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Full-Text Articles in Medicine and Health Sciences

Using Picture Schedules In Medical Settings For Patients With An Autism Spectrum Disorder, A. Chebuhar, Ann Mccarthy, J. Bosch, S. Baker Apr 2013

Using Picture Schedules In Medical Settings For Patients With An Autism Spectrum Disorder, A. Chebuhar, Ann Mccarthy, J. Bosch, S. Baker

Ann Marie McCarthy

Autism is a neurobiological disorder that compromises ability to communicate and can be accompanied by anxiety, particularly for those in unfamiliar settings with unknown people. To improve communication, children with autism often relate well to pictures; however the literature describes no studies of picture schedules for patients with autism in medical settings. Our pilot project demonstrates how picture schedules for medical settings can relieve anxiety in children with autism and suggests that this approach should be employed as an innovative way to interact with patients with autism.


Building A Computer Program To Support Children, Parents, And Distraction During Healthcare Procedures, Kirsten Hanrahan, Ann Mccarthy, C. Kleiber, K. Ataman, W. Street, M. Zimmerman, Anne Ersig Apr 2013

Building A Computer Program To Support Children, Parents, And Distraction During Healthcare Procedures, Kirsten Hanrahan, Ann Mccarthy, C. Kleiber, K. Ataman, W. Street, M. Zimmerman, Anne Ersig

Ann Marie McCarthy

This secondary data analysis used data mining methods to develop predictive models of child risk for distress during a healthcare procedure. Data used came from a study that predicted factors associated with children's responses to an intravenous catheter insertion while parents provided distraction coaching. From the 255 items used in the primary study, 44 predictive items were identified through automatic feature selection and used to build support vector machine regression models. Models were validated using multiple cross-validation tests and by comparing variables identified as explanatory in the traditional versus support vector machine regression. Rule-based approaches were applied to the model …


Issues In Measuring Children's Preferred Style Of Coping With Pain, Ann Mccarthy, Charmaine Kleiber, Kirsten Hanrahan Apr 2013

Issues In Measuring Children's Preferred Style Of Coping With Pain, Ann Mccarthy, Charmaine Kleiber, Kirsten Hanrahan

Ann Marie McCarthy

No abstract provided.


The Impact Of Household Investments On Early Child Neurodevelopment And On Racial And Socioeconomic Developmental Gaps: Evidence From South America, Ann Mccarthy May 2012

The Impact Of Household Investments On Early Child Neurodevelopment And On Racial And Socioeconomic Developmental Gaps: Evidence From South America, Ann Mccarthy

Ann Marie McCarthy

This paper assesses the effects of household investments through child educating activities on child neurodevelopment between the ages of 3 and 24 months, and evaluates whether investments explain racial and socioeconomic developmental gaps in South America. Quantile regression is used to evaluate the heterogeneity in investment effects by unobserved developmental endowments. The study finds large positive investment effects on early child neurodevelopment, with generally larger effects among children with low developmental endowments (children at the left margin of the development distribution). Investments explain part of the observed racial gaps and the whole socioeconomic developmental gap. Investments may compensate for low …


Application Of Neurodevelopmental Screening To A Sample Of South American Infants: The Bayley Infant Neurodevelopmental Screener (Bins), Anne Mccarthy, G. Wehby, S. Barron, G. Aylward, E. Castilla, L. Javois, N. Goco, J. Murray May 2012

Application Of Neurodevelopmental Screening To A Sample Of South American Infants: The Bayley Infant Neurodevelopmental Screener (Bins), Anne Mccarthy, G. Wehby, S. Barron, G. Aylward, E. Castilla, L. Javois, N. Goco, J. Murray

