Medicine and Health Sciences Commons^™

Dynamic Contrast-Enhanced Mri Of Pancreatic Islet Transplants, Nathaniel K. Chan

Loma Linda University Electronic Theses, Dissertations & Projects

Since its discovery in 1922, insulin has been the life-saving treatment for type 1 diabetes mellitus. As the disease is caused by the loss of insulin-producing pancreatic islets, transplantation of donor islets has the potential to not only supplement insulin replacement therapy but to cure type 1 diabetes. However, long-term insulin independence (> 2 years post-transplant) remains a challenge partly due to low islet blood flow immediately following transplantation leading to hypoxic stress on islets. The goal of our studies is to improve islet engraftment by monitoring and promoting the regrowth and maturation of new islet blood vessels in a …

Dna Repair Of 8-Oxo-7,8-Dihydroguanine Lesions In Porphyromonas Gingivalis, Leroy G. Henry Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

The persistence of Porphyromonas gingivalis in the inflammatory environment of the periodontal pocket requires an ability to overcome oxidative stress. DNA damage is a major consequence of oxidative stress. Unlike other organisms, a non-base excision repair mechanism for the removal of 8-oxo-7,8-dihydroguanine (8-oxoG) in P. gingivalis was suggested. Because the uvrB gene is known to be important in nucleotide excision repair, the role of this gene in the repair of oxidative stress-induced DNA damage was investigated. A 3.1 kb fragment containing the uvrB gene was PCR-amplified from the chromosomal DNA of P. gingivalis W83. This gene was insertionally inactivated using …

Novel Molecules That Regulate Bone Formation And Bone Resorption, Gabriel Robert Linares

Loma Linda University Electronic Theses, Dissertations & Projects

Osteoporosis is a disease characterized by decreased bone mass and microarchitectural deterioration of bone. Bone loss occurs when the increased bone resorption that occurs with age is not compensated by a corresponding increase in bone formation. Therefore, understanding the mechanisms which regulate bone formation and bone resorption is important for developing diagnostic and treatment strategies for osteoporosis. In my dissertation, we investigated the role of Glutaredoxin 5 (Grx5), Diabetes and Obesity Related protein (DOR), and Claudin 18 (Cldn-18), novel molecules involved in regulating bone formation and bone resorption. We demonstrated that Grx5 protects osteoblasts from oxidative stress induced apoptosis via …

Nanomaterials And Block Copolymers For Overcoming Multidrug Resistance In Cancer, Wesley Livingstone

Loma Linda University Electronic Theses, Dissertations & Projects

The development of multidrug resistance in cancer is one of the leading causes for decreased chemotherapy efficacy and is particularly threatening to aggressive cancers such as that of the pancreas. In cancers where chemotherapy is amongst the few treatment options, it is crucial to develop chemotherapeutics that either bypass or control the development of multidrug resistance. Polymeric nanomaterials such as Pluronics® are of current interest due to their ability to perform these functions in addition to enhancing pro-apoptotic mechanisms. Using the respectively known chemosensitive and chemoresistant pancreatic adenocarcinoma cell lines MiaPaCa-2 and PANC-1, an in vitro analysis of the synergistic …

Influence Of Gender And Aerobic Training Background On Exercise-Induced Increase In Adiponectin, Pooja Pratap Mujumdar

Loma Linda University Electronic Theses, Dissertations & Projects

Adipose tissue secretes the adipokine, adiponectin (ADPN), which is insulinsensitizing, anti-inflammatory, and anti-atherogenic. Exercise training improves insulin sensitivity and lowers the risk of cardiovascular complications. As some of the metabolic effects of exercise training and ADPN overlap, exercise training has been proposed to increase ADPN. However, most single bout exercise, or short-term (ï‚£3 months) and constant-effort (fixed session duration, fixed number of sessions/week, and fixed intensity) exercise protocols do not produce increases in ADPN in untrained and trained cohorts. Furthermore, most exercise studies were conducted on male-female mixed gender cohorts or male/female single gender cohorts. As a result, no direct …

Cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function And T Cell Morphogenesis, Oludare Jeremiah Odumosu

