Medicine and Health Sciences Commons^™

Systemic Treatment Of Patients With Metastatic Breast Cancer: Asco Resource-Stratified Guideline, Sana Al Sukhun, Sarah Temin, Carlos H Barrios, Nicoleta Zenovia Antone, Yanin Chavarri Guerra, Mariana Chavez-Macgregor, Rakesh Chopra, Michael A Danso, Henry Leonidas Gomez, N'Da Marcelin Homian, Alaa Kandil, Benda Kithaka, Bogda Koczwara, Beverly Moy, Gertrude Nakigudde, Fernando Enrique Petracci, Hope S Rugo, Nagi S El Saghir, Banu K Arun

Faculty, Staff and Student Publications

Purpose: To guide clinicians and policymakers in three global resource-constrained settings on treating patients with metastatic breast cancer (MBC) when Maximal setting-guideline recommended treatment is unavailable.

Methods: A multidisciplinary, multinational panel reviewed existing ASCO guidelines and conducted modified ADAPTE and formal consensus processes.

Results: Four published resource-agnostic guidelines were adapted for resource-constrained settings; informing two rounds of formal consensus; recommendations received ≥75% agreement.

Recommendations: Clinicians should recommend treatment according to menopausal status, pathological and biomarker features when quality results are available. In first-line, for hormone receptor (HR)-positive MBC, when a non-steroidal aromatase inhibitor and CDK 4/6 inhibitor combination is unavailable, …

Voluntary Wheel Running Prevents Formation Of Membrane Attack Complexes And Myelin Degradation After Peripheral Nerve Injury, Suzanne M Green-Fulgham, Michael J Lacagnina, Kendal F Willcox, Jiahe Li, Michael E Harland, Adriano Polican Ciena, Igor R Correia Rocha, Jayson B Ball, Renee A Dreher, Younus A Zuberi, Joseph M Dragavon, Marucia Chacur, Steven F Maier, Linda R Watkins, Peter M Grace

Faculty, Staff and Student Publications

Regular aerobic activity is associated with a reduced risk of chronic pain in humans and rodents. Our previous studies in rodents have shown that prior voluntary wheel running can normalize redox signaling at the site of peripheral nerve injury, attenuating subsequent neuropathic pain. However, the full extent of neuroprotection offered by voluntary wheel running after peripheral nerve injury is unknown. Here, we show that six weeks of voluntary wheel running prior to chronic constriction injury (CCI) reduced the terminal complement membrane attack complex (MAC) at the sciatic nerve injury site. This was associated with increased expression of the MAC inhibitor …

Efficacy And Safety Of Trastuzumab Deruxtecan In Patients With Her2-Expressing Solid Tumors: Primary Results From The Destiny-Pantumor02 Phase Ii Trial, Funda Meric-Bernstam, Vicky Makker, Ana Oaknin, Do-Youn Oh, Susana Banerjee, Antonio González-Martín, Kyung Hae Jung, Iwona Ługowska, Luis Manso, Aránzazu Manzano, Bohuslav Melichar, Salvatore Siena, Daniil Stroyakovskiy, Anitra Fielding, Yan Ma, Soham Puvvada, Norah Shire, Jung-Yun Lee

Faculty, Staff and Student Publications

PURPOSE: Trastuzumab deruxtecan (T-DXd) is a human epidermal growth factor 2 (HER2)-directed antibody-drug conjugate approved in HER2-expressing breast and gastric cancers and HER2-mutant non-small-cell lung cancer. Treatments are limited for other HER2-expressing solid tumors.

METHODS: This open-label phase II study evaluated T-DXd (5.4 mg/kg once every 3 weeks) for HER2-expressing (immunohistochemistry [IHC] 3+/2+ by local or central testing) locally advanced or metastatic disease after ≥1 systemic treatment or without alternative treatments. The primary end point was investigator-assessed confirmed objective response rate (ORR). Secondary end points included safety, duration of response, progression-free survival (PFS), and overall survival (OS).

RESULTS: At primary …

Hypoxia-Adenosine Axis As Therapeutic Targets For Acute Respiratory Distress Syndrome, Katherine Figarella, Jieun Kim, Wei Ruan, Tingting Mills, Holger Klaus Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

The human respiratory and circulatory systems collaborate intricately to ensure oxygen delivery to all cells, which is vital for ATP production and maintaining physiological functions and structures. During limited oxygen availability, hypoxia-inducible factors (HIFs) are stabilized and play a fundamental role in maintaining cellular processes for hypoxia adaptation. First discovered during investigations of erythropoietin production regulation, HIFs influence physiological and pathological processes, including development, inflammation, wound healing, and cancer. HIFs promote extracellular adenosine signaling by enhancing adenosine generation and receptor signaling, representing an endogenous feedback mechanism that curbs excessive inflammation, supports injury resolution, and enhances hypoxia tolerance. This is especially …

Evaluation Of Ion Chamber Response For Applications In Electron Flash Radiotherapy, Kevin Liu, Shannon Holmes, Brian Hooten, Emil Schüler, Sam Beddar

Faculty, Staff and Student Publications

Ion chambers are required for calibration and reference dosimetry applications in radiation therapy (RT). However, exposure of ion chambers in ultra-high dose rate (UHDR) conditions pertinent to FLASH-RT leads to severe saturation and ion recombination, which limits their performance and usability. The purpose of this study was to comprehensively evaluate a set of commonly used commercially available ion chambers in RT, all with different design characteristics, and use this information to produce a prototype ion chamber with improved performance in UHDR conditions as a first step toward ion chambers specific for FLASH-RT. The Advanced Markus and Exradin A10, A26, and …

Quantifying The Effect Of 4-Dimensional Computed Tomography-Based Deformable Dose Accumulation On Representing Radiation Damage For Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Standard-Fractionated Intensity-Modulated Radiation Therapy, Yulun He, Guillaume Cazoulat, Carol Wu, Stina Svensson, Lusmeralis Almodovar-Abreu, Bastien Rigaud, Emma Mccollum, Christine Peterson, Zachary Wooten, Dong Joo Rhee, Peter Balter, Julianne Pollard-Larkin, Carlos Cardenas, Laurence Court, Zhongxing Liao, Radhe Mohan, Kristy Brock

Faculty, Staff and Student Publications

Purpose: The aim of this study was to investigate the dosimetric and clinical effects of 4-dimensional computed tomography (4DCT)-based longitudinal dose accumulation in patients with locally advanced non-small cell lung cancer treated with standard-fractionated intensity-modulated radiation therapy (IMRT).