Ann Marie McCarthy

OBJECTIVE: To evaluate the utility of the Bayley Infant Neurodevelopmental Screener (BINS), standardized in the US, for South American infants, 3-24 months of age. METHODS: Thirty-five physicians administered the BINS to 2471 South American infants recruited during routine well-child visits, 578 (23%) from Brazil and 1893 (77%) from six other South American countries. The BINS was translated into Spanish and Portuguese and participating physicians were trained to administer the BINS. Physician inter-rater agreement with training tapes was 84.4%; test-retest reliability for age item sets ranged from 0.80 to 0.93 (Pearson's r). Infants were classified into being at low, moderate, or …


Clinical Features And Outcomes Of 98 Children And Adults With Dense Deposit Disease, Der-Fa Lu, M. Moon, L. Lanning, Anne Mccarthy, R. Smith May 2012

Clinical Features And Outcomes Of 98 Children And Adults With Dense Deposit Disease, Der-Fa Lu, M. Moon, L. Lanning, Anne Mccarthy, R. Smith

Ann Marie McCarthy

BACKGROUND: Dense deposit disease (DDD) is an ultra-rare renal disease. METHODS: In the study reported here, 98 patients and their families participated in a descriptive patient-centered survey using an online research format. Reports were completed by patients (38%) or their parents (62%). Age at diagnosis ranged from 1.9 to 38.9 years (mean 14 years). RESULTS: The majority of patients presented with proteinuria and hematuria; 50% had hypertension and edema. Steroids were commonly prescribed, although their use was not evidence-based. One-half of the patients with DDD for 10 years progressed to end-stage renal disease (ESRD), with young females having the greatest …


The Impact Of Maternal Smoking During Pregnancy On Early Child Neurodevelopment, G. L. Wehby, K. Prater, Anne Marie Mccarthy, E. E. Castilla, J. C. Murray May 2012

The Impact Of Maternal Smoking During Pregnancy On Early Child Neurodevelopment, G. L. Wehby, K. Prater, Anne Marie Mccarthy, E. E. Castilla, J. C. Murray

Ann Marie McCarthy

Early child neurodevelopment has major impacts on future human capital and health. However, not much is known about the impacts of prenatal risk factors on child neurodevelopment. This study evaluates the effects of maternal smoking during pregnancy on child neurodevelopment between 3 and 24 months of age and interactions with socioeconomic status (SES). Data from a unique sample of children from South America are employed. Smoking has large adverse effects on neurodevelopment, with larger effects in the low SES sample. The study results highlight the importance of early interventions beginning before and during pregnancy for enhancing child development and future …


Parent Behavior And Child Distress During Urethral Catheterization, Charmaine Kleiber, Ann Marie Mccarthy Mar 2012

Parent Behavior And Child Distress During Urethral Catheterization, Charmaine Kleiber, Ann Marie Mccarthy

Ann Marie McCarthy

ISSUES AND PURPOSE: Researchers need a clear understanding of the natural behaviors parents use to help their children cope. This study describes the relationships between naturally occurring parent behaviors and child distress behaviors during urethral catheterization. DESIGN AND METHODS: In this descriptive study, researchers videotaped the behaviors of parent-child interactions during urethral catheterization. RESULTS: Parents used distraction to maintain calm behavior during the first part of the procedure and used more reassurance when the children started to become distressed. Seven of the nine children displayed calm behavior at least half the time following distraction. Parental reassurance did not decrease distress …


Parent Behavior And Child Distress During Urethral Catheterization, Charmaine Kleiber, Ann Marie Mccarthy Mar 2012

Parent Behavior And Child Distress During Urethral Catheterization, Charmaine Kleiber, Ann Marie Mccarthy

Ann Marie McCarthy

ISSUES AND PURPOSE: Researchers need a clear understanding of the natural behaviors parents use to help their children cope. This study describes the relationships between naturally occurring parent behaviors and child distress behaviors during urethral catheterization. DESIGN AND METHODS: In this descriptive study, researchers videotaped the behaviors of parent-child interactions during urethral catheterization. RESULTS: Parents used distraction to maintain calm behavior during the first part of the procedure and used more reassurance when the children started to become distressed. Seven of the nine children displayed calm behavior at least half the time following distraction. Parental reassurance did not decrease distress …