Loma Linda University Electronic Theses, Dissertations & Projects

Type 1 diabetes mellitus is a chronic inflammatory disease in which the insulin and glutamic acid decarboxylase producing β-cells of the pancreatic islets are killed by autoreactive cells of the immune system in response to a loss of tolerance. Early experiments showed that self-tolerance could be partially restored by oral inoculation with small amounts of insulin. Later experiments showed that insulin autoantigen induced immune tolerance could be greatly enhanced by linkage of β-cell autoantigens (Auto Ag) to adjuvant molecules such as the non-toxic cholera enterotoxin B subunit (CTB). To identify mechanisms responsible for CTB-autoantigen fusion protein suppression of diabetes autoimmunity, …

Foundation For Evaluating Injured Firefighters Returning To Work, Deanna Stover

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to establish a foundation for developing an evidence-based assessment guideline to be used by nursing and medical personnel when evaluating a firefighter's ability to return to work after a lower extremity injury. Two on-line survey instruments were used to record the opinions and beliefs of healthcare providers and firefighters. The final samples included 63 California healthcare providers (with and without professional work experience with firefighters) and 312 California firefighters. Most of the healthcare providers with professional work experience with firefighters use the National Fire Protection Association (NFPA) 1582 Standard on Comprehensive Occupational Medical Program …

African Americans With Diabetes: Couples’ Support Program Development Project, Zanetta Fern Carlene Van Putten

Loma Linda University Electronic Theses, Dissertations & Projects

Diabetes is reaching epidemic proportions in the United States with a record 25.8 million diagnosed in 2010 compared to 20.8 million in 2005. African Americans have the highest prevalence of diabetes in the United States. Social support related to medical conditions has been found effective in increasing treatment adherence. The purpose of this study is to gain a clearer understanding of diabetes support within African American couples’ relationships. This study explores the definition of support from the perspective of African American couples when at least one member has been diagnosed with diabetes. Couples were recruited from Riverside and San Bernardino …

Child And Family Responses To Weight Management Programs : A Qualitative Investigation, Andra Lynn Fjone

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The purpose of this study is to explore what happens within families in which a child participates in a pediatric weight management program for the treatment of overweight or obesity and identify strategies and processes for successful weight management.

Method: A qualitative approach was used to collect data from seven families. Individual interviews were conducted with parents, target children, and siblings. Data was analyzed within families and compared between families.

Results: Grounded theory analysis revealed three major essential themes: Shared Burden, Family Congruence, and Collaboration. Descriptive analysis was used to identify recommendations for improving family based weight management programs. …

The Association Of Religious Coping On Reports Of Low Back Pain And Inflammatory Markers, Jacqueline D. Bougie

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic pain is the most common cause of disability in the United States with depression, anxiety, and stress often occurring co-morbidly. The purpose of the study was to explore how religion may modulate the frequency of back pain, influence inflammatory markers, influence the use of medications, and impact functional ability.

Participants were from the Biological Manifestations of Religion Study (BioMRS; N= 508) and the Psychological Manifestations of Religion Study (PsyMRS; N = 10,988). All participants completed a 20-page questionnaire and BioMRS participants provided blood, salivary, and urine samples, performance tests, and learning tests all collected within 1 week of …

A High Fiber Diet Versus A Low-Carbohydrate Diet For Weight Loss In Obese Individuals With Or Without Type 2 Diabetes, Neal G. Malik

Loma Linda University Electronic Theses, Dissertations & Projects

In the United States, obesity rates have climbed steadily over the years. Many different diets for weight loss have been proposed and studied, yet no one diet seems to clearly be more beneficial. Among diets that have been promoted are those high in fiber and low in carbohydrates, yet thus far, results of these studies have been mixed.

Using a 2x2 complete factorial design, 173 obese men and women with or without type 2 diabetes were randomized to one of two conditions: (a) a high fiber diet (> 40 grams of fiber per day for women, >50 grams of fiber …

Perceived Barriers And Benefits Of Hiv Voluntary Counseling And Testing Among University Students In Nigeria, Clara Egbealele Omogbai

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Nigeria, the most populous country in Africa is one of the sub- Saharan nations most affected by HIV and AIDS. However, due to stigma most people at risk of infection refuse testing, thereby likely increasing the transmission of HIV. Voluntary counseling and testing (VCT) has been shown to influence behavior change and it is important to explore how to increase rates of VCT in young people who may experiment with sexual activity in this environment that holds increased risks due to nationally elevated rates of HIV.

