Medicine and Health Sciences Commons^™

Effect Of Disulfiram On The Urinary Excretion Of 5-Hydroxytryptophol And 5-Hydroxyindoleacetic Acid In Subjects Consuming Serotonin Rich Foods, Amy G. Tordecilla

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of disulfiram and/or serotonin rich foods (SRF) on the urinary excretion of 5-hydroxytryptophol (5-HTOL) and 5-hydroxyindoleacetic acid (5-HIAA) in normal male subjects was investigated. Urine collections were obtained on 1) regular serotonin free diet, 2) SRF, 3) serotonin free diet with disulfiram, and 4) SRF with disulfiram. Urinary excretion of 5-HTOL in ug/gm creatinine during disulfiram administration was 112.0 ± 24.1. Five HTOL (ug/gm creatinine) with disulfiram and SRF increased to 1532 ± 352.0 (p < 0.001). Five-HIAA (mg/g creatinine) before and after SRF was 3.4 ± .44 and 33.1 ± 6.1 respectively, p < 0.001. With disulfiram and SRF the excretion of was 24.2 ± 3.2 mg/g creatinine which was significantly greater than when on the regular diet (p < 0.001) than the excretion on SRF alone (p < 0.05)

Key words: Disulfiram, serotonin, 5-hydroxytryptophol, 5-hydroxyindoleacetic acid, urinary excretion, high performance liquid chromatography, alcoholism

The Relationship Between Depression, Dyspnea, And Physical Activity In Patients With Severe Chronic Obstructive Pulmonary Disease, Carolyn J. Calhoun

Loma Linda University Electronic Theses, Dissertations & Projects

This correlational descriptive study investigated the relationship between depression, degree of dyspnea, and performance of daily activities in male and female patients with severe chronic obstructive pulmonary disease (COPD). The problem was to determine (a) the influence of depression on the degree of dyspnea experienced and performance of daily activities, and (b) the relationship between the degree of dyspnea experienced and the performance of daily activities by male and female patients with severe COPD.

This study contained a convenience sample of 49 patients who met the research criteria (38 males, 10 females, and one patient unidentified as to gender). All …

The Stability Of Mandibular Bilateral Sagittal Split Osteotomy Advancements Using Rigid Skeletal Fixation, Michael E. Fox

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Effect Of Photoperiod On Developmental Morphology And Enolase Isoenzyme Immunohistochemistry In Rat And Djungarian Hamster Superficial Pineal Glands, Chalmer D. Mcclure

Loma Linda University Electronic Theses, Dissertations & Projects

The best understood functional activity of the pineal gland is its diurnal production of melatonin in response to environmental lighting cues. Several enzymes of the melatonin pathway respond to daily photoperiod changes, for example hydroxyindole-O-methyltransferase (HIOMT) and serotonin N-acetyltransferase (SNAT). Increased levels of the glycolytic enzyme neuron-specific enolase (NSE) are thought to reflect increased physiological demands placed on neurons and neuroendocrine tissues. Homodimer non-neuronal enolase isoenzyme (NNE) is immunolocalized to cells, and the hybrid enolase (consisting of subunits from NSE and NNE) has been seen in cerebellar stellate and basket cells. Although not rate limiting, concentrations of both NSE and …

The Concentration Of Prostaglandin E2 In Periradicular Lesions, Steve N. Mcnicholas

Loma Linda University Electronic Theses, Dissertations & Projects

Prostaglandins (PG) have been implicated in pathogenesis of periapical lesions. The purpose of this study was to determine the concentrations of PGE₂ in human periapical lesions. Periapical specimens from patients with clinical signs and symptoms of chronic and acute apical periodontitis were obtained and immediately frozen in liquid nitrogen. Periradicular tissues from unerupted third molars were frozen and used as controls. The concentration of PGE₂ was determined by radioimmunoassay. Low levels of PGE₂ were found in the control tissues as compared to those detected in chronic and acute lesions. A significantly higher level of PGE₂ was …

The Effect Of An Anti-Osteoclastic Agent And A Collagen Sponge On Root Resorption Following Regenerative Periodontal Surgery In The Dog, Rudolf Hahn

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies indicate that root resorption is a frequent sequela to significant amounts of periodontal repair following experimental regenerative periodontal surgical procedures in animal models. To study if root resorption can be reduced or prevented, periodontal repair was evaluated in large horizontal circumferential defects in the dog in the absence of influence from the oral environment. Diphosphonate (Cl₂ MDP) applied topically to the root surfaces prior to wound closure as well as the use of a collagen sponge membrane (Helistat®) draped over the root surfaces and a control with no additional treatment after defect creation were the modalities employed. …

Religious Commitment As A Predictor Of Health Behavior And Health Status In A Selected Population, Donald George King

Loma Linda University Electronic Theses, Dissertations & Projects

Religious beliefs and behaviors are multidimensional and they profoundly determine the ways we respond to health and illness, suffering and death. Researchers have designed numerous scales to measure different dimensions of religious commitment, beliefs and behaviors. A thorough review of the literature has shown general relationships between religion and health, but no researcher has developed an instrument measuring dimensions of religious commitment specifically relevant to health behaviors.