The Influence Of Second Intermediate Host Dispersion Pattern Upon The Transmission Of Cercariae Of Echinoparyphium Recurvatum (Digenea: Echinostomatidae), Ann Mccarthy Mar 2012

The Influence Of Second Intermediate Host Dispersion Pattern Upon The Transmission Of Cercariae Of Echinoparyphium Recurvatum (Digenea: Echinostomatidae), Ann Mccarthy

Ann Marie McCarthy

Transmission of cercariae of the echinostome digenean Echinoparyphium recurvatum was observed in experimental populations of the second intermediate host snail Lymnaea peregra. Populations of 100 snails were distributed among plastic mesh cages in an infection arena to produce different patterns of host dispersion. Cercarial transmission was investigated in host populations showing three separate patterns of host dispersion; Ideal Regular, Random and Contagious ('Clumped'). Levels of cercarial transmission in populations showing each type of dispersion pattern were found to be significantly different. The highest rate of cercarial transmission occurred in the contagiously dispersed host population, and the lowest in the randomly …


Speciation Of Echinostomes: Evidence For The Existence Of Two Sympatric Sibling Species In The Complex Echinoparyphium Recurvatum (Von Linstow 1873) (Digenea: Echinostomatidae), Ann Mccarthy Mar 2012

Speciation Of Echinostomes: Evidence For The Existence Of Two Sympatric Sibling Species In The Complex Echinoparyphium Recurvatum (Von Linstow 1873) (Digenea: Echinostomatidae), Ann Mccarthy

Ann Marie McCarthy

Evidence for the existence of 2 first intermediate host-specific sibling species of the 45 collar-spined echinostome Echinoparyphium recurvatum is presented. Experimental studies on their life-cycles were carried out under controlled laboratory conditions. The two entities were found to be morphologically indistinguishable in all major respects, yet they exhibited distinct biological characteristics. One of the sibling species utilizes the freshwater lymnaeid pulmonate snail Lymnaea peregra as first intermediate host, and the adults occur in the anterior small intestine of the wildfowl experimental definitive host Anas platyrhynchos. The other utilizes the freshwater mesogastropod prosobranch snail Valvata piscinalis as first intermediate host, and …


Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray Mar 2012

Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray

Ann Marie McCarthy

BACKGROUND: The contribution of birth defects, including cleft lip and palate, to neonatal and infant mortality and morbidity is substantial. As other mortality and morbidity causes including infections, hygiene, prematurity, and nutrition are eradicated in less developed countries, the burden of birth defects will increase proportionally. METHODS/DESIGN: We are using cleft lip and palate as a sentinel birth defect to evaluate its burden on neonatal and infant health and to assess the effectiveness of systematic pediatric care during the first month and first two years of life in decreasing this burden. The neonatal intervention, consisting of weekly pediatric evaluation and …


Factors Associated With Academic Achievement In Children With Type 1 Diabetes, Ann Mccarthy, S. Lindgren, M. Mengeling, E. Tsalikian, J. Engvall Oct 2011

Factors Associated With Academic Achievement In Children With Type 1 Diabetes, Ann Mccarthy, S. Lindgren, M. Mengeling, E. Tsalikian, J. Engvall

Ann Marie McCarthy

OBJECTIVE: To examine academic achievement in children with diabetes and to identify predictors of achievement. RESEARCH DESIGN AND METHODS: Participants were 244 children, ages 8-18 years, with type 1 diabetes. Measures included school-administered standardized achievement tests (Iowa Tests of Basic Skills and Iowa Tests of Educational Development [ITBS/ITED]), grade point averages (GPAs), school absences, behavioral assessment, age at disease onset, hospitalizations, and HbA(1c). Statistical differences between subgroups of children were evaluated using t test and ANOVA, statistically controlling for socioeconomic status. Regression analyses were carried out to examine predictors of academic performance. RESULTS: Reading scores and GPA were lower for …