Purpose. To examine intention to use HIV voluntary counseling and testing (VCT) services …

Marital Experience And Spirituality Among Physician Couples, Elisabeth Vonegen Esmiol

Loma Linda University Electronic Theses, Dissertations & Projects

This study will examine how marital experience and spirituality interact in the lives of physician couples. Physicians’ increasing openness to spiritual issues inherent in treating the ill and suffering (King, 2000; Thorsen, Harris & Oman, 2001), the growing number of women entering the medical profession and becoming physician and dual physician couples (Levinson & Lurie, 2004; Brotherton & Etzel, 2008), and physicians’ work-related stress (Transue, 2004; Wicks, 2006) and the resulting pressures and time constraints on medical marriages (Sotile & Sotile, 2000) make studying this population particularly relevant. Interviews with twenty two married, professional couples, in which at least one …

The Relation Of Fitness Assessment Feedback To Intrinsic Motivation And Physical Activity Among College Students, Laura Chandler

Loma Linda University Electronic Theses, Dissertations & Projects

Physical inactivity is a major public health concern in the United States and is no less of a concern among college students. According to the 2000 National College Health Assessment, as cited by Kilpatrick, Herbert, and Bartholomew (2005), only 38% of college students participate in regular vigorous activity, and only 20% participate in regular moderate activity. This study focused on how fitness assessment results affect intrinsic motivation for physical activity in college students. The specific mechanism examined was that between the constructs of intrinsic motivation, competence and autonomy from the self determination theory (SDT) and cognitive evaluation theory (CET). Approximately …

Relationship Of Vitamin D Levels To Blood Pressure In A Biethnic Cohort, Rosario O. Sakamoto

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Serum hydroxyvitamin D [25(OH)D] has been well-accepted as not an ordinary vitamin but a pro-hormone that has many benefits beyond its well-known effects on bone. Cardiovascular risk factors such as hypertension remain a huge health burden and Blacks have been recognized to have higher prevalence of hypertension compared to non-Hispanic Whites. Despite increasing evidence of the benefits of vitamin D on blood pressure control, there is much more to be learned about the relationship of serum 25(OH)D to blood pressure among different ethnicities.

Purpose: The goal of this study was to determine whether vitamin D serum 25(OH)D levels were …

Predicting Mammography Screening And Breast Self-Examination Among Hispanic And Non-Hispanic White Women In Orange County, California, Sanam Kazemi

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose. Breast cancer is the second leading cause of cancer deaths among Hispanic/Latina women who are one of the fastest growing ethnic groups in the United States. Although Hispanic women have a lower incidence of breast cancer when compared to non-Hispanic White women, they are more likely to develop breast cancer at an advanced stage. In California, Hispanic women have the lowest rate of insurance coverage compared to other ethnic groups.

Method. The study was a cross-sectional observational study among Hispanic/Latino and non-Hispanic White women, ages 30-64 years. I examined intention to obtain a mammogram or breast self-exam …

Yearnings: Stories Of Insecure Attachment And The Journey To Connect To God, John Bracy

Loma Linda University Electronic Theses, Dissertations & Projects

Utilizing grounded theory and the semi-structured interviews of25 participants, this study sought to understand how an insecure attachment affects one's relationship with God. Participants' stories suggested that: I) one's struggle to connect with God was a part of their struggle to connect with others; 2) that experiencing others as safe and responsive contributed to building a more secure attachment with God; and 3) that attachment is less a fixed style and more of an ongoing process: defined as gradual changes made by the participants towards the set-goal of feeling safe and secure. Four major processes were identified: I) finding what …

How Transnational Couples Deal With Teen Substance Use: A Socio-Contextual View, Alicia Marquez

Loma Linda University Electronic Theses, Dissertations & Projects

Using the lenses of social constructionism and critical feminist theory, this dissertation examines how transnational Mexican couples in the agricultural town of Mecca, Southern California, respond to the crisis created by their adolescent children using illegal substances.