In this study, scale items were developed to measure three dimensions of religious beliefs thought by Kenneth Vaux (1976) to be related to health behavior--purity of life, peace in existence, and belief in …

Feasibility Of An Extraoral Method For Predicting Manibular Incisor Relapse, Mark J. Saylor

Loma Linda University Electronic Theses, Dissertations & Projects

The author undertook to develop an extraoral model for predicting mandibular incisor relapse similar to the model described by Harvey and Sheldon Peck. Whereas the Peck and Peck method involves intraoral measurements, the method described in this paper relied on the taking of measurements from the patient's pre-treatment plaster models. Two hundred and sixty teeth were measured both orally and on plaster casts, and several statistical tests were performed to isolate any differences between the intraoral and extraoral methods. The principal difference was identified as the faciolingual measurement of the incisor, due to the height of contour often being subgingival …

Process Of Health Care Decision Making Among Khmer Immigrants, Barbara Frye

Loma Linda University Electronic Theses, Dissertations & Projects

This qualitative study examined the congruence between health beliefs and behavior as reported by 30 Cambodian (Khmer) refugee women in Southern California. Utilizing in-home interviewing in the Khmer language, data was gathered on 226 illness episodes occurring among 157 family members over an eight-month span. Informants reported a strong maternal role in health care decision making with all ages of children. Adult decision making demonstrated an individualistic pattern. Causes of illness were attributed primarily to humeral imbalances and illness avoidance behavior reflected these beliefs. Treatment was a blend of scientific and traditional medicine. Health care was accessed in settings of …

Misfit Between Motivational Style And Type Of Job Demand As A Factor In Developing Occupational Stress, Arlene Gray Blix

Loma Linda University Electronic Theses, Dissertations & Projects

Occupational stress is costly in terms of human suffering and impaired organizational effectiveness. Occupational stress involves the interface between the individual worker and the work environment. The purpose of the study was to analyze the fit between motivational style and the type of job demands as a contributing factor in developing occupational stress symptoms. A literature review of occupational stress models was conducted. The six models compared and contrasted included the Person-Environment fit model (French, Rodgers, & Cobb, 1974), Integrative Transactional Model (Schuler, 1982), Organizational Stress Models (Ivancevich & Matteson, 1987; Parker & DeCotiis, 1983), Facet Analysis Model (Beehr & …

Autonomic Nervous System And Cholesterol Transport, Yuan-Line Hung

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of autonomic nervous system on cholesterol transport is of clinical interest because the relationship between lipoprotein metabolism and atherogenesis is expressed in coronary artery disease.

Generally speaking, beta blockers increase serum VLDL level but decrease both HDL and HDL₂ cholesterol levels without affecting the LDL in humans. We are unaware of reports concerning the effects of metoprolol on lipoprotein metabolism nor comparison of the effects of metoprolol and propranolol in the unhandled rat model. In part I we employed the unhandled rats to compared the effects of these 2 drugs administered with the drinking water in order …

Needs Of Family Members Of Patients In The Critical Care Unit And The Nurse's Perception Of Those Needs, Nicolle C. Sobieszyk

Loma Linda University Electronic Theses, Dissertations & Projects

The family is greatly affected when one member is admitted to a critical care unit. Critical care nurses are in an ideal position to help families cope with the crisis of a critical illness. Those who are knowledgeable of family member needs will provide more compassionate and effective nursing care to both the patient and family.

This study investigated the needs of family members of patients in the critical care unit and compared them to the critical care nurse's perception of those needs. The sample consisted of 55 critical care nurses and 51 family members of critically ill patients from …

Load Deformation Test Of Metal Brackets : A Comparative Study, Luke K. Choi

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine the effect material and design (slot torque degree and wing type) had on the force and stress to permanently deform metal brackets.

Fourteen different types of metal brackets were tested and categorized into three categories. The three categories were: raw material composition, slot torque degree, and wing type. There were 5 types of raw materials (310SS, 316L, 303SE, 3038, and 17-4PH), 3 types of slot torque degree (0 degree, 7 degree, and 12 degree), and 4 types of wing design (mini twin, single, regular twin, and modified twin). All brackets were tested …

Facial Typing Methods : A Comparative Study, James A. Grabow

Loma Linda University Electronic Theses, Dissertations & Projects

Facial typing methods are used to determine to which of three basic facial pattern categories an individual patient belongs. These three categories are mesofacial, brachyfacial, and dolichofacial. It is important to establish the correct facial type because the reaction to treatment mechanics and the stability of the denture is dependent upon the analysis of the facial patterns. The purpose of this paper was to show a comparative study of facial typing classification methods used on 100 patients (47 boys and 53 girls). The eight different methods used were as follows: Bioprogressive, Ricketts LLU1, LLU2, QuickCeph™, Jarabak, Facial-Mandibular Index, and Steiner. …

