Medicine and Health Sciences Commons^™

Differential Effects Of Verbal And Written Disclosure On Perceptions Of A Child Who Stutters, Peyton Mcknight

Honors Theses

This study measured perceptions of a 12-year-old boy who stutters, relative to perceived speech skills and personal characteristics, as a function of seven potential stuttering disclosure conditions, featuring either a personal verbal disclosure, written disclosure, or no disclosure, delivered by various authors (i.e., self/child, mother, teacher). 641 participants college-aged adults were randomly assigned to one of seven stuttering disclosure groups: no disclosure control, verbal self-disclosure, written self-disclosure, verbal mother disclosure, written mother disclosure, verbal teacher disclosure, or written teacher disclosure. Participants in the control group viewed a brief video of a 12-year-old male who stutters reciting a short passage. Participants …

Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier

Honors Theses

Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …

A Raman Spectroscopic And Quantum Chemical Investigation Of Serotonin, It's Intramolecular Interactions, And The Solvent Effects Of Methanol, Ethanol, And Water, Mallory Loe

Honors Theses

Serotonin, or 5-hydroxytryptamine, is a neurotransmitter and metabolite vital to the normal function of the cardiovascular, gastrointestinal, and nervous systems. Although it might be colloquially known as the ‘happiness drug,’ malfunctions in serotoninergic pathways can result in mental health disorders, heart disease, irritable bowel syndrome, and even collateral death. Without a current method to directly measure, or even detect, serotonin in the human body, these diseases, along with many others, pose a threat of developing without proper warning. Raman spectroscopy presents a unique method to vibrationally characterize molecules based upon the inelastic scattering of light. Serotonin’s unique, amphipathic structure presents …

Baseline Health Assessment Of A Rural Delta Community, Sydney Mitchell

Honors Theses

The Lower Mississippi Delta is characterized by poverty, chronic health issues, health disparities, and food insecurity. The rural Delta communities are primarily African American, experiencing disproportionately higher rates of poverty, job loss, and chronic health problems. Historically, chronic health issues have persisted in these areas over time, including obesity, hypertension, and diabetes, which have only seemed to increase in this region. The food environment in this rural region tends to assist in the creation of the largely obesogenic population which, in turn, contributes to the increased prevalence of diabetes and hypertension and a lower quality of life. Many residents in …

The Histone Deacetylase Inhibitor Largazole: A Potential Chemotherapeutic Agent, Hannah Lynn Carson

Honors Theses

Histone deacetylase enzymes are known for their inherent activity as epigenetic modifiers. Although, they have become recognized for their role in cancer progression and other diseases. But also, histone deacetylases have other non-histone targets, for example, microtubules, which play important roles in cancer metastasis, apoptosis, and replication. With histone deacetylase inhibitors (HDACi), our research explored HDACi effects on breast cancer cell lines. The overall goal was to understand the potential of largazole, a class one histone deacetylase inhibitor on breast cancer cell lines. The research consisted of two parts: sulforhodamine B (SRB) viability assays under hypoxic and normoxic conditions. The …

The Effects Of Acute Exercise And Psychological Stress On Episodic Memory, Lauren Koehler

Honors Theses

Research has suggested that exercise has an effect on memory function. Studies have also shown that exercise mitigates the effects of stress. The relationship between exercise and stress in regard to memory function is noteworthy. There has been little research on this relationship in young adults. This thesis discusses the effects of acute exercise on the episodic memory of young adults when they are exposed to a psychosocial stressor. The results of the research study show that acute aerobic exercise before memory encoding or consolidation was not associated with memory function after exposure to a stressor. Future research in this …

An Evaluation Of Community Based Food Intervention: Cooking Matters In Charleston, Ms, Lindsay Fournier