As part of the Contemporary Couples’ Study of Loma Linda University, sixteen

families were interviewed about how this problem affected their lives. The rich stories

collected were analyzed using the Strauss and Corbin (1998) guidelines for qualitative

research, in order to identify grounded theory that would inform services to this population.

Results suggest that these couples’ relationships are organized around the world of …

The Association Between Body Mass Index And Dental Caries In Hispanic Elementary School Children, Mary Creske

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Dental caries is the most common chronic disease of children ages 6 to 11. According to the U.S. Department of Health and Human Services, 41% of the children in this age group experience decay in their primary teeth. Since 1980 the number of overweight children ages 6 to 11 has doubled. Childhood obesity is currently the most prevalent nutritional condition of children in the U.S.

Purpose: The purpose of this observational study was to determine if there is an association between childhood dental caries and childhood obesity. The study also explored the effects of diet and other covariates.

Method: …

Self-Reported Exercise And Risk Of Osteoporosis In Prostate Cancer Patients Receiving Androgen Deprivation Therapy, Lori J. Mennen-Winchell

Loma Linda University Electronic Theses, Dissertations & Projects

Prostate cancer is stimulated to grow in response to testosterone. Androgen deprivation therapy (ADT) leads to chemical castration and suppression of prostate cancer cell production. Testosterone levels less then 300ng/ml decreases bone mineral density and could result in osteoporosis. Studies have shown that during the first year of ADT, fracture risk, mainly in hips and spine increases about 50%. In men, 40% of hip fractures result in death. Exercise may reduce the risk of osteoporosis and thus contribute to the prevention of hip and other fractures. There is limited data regarding whether exercise is associated with a reduced risk of …

Factors That Inhibit Or Enhance Maternal Coping With Stillbirth In Chhattisgarh, India, Lisa R. Roberts

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Over half of the known stillbirths occur in four highly populated countries—India among them. While acknowledged as a significant public health issue in western societies, little is known about maternal coping with stillbirth in developing countries. The purpose of this mixed methods study is to explore how issues of gender and power, social support, coping efforts, and religious beliefs influence perinatal grief outcomes among poor women in rural Chhattisgarh, India.

Methods: In Phase 1 of this mixed methods study, grounded theory methods were used to explore perceptions regarding stillbirth. A de-identified medical records review of 536 deliveries at Christian …

Role Of Breastfeeding And Current Lifestyle On Maternal Long-Term Weight Change, Denise R. Hinds

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Evidence suggests that prolonged and exclusive breastfeeding is associated with health benefits to children and nursing mothers beyond the period of breastfeeding. Studies that support the role of breastfeeding in postpartum weight change primarily focused on short-term weight change (within 12 to 24 months postpartum) (Binns et al. 2003; Lederman 2004; Johnson et al. 2006), while few focused on the association between breastfeeding and long-term weight change (5 years or more postpartum) (Rooney, Schauberger et al. 2005).

Purpose: This study investigated the role of breastfeeding in long-term weight change, specifically 1) whether breastfeeding protects against weight gain, and 2) …

Igf2 Promotes Activation Of Estrogen Receptors In Basal-Like Breast Cancer Cells, Angelique Richardson

Loma Linda University Electronic Theses, Dissertations & Projects

The autocrine-paracrine effects of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both members of the tyrosine- kinase receptors family. The activation of Estrogen Receptor (ER) is also very important in BC growth and progression. As BC progresses to estrogen-independent growth, the IGF-1R and the estrogen receptor (ER) interact in crosstalk mechanisms that are synergistic and results in enhanced activation of both receptors signaling cascades. This …

The Effects Of Consumption Of California Dried Mission Figs On Serum Lipid Concentrations In Hyperlipidemic Adults, Joycelyn M. Peterson

Loma Linda University Electronic Theses, Dissertations & Projects

Background: The National Cholesterol Education Program and American Heart Association have recommended the use of functional or cholesterol-reducing foods, some categories of which include viscous or soluble fibers, soy protein, plant sterols, and nuts, as aids to reduce serum cholesterol concentrations. Figs are a rich source of viscous fiber and antioxidants. Fig consumption has not been studied in regard to effects in reducing serum lipid concentrations. In previous pilot data, increasing fig consumption for six weeks among volunteers was found to be feasible.