Regulation Of Epidermal Growth Factor Receptor Synthesis By Retinoic Acid And Dexamethasone, Kerby C. Oberg

Loma Linda University Electronic Theses, Dissertations & Projects

Fetal rat lung (FRL) cells incubated in the presence of retinoic acid or dexamethasone exhibit altered ¹²⁵I-epidermal growth factor (EOF) binding capacity. Retinoic acid enhances ¹²⁵I-EGF binding 3-fold following 24 hours of 37° incubation. In contrast, FRL cells incubated in the presence of dexamethasone display a 2-fold reduction in ¹²⁵I-EGF binding capacity. The change in binding capacity, induced by either hormone, was due to alterations in the average number of receptors per cell as determined by Scatchard analysis of ¹²⁵I-EGF binding. In the absence of retinoic acid or dexamethasone, FRL cells were calculated to have approximately …

A Statistical Evaluation Of Class Iii Indicators In A Caucasian Population, Javier Canut

Loma Linda University Electronic Theses, Dissertations & Projects

In order to evaluate the significance of seven Class III indicators (molar relation, cranial deflection, ramus position, porion location, Xi to Pt Vertical, Xi to SNa Vertical and Xi-S-Na angle) seventy cases with a Class III malocclusion and excessive facial depth were selected from the files of the Loma Linda University Orthodontic Department, Loma Linda University Oral Surgery Department and Fundacion Jimenez Diaz Hospital Orthodontic Department (Madrid, Spain), and compared to a control group of seventy non-Class III cases.

Means and standard deviations of all variables were calculated and compared between the sample and control groups. Significant differences were determined …

Enhancement Of Intratumor Antibody Distribution With A Bifunctional Antibody Delivery System And With Hyperthermia, Karen Lynn King

Loma Linda University Electronic Theses, Dissertations & Projects

The intratumor distribution of a new monoclonal antibody-hapten-based delivery system was examined. From two marine antibodies, Hybritech, Inc. has developed a bifunctional antibody (BPA) with specificities against CEA (ZCE-025 or GEM 231) and against one of two derivatives of [¹¹¹In]-benzyl-EDTA (CHA 255), EOTUBE or BLEDTA IV, to form ZCE/CHA or CEM/CHA. BFA accumulates in CEA-expressing tissue and clears from non-antigenic tissues prior to administration of an [¹¹¹In]-hapten.

Using five groups of nude mice bearing human colon tumor xenografts (T380), we evaluated different carriers of [¹¹¹In]-EOTUBE to prelocalized ZCE/CHA. We administered all antibodies and haptens …

Co-Cr Comparison Between Untreated & Treated Cl Ii Div 1 Cases, James W. Davis

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this retrospective study was to compare the COCR differences in pretreatment and posttreatment CI II Div I patients. Similar sample groups were chosen from patients of the graduate orthodontic clinic at Loma Linda University School of Dentistry.

Each patient's models were mounted on a Sam II articulator using a face bow transfer and a centric relation check bite. The COCR discrepancies in the anterior-posterior, superior-inferior, and side-shift dimensions were determined with the Mandibular Position Indicator.

Using t-test analyses, statistically significant differences were found between the pretreatment and posttreatment groups, with the posttreatment sample exhibiting a smaller CO-CR …

In Vitro Evaluation Of Cancer Patient Immune Responses Following Infusion Of Radiolabeled Murine Monoclonal Antibody, Kelly A. King

Loma Linda University Electronic Theses, Dissertations & Projects

Several monoclonal antibody (MAb) types derived from mice have been developed specifically for the use of targeting human tumors. The specificity of these murine MAb’s for their respective tumor antigens is very high making them potentially good immunotherapeutic agents for cancer treatment and diagnosis. A limiting factor in using these murine MAb’s in patients is the development of human anti-mouse antibody (HAMA). The presence of HAMA may reduce the effectiveness of MAb for tumor targeting. If patient sensitization could be quickly detected following the initial infusion of MAb, then future infusion could be altered or terminated to prevent further sensitization. …

Regeneration Of Meissner Corpuscles In Diabetic Mice Following Median Nerve Crush, Bonnie J. Forrester

Loma Linda University Electronic Theses, Dissertations & Projects

The hyperglycemic metabolic condition found in diabetes mellitus leads to the development of sensory neuropathies and causes delayed and incomplete neuronal regeneration. Diabetic sensory neuropathy has been shown to contribute to the impairment of light touch and low frequency vibratory perception. It is proposed that the regeneration of receptors that detect these sensations will be delayed and incomplete in diabetic animals with uncontrolled hyperglycemia. This study addresses the effects of diabetes on the regeneration of Meissner corpuscles, distal sensory endings that perceive light touch and low frequency vibration.

Corpuscles from 60 diabetic mice, and their age-matched, non-diabetic littermates, were examined …