Honors Theses

The purpose of this study is to evaluate the effectiveness of Cooking Matters classes in producing improvement in individuals’ cooking skills and confidence, as well as their eating behaviors, shopping skills, and perceptions of cooking in rural Charleston, MS. These classes have reported great success in more urban areas such as Atlanta, GA; Philadelphia, PA; and Washington, DC; however, different challenges may be faced in rural Mississippi. To study the effectiveness of the interventions in a new context, pre- and post-intervention self-report surveys were performed and evaluated using Wilcoxon statistical analysis as well as paired sample t tests, and bootstrap …

Multi-Generational Effects Of ∆9-Tetrahydrocannabinol Exposure On Gene Expression In Liver Tissue, Kayla Lovitt

Honors Theses

Cannabis is the most commonly used, cultivated, and trafficked illicit drug worldwide. Increased availability and acceptance of cannabis and cannabinoid-containing products provide the necessity for understanding how these substances influence aging. In this study, zebrafish (Danio rerio) were exposed to concentrations of Δ⁹-tetrahydrocannabinol (THC) (0.08, 0.4, 2 µM) during embryonic-larval development, the effects on aging were measured 30 months later and in the offspring of the exposed fish (F1 generation. We observed results indicating a biphasic and hormetic effect. Treatment with the lowest concentration of THC significantly increased egg production, while higher concentrations resulted in impaired …

Audibility, Cost-Acceptibility And Cosmetic Appearance Of Iqbuds Boost In Adults Over The Age Of 50, Madison Dacus, Vishakha Rawool

Honors Theses

Background: Hearing loss affects 48 million Americans and up to 86% of all adults with hearing loss may not wear hearing aids. Untreated hearing loss is associated with social withdrawal, depression, stress, loss of income, and dementia. Even so, people still tend not to buy or wear hearing aids for a variety of reasons. One recently suggested solution to this problem is low-cost, over the counter (OTC) hearing aids, nicknamed “hearables” This study evaluated the audibility, cost-acceptability and cosmetic appearance of one OTC, IQBuds BOOST.

Methods: Fourteen men and 12 women over 50 years with a hearing loss participated in …

Feminism And Low Breastfeeding Rates In France, Megan Wadsworth

Honors Theses

Breastfeeding rates in France are among the lowest in high-income countries, indicating that French mothers do not breastfeed for nearly as long as is recommended by healthcare professionals and international health organizations. French government, society and conflicting feminist perspectives all influence the likelihood that mothers will breastfeed. The French government has regulations in place to protect women’s right to breastfeed in public and in the workplace, but it is unclear if these are truly beneficial for French women. French society is a seemingly inhospitable environment in which mothers do not feel safe and secure to breastfeed publicly. Motherhood and feminism …

Vital Signs: Exploring Medical American Sign Language Interpreting Services In Mississippi, Morgan Pfleger

Honors Theses

This research involves the regulation, education and training, and availability of medical sign language interpreters in Mississippi, a topic that is seldom studied. The research consisted of a review of past literature on topics related to interpretation and Deaf and hard-of-hearing population, systematic policy review, and interviews with 9 individuals from 7 different medical facilities and one interview with 4 participants together in Mississippi including primary care providers, hospitals, and community health centers. These data were used to explore the interpreting services being provided for those using sign language in Mississippi. Both national and state policies require that alternative methods …

Synthesis Of Pharmaceutical And Personal Care Products And Pesticide Metabolites Of Environmental Concern, Isaiah Edwards

Honors Theses

Human pollution of aquatic environments by introduction of pharmaceutical and personal care products (PPCPs) as well as agrichemicals presents a grave threat to the health of aquatic organisms. Many of these chemicals not only exhibit toxicity to the species of complex ecosystems at various levels but also undergo metabolic transformation into moieties that have different and sometimes more potent physiochemical profiles. PPCP and pesticides as well as their metabolites impact organisms via a number of different mechanisms, with the most serious arguably being endocrine disruption. Two emerging pollutants, gemfibrozil and bifenthrin, possess naturally occurring metabolites that were determined to warrant …

