Medicine and Health Sciences Commons^™

Improving The Inference Of Some Experiemtal Studies By Using Ranked Auxiliary Covariates, Rajai Jabrah

Electronic Theses and Dissertations

In many studies, the measurement of sampling units according to the response variable is costly or time consuming, however, it is possible to rank sampling units according to baseline auxiliary covariates, which are available, easily obtainable, and cost efficient. In these cases, when estimating the population mean, Ranked Set Sampling (RSS) can be a more efficient sampling method than the Simple Random Sampling (SRS) method. In this dissertation, we propose a modified approach of the RSS method to allocate units into an experimental study, aimed to compare two or more groups.

Ranked auxiliary covariates, which are typically correlated with the …

The Effect Of Half Time Sports Drink Ingestion On Subsequent Half Performance In U16 Female Soccer Players During Consecutive Matches, Nadima Skeff Ms, Brandonn Harris, Amy Jo Riggs, Adam Wells, John Dobson, Nicholas Coker

Electronic Theses and Dissertations

The purpose of this study was to evaluate the effect of halftime sports drink ingestion on second half performance in U16 female soccer players using GPS technology. While 12 players initially took part in the study, only six players were included in the analysis (age, 15.97±0.45 years; height, 159.62±5.35cm; body mass, 54.87±4.25; body mass index, 21.58±2.10 kg·m^-2). In a double-blinded study design, twelve U16 female soccer players were randomly assigned to two groups (carbohydrate- sports drink or placebo). During half time of each game, players were provided with 500 ml of a drink and consumed the same liquid …

Saffron Extract And Its Active Constituents As Preventative And/Or Treatment Agents For Prostate Cancer Using In Vitro And In Vivo Models, Faisal Fayih Albaqami

Electronic Theses and Dissertations

Saffron extract and its active constituents were evaluated as chemopreventatives and/or treatments for prostate cancer. Different models of prostate cancer (in vitro and in vivo) were used for studying saffron and its constituents’ mechanisms. In normal prostate cells, saffron extract, crocetin, and safranal, in non-toxic concentrations, possessed antioxidant properties against the reactive oxygen species induced by H2O2 which further supports saffron constituents as chemopreventative agents. Moreover, saffron and its active constituents produced cytotoxicity in prostate cancer cells through intrinsic apoptosis pathways. Potential efficacy in minimizing prostate cancer metastasis was also examined. Saffron extract, crocetin, and safranal decreased the migration and …

Evaluation And Enhancement Of Physical Stability Of Amorphous Solid Dispersions, Xin Feng

Electronic Theses and Dissertations

A major concern during formulation development has been to enhance the dissolution rate and bioavailability of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the crystalline forms.[3],[4] For drugs which bioavailability is limited by aqueous solubility (biopharmaceutical classification system (BCS) class II drugs), which is a significant number of recently discovered drug candidates, the improved solubility may lead to enhanced bioavailability.[5-7] Oral absorption of APIs depends on two broad, but crucial, events, namely drug solubilization and gastrointestinal permeation.[8] …

Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael

Electronic Theses and Dissertations

Due to the pressing need for new disease-modifying drugs for Alzheimer’s disease (AD), new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover α-secretase levels and decrease toxic Aβ levels, thereby restoring synaptogenesis and cognitive function. In this way, we aim to develop …

Biological And Psychosocial Risk Factors Of Stroke In African Americans Enrolled In The Jackson Heart Study (Jhs), Sasikiran Nunna

Electronic Theses and Dissertations

Objectives: the objective of this study is to estimate the impact of biological, psychosocial and other risk factors on stroke in African Americans enrolled in the JHS and determine the population attributable risk of risk factors. Methods: this study used a nested case control design. Cases were patients with stroke during the follow up period. Corresponding controls were selected from subjects who are alive at that time period and who are at risk of stroke by matching on the person-years spent in the cohort. Odds ratios (OR) and population attributable risks (PAR) were calculated to understand the association of risk …

Alcohol Use As A Precipitant And Comorbidity In Primary Headache, Rachel Davis

Electronic Theses and Dissertations

Migraine and tension-type headache (tth) are two of the most prevalent pain conditions diagnosed throughout the world and can be extremely disabling with many economic, social, physical and psychological health costs. A plethora of research indicates a strong, positive association between co-occurring psychiatric disorders (e.g., major depressive disorder, anxiety, panic) and migraine and tth, however co-occurring alcohol-use disorders are relatively unexplored. The limited studies that have explored alcohol-use disorders have produced mixed findings, potentially as a result of differing methodology, sample source, and the debated precipitating nature of alcohol use on headache. An abundance of research suggests that many environmental …

