Medicine and Health Sciences Commons^™

A Transmission Electron Microscopy Study Of Early Changes In Hypoxic Pulps, Nah Nah Chen

Loma Linda University Electronic Theses, Dissertations & Projects

Early cellular changes in pulps whose blood supplies were severed were studied using transmission electron microscopy (TEM). Twenty-eight extracted teeth were divided into seven equal groups. Except for the 0 hour group, all other teeth were incubated in Tyrode solution at 37°C, after extraction. After 1/4, 1/2, 1, 2, 4, and 8 hours, teeth were split open and the pulps were processed for light and transmission electron microscopy and evaluated for cellular changes. Except for nuclear pyknosis in the 4 and 8 hour groups, light microscopic examination revealed very little changes when compared with that of TEM examination. With the …

Effects Of Oral Hygiene Measures On Clinical And Microbiological Parameters Of Periodontal Disease, Bruno Loos

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of a 12-week period of oral hygiene alone on gingival conditions and subgingival microflora in 15 patients with severe periodontitis were investigated. In addition, subgingival microsamples were compared during this oral hygiene phase with those obtained 1 week after debridement. Clinical measurements and subgingival samples from selected sites were taken at week 0 (baseline), week 6, and week 12. Microbial samples were also taken at week 13, that is, one week following debridement. At week 0 the patients were instructed in supragingival plaque control and at week 6 the hygiene regimen was supplemented with the subgingival use of …

A Non-Human Primate Model For Studying Corticotomy-Facilitated Orthodontic Tooth Movement, R. David Rynearson

Loma Linda University Electronic Theses, Dissertations & Projects

This study was undertaken to test the hypothesis that a corticotomised tooth moves as a tooth-bone unit when under orthodontic force. A non-human primate model was designed to test the hypothesis. The non-human primate selected was Macaca fasicularis. Three adult males with erupted third molars were chosen so that extrapolation could be made to the adult human. The methods employed included the following: 1) Each animal had one treatment quadrant and one control quadrant per arch; 2) Pre-op and post-op study models were made; 3) All 2nd premolars, 2nd molars, and 3rd molars were banded; 4) A full-thickness flap …

Magnetic Forces For Intrusion Of Buccal Segments In Dolichofacial Individuals With Anterior Open Bite : A Report Of Six Cases, Rosa Maria I. Reimann-Blaseio

Loma Linda University Electronic Theses, Dissertations & Projects

The correction of anterior open bite in dolichofacial individuals with magnetic forces has been studied. The attempt was made to intrude buccal segments by using interarch magnets set in repulsion in order to correct the anterior open bite of six dolichofacial patients. It was expected to intrude the posterior sections with these magnetic forces, to autorotate the mandible and to close the anterior open bite by decreasing the lower facial height and rotating the facial axis closed. The magnets were placed in each arch only on those teeth that needed intrusion, mainly second premolars and existing molars, for a period …

The Incidence And Magnitude Of Tooth-Size Discrepancies In Caucasians, Blacks And Hispanics, Dana R. Shaltry

Loma Linda University Electronic Theses, Dissertations & Projects

The present investigation utilized the Bolton Analysis to determine the incidence and magnitude of tooth-size discrepancy in a sample of 227 orthodontic patients. Sliding calipers were used to measure the mesiodistal width of the permanent dentition on pretreatment study models of 120 Caucasian, 51 Black, and 56 Hispanic patients. The overall and anterior ratios were analyzed and the frequency and magnitude of excess maxillary and mandibular tooth structure was determined. Each racial group demonstrated a significant incidence of tooth-size discrepancy in the maxillary and mandibular arches of a magnitude (> 0.5mm) which would require some form of correction. In addition, …

The Determination Of Antibody Levels In Endodontic Patients Against Eleven Microorganisms Using Ifa And Elisa Techniques, William C. Payne

Loma Linda University Electronic Theses, Dissertations & Projects

Endodontic (root canal) infections are generally considered to be caused by the invasion of microorganisms which destroy pulp tissue and extend to the periapical region. No definitive study has identified a specific bacterium or group of bacteria as etiological agents. We quantitively measured antibodies present in the serum of 30 normal individuals and patients with either chronic (n = 30) or acute (n = 30) periapical lesions with the indirect fluorescent antibody (IFA) and enzyme-linked immunosorbent assay (ELISA) for IgG and IgM against 11 oral microorganisms routinely isolated from such lesions. The results were analyzed statistically. Analysis of variance of …