Design And Synthesis Of Novel Analogs As Potential Antitubercular Agents, Peggy Mccluggage

Honors Theses

Tuberculosis (TB) is an infectious, airborne disease which primarily infects the lungs. One-third of the world’s population is currently estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative agent for TB [1]. Current treatment for this disease requires at least six months of taking multiple antibiotics with undesirable side effects [2]. Difficulty in complying to this regimen as well as the prevalence of HIV/AIDS has led to antimicrobial resistance seen in Mtb. In order to combat the Multi-Drug Resistant and Extensively-Drug Resistant strains of the disease-causing bacteria, preventative care and novel antibiotics are urgently needed [3]. The purpose for …

How Misinformation And Mistrust Compound The Threat Of Epidemics, William Boyd

Honors Theses

This thesis was conducted to study the effects of misinformation and medical mistrust on the public health field. I use the events of the Chapare Virus outbreak in Bolivia in the summer of 2019 and the public dialogue during that time period to discuss these themes. I used data from market survey's in La Paz, newspaper articles from Página Siete, and Tweets from the time period of the outbreak. My findings suggest that misinformation and medical mistrust affected public health measures, which has major implications for the way the public health field should address future public health events.

A Look Into The Impacts Of Tele-Optometry Expansion, Anna Hulsey

Honors Theses

Objective This study aims to assess the health and economic costs and benefits to society and patients resulting from the expansion of telemedicine into online refractive exams and to determine the likelihood of potential consumers to utilize such services. Methods A paper survey was distributed at the Inaugural Cempa Health Fair in October of 2019 to both vendors and participants. 105 responses were used to evaluate personal perceptions, practices, and likelihood across a diverse range of demographics. Responses were then entered and analyzed using descriptive statistics and percentages/frequencies. Results Results showed respondents were most attracted to online refractive exams due …

Overcoming Barriers To The Implementation Of Early Warning Systems To Reduce The Maternal Mortality Rate In The United States Of America, Emily Hopkins

Honors Theses

The United States has the highest Maternal Mortality Rate in the developed world, and it has been increasing since 1987. To combat this problem, researchers have developed Early Warning Systems (EWS) to identify when a woman is developing signs of a life-threatening problem during the maternal period. The goal of this research is to identify if these early warning systems are being used in U.S. hospitals, and, if not, what the best way is to implement them. Several interviews were performed with hospitals across the U.S. and the transcripts were run through the analyzing software NVivo. Each transcript will be …

“A Moral Imperative To Prevent Aids”: Race And Religion In Atlanta’S Aids Activism, 1981-1993, Madison Bailey

Honors Theses

The early years of the AIDS epidemic marked a tumultuous period of American history, calling into question the authority of doctors and the ability of scientists to cure disease. Already marginalized groups, such as gay men and intravenous drug users, appeared to be most vulnerable to a deadly virus with no cure or effective treatments. In the face of discrimination, activists rose up to provide necessary services for AIDS patients and advocate on their behalf. This activism uniquely characterized the early AIDS epidemic and permanently changed the field of biomedical research. The current historiography of AIDS activism tends to focus …

Fatty Acid Mediated Alterations In Biofilm Formation With Vibrio Cholerae, Isabel Gray

Honors Theses

Vibrio cholerae is a Gram-negative bacterium known as a waterborne pathogen. It is often found in marine conditions and can infect humans through ingestion. V. cholerae is responsible for cholera, a disease characterized by profuse diarrhea, vomiting, and other dehydration symptoms. Ultimately, severe cases can cause extreme electrolyte imbalances, shock, and acute renal failure which lead to death in a short period of time. Annually, V. cholerae causes approximately 3 million cases of cholera and 100,000 deaths worldwide. V. cholerae can persist in motile and biofilm lifestyles under aquatic and host conditions, a unique biphasic lifestyle that contributes to Vibrio’s …

Sexual Health Assessments In Nursing Practice: Quantitative Analysis Of Nurses’ Behaviors And Perceptions, Allison Culp