Multi-Scale Nanoindentation For Characterization Of Oil Shales, Zachary N. Miller

Electronic Theses and Dissertations

Studies of the effects of polishing techniques, scale of nanoindentation, and petrophysical properties were conducted on both Woodford and Tuscaloosa Marine Shale. Polishing procedures include both an in-house developed, mechanical sample preparation protocol as well as ion beam milling. The elastic modulus and hardness of each mechanically polished sample was found to have larger value than those that were ion-milled. Additionally, at low loads, the samples resulted in having high standard deviation. This high deviation was found to be significantly reduced by testing at higher loads. The variations in results between mechanically polished and ion beam milled samples is believed …

Sedentary Behavior-Inducing Randomized Control Intervention On Various Health-Related Outcomes In Active, Young Adults, Meghan Edwards

Electronic Theses and Dissertations

An expansive body of literature has established the positive effects of physical activity on a number of health-related outcomes, including chronic disease prevention (both physiological and psychological). In addition to growing information regarding the benefits of physical activity, recent research has suggested the need to focus future studies on the effects of sedentary behavior (independent of physical activity) on one’s wellbeing. The majority of existing research on sedentary behavior, however, has used cross-sectional study designs. The few experimental studies on sedentary behavior have primarily focused on minimizing prolonged sedentary behavior among inactive individuals, rather than inducing sedentary behavior. We hypothesized …

Examining The Association Between Leisure Coping Strategies And Mental Health Among College Students, Karolyne Helen Rehner

Electronic Theses and Dissertations

No abstract provided.

The Relationship Between Traumatic Events And Psychological Symptomatology And The Moderating Role Of Mentalization, Sean Fowler

Electronic Theses and Dissertations

Traumatic events can lead to a number of disparate psychological responses. Ranging from diagnosable psychological symptomatology to little or no distress, the outcomes of potentially traumatic events are difficult to narrow down. Research on individual differences has indicated the potential for a number of characteristics that influence the relationship between traumatic events and psychological well-being. Some researchers have proposed that one of these factors, an individual’s ability to mentalize, can influence the onset of psychological symptoms after a traumatic event. Mentalization is seen as one’s ability to maintain a sense of self, which enables understanding and differentiating between one’s own …

Evaluation Of Tattoo Artists' Perceptions Of Tattoo Regulations In The United States, Jessica L.C. Sapp

Electronic Theses and Dissertations

Background: With the increasing popularity in recent years, tattoos are no longer considered taboo but rather becoming a mainstream mode of self-expression so the inherent risks associated with tattooing could have a greater impact on the public’s health.

Objective: The study aims to gain an understanding and describe the perceptions and opinions of tattoo artists regarding tattoo regulations in the United States.

Methods: Data were collected through an online survey using a descriptive, survey research design. Survey responses were used from 1,315 study participants.

Results: There were 5 health policy related items evaluated: 1) tattoo artists should be licensed, 2) …

Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil

Electronic Theses and Dissertations

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …

A Mixed Methods Assessment Of The Implementation Of Electronic Health Records In Local Health Departments, Karmen S. Williams

Electronic Theses and Dissertations

Background: Electronic Health Record (EHR) implementation has seen great advances in health care, but the movement is leaving public health agencies behind. EHRs have shown improvement in operational and societal outcomes when implemented. Scarce allocation of resources, lack of trained staff, and security are limiters to implementation, despite the varied benefits of EHRs. The objective of this research is to establish a comprehensive view of EHR implementation in local health departments (LHDs) through assessing the status of implementation, benefits, barriers, and strategies to overcome challenges. Methods: This research uses a mixed methods approach to assess 49 key-informant interviews and 324 …

Clinical Characteristics Of Active Individuals With Chronic Ankle Instability, Mary Elizabeth Winningham

Electronic Theses and Dissertations

Ankle sprains, specifically to the lateral ligament complex, are one of the most common injuries seen during athletic participation and may lead to chronic ankle instability (CAI).¹ Residual symptoms of CAI can include feelings of giving way and instability as well as, persistent weakness, pain during activity, and self-reported disability, which may affect postural control and functional performance.² The purpose of this study was to determine if there was a relationship between perceived kinesiophobia and dorsiflexion range of motion (DROM), measures of dynamic postural control, and measures of functional performance, within active individuals with CAI. Thirty-seven physically active …