Objective: To evaluate the effect of the consumption of California dried mission figs on serum lipid …

Long-Term Hypoxia Regulates Cortisol Biosynthesis In The Ovine Fetal Adrenal Cortex, Vladimir Enrique Vargas

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies demonstrated enhanced fetal adrenal cortisol biosynthesis following exposure to long-term hypoxia (LTH). The studies presented here were designed to determine the mechanism(s) regulating this important adaptive endocrine response. Ewes were maintained at high altitude (3,820 m) from approximately day 40 to 138-141 of gestation. Fetal adrenal glands were then collected from LTH and age matched normoxic controls. Dispersed fetal adrenal cortical cells (FACs) were untreated, treated with ACTH, treated in combination with ACTH precursors (POMC and 22-kDa pro-ACTH), or pre-treated with H-89 and or UO126 followed by ACTH treatment. Following ACTH treatment, cortisol biosynthesis increased in both groups …

Cerebral Amyloid Angiopathy And Transition Metals In Alzheimer's Disease, Matthew Schrag

Loma Linda University Electronic Theses, Dissertations & Projects

Alterations in brain metals homeostasis and particularly brain iron overload have been postulated to play a role in Alzheimer's disease, contributing to oxidative stress and neuronal injury; however, the source of this iron is not clear and may be due to metabolic derangement(s), failed iron clearance mechanisms or exogenous deposition such as through bleeding. This series of studies was designed to evaluate the extent of metals dyshomeostasis in the Alzheimer's disease brain and specifically whether microvascular bleeding is a major contributor to Alzheimer's disease-related iron overload. Cerebral amyloid angiopathy (CAA) is a vascular manifestation of Alzheimer's disease present to some …

Coronary Heart Disease Mortality And Long-Term Exposure To Ambient Particulate Air Pollutants In Elderly Nonsmoking California Residents, Lie Hong Chen

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.

The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter

In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models …

The Role Of Ambient Air Pollution In The Occurrence Of Emphysema, Shiva Metghalchi

Loma Linda University Electronic Theses, Dissertations & Projects

Emphysema is the most common cause of death from respiratory disease in the United States. Emphysema is most common among people aged 50 and older. Those with a genetic predisposition to emphysema may experience the onset as early as their thirties or forties. Men are more likely than women to develop emphysema, but female cases are increasing as the number of female smokers rises.

In the past few years, etiological and pathogenic research has been carried out in an attempt to determine the reason for an increase in deaths and other health problems associated with air pollution, and there have …

Effects Of Acculturation On Hiv/Aids Sexual Risk Behaviors Among Asian And Pacific Islander (Api) Women, Margaret Cabotage Salud

Loma Linda University Electronic Theses, Dissertations & Projects

Background. In the US women are the fastest growing group for sexually transmitted infections (STIs), including HIV and AIDS. In addition, the estimated AIDS cases among female adults and adolescents, aged 13-19, increased from 7% in 1985 to approximately 26% in 2002. Most infections occur by heterosexual transmission with 53% occurring through contact with a high-risk sexual partner. While overall HIV/AIDS rates in the Asian Pacific Islander (API) community remain low, they are rising and HIV testing rates, one of the major prevention strategies for HIV, are lower than that of other populations. Furthermore, very little is known about APIs …

Spirituality, Religiosity, And Weight Management In Black Women, Shené L. Bowie

Loma Linda University Electronic Theses, Dissertations & Projects

Background

Obesity is a major concern in the United States and Black Americans are among those with the highest rates of overweight, obesity, and related co- morbidities. While weight loss among Black women has been studied within the context of a faith-based setting, there is little information about the relationship between spirituality, or relationship with the transcendent, and self-efficacy in the achievement and maintenance of a healthy weight.

Purpose

The purpose of this study was to analyze the relationships among spirituality, self-efficacy for physical activity and healthy eating, and body composition measures among Black women over the period of participation …