Honors Theses

Sexual health is an important yet often neglected component of patient care. Most research on sexual health assessment and its place in nursing occurred from the 1970s to the early 2000s, leaving a gap in understanding nurses’ current attitudes and beliefs toward assessing patients’ sexual health. Frequencies by which sexual health assessments (SHA) are performed by nurses today is also unknown. The objective of this study was to provide an updated understanding of attitudes, beliefs, and practices of nurses regarding SHA. An online-based Likert-scale survey was administered via social media platforms for professional nurses to complete. Results indicate that nurses …

Perspectives Relating To Multicultural Training With Speech-Language Pathologists, Evy Jewell Hayes

Honors Theses

The goal of this project is to assess whether Speech-Language Pathologists (SLPs) feel adequately prepared and comfortable interacting with multicultural clients. To assess if an SLP feels prepared to interact with, to assess, to teach, or to treat a multicultural client, a 25-question survey was developed. The survey included questions pertaining to the SLPs’ experiences with other cultures, both professional and personal, if the SLP speaks more than one language, and if the SLP has received any formal training on how to interact with multicultural clients. The survey was sent out via email to 814 licensed SLPs practicing in pre-school, …

Analysis Of The Soil Lead Contamination Issue Of South Chattanooga, Tesros Cherian

Honors Theses

Childhood lead poisoning is an ongoing health threat despite actions taken by governmental bodies to remove lead from gasoline, paint, and other various household objects in which lead is found. In South Chattanooga specifically, lead has been found in the soil at such a level it is considered a public health threat, especially to children under the age of six. This situation has caused the Environmental Protection Agency (EPA) to name the South Chattanooga area as a Superfund site known as the Southside Chattanooga Lead Superfund site. This designation has resulted in multiple community meetings between EPA officials and Chattanooga …

Whole Word Vs Phoneme Error Scoring For Audiological Word Recognition Testing, Jennifer C. Arnoult

Honors Theses

The purpose of this study was to investigate a possible alternative method of scoring for word recognition testing. The current whole word scoring method is inefficient and often inconsistent with a client’s pure tone average scores, and previous research has suggested that phoneme error scoring may be a more effective and accurate scoring method. This project analyzed the audiogram and word recognition test scores of seventeen adult clients. The test used was the standard twenty-five-word list NU-6 test. The researchers analyzed the results from whole word scoring and phoneme error scoring of the same tests and compared the results to …

An Evaluation Of The Eating Behaviors Of Honors College Undergraduate Students At The University Of Mississippi, Anna Bouthillier

Honors Theses

Eating disorders are defined as an illness that changes one’s relationship with food, that ultimately affects one’s emotions, thoughts, and physical well-being. Three types of eating disorders most commonly diagnosed are anorexia nervosa, bulimia nervosa, and disordered eating. It is important to note that disordered eating is a term used to describe abnormal eating behaviors and feelings related to food that may or may not fall into a certain diagnostic category (Anderson, 2018). Many college students today are diagnosed with an eating disorder or disordered eating as a result of the increasing anxiety and pressures experienced at this age.

The …

Designing An Antibiotic Eluting Trauma Screw To Reduce Short Term Infection In Bone Fractures, Dominic Lincoln

Honors Theses

Orthopedic infection in the United States is one of the most common and severe health risks faced by trauma patients. The most prevalent infection is orthopedic and trauma device-related infection (ORDI) and often occurs in long bones at the fracture site. The purpose of this paper is to explore this infection, its causes, and solutions currently on the market while providing novel solutions to the problem. The designs proposed will be evaluated for their effectiveness and value, while attempting to keep costs low for all stakeholders. The feasibility of patenting these ideas will also be considered, as will the testing …

Lectin Properties Of Synthetically Produced Glucuronate, Alginate, And Related Boronates, Vanessa Angel