Methods and materials: Sixty-seven patients were retrospectively selected from a randomized clinical trial. Their original IMRT plan, planning and verification 4DCTs, and ∼4-month posttreatment follow-up CTs were imported into a commercial treatment planning system. Two deformable image registration algorithms were implemented for dose accumulation, and their accuracies were assessed. The planned and accumulated doses computed using average-intensity images or phase images were …

First Evidence Of Microplastic Inhalation Among Free-Ranging Small Cetaceans, Miranda K Dziobak, Andreas Fahlman, Randall S Wells, Ryan Takeshita, Cynthia Smith, Austin Gray, John Weinstein, Leslie B Hart

Faculty, Staff and Student Publications

Plastic is a ubiquitous environmental contaminant, resulting in widespread exposure across terrestrial and marine spaces. In the environment, plastics can degrade into microparticles where exposure has been documented in a variety of fauna at all trophic levels. Human epidemiological studies have found relationships between inhaled microplastics and oxidative stress and inflammation. Previous studies of bottlenose dolphins (Tursiops truncatus) have reported prevalent exposure to plasticizing chemicals (e.g., phthalates) as well as particle loads in gastrointestinal tracts, but exposure from inhalation has not yet been studied. The objective of this study was to determine if inhalation is a viable route of microplastic …

In Vivo Scanning Laser Fundus And High-Resolution Oct Imaging Of Retinal Ganglion Cell Injury In A Non-Human Primate Model With An Activatable Fluorescent-Labeled Tat Peptide Probe, Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms

Faculty, Staff and Student Publications

The optical imaging agent TcapQ488 has enabled imaging of retinal ganglion cell (RGC) injury in vivo in rodents and has potential as an effective diagnostic probe for early detection and intervention monitoring in glaucoma patients. In the present study, we investigated TcapQ488 in non-human primates (NHPs) to identify labeling efficacy and early signals of injured RGC, to determine species-dependent changes in RGC probe uptake and clearance, and to determine dose-limiting toxicities. Doses of 3, 6, and 12 nmol of TcapQ488 were delivered intravitreally to normal healthy NHP eyes and eyes that had undergone hemiretinal endodiathermy axotomy (HEA) in the inferior …

Patterns Of Failure For Recurrent Head And Neck Squamous Cell Carcinoma Treated With Salvage Surgery And Postoperative Imrt Reirradiation, Abdallah S R Mohamed, Geoffrey V Martin, Sweet Ping Ng, Vinita Takiar, Beth M Beadle, Mark Zafereo, Adam S Garden, Steven J Frank, C David Fuller, G Brandon Gunn, William H Morrison, David I Rosenthal, Jay Reddy, Amy Moreno, Anna Lee, Jack Phan

Faculty, Staff and Student Publications

PURPOSE/OBJECTIVES: The purpose of this study was to evaluate patterns of locoregional recurrence (LRR) after surgical salvage and adjuvant reirradiation with IMRT for recurrent head and neck squamous cell cancer (HNSCC).

MATERIALS/METHODS: Patterns of LRR for 61 patients treated consecutively between 2003 and 2014 who received post-operative IMRT reirradiation to ≥ 60 Gy for recurrent HNSCC were determined by 2 methods: 1) physician classification via visual comparison of post-radiotherapy imaging to reirradiation plans; and 2) using deformable image registration (DIR). Those without evaluable CT planning image data were excluded. All recurrences were verified by biopsy or radiological progression. Failures were …

Case Report: Early Acute Kidney Failure In An 11-Year-Old Boy With Dent Disease Type 1, Nicolette Murphey, Craig Authement, Paul Hillman, Samhar I Al-Akash, Kate Richardson

Faculty, Staff and Student Publications

Dent disease type 1 (Dent 1) is a rare X-linked genetic condition which impacts kidney function and is caused by pathogenic variants in CLCN5. Affected males typically develop low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and other symptoms. Kidney failure often occurs between the third to fifth decade of life. Here, we report an 11-year-old boy with Dent 1 and a severe kidney disease phenotype. The patient presented with flank pain, nocturnal enuresis, foamy urine, and increased urinary frequency. He was found to have nephrotic-range proteinuria, without hypoalbuminemia, and a significantly decreased estimated glomerular filtration rate at presentation. Further, he …

Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill

Faculty, Staff and Student Publications

Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …

Linking Trauma To Mental Health In The Statewide Texas Youth Depression And Suicide Research Network (Tx-Ydsrn), Lynnel C Goodman, Joshua S Elmore, Taryn L Mayes, Abu Minhajuddin, Holli Slater, Joseph C Blader, Israel Liberzon, Regina B Baronia, Emily J Bivins, Jacquelyn M Lagrone, Sierra Jackson, Sarah L Martin, Ryan Brown, Jair C Soares, Sarah M Wakefield, Madhukar H Trivedi

Faculty, Staff and Student Publications

Rates of youth depression and suicide are rising worldwide and represent public health crises. The present study examined the relationship between trauma history and symptoms of depression, suicidal ideation, and anxiety among suicidal and depressed youth. A diverse group of 1000 8-20-year-olds enrolled in the statewide Texas Youth Depression and Suicide Research Network (TX-YDSRN) reported their trauma history (Traumatic Events Screening Inventory for Children) and symptoms of depression (Patient Health Questionnaire for adolescents; PHQ-A), anxiety (Generalized Anxiety Disorder scale; GAD-7), and suicidality (Concise Health Risk Tracking scale; CHRT-SR). Nearly half of the sample reported exposure to multiple categories of traumatic …

