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Articles 61 - 85 of 85
Full-Text Articles in Medicine and Health Sciences
Real-World, Multicentre Evaluation Of The Incidence And Risk Factors For Non-Susceptible Stenotrophomonas Maltophilia Isolates, Bruce M. Jones, Jamie L. Wagner, Daniel B. Chastain, P. Brandon Bookstaver
Real-World, Multicentre Evaluation Of The Incidence And Risk Factors For Non-Susceptible Stenotrophomonas Maltophilia Isolates, Bruce M. Jones, Jamie L. Wagner, Daniel B. Chastain, P. Brandon Bookstaver
Faculty and Student Publications
Background: Stenotrophomonas maltophilia is a cause of infection most commonly in the opportunistic host. Trimethoprim-sulfamethoxazole and levofloxacin are considered first-line treatment agents. With reports of increasing resistance to these first-line agents, it is important to determine risk factors associated with a non-susceptible isolate. Methods: This was a real-world, multicentre, retrospective case-control study from five centres in the southeast United States evaluating S. maltophilia. The primary outcome was risk factors associated with non-susceptibility of S. maltophilia isolates to ≥1 antimicrobial agents. Secondary outcomes include incidence of S. maltophilia non-susceptibility, all-cause mortality, and 30-day readmission rates. Results: There were 325 patients included …
Chemical Composition Analysis, Cytotoxic, Antimicrobial And Antioxidant Activities Of Physalis Angulata L.: A Comparative Study Of Leaves And Fruit, Jayachithra Ramakrishna Pillai, Adil Farooq Wali, Godfred Antony Menezes, Muneeb U. Rehman
Chemical Composition Analysis, Cytotoxic, Antimicrobial And Antioxidant Activities Of Physalis Angulata L.: A Comparative Study Of Leaves And Fruit, Jayachithra Ramakrishna Pillai, Adil Farooq Wali, Godfred Antony Menezes, Muneeb U. Rehman
Faculty and Student Publications
Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration-and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract …
Safety And Pharmacokinetics Of Intranasally Administered Heparin, Hannah M. Harris, Katherine L. Boyet, Hao Liu, Rohini Dwivedi
Safety And Pharmacokinetics Of Intranasally Administered Heparin, Hannah M. Harris, Katherine L. Boyet, Hao Liu, Rohini Dwivedi
Faculty and Student Publications
Purpose: Intranasally administered unfractionated heparin (UFH) and other sulfated polysaccharides are potential prophylactics for COVID-19. The purpose of this research was to measure the safety and pharmacokinetics of clearance of intranasally administered UFH solution from the nasal cavity. Methods: Double-blinded daily intranasal dosing in C57Bl6 mice with four doses (60 ng to 60 μg) of UFH was carried out for fourteen consecutive days, with both blood coagulation measurements and subject adverse event monitoring. The pharmacokinetics of fluorescent-labeled UFH clearance from the nasal cavity were measured in mice by in vivo imaging. Intranasal UFH at 2000 U/day solution with nasal spray …
Effect Of Repeated Eccentric Exercise On Muscle Damage Markers And Motor Unit Control Strategies In Arm And Hand Muscle, Sunggun Jeon, Xin Ye, William M. Miller, Jun Seob Song
Effect Of Repeated Eccentric Exercise On Muscle Damage Markers And Motor Unit Control Strategies In Arm And Hand Muscle, Sunggun Jeon, Xin Ye, William M. Miller, Jun Seob Song
Faculty and Student Publications
To examine the contralateral repeated bout effect (CL-RBE) on muscle damage markers and motor unit (MU) control strategies, seventeen healthy adults performed two bouts of 60 eccentric contractions with elbow flexor (EF group; n = 9) or index finger abductor (IA group; n = 8) muscles, separated by 1 week. All participants randomly performed eccentric exercise on either the right or left arm or hand muscles, and muscle damage markers and submaximal trapezoid contraction tests were conducted pre, post, 1- and 2-day post eccentric protocol. One week after the first bout, the same exercise protocol and measurements were performed on …
Which Pharmacists Are Performing Antimicrobial Stewardship: A National Survey And A Call For Collaborative Efforts, Brandon Dionne, Jamie L. Wagner, Daniel B. Chastain, Meagen Rosenthal
Which Pharmacists Are Performing Antimicrobial Stewardship: A National Survey And A Call For Collaborative Efforts, Brandon Dionne, Jamie L. Wagner, Daniel B. Chastain, Meagen Rosenthal
Faculty and Student Publications
Abstract Objectives: To determine how pharmacists with formal antimicrobial stewardship program (ASP) responsibilities prioritize their time and pharmacists without formal antimicrobial stewardship program responsibilities contribute to ASP activities. Design: A nationwide survey. Respondents: Members of the American College of Clinical Pharmacy who subscribe to the following practice and research network e-mail listservs: infectious diseases, adult medicine, cardiology, critical care, hematology-oncology, immunology and transplantation, and pediatrics. Methods: A survey was distributed via listservs. Respondents were asked about their personal and institutional demographics and ASP activities. Results: In total, 245 pharmacists responded: 135 pharmacists with formal antimicrobial stewardship program responsibilities; 110 pharmacists …