Evaluation Of A School Re-Entry Nursing Intervention For Children With Cancer, Ann Mccarthy, Janet Williams, C. Plumer Oct 2011

Evaluation Of A School Re-Entry Nursing Intervention For Children With Cancer, Ann Mccarthy, Janet Williams, C. Plumer

Ann Marie McCarthy

A retrospective qualitative design was used to identify and compare the concerns, parents, teachers, and children have regarding school re-entry after a cancer diagnosis and to describe the impact of a school re-entry program on parents', teachers', and children's concerns. Audiotaped, semistructured interviews were obtained from a convenience sample of 10 children with cancer (ages 5 to 13 years), 10 mothers, and nine teachers. All participants were positive about the school re-entry nursing intervention, which is described. Results of content analyses indicate that before the intervention, mothers were concerned about their child's safety and peer teasing; teachers were concerned about …


Nurse Practitioner-Patient Interactional Analyses During Well-Child Visits, C. Webster-Stratton, J. Glascock, Ann Mccarthy Oct 2011

Nurse Practitioner-Patient Interactional Analyses During Well-Child Visits, C. Webster-Stratton, J. Glascock, Ann Mccarthy

Ann Marie McCarthy

No abstract provided.


Integrating Molecular Genetics Analyses Into Clinical Research, D. Schutte, Ann Mccarthy, M. Floria-Santos, Kirsten Hanrahan, J. Murray, Charmaine Kleiber Oct 2011

Integrating Molecular Genetics Analyses Into Clinical Research, D. Schutte, Ann Mccarthy, M. Floria-Santos, Kirsten Hanrahan, J. Murray, Charmaine Kleiber

Ann Marie McCarthy

The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable to molecular genetics approaches. Both human and animal model research suggests that differences in these responses may be related, in part, to variation in the genes that modulate sensation and behavior. The authors are currently managing a large cross-disciplinary research effort to identify child characteristics, including genotypes, that predict the degree of distress displayed by children …


The Child With Leukemia: The Disease And Its Treatment, G. Foley, Ann Mccarthy Oct 2011

The Child With Leukemia: The Disease And Its Treatment, G. Foley, Ann Mccarthy

Ann Marie McCarthy

No abstract provided.


A Descriptive Study Of Individuals With Membranoproliferative Glomerulonephritis, Der-Fa Lu, Anne Mccarthy, L. Lanning, C. Delaney, C. Porter Oct 2011

A Descriptive Study Of Individuals With Membranoproliferative Glomerulonephritis, Der-Fa Lu, Anne Mccarthy, L. Lanning, C. Delaney, C. Porter

Ann Marie McCarthy

OBJECTIVE: Membranoproliferative Glomerulonephritis (MPGN) is one of a group of glomerulonephritides that often begins in childhood and progresses to renal failure. The purpose of this paper is to describe the initial results of a patient-driven database on individuals with MPGN. SAMPLE/SETTING: Patients with MPGN Types I, II, and III and their family members were recruited to this survey study. DESIGN: A population survey design was used. METHODS: A survey was developed for this study that obtained information from the individual with MPGN or a guardian on: patient information, family/patient health history, history of PGN, medications, course of MPGN, history of …


Advanced Practice Nursing In Iowa, G. Felton, M. Aquilino, G. Bulechek, M. Clark, Patricia Clinton, Ann Mccarthy Oct 2011

Advanced Practice Nursing In Iowa, G. Felton, M. Aquilino, G. Bulechek, M. Clark, Patricia Clinton, Ann Mccarthy

Ann Marie McCarthy

No abstract provided.


Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray Oct 2011

Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray

Ann Marie McCarthy

BACKGROUND: The contribution of birth defects, including cleft lip and palate, to neonatal and infant mortality and morbidity is substantial. As other mortality and morbidity causes including infections, hygiene, prematurity, and nutrition are eradicated in less developed countries, the burden of birth defects will increase proportionally. METHODS/DESIGN: We are using cleft lip and palate as a sentinel birth defect to evaluate its burden on neonatal and infant health and to assess the effectiveness of systematic pediatric care during the first month and first two years of life in decreasing this burden. The neonatal intervention, consisting of weekly pediatric evaluation and …


Fetal Alcohol Syndrome: A Review And Case Presentation, E. Lindor, Ann Mccarthy, M. Mcrae Oct 2011

Fetal Alcohol Syndrome: A Review And Case Presentation, E. Lindor, Ann Mccarthy, M. Mcrae

Ann Marie McCarthy

No abstract provided.


How Fluoride Works: A Better Understanding, Ann Mccarthy Oct 2011

How Fluoride Works: A Better Understanding, Ann Mccarthy

Ann Marie McCarthy

No abstract provided.


The Integrated Health Professions Education Program Seminar, Elizabeth Swanson, C. Taylor, A. Valentine, Ann Mccarthy Oct 2011

The Integrated Health Professions Education Program Seminar, Elizabeth Swanson, C. Taylor, A. Valentine, Ann Mccarthy

Ann Marie McCarthy

Powerful dynamics of change require practitioners from all disciplines to be prepared to work in interdisciplinary teams, competently access health and information technologies, and understand the multiple functions required for adequate healthcare provision. The University of Iowa's Integrated Health Professions Program is a state-funded effort designed to provide students with a common educational experience to enable them to work collaboratively in underserved or rural settings. Students take part in a series of team-building seminars including technology-based instruction and activities in conjunction with visits to community clinical sites. The authors discuss the experiential, collaborative, and cooperative forms of learning that take …


Changes In Medications Administered In Schools, Ann Mccarthy, M. Kelly, S. Johnson, J. Roman, M. Zimmerman Oct 2011

Changes In Medications Administered In Schools, Ann Mccarthy, M. Kelly, S. Johnson, J. Roman, M. Zimmerman

Ann Marie McCarthy

The purpose of this descriptive, cross-sectional study was to determine if there have been changes in the type and number of attention deficit/hyperactivity disorder (AD/HD) medications administered in schools since the introduction of long-acting stimulants. A survey was sent to 1,000 school nurses randomly selected from the National Association of School Nurses membership, with 339 returned (34%). Between 2000 and 2003 the proportion of students receiving any prescription medication (2.9/100 vs. 1.0/100), methylphenidate (1.2 vs. 0.2), or amphetamine/dextroamphetamine (0.3/100 vs. 0.1/100) was significantly reduced ( p < .0001). High school students took fewer prescription ( p < .0001) and AD/HD medications ( p < .0001), but more nonprescription medications than other students. A total of 163 different prescription medications and 28 nonprescription medications were administered during the typical school day. This study suggests that the use of long-acting stimulants has significantly reduced the number of prescription medications administered in schools. This reduction has been accompanied by a dramatic increase in the range of medications administered, making the medication administration process in schools more complex, not less.


Evidence-Based Practice Guidelines And School Nursing, S. Adams, Ann Mccarthy Oct 2011

Evidence-Based Practice Guidelines And School Nursing, S. Adams, Ann Mccarthy

Ann Marie McCarthy

The use of evidence-based practice (EBP) has become the standard of health care practice. Nurses are expected to use best evidence on a wide range of topics, yet most nurses have limited time, resources, and/or skills to access and evaluate the quality of research and evidence needed to practice evidence-based nursing. EBP guidelines allow nurses and other health care workers to have research information collected, analyzed, and condensed into specific practice recommendations by experts. This article defines EBP guidelines and discusses the process of guideline development, including identification of topics, systematic literature searches, and evaluation and rating of research. Criteria …


Family Perceptions Of Medication Administration At School: Errors, Risk Factors, And Consequences, D. Clay, K. Farris, Ann Mccarthy, M. Kelly, R. Howarth Oct 2011

Family Perceptions Of Medication Administration At School: Errors, Risk Factors, And Consequences, D. Clay, K. Farris, Ann Mccarthy, M. Kelly, R. Howarth