Analysis Of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance, Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes De Sousa, Mario L Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T Spiotto, Ehab Y Hanna, Daniel J Mcgrail, Adel K El-Naggar, Renata Ferrarotto

Faculty, Staff and Student Publications

B7-H4 (VTCN1), a member of the B7 family, is overexpressed in several types of cancer. Here we investigated the pattern of expression of B7-H4 in salivary gland carcinomas (SGC) and assessed its potential as a prognostic marker and therapeutic target. Immunohistochemistry (IHC) analyses were performed in a cohort of 340 patient tumors, composed of 124 adenoid cystic carcinomas (ACC), 107 salivary duct carcinomas (SDC), 64 acinic cell carcinomas, 36 mucoepidermoid carcinomas (MEC), 9 secretory carcinomas (SC), as well as 20 normal salivary glands (controls). B7-H4 expression was scored and categorized into negative (< 5% expression of any intensity), low (5%-70% expression of any intensity or >70% with weak intensity), or high ( …

Meta-Analysis Of The Vmp-Like Sequences Of Lyme Disease Borrelia: Evidence For The Evolution Of An Elaborate Antigenic Variation System, Steven J Norris, Kalvis Brangulis

Faculty, Staff and Student Publications

VMP-like sequence (vls) antigenic variation systems are present in every Lyme disease Borrelia strain with complete genome sequences. The linear plasmid-encoded vls system consists of a single expression site (vlsE) and contiguous array(s) of silent cassettes that have ~90% identity with the central cassette region of the cognate vlsE gene; antigenic variation occurs through random, segmental, and unidirectional recombination of vls silent cassette sequences into the vlsE expression site. Automated annotation programs do not accurately recognize vls silent cassette sequences, so these regions are not correctly annotated in most genomic sequences. In this study, the vls …

Best Practice Recommendations For The Management Of Anxiety During The Pegvaliase Journey, Kendra J Bjoraker, Caroline Eggerding, Elisheva Ellenberg, Suzanne Hollander, Brittany M Holmes, Kristin Lindstrom, Markey Mcnutt, Suzanne Miller, Hope Northrup, Meaghan Rogers, Sarah Rose, Mia Scott, Soo Shim, Bridget Wardley, Leah Wessenberg, Deborah A Bilder

Faculty, Staff and Student Publications

Background: Pegvaliase, an enzyme substitution therapy, is a treatment option for phenylketonuria (PKU). Due to the neuropathophysiology and disease burden of PKU, individuals can experience baseline anxiety unrelated to pegvaliase therapy. In addition, there are aspects of pegvaliase therapy that may be anxiety-inducing for those considering or receiving treatment. The aim of this manuscript is to present best practice recommendations for the identification and management of anxiety symptoms that can occur along the pegvaliase journey.

Methods: A modified Delphi approach was used to seek consensus among a multidisciplinary panel of experts. To this end, an in-person meeting was held that …

Tissue Transglutaminase: A Multifunctional And Multisite Regulator In Health And Disease, Zhouzhou Yao, Yuhua Fan, Lizhen Lin, Rodney E Kellems, Yang Xia

Faculty, Staff and Student Publications

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a broad range of cellular and metabolic functions carried out in a variety of cellular compartments. In addition to transamidation, TG2 also functions as a Gα signaling protein, a protein disulfide isomerase (PDI), a protein kinase, and a scaffolding protein. In the nucleus, TG2 modifies histones and transcription factors. The PDI function catalyzes the trimerization and activation of heat shock factor-1 in the nucleus and regulates the oxidation state of several mitochondrial complexes. Cytosolic TG2 modifies proteins by the addition of serotonin or other primary amines and in this …

The Feasibility Of Health Professional Student Delivered Social Visits For Stroke Survivors With Loneliness, Jason Burnett, Jordan Broussard, Bronson Ciavarra, Louisa Smitherman, Mary Li, Emma Thames, Sharon Zachariah, Grace Kim, Rachel Pijnnaken, Hannah Zeller, John Halphen, Sean I Savitz, Namkee Choi, Jennifer E S Beauchamp

Faculty, Staff and Student Publications

Objectives: To examine the feasibility of a social phone call program to address social isolation and loneliness in stroke survivors.

Materials and methods: We paired 14 lonely community-living stroke survivors with 14 health professional students for 6-weekly unstructured social phone calls. Feasibility data and measures of social isolation, loneliness and other psychosocial metrics were collected pre- and post-intervention. Students journaled following each unstructured call to capture the informal conversation and their sentiments.

Results: Sixty-two percent of the targeted sample was interested. Fourteen eligible and interested participants were enrolled. The 13 (93%) participants completing all calls and surveys were an average …

Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, Bc, Canada, Antoine Dionne, Majeed Al-Zakri, Hubert Labelle, Julie Joncas, Stefan Parent, Jean-Marc Mac-Thiong, Firoz Miyanji, Baron Lonner, Ali Eren, Patrick Cahill, Peter Newton, Jennifer A Dermott, Liisa Jaakkimainen, Teresa To, Maryse Bouchard, Andrew Howard, David E Lebel, Sarah Hardy, Armaan K Malhotra, Jennifer Dermott, Dilani Thevarajah, Karen D A Mathias, Samuel Yoon, Rajendra Sakhrekar, Dorothy J Kim, Ayesha Hadi, Andrea Doria, Aya Mitani, David Lebel, Karen Mathias, Tracey Bastrom, Amer Samdani, Marjolaine Roy-Beaudry, Marie Beauséjour, Rachelle Imbeault, Justin Dufresne, Jessica Romeo, Holly Livock, Kevin Smit, James Jarvis, Andrew Tice, Vivien K Chan, Robert Cho, Selina Poon, David L Skaggs, Geoffrey K Shumilak, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Peter S Tretiakov, Oluwatobi Onafowokan, Jamshaid Mir, Ankita Das, Tyler Williamson, Pooja Dave, Bailey Imbo, Jordan Lebovic, Pawel Jankowski, Peter G Passias, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Vishal P Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Rémi Pelletier-Roy, Michael Asmussen, Manjot Birk, Taryn Ludwig, Fred Nicholls, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Aazad Abbas, Jay Toor, Gurjovan Sahi, Dusan Kovacevic, Johnathan Lex, Raja Rampersaud, Anthony V Perruccio, Nizar Mahomed, Mayilee Canizares, Maroun Rizkallah, Michel Alexandre Lebreton, Ghassan Boubez, Jesse Shen, Fidaa Alshakfa, Yousef Kamel, Galil Osman, Zhi Wang, Nikolaus Koegl, Brandon Herrington, Renan R Fernandes, Jennifer C Urquhart, Yoga R Rampersaud, Chris S Bailey, Ramtin Hakimjavadi, Tinghua Zhang, Zachary Devries, Eugene K Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe Phan, Noah Fine, Laura Stone, Mohit Kapoor, Alexandre Chênevert, Sonia Bédard, Greg Mcintosh, Julien Goulet, Jérome Couture, Csorn Investigators, Bernard Larue, Brent Rosenstein, Meaghan Rye, Alexa Roussac, Neda Naghdi, Luciana G Macedo, James Elliott, Richard Demont, Michael H Weber, Véronique Pepin, Geoffrey Dover, Maryse Fortin, Edisond Florial, Aditya Raj, Prarthan Amin, Yoga Raja Rampersaud, Abdullah A S M Alduwaisan, Kim Phan, Stephen Kingwell, Eugene Wai, Jeffrey Hebert, Sarah Nowell, Niels Wedderkopp, Amanda Vandewint, Neil Manson, Edward Abraham, Christopher Small, Najmedden Attabib, Erin Bigney, Michael Craig, Abdul Al-Shawwa, Kalum Ost, Saswati Tripathy, Nathan Evaniew, Bradley Jacobs, David Cadotte, Nicolas Dea, Jefferson R Wilson, Christopher S Bailey, Y Raja Rampersaud, W Bradley Jacobs, Philippe Phan Phan, Andrew Nataraj, David W Cadotte, Kenneth C Thomas, Jerome Paquet, Sean D Christie, Hamilton Hall, Charles G Fisher, Eva Y Liu, Amit R L Persad, Nathan Baron, Daryl Fourney, Husain Shakil, Jingyi Huang, Nader Fallah, Charlotte Dandurand, Csorn Investigators, Thamer Alfawaz, Tinghua Zhang, Alexandra Stratton, Eve Tsai, Eugene Wai, Stephen Kingwell, Zhi Wang, Philippe Phan, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Raphaële Charest-Morin, Greg Mcintosh, Michael G Fehlings, Karlo M Pedro, Mohammed Ali Alvi, Jessica C W Wang, Raphaële Charest-Morin, Nicolas Dea, Charles Fisher, Marcel Dvorak, Brian Kwon, Tamir Ailon, Scott Paquette, John Street, Charlotte Dandurand, Rohail Mumtaz, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Ragavan Manoharan, Greg Mcintosh, Yoga R Rampersaud, Jenna Smith-Forrester, Joanne E Douglas, Evan Nemeth, Jacob Alant, Sean Barry, Andrew Glennie, William Oxner, Lutz Weise, Sean Christie, Eva Y Liu, Amit R L Persad, Sabahat Saeed, Patrick Toyota, Jack Su, Braeden Newton, Nicole Coote, Daryl Fourney, Maria S Rachevits, Helen Razmjou, Susan Robarts, Albert Yee, Joel Finkelstein, Alysa Almojuela, Frederick Zeiler, Sarvesh Logsetty, Perry Dhaliwal, Mark Abdelnour, Yuxin Zhang, Eugene Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe T Phan, Csorn Investigators, Taylor A Smith, Christopher Small, Erin Bigney, Eden Richardson, Jillian Kearney, Neil Manson, Edward Abraham, Najmedden Attabib, Michael Bond, Stephan Dombrowski, Gwyneth Price, Jose Manuel García-Moreno, Jeffrey Hebert, Steven Qiu, Vithushan Surendran, Victoria Shi Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha, Ahmad Essa, Husain Shakil, Armaan Malhotra, James Byrne, Jetan Badhiwala, Eva Yuan, Yingshi He, Andrew Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Husain Shakil, Armaan K Malhotra, Eva Yuan, Christopher W Smith, Erin M Harrington, Rachel H Jaffe, Alick P Wang, Karim Ladha, Avery B Nathens, Jefferson R Wilson, Christopher D Witiw, Ryan V Sandarage, Ahmad Galuta, Eve C Tsai, Naama Rotem-Kohavi, Marcel F Dvorak, Jijie Xu, Nader Fallah, Zeina Waheed, Melody Chen, Nicolas Dea, Nathan Evaniew, Vanessa Noonan, Brian Kwon, Brian K Kwon, Toluyemi Malomo, Raphaële Charest-Morin, Scott Paquette, Tamir Ailon, Charlotte Dandurand, John Street, Charles G Fisher, Nicolas Dea, Manraj Heran, Marcel Dvorak, Rachael Jaffe, Peter Coyte, Brian