Self-Serving Bias In Performance Goal Achievement Appraisals: Evidence From Long-Distance Runners, Moonsup Hyun, Wonsok F. Jee, Christine Wegner, Jeremy S. Jordan, James Du, Taeyeon Oh
Self-Serving Bias In Performance Goal Achievement Appraisals: Evidence From Long-Distance Runners, Moonsup Hyun, Wonsok F. Jee, Christine Wegner, Jeremy S. Jordan, James Du, Taeyeon Oh
Faculty and Student Publications
While working with a long-distance running event organizer, the authors of this study observed considerable differences between event participants’ official finish time (i.e., bib time) and their self-reported finish time in the post-event survey. Drawing on the notion of self-serving bias, we aim to explore the source of this disparity and how such psychological bias influences participants’ event experience at long-distance running events. Using evidence of 1,320 marathon runners, we demonstrated how people are more likely to be subject to a biased self-assessment contingent upon achieving their best finish time at the event. The study samples were split into record-high-achieved …
Pharmacological Treatment For Bipolar Mania: A Systematic Review And Network Meta-Analysis Of Double-Blind Randomized Controlled Trials, Taro Kishi, Toshikazu Ikuta, Yuki Matsuda, Kenji Sakuma, Makoto Okuya, Ikuo Nomura, Masakazu Hatano, Nakao Iwata
Pharmacological Treatment For Bipolar Mania: A Systematic Review And Network Meta-Analysis Of Double-Blind Randomized Controlled Trials, Taro Kishi, Toshikazu Ikuta, Yuki Matsuda, Kenji Sakuma, Makoto Okuya, Ikuo Nomura, Masakazu Hatano, Nakao Iwata
Faculty and Student Publications
A systematic review and random-effects model network meta-analysis was conducted to compare the efficacy, acceptability, tolerability, and safety of pharmacological interventions for adults with acute bipolar mania. We searched PubMed, the Cochrane Library, and Embase databases for eligible studies published before March 14, 2021. Randomized controlled trials (RCTs) of oral medication monotherapy lasting ≥10 days in adults with mania were included, and studies that allowed the use of antipsychotics as a rescue medication during a trial were excluded. The primary outcomes were response to treatment (efficacy) and all-cause discontinuation (acceptability). The secondary outcomes were the improvement of mania symptoms and …
The Influence Of Social Determinants Of Health On The Provision Of Postpartum Contraceptives In Medicaid, Irene Nsiah, Nidhi Vij Mali, Marie Barnard, Swarnali Goswami
The Influence Of Social Determinants Of Health On The Provision Of Postpartum Contraceptives In Medicaid, Irene Nsiah, Nidhi Vij Mali, Marie Barnard, Swarnali Goswami
Faculty and Student Publications
Disparities continue to exist in the timely provision of postpartum contraception. This study aimed to identify prevalence and factors associated with postpartum contraception provision among women enrolled in Medicaid. A retrospective cohort study was conducted using the 2014 National Medicaid data, linked to county‐level social vulnerability index (SVI) data. Women aged 15–44 with a live birth in 2014 were included. Multivariable logistic regression was used to predict 3‐day provision of long‐acting reversible contraception (LARC) and 60‐day provision of most effective or moderately effective contraceptives (MMEC). Overall, 3‐day LARC provision was 0.2% while 60‐day MMEC was 36.3%. Significantly lower odds of …
Phytochemical Screening, In Vitro And In Silico Studies Of Volatile Compounds From Petroselinum Crispum (Mill) Leaves Grown In Saudi Arabia, Ahmed I. Foudah, Mohammad H. Alqarni, Aftab Alam, Mohammad Ayman Salkini
Phytochemical Screening, In Vitro And In Silico Studies Of Volatile Compounds From Petroselinum Crispum (Mill) Leaves Grown In Saudi Arabia, Ahmed I. Foudah, Mohammad H. Alqarni, Aftab Alam, Mohammad Ayman Salkini
Faculty and Student Publications
The herbal plant Petroselinum crispum (P. crispum) (Mill) is commonly available around the world. In this study, the leaves of the herbal plant P. crispum were collected from the central region of Al-Kharj, Saudi Arabia, to explore their in vitro pharmacological activity. Essential oil from the leaves of P. crispum was isolated using the hydrodistillation method. The composition of P. crispum essential oil (PCEO) was determined using Gas chromatography-mass spectrometry (GC-MS). A total of 67 components were identified, representing approximately 96.02% of the total volatile composi-tion. Myristicin was identified as the principal constituent (41.45%). The in vitro biological activity was …
A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula
A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula
Faculty and Student Publications
Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and …
Lip Reconstruction By Double Layer And Double Flap New Combination Technique: A Case Series, Antonio Cortese, Salvatore Catalano, Antonio Alberto Maria Giunta, Antonio Borri
Lip Reconstruction By Double Layer And Double Flap New Combination Technique: A Case Series, Antonio Cortese, Salvatore Catalano, Antonio Alberto Maria Giunta, Antonio Borri
Faculty and Student Publications
