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Full-Text Articles in Medicine and Health Sciences
Intranasal Administration Of Exosome Packaged Catalase-Skl, A Novel Antioxidant Delivery System Across The Blood-Brain Barrier In Mice: Biodistribution And Safety, Qingfan Liu
Electronic Thesis and Dissertation Repository
A core pathological feature of AD is the over-production of reactive oxygen species (ROS), which mediate oxidative stress in the brain. Peroxisomes play a crucial role in mitigating ROS accumulation due to the presence of catalase, an antioxidant enzyme found within the organelle. As the brain ages, progressive dysfunction of peroxisomes and decreased localization of catalase into the organelle contributes to elevated ROS. A suitable therapy to address the increased accumulation of ROS in AD has yet to be identified. Our team has engineered a recombinant derivative of the antioxidant enzyme catalase (CAT-SKL) that specifically targets peroxisomes, thereby providing powerful …
Dna Damage And Oxidative Stress Induced-P53 Activity In Astrocytes Causes Growth Arrest, Sarah A. Humphrey
Dna Damage And Oxidative Stress Induced-P53 Activity In Astrocytes Causes Growth Arrest, Sarah A. Humphrey
Electronic Thesis and Dissertation Repository
An increasing body of evidence suggests that astrocytes play a key role in modulating neuronal fate during acute and chronic neurodegenerative conditions. Following CNS injury, an upregulation of p53 has been noted in both neurons and reactive astrocytes. p53 is an extremely important protein in determining cell fate decisions and its activation can result in the transcriptional induction of target genes that regulate apoptosis, autophagy, senescence and cell-cycle arrest. We found that p53 is upregulated in primary cortical astrocytes following oxidative stress and DNA damage and that this upregulation results in the p53-dependent transcriptional induction of several target genes involved …