Honors Theses

In the nineteenth century, researchers discovered that some proteins had the ability to agglutinate red blood cells (Goldstein, 1980). These proteins were found mainly in the seeds of leguminous plants and were named phytohemagglutinins or hemagglutinins. Particular hemagglutinins were able to agglutinate red blood cells (RBCs) of a specific blood type. Now a days, these proteins are more widely known as Lectins. Lectins are proteinaceous macromolecules of nonimmune origin, capable of interacting with carbohydrates to form complexes (Goldstein, 1980). Lectins sources derive mainly from leguminous plants, animals, fruiting bodies of fungi, and bacteria. This research focuses on identifying the lectin …

Bacterial Load In Virtual Reality Headsets, Benjamin Creel

Honors Theses

Virtual reality technology is a rapidly growing field of computer science. Virtual reality utilizes headsets which cover the user’s eyes, nose, and forehead. In this study, I analyzed the potential for these headsets to become contaminated with bacteria. The nosepieces and foreheads of two HTC Vive VR headsets of the Department of Computer Science of the University of Mississippi were sampled over the course of a seven-week Immersive Media (CSCI 447) course. Serial dilutions were performed, and samples were plated on various culture media. Following incubation, counts of bacteria were determined. DNA was extracted from bacterial growth on plates from …

A Study Of The Antioxidant Versus Pro-Oxidant Nature Of The Amyloid Beta Peptide And An Analysis Of The Natural Products, Isorhamnetin And Narignenin, As Antioxidants, Kaylee Holmes

Honors Theses

Alzheimer’s disease is a neurodegenerative disorder with no cure. Due to the widespread effects of this disease, abundant research efforts have gone towards finding a cure. The amyloid beta (Ab) peptide has been shown to be a potential cause of the disease due to destructive effects on tissues that it can have both by itself and through reactive oxygen species (ROS) generation. This study was performed in order to assess the structural properties of Ab₄₂monomers, fibrils and oligomers, to assess the antioxidant versus pro-oxidant behavior of the Ab peptide, and to assess the antioxidant nature of the natural …

The Effects Of Involvement In Religious Practices On Recovering Substance Users., Taylor Currier

Honors Theses

This paper reviews empirical studies focused on spirituality and its effects on those in the recovery process from substance abuse. This paper will look at qualitative studies as well as quantitative research to see which form has derived the best results on how spirituality has affected substance abuse recovery. Prolonged recovery is the goal for those that struggle with substance use. Behavior change is an important in sustaining sobriety with those dealing with addiction. It is predicted that those who engage in spiritual growth within their community have a higher likelihood of prolonged recovery than those that do not believe …

Investigating The Role Of Rap1a In Medial Arterial Vascular Calcification, Amelia Grace Haydel

Honors Theses

Cardiovascular disease is the leading cause of death in the United States with one of the major contributors being vascular calcification, characterized by the deposition of calcium-phosphate hydroxyapatite. Once thought to be a passive process due to aging, medial vascular calcification is becoming better understood as a tightly regulated, cellmediated process. Vascular smooth muscle cells (VSMCs) within the medial arterial layer respond to inflammation, oxidative stress, and changes in pyrophosphate levels, which induce differentiation into osteoblast-like cells. Fibroblasts within the adventitial layer (AFBs) also alter their function in response to vascular calcification signaling, although this is largely understudied. The AGE/RAGE …

Intervention Approaches And Potential Impacts Of Nutrition Education In Youth Ages 3-14, Lauren Barnhard

Honors Theses

This thesis explores the key factors impacting the health disparities associated with inadequate fruit and vegetable (FV) consumption in youth throughout America. Forms of nutrition education may be an effective means to increase FV consumption in youth, especially when utilizing specific teaching techniques such as taste education, experiential learning, enhanced curriculum, and adhering to age specific programming. According to the CDC, American students receive less than 8 hours of required nutrition education each school year, far less than the 40 to 50 hours that are indicated to affect behavior change. This signifies a need for increased program development and implementation …