In the past, lip reconstruction after ablative surgery has been performed by primary closure and more recently by free flap transfer technique. Cheek’s skin flap has been used to reconstruct the lower lip cutaneous portion. This study presents a reconstructive method for the vermillion and the lip’s cutaneous portion using the Goldstein-Robotti techniques (for the vermillion) and the buccinator flap to reconstruct the cutaneous lip portion and the perioral muscles. This procedure allows a complete reconstruction with a double layer technique for defects of more than one-third of both lips, together or alone, including modiolus, showing satisfactory functionality and aesthetics. …
Do Formulation And Dose Of Long-Term Opioid Therapy Contribute To Risk Of Adverse Events Among Older Adults?, Monika Salkar, Sujith Ramachandran, John P. Bentley, Ike Eriator
Do Formulation And Dose Of Long-Term Opioid Therapy Contribute To Risk Of Adverse Events Among Older Adults?, Monika Salkar, Sujith Ramachandran, John P. Bentley, Ike Eriator
Faculty and Student Publications
Background: Chronic non-cancer pain (CNCP) is highly prevalent in older adults and long-term opioid therapy (LTOT) has been used to manage chronic pain. However, the safety of LTOT among older adults with CNCP is not well-established and there is a need to identify therapy-related risk factors of opioid-related adverse events among older adults. Objective: To evaluate the relationship between opioid dose and formulation and the risk of opioid-related adverse events among Medicare-eligible older adults on LTOT. Design: Nested case-control study. Participants: Older Medicare beneficiaries (N=35,189) who received > 3 opioid prescriptions with a total days-supply of >45 days within a 90-day …
Designing A Clinical Study With Dietary Supplements: It's All In The Details, Z. Elizabeth Floyd, David M. Ribnicky, Ilya Raskin, Daniel S. Hsia
Designing A Clinical Study With Dietary Supplements: It's All In The Details, Z. Elizabeth Floyd, David M. Ribnicky, Ilya Raskin, Daniel S. Hsia
Faculty and Student Publications
A successful randomized clinical trial of the effect of dietary supplements on a chosen endpoint begins with developing supporting data in preclinical studies while paying attention to easily overlooked details when planning the related clinical trial. In this perspective, we draw on our experience studying the effect of an ethanolic extract from Artemisia dracunculus L. (termed PMI-5011) on glucose homeostasis as a potential therapeutic option in providing resilience to metabolic syndrome (MetS). Decisions on experimental design related to issues ranging from choice of mouse model to dosing levels and route of administration in the preclinical studies will be discussed in …
Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran
Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran
Faculty and Student Publications
As part of our research group's continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities …
Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson
Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson
Faculty and Student Publications
While overall survival with multiple myeloma (MM) has improved, patients suffer from overwhelming tumor burden, MM-associated comorbidities, and frequent relapses requiring administration of salvage therapies. As a result, this vicious cycle is often characterized by cumulative immunodeficiency stemming from a combination of disease- and treatment-related factors leading to neutropenia, T-cell deficiency, and hypogammaglobulinemia. Infectious etiologies differ based on the duration of MM and treatment-related factors, such as number of previous treatments and cumulative dose of corticosteroids. Herein, we present the case of a patient who was receiving pomalidomide without concomitant corticosteroids for MM and was later found to have cryptococcosis, …
Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole
Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole
Faculty and Student Publications
In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the HIV-1 trans-activator of transcription (Tat) protein disrupts neuroendocrine function in mice partly by dysregulating mitochondria and neurosteroidogenesis. We hypothesized that conditional Tat expression in middle-aged male transgenic mice [Tat(+)] would promote age-related comorbidities compared to age-matched controls [Tat(−)]. We expected Tat to alter steroid hormone milieu consistent with behavioral deficits. Middle-aged Tat(+) mice had lower circulating testosterone and …
Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le
Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le
Faculty and Student Publications
Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides. We optimized the reaction conditions to control the selectivity of the production of isoxazoles and circumvent other competing reactions, such as O-imidoylation or hetero [3 + 2]-cycloaddition. The reaction happens fast in water and completes within 1-2 hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to …
Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi
Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi
Faculty and Student Publications
Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemo-type novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs …
1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya
1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya
Faculty and Student Publications