A Study Of The Relationship Between Incisor Intrusion And Root Resorption, W. Michael Mcfadden

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the relationship between maxillary and mandibular incisor intrusion and root resorption. Age, sex, facial type, treatment time, extraction versus non-extraction therapy, width of the symphysis, and the angle of the incisors to skeletal reference planes were also studied for their relationship to intrusion and root resorption. Thirty-eight cases treated with utility arches for intrusion were selected. Root shortening was found to average 1.84 mm for maxillary incisors and 0.61 mm for mandibular incisors. Intrusion of incisors in a population that exhibited growth was found to be one of "holding against growth". No relationship was found to exist …

Case-Control Study Of Vitamin A Intake And Colorectal Cancer In Seventh-Day Adventists, John William Morgan

Loma Linda University Electronic Theses, Dissertations & Projects

Colorectal cancer is the second most common cause of cancer deaths in Americans; producing approximately 60,000 deaths in Americans each year. Studies of high and low risk populations have suggested a dietary etiology for colorectal cancer, although investigations of specific dietary factors have produced inconsistent results.

Population based studies of California Seventh-day Adventists demonstrate dietary variety regarding factors suspected as important in the etiology of colorectal cancer. These studies document a substantially reduced mortality and incidence from colorectal cancer in Seventh-day Adventists when compared to other California Populations. Although specific reasons for this difference remain obscure, the 'Unique lifestyle and …

A Comparison Of Liquid And Gel Etchants Determining Shear And Tensile Bond Strengths Of Four Orthodontic Adhesives, Gary M. Edgmon

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to compare liquid and gel etchants (37% phosphoric acid) by measuring tensile and shear bond strengths of four orthodontic adhesive systems.

Four orthodontic adhesives were tested on 287 extracted human teeth, 144 of which were etched with liquid and 143 with gel. The four adhesives tested were Concise-3M, Challenge-Ormco (new product), Unite-Unitek (no mix), and Fuji Glass-ionomer filling material or cement.

To eliminate the use of wire for bracket engagement during testing, two devices were designed and machined for direct attachment to the Instron testing machine: a rigid push rod for shear force and …

An Ethical Analysis Of Alternatives In Childbirth, William K. Faber

Loma Linda University Electronic Theses, Dissertations & Projects

This discussion concerns the ethical aspects of decisions regarding the various options of place, attendant and method for the actual delivery of infants. It focuses on the moral claims of childbearing women and fetuses and the roles of health care providers and society at large during the brief, but significant, transitional period between the state of pregnancy and the state of separate parent-child relations. The author's thesis is divided into two major components. The first component is that certain alternatives to what has become the typical U.S. childbirth experience are, under appropriate circumstances, safe and provide benefits which justify their …

Treatment Of Periodontal Furcation Defects, Bernard Gantes

Loma Linda University Electronic Theses, Dissertations & Projects

This report provides an abbreviated review of the literature on treatment and prognosis of periodontal furcation lesions. In addition, it describes a surgical technique designed to accomplish bone regeneration in class II furcation defects, together with the rationale for the development of this procedure. Results of treatment of 30 defects with this technique are presented in a subsequent report (Gantes et al. 1987).

Changes In The Cant Of The Occlusal Plane Evaluated In Treatment And Its Stability In Retention, Bruce S. Heinrich

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to test the hypothesis that occlusal plane changes induced by orthodontic treatment remain stable during retention, and to show that the occlusal plane cant is related to facial type and occlusal classification.

A comparison of facial type, occlusal classification, extraction status, and growth status was provided. The sample consisted of pretreatment, posttreatment, and postretention cephalometric radiographs of 156 orthodontic cases from the records of Loma Linda University School of Dentistry, Department of Orthodontics. Changes in the cant of the occlusal plane were evaluated by the Frankfort horizontal to occlusal plane angle.