Ann Marie McCarthy

Medications are administered every day in schools across the country. Researchers and clinicians have studied school nurses' and educators' experiences with medication administration, but not the experiences of children or their parents. This study examined medication administration from the child and parent perspectives to (a) determine problems children experience with medicines at school, (b) clarify risk factors for medication errors, and (c) examine the perceived impact of medication errors on school performance and social relationships. Participants included children ages 8 to 18 years (n=157) being treated at a large Midwestern Children's Hospital in diabetes, asthma, and Attention Deficit Hyperactivity Disorder …


Infant And Preschool Well-Child Care: Master's- And Nonmaster's-Prepared Pediatric Nurse Practitioners, J. Glascock, C. Webster-Stratton, Ann Mccarthy Oct 2011

Infant And Preschool Well-Child Care: Master's- And Nonmaster's-Prepared Pediatric Nurse Practitioners, J. Glascock, C. Webster-Stratton, Ann Mccarthy

Ann Marie McCarthy

The nursing and medical literature reveals considerable debate over whether graduate or continuing education is the appropriate level for nurse practitioner preparation. These arguments have been rhetorical since the research literature lacks data on the scope of practice of master's- and nonmaster's-prepared nurse practitioners. The purpose of this study was to examine possible differences between the two types of practitioners in one area--well-child care provided by pediatric nurse practitioners (PNPs). A total of 236 master's- and nonmaster's-prepared PNPs completed a background questionnaire and checklists of nursing activities involving infant and preschool well-child care. Analysis of study results showed that master's …


Innovative Approaches For Teaching Children With Chronic Conditions, J. Engvall, Ann Mccarthy Oct 2011

Innovative Approaches For Teaching Children With Chronic Conditions, J. Engvall, Ann Mccarthy

Ann Marie McCarthy

No abstract provided.


Intervention Research In Highly Unstable Environments, Kathleen Buckwalter, M. Grey, B. Bowers, Ann Mccarthy, D. Gross, M. Funk, C. Beck Oct 2011

Intervention Research In Highly Unstable Environments, Kathleen Buckwalter, M. Grey, B. Bowers, Ann Mccarthy, D. Gross, M. Funk, C. Beck

Ann Marie McCarthy

This article highlights issues and presents strategies for conducting intervention research in highly unstable environments such as schools, critical care units, and long-term care facilities. The authors draw on their own experiences to discuss the challenges that may be encountered in highly unstable settings. The concept of validity provides a framework for understanding the value of addressing the many methodological issues that can emerge in settings characterized by instability. We explain unstable environments by elaborating on knowable elements that contribute to instability. Strategies are provided for improving success of intervention research in unstable settings by carrying out an environmental assessment …


Hexosamine Biosynthesis Pathway Flux Contributes To Insulin Resistance Via Altering Membrane Phosphatidylinositol 4,5-Bisphosphate And Cortical Filamentous Actin, P. Bhonagiri, G. R. Pattar, E. M. Horvath, K. M. Habegger, Ann Mccarthy, J. S. Elmendorf Oct 2011

Hexosamine Biosynthesis Pathway Flux Contributes To Insulin Resistance Via Altering Membrane Phosphatidylinositol 4,5-Bisphosphate And Cortical Filamentous Actin, P. Bhonagiri, G. R. Pattar, E. M. Horvath, K. M. Habegger, Ann Mccarthy, J. S. Elmendorf

Ann Marie McCarthy

We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) causes the PIP(2)/F-actin dysregulation and insulin resistance induced by hyperinsulinemia. Increased HBP activity was detected in 3T3-L1 adipocytes cultured under conditions closely resembling physiological hyperinsulinemia (5 nm insulin for 12 h) and in cells where HBP activity was amplified by 2 mm glucosamine (GlcN). Both the physiological hyperinsulinemia and experimental GlcN challenge induced comparable losses of PIP(2) and F-actin. In addition to protecting against …