The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neuroinflammatory or neurodegenerative component while avoiding the adverse psychotropic effects that accompany CB1 receptor-based therapies. With the appreciation that CB2-selective ligands show marked functional selectivity, there is a renewed opportunity to explore this promising area of research from both a mechanistic as well as a therapeutic perspective. In this research, we are interested in the discovery of new chemotypes as highly selective CB2 modulators, which may serve as good starting points for further …
Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar
Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar
Faculty and Student Publications
Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the progenitors in ocular antifungal therapy. Nanostructured lipid carriers (NLCs) have been widely examined for ocular penetration enhancement and distribution to deeper ocular tissues. The objective of the current study was to prepare NLCs loaded with a combination of CIP and NT (CIP-NT-NLCs) and embed them in an in-situ gelling system (CIP-NT-NLCs-IG). This novel formulation will target the co-delivery of CIP …
The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean
The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean
Faculty and Student Publications
Chronic kidney disease (CKD) is directly influenced by the deleterious effects of systemic inflammation and oxidative stress. The vascular endothelium may transiently respond to aerobic exercise and improve post-exercise vascular renal function in moderate stages of CKD. Brachial artery flow-mediated dilation (FMD) is a nitric-oxide-dependent measure of endothelial function that is transiently potentiated by exercise. The purpose of the study was to determine the acute influence of a single bout of high-intensity interval exercise (HIIE) or steady-state moderate-intensity exercise (SSE) on endothelial dysfunction in moderate stages of CKD. Twenty participants (n = 6 men; n = 14 women) completed 30 …
Optimal Frequency Intensity Of Physical Activity To Reduce The Risk Of Hypertension In The Korean Population, Jang Won Son, Sukho Lee, Minsoo Kang, Yun A. Shin, Jae Hyun Kim
Optimal Frequency Intensity Of Physical Activity To Reduce The Risk Of Hypertension In The Korean Population, Jang Won Son, Sukho Lee, Minsoo Kang, Yun A. Shin, Jae Hyun Kim
Faculty and Student Publications
PURPOSE: Regular physical activity (PA) is an effective lifestyle modification for preventing hypertension. This study aimed to analyze the optimal frequency of PA required to reduce the incidence of hypertension in the Korean population. Most Korean studies have included only small samples and limited age ranges. METHODS: The present study analyzed 16,299,865 participants aged ≥20 years (44.25±12.74 years) from the 2009 to 2012 Korean National Health Insurance Corporation Survey database. The International Physical Activity Questionnaire was used to assess the frequency and intensity of physical activity. Hazard ratios for incident hypertension were analyzed by physical activity participation, age, and sex …
Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han
Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han
Faculty and Student Publications
The purpose of this study was to determine the effectiveness of physical activity intensity prescription using real-time cadence on achieving the required intensities for health benefits. Forty adults (18–65 years) participated in the study. The intensity prescriptions included Rating of Perceived Exertion, Talk Test, Heart Rate, and Real-Time Cadence. The participants performed a2-min trial for both moderate- and vigorous-intensity according to each prescription. Atri-axial accelerometer was used as acriterion measure. After completion of the trials, participant’s preference for the prescriptions was assessed by three domains (e.g., understanding, performing, maintaining). The compliance and achievement rates of RC were calculated and compared …
Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab
Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab
Faculty and Student Publications
New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and 19.56 µM against A549 and HCT-116, respectively. Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT). Compound 12b was the most potent member showing an IC50 value of 0.016 µM. In addition, compound 12b showed noticeable …
Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu
Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu
Faculty and Student Publications
Flunixin meglumine (FM) is a nonsteroidal anti-inflammatory drug limited by irritation of the respiratory tract and mucosa in veterinary tissue. This study aimed to develop a taste-masked FM solid dispersion (SD) by hot-melt extrusion (HME) and formulate an orally disintegrating tablet (ODT) with selected excipients by direct compression. Eudragit® E PO was chosen as the matrix, and HME parameters were optimized: extrusion temperature, 135℃; screw speed, 100 rpm; and drug loading, 20%. Characterization techniques proved that FM was rendered amorphous in the HME extrudate. In vitro dissolution studies showed that FM SD released significantly slower than the corresponding physical mixture …