Results showed that …

Histologic Host Response To Polyoxymethylene Prosthesis As A Temporomandibular Joint Condylar Replacement, Frederick R. Mathews

Loma Linda University Electronic Theses, Dissertations & Projects

Polyoxyinethylene (Delrin) is a polyacetyl homopolymer which has been used successfully in many orthopedic joint replacements. To determine histologic host response to Delrin as a temporomandibular joint condylar replacement condyles were removed from ten fully mature macaca fasicularis monkeys. The condyles were replaced with a total prosthetic Delrin condyle attached to a titanium mesh. Specimens obtained at one, two, and six months indicated total acceptance of the Delrin, remodeling of the glenoid fossa and formation of bone between the middle cranial fossa and the roof of the glenoid fossa. These findings would indicate Delrin is a viable option for condylar …

Evaluating The Effect Of Family Stroke Education On The Anxiety Levels Of Families Of Stroke Patients, Keri Lynne Kuniyoshi

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Fasting Plasma Amino Acids In Relation To Serum Lipids In Human Male Subjects, Helen G. Mendiola

Loma Linda University Electronic Theses, Dissertations & Projects

The association of fasting plasma amino acids with serum lipids was studied in 23 healthy human male subjects with ages ranging from 31 to 62 years (45±9, mean± SD). There were 12 normocholesterolemic (serum cholesterol = 183±17 mg/dL) and 11 hypercholesterolemic (271±27 mg/dL) subjects. Venous blood samples were drawn three times at weekly intervals. Plasma amino acids were determined by ion-exchange chromatography, and serum cholesterol and triglycerides by enzymatic methods. Hypercholesterolemic subjects had significantly higher lysine and lower serine levels than normocholesterolemic subjects (p < .05). Serum cholesterol levels were positively correlated with plasma levels of lysine, ornithine and the lysine/arginine ratio (p < .04); and negatively correlated with phenylalanine and urea (p < .05). Serum triglyceride levels were positively correlated with plasma levels of lysine, glutamic acid, and valine (p <. 02); and negatively correlated with serine, glutamine, and asparagine (p < .04). These results add support to the hypothesis that specific plasma amino acids are associated with the metabolism of serum lipids.

Fetal Whole-Body Fluid, Cardiovascular And Endocrine Dynamics : Computer Analysis Of Regulatory Mechanisms, Peter Stuart Gold

Loma Linda University Electronic Theses, Dissertations & Projects

The dynamics of transcapillary fluid and protein distribution and endocrine regulation of cardiovascular function were studied in chronically instrumented fetal sheep during the third trimester. Average experimental changes in vascular pressures, blood volume, plasma hormone concentrations, hematocrit and plasma protein concentration were analyzed using mathematical modeling and parameter optimization techniques in order to determine values for the major parameters which regulate fluid, protein and endocrine dynamics and to determine endocrine dose-response relationships to changes in cardiovascular function. The hormones which were considered are arginine vasopressin (AVP), angiotensin II (AII), epinephrine (EPI) and norepinephrine (NE). Vascular disturbances which were considered include …

Pre-Orthodontic Radiography Of The Temporomandibular Joint, Stephen G. Tracey

Loma Linda University Electronic Theses, Dissertations & Projects

The dental profession has given increased attention to temporomandibular joint problems in recent years. Many orthodontists have shown professional concern by taking pretreatment lateral tomograms to assess developmental abnormalities, previous injury, pathology, and condylar position. The purpose of this study was to determine the consistency of orthodontists in evaluating lateral tomograms and panoramic films, particularly when used prior to treatment. Lateral tomograms and panoramic films of 60 single joints were evaluated by 4 orthodontists on two separate occasions. A questionnaire was completed for each radiograph observed and responses were compared for interobserver and intraobserver [aggreement]. Statistically, results showed little to …

Effects Of A Structured Pretransfer Teaching Protocol On The Reduction Of Transfer Stress In Clients With Myocardial Infarction, Maureen R. Brennan Westphal

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

The Effects Of Certain Oral Bacteria On The In Vitro Growth Of Bacteroides Gingivalis, Steven G. Morrow

