Medicine and Health Sciences Commons^™

Development Of Novel Antifungal Peptides Based On A Natural Model Of Histatin-5 Peptide, Duy Tu Nguyen

Graduate Theses and Dissertations

Our research group is working toward the development of novel antifungal peptides based on a natural model of peptide histatin-5. Histatin-5 is found in human saliva and known to protect our body against oral infections by Candida species. Candidiasis, or an infection caused by Candida species, is considered one of the most medically important fungal infections worldwide. Blood stream infections caused by Candida species are the fourth leading cause of hospital-acquired fungal infections that is associated with high mortality rates and high costs of treatment. This study investigated the modes of action of histatin-5 with the use of one 16-mer …

Ccaat-Binding Factor As A Transcriptional Regulator Of Cyc1 In Candida Albicans, Carmen S. Padilla-Marcia

Graduate Theses and Dissertations

Candida albicans is a normal commensal of the human flora; however, under appropriate circumstances this organism can become pathogenic to the host and cause life threatening conditions. In fact, Candida species are the fourth most common nosocomial infection in the Unites States with a mortality rate of over 30%

The CCAAT binding factor is a multi-protein transcription factor highly conserved in eukaryotes. It binds specifically to the consensus sequence 5'-CCAAT-3' in promoters and it is one of the most common cisacting elements in eukaryotes promoters. This transcription factor is composed of three DNA binding subunits; Hap2p, Hap3p and Hap5. In …