder among diabetic patients. Oxidative stress and inflammation are strongly involved in pathophysiology of diabetes induced depression. Rutin is major flavonoid that is proved to have neuroprotective effect through antioxidant and anti-inflammatory effects.

Methods: Twenty four male Wistar rats were distributed (8/group) into control, diabetic and diabetic+Rutin groups. The depressive like behavior of the animals was conducted by forced swim test (FST). Fasting serum glucose, serum glycosylated hemoglobin A1c (Hb A1c), malondialdehyde (MDA), total antioxidant capacity, …

Diabetes Mellitus And Hypertension Are Common Comorbidities Among Covid-19 Hospitalized Patients In Egypt: A Single-Center Retrospective Study, Ashraf A. Askar, Esmail Osman, Mustafa A. Younis, Safaa Khalaf, Tamer Mohamed

Menoufia Medical Journal

Background Since the announcement of the COVID-19 catastrophic release in 2019, several studies had been conducted to investigate all the circumstances accompanied by or that have resulted from this viral infection. Objective The aim was to investigate the most common comorbidities and associated clinical risk factors among COVID-19 hospitalized patients admitted to Sohag Fever Hospital, Sohag Governorate, Egypt. Patients and methods In this study, 250 patients of those registered or admitted to Sohag Fever Hospital, Sohag Governorate, Egypt, were included during the pandemic COVID-19 period between October 2020 and February 2021. A total of 150 patients had positive PCR finding …

Comparative Study Between Doppler Ultrasound And Computed Tomography Angiography In Diabetic Lower Limb Arterial Insufficiency, Mahmoud A. M Abo Hendy, Rehab M. Habib, Zeinab A. Ali

Menoufia Medical Journal

Objective This work aimed to highlight the role of color Doppler ultrasound in the assessment of lower limb arterial insufficiency in patients with diabetes as well as the characteristics of lower limb arterial disease in diabetic patients. Background Diabetic lower limb arterial insufficiency is a major health problem affecting the individuals and community health. Doppler ultrasound is a widespread relatively cheap examination with no health hazards of radiation. Hence, we considered studying the role of Doppler ultrasound in determining the characteristics of lower limb arterial diabetic insufficiency and its level of accuracy. Patients and methods One hundred diabetic patients with …

Vitamin D Receptor (Bsmi) Gene Polymorphism And Type 2 Diabetes Mellitus In An Egyptian Population, Ahmed R. Tawfeek, Gehan A. Tawfeek, Shimaa M. Aboelyazeid Ellayen, Waleed M. Fathy

Menoufia Medical Journal

Objective The aim of this study was to evaluate the association between vitamin D receptor (VDR) (BsmI) gene polymorphism and genetic susceptibility to type 2 diabetes mellitus (T2DM) in an Egyptian population. Background The VDR gene is a candidate gene for susceptibility to several diseases. Studies on the association between VDR polymorphisms and T2DM in different ethnic populations are yet inconclusive. Patient and methods The present study was a case–control study conducted at the Department of Clinical Pathology, College of Medicine, Menoufia University, during the period from May 2015 to December 2016. We included 120 patients, …

A Study On The Effect Of Estrogen On The Insulin Signaling Pathway In Diabetic Rats, Amal I. Ali, Anwaar M. Shaban, Gergiss Y. Hana, Sally S. Donia

Menoufia Medical Journal

Background Diabetes mellitus (DM) is a worldwide metabolic disorder that is associated with many complications. Recently, it has been noted that estrogen has a beneficial effect on type II DM. Objective The aim of this study was to prove that the use estrogen could improve the metabolic state in type II DM. Materials and methods Eighty adult female albino rats weighing 200–250 g were used. Diabetes was induced by means of a single intraperitoneal injection of streptozotocin 40 mg/kg. Rats were divided into the following groups: the control group (group C); the ovariectomized control group (group OVX C); the diabetic …

Type Ii Diabetic Patients«Sq» Satisfaction With The Management Plan In Family Health Centers In Port Said City, Egypt, Ahmed Ragheb, Nagwa N. Hegazy, Taghred M. Farahat, Wesam Yousef

Menoufia Medical Journal

Objective The aim of the study was to assess  type II diabetic patients«SQ» satisfaction with the management plan in family health centers (FHCs) in Port Said city. Background Diabetes mellitus is a common and potentially disabling chronic disease, with increased risk for microvascular and macrovascular complications. Patients and methods A cross-sectional study was carried out on 150 participants after calculation of the sample size. All diabetic participants who were registered at all FHCs were interviewed using semistructured questionnaires to obtain sociodemographic characteristics and to assess type II diabetic patients«SQ» satisfaction toward counseling and treatment plans. This was followed by a …

Β-Cell Plasticity, Ahmed A. Shoaib, Mohammed A. Farahat, Nabil A. El-Kafrawy

Menoufia Medical Journal

Objective: The aim of this study was to present the current trends and methodologies in the preservation of the β-cell function by targeting the β-cell mass. Data sources: Medical text books and also the ScienceDirect database were searched from the start date of the database and a search was performed on January 2014 with no language restrictions. Data selection: The selected articles are systematic reviews and experimental studies that address the β-cell plasticity and the β-cell mass and plasticity. Data extraction: Extraction was performed according to the quality, validity, and originality of the selected reviews and studies that fulfilled the …

Osteoprotegerin In Type 2 Diabetic Patients With Microalbuminuria, Gehan K. El-Saeed, Rawaby A. Atta, Said S. Ahmed Khamis, Seham Khodeer

Menoufia Medical Journal

Objectives: The aim or the study is to study the role of osteoprotegerin (OPG) in type 2 diabetic (T2DM) patients with microalbuminuria as an early marker of atherosclerosis. Background: OPG is a bone-related glycopeptide produced by vascular smooth muscle cells because of arterial damage. OPG is a glycoprotein that is part of the tumor necrosis factor receptor superfamily mainly involved in bone metabolism, but it is also found in various other tissues such as vascular smooth muscle cells. Participants and methods: The study included 80 individuals divided into three groups: group I included 20 T2DM patients without microalbuminuria, group II …

Additive Effect Of Ozone Therapy To Insulin In The Treatment Of Diabetic Rats, Mamdouh El-Ridi, Safaa El-Kotb, Sally Donia, Sherif Zalat, Sohair Saleh

Menoufia Medical Journal

Background Chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the heart and blood vessels. Therapy in the past few decades was mainly aimed at reducing hyperglycemia. It became clear that ameliorating oxidative stress through treatment with antioxidants might be an effective strategy for reducing diabetic complications. Medical ozone treatment may be useful in the treatment of diabetes and its complications. Objective This study aims to show the additive effect of ozone to insulin in the treatment of diabetes in rats. Materials and methods Diabetes was induced by an intraperitoneal injection of streptozotocin …