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of nine gram positive and grain negative cocci and bacilli, which are indigenous to the oral cavity, on the in vitro growth of Bacteroides gingivalis was examined in this study. A pure culture of B. gingivalis is was obtained from the American Type Culture Collection. The nine oral test organisms were Streptococcus mitis, Streptococcus mutans, Streptococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Corynebacteriurn hofmanii, Lactobacillus acidophilus, Branhamella catarrhalis, and Escherichia coli. The effect on the growth of B. gingivalis of the nine test organisms was evaluated on a solid medium by use of …

Early Identification Of Risk For Noncompliance In Tuberculosis Patients, Penny Klein Weismuller

Loma Linda University Electronic Theses, Dissertations & Projects

In this descriptive study of early identification of risk for noncompliance to tuberculosis treatment or prevention regimens, 523 patients, from four ethnic groups, were rated by nurses trained as participant-observers of several predictive factors. The predictive factors included acceptance of diagnosis. attentiveness, eye contact, the treatment's interference with the patient's lifestyle, fear of side effects, fear of needed medical procedures, and the presence and degree of the patient's social support. An observational measure by the nurse of the patient's Health Locus of Control was also included. The patient was asked to provide a self-rating on the degree of difficulty anticipated …

The Effect Of Dietary Fat Level On Tumor Development And Immunity In Balb/C Mice Fed Casein Of Wheat Gluten As Protein And Challenged With Herpes Type 2-Transformed Cells, Helen Drakou

Loma Linda University Electronic Theses, Dissertations & Projects

A high percentage of fat in the diet has been implicated through epidemiological studies in several human cancers. Studies in experimental animals have produced evidence that increasing the fat in the diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …

Sprague-Dawley Rats Fed Milk Or Beef Protein : Differences In Response To 1,2-Dimethylhydrazine Carcinogenesis, Stanley W. L. Ng

Loma Linda University Electronic Theses, Dissertations & Projects

Colon cancer is responsible for a high percentage of cancer deaths in developing countries, and there is convincing epidemiological evidence that meat protein and fat in the diet increase the incidence of this form of cancer. An animal tumor model which has been used by many investigators interested in colon cancer is the 1,2-dimethylhydrazine (DMH)-rat or DMH-mouse tumor model. In previous work done in this laboratory the DMH-BALB/c mouse tumor model was used to compare the production of colon tumors in mice fed a diet using non-fat powdered milk as a source of protein with those in mice fed beef …

Relationship Between Dietary Intake And Reproductive Hormones In Premenopausal Vegetarian And Nonvegetarian Seventh-Day Adventist Women, Joan M. Spuehler

Loma Linda University Electronic Theses, Dissertations & Projects

There is evidence that specific nutrients may modify hormonal balance and contribute to breast cancer etiology. To investigate the relationship between dietary nutrients and plasma reproductive hormones and to determine hormone-nutrient interrelationships, we measured plasma estrogens, androgens. progesterone and prolactin levels in 10 premenopausal Seventh-day Adventist (SDA) vegetarian and 10 premenopausal SDA nonvegetarian women. Over three days in each of three consecutive months. diet records and fasting midluteal blood samples were collected. The nonvegetarians consumed significantly more protein, total and saturated fats, oleic and linoleic acids, and cholesterol than did the vegetarians. Hormonal status of the two groups did not …

A Semiquantitative Analysis Of The Chorda Tympani Taste Pathway In The Rat Brain With The 2-Deoxyglucose Method, Charles L. Hardison

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis is based on a semiquantitative analysis of four nuclear relay centers [nucleus tractus solitarius (NTS), parabrachial nucleus (PBN), ventroposteromedial nucleus (VPM), gustatory neocortex (GNC)] in the chorda tympani nerve pathway. Metabolic changes were examined by the 2-deoxyglucose method in which one chorda tympani nerve was chemically stimulated and its contralateral side lesioned. Coronal sections of four taste centers were prepared for autoradiography and Nissl staining. Densities of the autoradiograms were determined by means of a video based image processor. Relative differences in the optical density ratios of the stimulated versus lesioned nuclear grey matter areas to white matter …

Language Disabilities Of Delinquent Adolescents, Sue E. Eaton

Loma Linda University Electronic Theses, Dissertations & Projects

Many studies have been conducted on the prevalence of learning disabilities in the population of juvenile delinquents (Holte, 1972; Broder, Dunivant, Smith, and Sutton, 1981; Meltzer, 1983; Bachara and Zada, 1978). One investigation conducted by the United States Government, found that juvenile delinquents have severe learning problems (Reed and Heilman, 1981).