Chan, Armaan Malhotra, Rebecca Hancock-Howard, Jefferson Wilson, Christopher Witiw, Newton Cho, Jordan Squair, Viviana Aureli, Nicholas James, Lea Bole-Feysot, Inssia Dewany, Nicolas Hankov, Laetitia Baud, Anna Leonhartsberger, Kristina Sveistyte, Michael Skinnider, Matthieu Gautier, Katia Galan, Maged Goubran, Jimmy Ravier, Frederic Merlos, Laura Batti, Stéphane Pagès, Nadia Bérard, Nadine Intering, Camille Varescon, Stefano Carda, Kay Bartholdi, Thomas Hutson, Claudia Kathe, Michael Hodara, Mark Anderson, Bogdan Draganski, Robin Demesmaeker, Leonie Asboth, Quentin Barraud, Jocelyne Bloch, Grégoire Courtine, Sean D Christie, Ryan Greene, Mustafa Nadi, Jacob Alant, Sean Barry, Andrew Glennie, Bill Oxner, Lutz Weise, Lisa Julien, Clara Lownie, Marcel F Dvorak, Cumhur F C Öner, Charlotte Dandurand, Alexander Joeris, Klaus Schnake, Mark Phillips, Alexander R Vaccaro, Richard Bransford, Eugen Cezar Popescu, Mohammed El-Sharkawi, Shanmuganathan Rajasekaran, Lorin M Benneker, Greg D Schroeder, Jin W Tee, John France, Jérôme Paquet, Richard Allen, William F Lavelle, Emiliano Vialle, Nicolas Dea, Antoine Dionne, David Magnuson, Andréane Richard-Denis, Yvan Petit, Francis Bernard, Dorothy Barthélémy, Jean-Marc Mac-Thiong, Lukas Grassner, Daniel Garcia-Ovejero, Evelyn Beyerer, Orpheus Mach, Iris Leister, Doris Maier, Ludwig Aigner, Angel Arevalo-Martin, Mark Alexander Maclean, Antoinette Charles, Miltiadis Georgiopoulos, Raphaële Charest-Morin, Rory Goodwin, Michael Weber, Emile Brouillard, Andréane Richard-Denis, Antoine Dionne, Ismail Laassassy, Paul Khoueir, Étienne Bourassa-Moreau, Gilles Maurais, Jean-Marc Mac-Thiong, Julien Francisco Zaldivar-Jolissaint, Nicolas Dea, Aysha Allard Brown, Kitty So, Neda Manouchehri, Megan Webster, Jay Ethridge, Audrey Warner, Avril Billingsley, Rochelle Newsome, Kirsten Bale, Andrew Yung, Mehara Seneviratne, Jimmy Cheng, Jing Wang, Shenani Basnayake, Femke Streijger, Manraj Heran, Piotr Kozlowski, Brian K Kwon, Jeff D Golan, Lior M Elkaim, Qais Alrashidi, Miltiadis Georgiopoulos, Oliver J Lasry, Drew A Bednar, Alyson Love, Soroush Nedaie, Pranjan Gandhi, Prarthan C Amin, Aditya Raj, Greg Mcintosh, Christopher J Neilsen, Ganesh Swamy, Raja Rampersaud, Amanda Vandewint, Y Raja Rampersaud, Jeffrey Hebert, Erin Bigney, Neil Manson, Najmedden Attabib, Chris Small, Eden Richardson, Jill Kearney, Edward Abraham, Raja Rampersaud, Aditya Raj, Nanadan Marathe, Greg Mcintosh, Manmeet Dhiman, Taylor J Bader, David Hart, Ganesh Swamy, Neil Duncan, Manmeet Dhiman, Taylor J Bader, Dragana Ponjevic, John R Matyas, David Hart, Ganesh Swamy, Neil Duncan, Connor P O'Brien, Jeffrey Hebert, Erin Bigney, Jillian Kearney, Eden Richardson, Edward Abraham, Neil Manson, Najmedden Attabib, Christopher Small, Luke Larochelle, Gabriella Rivas, James Lawrence, Robert Ravinsky, Dorothy Kim, Jennifer Dermott, Aya Mitani, Andrea Doria, Andrew Howard, David Lebel, Jennifer A Dermott, Lily S Switzer, Dorothy J Kim, David E Lebel, Chanelle Montpetit, Nicolas Vaillancourt, Brent Rosenstein, Maryse Fortin, Emma Nadler, Jennifer Dermott, Dorothy Kim, David E Lebel, Daniel Wolfe, Brent Rosenstein, Maryse Fortin, Daniel Wolfe, Geoffrey Dover, Mathieu Boily, Maryse Fortin, Husain Shakil, Armaan K Malhotra, Jetan H Badhiwala, Vishu Karthikeyan, Yingshi He, Michael G Fehlings, Arjun Sahgal, Nicolas Dea, Alex Kiss, Christopher D Witiw, Donald R Redelmeier, Jefferson R Wilson, Marco Pérez Caceres, Véronique Freire, Jesse Shen, Fidaa Al-Shakfa, Omer Ahmed, Zhi Wang, William Chu Kwan, Scott L Zuckerman, Charles G Fisher, Ilya Laufer, Dean Chou, John E O'Toole, Markus Schultheiss, Michael H Weber, Daniel M Sciubba, Markian Pahuta, John H Shin, Michael G Fehlings, Anne Versteeg, Matthew L Goodwin, Stefano Boriani, Chetan Bettegowda, Aron Lazary, Alessandro Gasbarrini, Jeremy J Reynolds, Jorrit-Jan Verlaan, Arjun Sahgal, Ziya L Gokaslan, Laurence D Rhines, Nicolas Dea, Van Tri Truong, The Khanh Dang, Galil Osman, Fidaa Al-Shakfa, Danielle Boule, Jesse Shen, Zhi Wang, Maroun Rizkallah, Ghassan Boubez, Jesse Shen, Philippe Phan, Fidaa Alshakfa, Danielle Boule, Celine Belguendouz, Rayane Kafi, Sung-Joo Yuh, Daniel Shedid, Zhi Wang, Zhi Wang, Jesse Shen, Ghassan Boubez, Fidaa Alshakfa, Daniele Boulé, Celine Belguendouz, Rayane Kafi, Philippe Phan, Daniel Shedid, Sung-Joo Yuh, Maroun Rizkallah, Yan Gabriel Morais David Silva, Luis Weber, Felipe Leão, Ahmad Essa, Armaan K Malhotra, Husain Shakil, James Byrne, Jetan Badhiwala, Avery B Nathens, Tej D Azad, Eva Yuan, Yingshi He, Andrew S Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Michael Craig, Nick Guenther, Jan Valosek, Maxime Bouthillier, Naga Karthik Enamundram, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian Kwon, Jean-Marc Mac-Thiong, Philippe Phan, Jerome Paquet, Mathieu Guay-Paquet, Julien Cohen-Adad, David Cadotte, Antoine Dionne, Jean-Marc Mac-Thiong, Heather Hong, Dilnur Kurban, Jijie Xu, Dorothy Barthélémy, Sean