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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Testing Children For Genetic Predispositions: Is It In Their Best Interest?, Diane E. Hoffmann, Eric A. Wulfsberg
Testing Children For Genetic Predispositions: Is It In Their Best Interest?, Diane E. Hoffmann, Eric A. Wulfsberg
Faculty Scholarship
No abstract provided.
Colloquium - Gender, Law And Health Care: New Perspectives For Teaching And Scholarship: The Role Of Gender In Law And Health Care, Karen H. Rothenberg
Colloquium - Gender, Law And Health Care: New Perspectives For Teaching And Scholarship: The Role Of Gender In Law And Health Care, Karen H. Rothenberg
Faculty Scholarship
No abstract provided.
Purification Of A Variant-Specific Surface Protein Of Giardia Lamblia And Characterization Of Its Metal-Binding Properties, Mark R. Chance
Purification Of A Variant-Specific Surface Protein Of Giardia Lamblia And Characterization Of Its Metal-Binding Properties, Mark R. Chance
Faculty Scholarship
Giardia lamblia, an intestinal parasite of humans and other vertebrates, undergoes surface antigenic variation by modulating the expression of different variant-specific surface proteins (VSP). VSPs are cysteine-rich surface proteins that bind zinc and other heavy metals in vitro. We developed an immunoaffinity chromatographic method to purify a VSP in order to determine its biochemical properties. The sequences of two different proteolytic fragments agreed with the sequence deduced from the cloned gene, and amino-terminal sequence indicated the removal of a 14-residue signal peptide, consistent with the transport of VSP to the cell surface. The protein is not glycosylated and has an …