Learning disabilities appear in eight to 10 percent of all school age children and adolescents. Of that group, 39 to 63 percent show a language disorder syndrome which may negatively affect school learning over a broad range of the curriculum area (Semel and Wiig, 1980). The prevalence of learning …

The Use Of Dura Mater As A Meniscus Replacement In Tmj Surgery, Kim J. Dipasquale

Loma Linda University Electronic Theses, Dissertations & Projects

Internal derangement of the temporomandibular joint is recognized as a problem of significant magnitude in both medical and dental circles. The last decade has seen a steady progression in the knowledge and sophistication of not only the anatomy and physiology of the temporomandibular joint, but also in the techniques of non-surgical and surgical management of internal derangements. Surgical correction of the unrepairable disc has typically been addressed by performing a menisectomy followed by placement of a non-physiologic implant material.

The animal study reported here was performed in order to evaluate the histologic fate and biological compatibility of freeze-dried dura when …

Amount Of Root Shortening Related To Type Of Fixed Appliance : A Comparison Of The 0.018" And 0.022" Bracket Slot, Thomas L. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine if a different incidence and severity of maxillary incisor apical root resorption occurs in cases treated with the 0.018 inch versus 0.022 inch slot in standard edgewise mechanics. A consecutively treated sample of 240 patients (98 boys and 142 girls), with a mean age of 13.4 years from the orthodontic clinic at Loma Linda University were studied. 120 of the cases were treated using 0.018" bracket slot with standard edgewise mechanics and 120 were treated using 0.022" non-torqued full banded standard edgewise mechanics. 60 of the cases in each of the above …

An Immunochemical Analysis Of Alcoholic Hyaline And Its Relationship To Keratin Intermediate Filaments, David L. Drexler

Loma Linda University Electronic Theses, Dissertations & Projects

Alcoholic Hyaline (AH) and keratin intermediate filaments possess ultrastructural, biochemical and immunochemical similarities. This study compares human AH, human stratum corneum keratin (HSCK) and normal human liver cytokeratin (HCK) by quantitative immunochemical means, using polyclonal as well as monoclonal antibodies. Enzyme-linked immunosorbent assays (ELISAs) were employed, as well as "immunoblotting" and immunocytochemical techniques. HCK was isolated using Triton X-100 and "high-salt” buffers and exhibited seven major polypeptide bands on SDS-PAGE (41-58 kd). Antisera were made toward HCK and the two major HCK bands. Other immunochemicals included antisera toward AH, the three major AH bands, and HSCK, as well as 3 …

Axial Morphology And Angulation Of The Condyle In Relation To Malocclusions In Different Age Groups, Gerald P. Tadej

Loma Linda University Electronic Theses, Dissertations & Projects

Recent studies have shown that forces applied to the mandible during functional appliance and other orthodontic therapies produce measurable changes in the TMJ. It was postulated that specific malocclusions might also apply forces that could produce specific changes in the horizontal morphology of the TMJ. This study involved 104 pretreatment orthodontic patients, 44 males and 60 females. A submento-vertex analysis was performed and correlated with clinical findings including age, sex, malocclusion type, facial type, TMJ symptoms, tooth eruption sequence, crossbites and midline discrepancies. All possible correlations between the radiographic findings and the clinical malocclusions were tested with ANOVA. The width …

Effects Of Lateral Mandibular Expansion On Mandibular Morphology In The Growing Rat : A Comparative Study Of Treatment Effects With Orthopaedic And/Or Surgical Procedures, Eric Looi

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to investigate the effects of mandibular expansion by orthopaedic and surgical procedures in the growing rat mandible.

Sixty-four 35 day old Sprague Dawley Harlan rats were divided into four groups of 16 rats each and categorized as the control, orthopaedic expansion, surgery without graft and surgery with graft respectively. Prefabricated appliances were used for orthopaedic expansion of the mandibles and maintaining surgical expansion at the symphysis in the respective groups. Oxytetracycline were given intraperitoneally to mark areas of bone remodeling. Half the number of rats from each group were sacrificed at the end of …