Christie, Daryl Fourney, Gary Linassi, Adalberto Loyola Sanchez, Jérôme Paquet, Vidya Sreenivasan, Andrea Townson, Eve C Tsai, Andréane Richard-Denis, William Chu Kwan, Pedram Laghaei, Harsh Kahlon, Tamir Ailon, Raphael Charest-Morin, Charlotte Dandurand, Scott Paquette, Nicholas Dea, John Street, Charles G Fisher, Marcel F Dvorak, Brian K Kwon, Jérémie Thibault, Antoine Dionne, Mohamed Al-Sofyani, Rémi Pelletier-Roy, Andréane Richard-Denis, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong, Maxime Bouthillier, Jan Valošek, Naga Karthik Enamundram, Mathieu Guay-Paquet, Nick Guenther, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian K Kwon, Jean Marc Mac-Thiong, Philippe Phan, David Cadotte, Julien Cohen-Adad, Luke Reda, Colton Kennedy, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Colton Kennedy, Luke Reda, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Maryam Rezaeezadeh Roukerd, Maitreya Patel, Eve Tsai, Ahmad Galuta, Sasi Jagadeesan, Ryan Vimukthie Sandarage, Philippe Phan, Wojtek Michalowski, William Van Woensel, Khushdeep Vig, Jillian Kazley, Abdul Arain, Gabriella Rivas, Robert Ravinsky, James Lawrence, Shaurya Gupta, Jibrahn Patel, Isaac Turkstra, Kirill Pustovetov, Victor Yang, W Bradley Jacobs, Gonzalo Mariscal, Christopher D Witiw, James S Harrop, Ahmed Essa, Christopher D Witiw, Gonzalo Mariscal, W Bradley Jacobs, James S Harrop, Ahmed Essa, Jin Tong Du, Ahmed Cherry, Rajesh Kumar, Nadia Jaber, Michael Fehlings, Albert Yee, Siril Teja Dukkipati, Mark Driscoll, Elizabeth Byers, Justin L Brown, Michelle Gallagher, James Sugar, Shannon Rockall, James Hektner, Scott Donia, John Chernesky, Vanessa K Noonan, Aaron A Varga, Flo Slomp, Emily Thiessen, Nataliya Lastivnyak, Linda Slater Maclean, Vanessa Ritchie, Aaron Hockley, Lutz M Weise, Christine Potvin, Peggy Flynn, Sean Christie, Isaac Turkstra, Bruno Oppermann, Marcelo Oppermann, Shaurya Gupta, Jibrahn Patel, Kirill Pustovetov, Kenneth Lee, Chaoliang Chen, Mohammadmahdi Rastgarjazi, Victor Yang, Sarah Hardy, Samuel Strantzas, Alison Anthony, Jennifer Dermott, Mike Vandenberk, Samer Hassan, David Lebel, Yan Gabriel Morais David Silva, Bernard Larue, Jerome Couture, Newton Pimenta, Jocelyn Blanchard, Alexandre Chenevert, Julien Goulet, Ryan Greene, Sean D Christie, Amanda Hall, Holly Etchegary, Alwalaa Althagafi, Jae Han, Ryan Greene, Sean Christie, Gwynedd Pickett, Christopher Witiw, James Harrop, W Bradley Jacobs, Gonzalo Mariscal, Ahmed Essa, W Bradley Jacobs, Gonzalo Mariscal, Christopher Witiw, James S Harrop, Ahmed Essa, Timothy Lasswell, Parham Rasoulinejad, Richard Hu, Chris Bailey, Fawaz Siddiqi, Abdulrahman Hamdoon, Mohamed Amin Soliman, Juhi Maraj, Deven Jhawar, Balraj Jhawar, Kirsten A Schuler, Lindsay D Orosz, Tarek Yamout, Brandon J Allen, Wondwossen T Lerebo, Rita T Roy, Thomas C Schuler, Christopher R Good, Colin M Haines, Ehsan Jazini, Kalum J Ost, Abdul Al-Shawwa, David Anderson, Nathan Evaniew, Bradley W Jacobs, Peter Lewkonia, Fred Nicholls, Paul T Salo, Kenneth C Thomas, Michael Yang, David Cadotte, Mohamed Sarraj, Nathasha Rajapaksege, Nicolas Dea, Nathan Evaniew, Greg Mcintosh, Markian Pahuta, Hani Nouran Alharbi, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Sara Gustafson, Ian Polyzois, Trevor Gascoyne, Michael Goytan, Drew Alexander Bednar, Mohamed Sarra, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Ravi Ghag, Samuel Kirk, Otis Shirley, Jeffrey Bone, Andrew Morrison, Firoz Miyanji, Amit Parekh, Ethan Sanders, Manjot Birk, Fred Nicholls, Kevin Smit, Holly Livock, Jessica Romeo, James Jarvis, Andrew Tice, Sofía Frank, Hubert Labelle, Stephan Parent, Soraya Barchi, Julie Joncas, Jean-Marc Mac-Thiong, Jérémie Thibault, Julie Joncas, Soraya Barchi, Stefan Parent, Marie Beausejour, Jean-Marc Mac-Thiong, Antoine Dionne, Jean-Marc Mac-Thiong, Stefan Parent, Jesse Shen, Julie Joncas, Soraya Barchi, Hubert Labelle, Manjot S Birk, Fred Nicholls, Rémi Pelletier-Roy, Ethan Sanders, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Zeeshan Sardar, Elen Mullaj, David Lebel, Jennifer Dermott, Natasha Bath, Karen Mathias, Deepa Kattail, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Stephen J Lewis, Taylor J Bader, Manmeet Dhiman, David Hart, Neil Duncan, Paul Salo, Ganesh Swamy, Stephen Joel Lewis, Peyton Lloyd Lawrence, Justin Smith, Ferran Pellise, Zeeshan Sardar, Peyton Lloyd Lawrence, Stephen Joel Lewis, Justin Smith, Ferran Pellise, Zeeshan Sardar, Jordan J Levett, Abdulrhman Alnasser, Uri Barak, Lior M Elkaim, Thien Sa Hoang, Naif M Alotaibi, Daipayan Guha, Isaac L Moss, Alexander G Weil, Michael H Weber, Phillip De Muelenaere, Kashif Parvez, John Sun, Olivia C Iorio, Brent Rosenstein, Neda Naghdi, Maryse Fortin, Felicia Manocchio, Ran Ankory, Lisa Stallwood, Henry Ahn, Hamza Mahdi, Abdul Naeem, Deven Jhawar, Milad Moradi, Balraj Jhawar, Steven Qiu, Vithushan Surendran, Victoria Shi, Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha

Faculty, Staff and Student Publications

No abstract provided.

Enhancement Pattern Mapping For Early Detection Of Hepatocellular Carcinoma In Patients With Cirrhosis, Newsha Nikzad, David Thomas Fuentes, Millicent Roach, Tasadduk Chowdhury, Matthew Cagley, Mohamed Badawy, Ahmed Elkhesen, Manal Hassan, Khaled M Elsayes, Laura Beretta, Eugene Jon Koay, Prasun Kumar Jalal

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Limited methods exist to accurately characterize the risk of malignant progression of liver lesions. Enhancement pattern mapping (EPM) measures voxel-based root mean square deviation (RMSD) of parenchyma and the contrast-to-noise (CNR) ratio enhances in malignant lesions. This study investigates the utilization of EPM to differentiate between HCC versus cirrhotic parenchyma with and without benign lesions.

METHODS: Patients with cirrhosis undergoing MRI surveillance were studied prospectively. Cases (n=48) were defined as patients with LI-RADS 3 and 4 lesions who developed HCC during surveillance. Controls (n=99) were patients with and without LI-RADS 3 and 4 lesions who did not …

Stroke Survivors’ Telemedicine Experiences During The Covid-19 Pandemic: A Phenomenological Investigation, Barbara Kimmel, Annette Walder, Anette Ovalle, Chethan P Venkatasubba Rao, Sean I Savitz, Mark Goldberg, Steven Warach, Salvador Cruz-Flores, Daiwai M Olson, Jane A Anderson

Faculty, Staff and Student Publications

PURPOSE: This study aimed to describe stroke survivors' experiences receiving telemedicine visits at the Lone Star Stroke Consortium during the COVID-19 pandemic.

MATERIALS AND METHODS: A qualitative descriptive phenomenological design was applied to gather patients' telemedicine experiences through in-depth interviews, using a study guide. Audio-recorded interviews were conducted via ZOOM and transcribed verbatim. Two independent reviewers used the Giorgi descriptive method to analyze the data and search for the essence of stroke survivors' follow-up telemedicine experiences during the COVID-19 pandemic.

RESULTS: Fifteen underserved patients were recruited: mean age, 51.8 (15.7), and 9 (60%) females. Three themes emerged: (1) vivid memory …

Siglec15, Negatively Correlated With Pd-L1 In Hcc, Could Induce Cd8+ T Cell Apoptosis To Promote Immune Evasion, Zheng Chen, Mincheng Yu, Bo Zhang, Lei Jin, Qiang Yu, Shuang Liu, Binghai Zhou, Jiuliang Yan, Wentao Zhang, Xiaoqiang Li, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Hui Li, Lei Guo

Faculty, Staff and Student Publications

Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was recently found to be an immune inhibitor with similar structure of inhibitory B7 family members. SIGLEC15 expression in HCC was explored in public databases and further examined by PCR analysis. SIGLEC15 and PD-L1 expression patterns were examined in HCC samples through immunohistochemistry. SIGLEC15 expression was knocked-down or over-expressed in HCC cell lines, and CCK8 tests were used to examine cell proliferative ability in vitro. Influences of SIGLEC15 expression on tumor growth were examined in immune deficient and immunocompetent mice respectively. Co-culture system of HCC cell lines and …

Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill

Faculty, Staff and Student Publications

Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …

Outcomes For Patients With Head And Neck Sarcoma Treated Curatively With Radiation Therapy And Surgery, Alison K Yoder, Ahsan Farooqi, Devarati Mitra, J Andrew Livingston, Dejka M Araujo, Erich M Sturgis, Ryan Goepfert, Andrew J Bishop, B Ashleigh Guadagnolo

Faculty, Staff and Student Publications

PURPOSE: Soft tissue sarcomas (STSs) of the head and neck (H&N) are rare malignancies that are challenging to manage. We sought to describe the outcomes of patients treated with curative intent using combined surgery and radiation therapy (RT) for H&N STS.

METHODS AND MATERIALS: We performed a single-institution retrospective review of patients with nonmetastatic STS of the H&N who were treated from 1968 to 2020. The Kaplan-Meier method was used to estimate disease-specific survival (DSS) and local control (LC). Multivariable analyses (MVAs) were conducted using Cox proportional hazards model.

RESULTS: One hundred ninety-two patients had a median follow-up of 82 …

Faslpr Gene Dosage Tunes The Extent Of Lymphoproliferation And T Cell Differentiation In Lupus, Ritu Bohat, Xiaofang Liang, Yanping Chen, Chunyu Xu, Ningbo Zheng, Ashley Guerrero, Jiakai Hou, Roshni Jaffery, Nicholas A Egan, Yaxi Li, Yitao Tang, Esra Unsal, Adolfo Robles, Si Chen, Angela M Major, Hadil Elldakli, Sang-Hyuk Chung, Han Liang, M John Hicks, Yong Du, Jamie S Lin, Xiqun Chen, Chandra Mohan, Weiyi Peng

Faculty, Staff and Student Publications

Sle1 and Fas^lpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Fas^lpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6.Sle1/Sle1.Fas^lpr/+ (Sle1homo.lprhet) and compared it with B6.Fas^lpr/lpr (lprhomo), B6.Sle1/Sle1 (Sle1homo), and B6.Sle1/Sle1.Fas^lpr/lpr (Sle1homo.lprhomo) strains. Whereas Sle1homo.lprhomo mice exhibited profound lymphoproliferation and early mortality, Sle1homo.lprhet mice had a lifespan comparable to B6 mice, with no evidence of splenomegaly or lymphadenopathy. Compared to B6 monogenic lupus strains, Sle1homo.lprhet mice exhibited significantly …

Benzodioxane-Benzamides As Promising Inhibitors Of Escherichia Coli Ftsz, Lorenzo Suigo, Begoña Monterroso, Marta Sobrinos-Sanguino, Carlos Alfonso, Valentina Straniero, Germán Rivas, Silvia Zorrilla, Ermanno Valoti, William Margolin

Faculty, Staff and Student Publications

The conserved process of cell division in bacteria has been a long-standing target for antimicrobials, although there are few examples of potent broad-spectrum compounds that inhibit this process. Most currently available compounds acting on division are directed towards the FtsZ protein, a self-assembling GTPase that is a central element of the division machinery in most bacteria. Benzodioxane-benzamides are promising candidates, but poorly explored in Gram-negatives. We have tested a number of these compounds on E. coli FtsZ and found that many of them significantly stabilized the polymers against disassembly and reduced the GTPase activity. Reconstitution in crowded cell-like conditions showed …

Parents' Stigmatizing Beliefs About The Hpv Vaccine And Their Association With Information Seeking Behavior And Vaccination Communication Behaviors, Ashley Hedrick Mckenzie, Ross Shegog, Lara S Savas, C Mary Healy, L Aubree Shay, Sharice Preston, Sharon Coan, Travis Teague, Erica Frost, Stanley W Spinner, Sally W Vernon

Faculty, Staff and Student Publications

Parents' stigmatizing beliefs about the HPV vaccine, such as beliefs that it promotes adolescent sexual activity, constitute a notable barrier to vaccine uptake. The purpose of this study is to describe the associations between parents' stigmatizing beliefs about the HPV vaccine, psychosocial antecedents to vaccination, and parents' intentions to vaccinate their children. Parents of vaccine-eligible children (

Genetic Loss Of Mir-205 Causes Increased Mammary Gland Development, Alessandra Cataldo, Douglas G Cheung, John P Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M Croce, Gianpiero Di Leva, Marilena V Iorio

Faculty, Staff and Student Publications

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205

Mir-142: A Master Regulator In Hematological Malignancies And Therapeutic Opportunities, Wilson Huang, Doru Paul, George A Calin, Recep Bayraktar

Faculty, Staff and Student Publications

MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive …

Predictive Metabolites For Incident Myocardial Infarction: A Two-Step Meta-Analysis Of Individual Patient Data From Six Cohorts Comprising 7897 Individuals From The Consortium Of Metabolomics Studies, Ana Nogal, Taryn Alkis, Yura Lee, Domagoj Kifer, Jie Hu, Rachel A Murphy, Zhe Huang, Rui Wang-Sattler, Gabi Kastenmüler, Birgit Linkohr, Clara Barrios, Marta Crespo, Christian Gieger, Annette Peters, Jackie Price, Kathryn M Rexrode, Bing Yu, Cristina Menni

Faculty, Staff and Student Publications

AIMS: Myocardial infarction (MI) is a major cause of death and disability worldwide. Most metabolomics studies investigating metabolites predicting MI are limited by the participant number and/or the demographic diversity. We sought to identify biomarkers of incident MI in the COnsortium of METabolomics Studies.

METHODS AND RESULTS: We included 7897 individuals aged on average 66 years from six intercontinental cohorts with blood metabolomic profiling (n = 1428 metabolites, of which 168 were present in at least three cohorts with over 80% prevalence) and MI information (1373 cases). We performed a two-stage individual patient data meta-analysis. We first assessed the associations …

Altered Outer Retinal Structure, Electrophysiology And Visual Perception In Parkinson's Disease, Katie K N Tran, Pei Ying Lee, David I Finkelstein, Allison M Mckendrick, Bao N Nguyen, Bang V Bui, Christine T O Nguyen

Faculty, Staff and Student Publications

BACKGROUND: Visual biomarkers of Parkinson's disease (PD) are attractive as the retina is an outpouching of the brain. Although inner retinal neurodegeneration in PD is well-established this has overlap with other neurodegenerative diseases and thus outer retinal (photoreceptor) measures warrant further investigation.

OBJECTIVE: To examine in a cross-sectional study whether clinically implementable measures targeting outer retinal function and structure can differentiate PD from healthy ageing and whether these are sensitive to intraday levodopa (L-DOPA) dosing.

METHODS: Centre-surround perceptual contrast suppression, macular visual field sensitivity, colour discrimination, light-adapted electroretinography and optical coherence tomography (OCT) were tested in PD participants (n = …