Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
The Eye As A Window To The Alzheimer’S Disease Brain, Fred Souza
The Eye As A Window To The Alzheimer’S Disease Brain, Fred Souza
All ETDs from UAB
Alzheimer’s disease (AD) is a debilitating, and the most prevalent, type of dementia that is manifested by cognitive deficits, anomalous protein metabolism, cell loss, and pathological alterations in several neurotransmitter systems, particularly the cholinergic and glutamatergic systems. Moreover, AD is associated with visual deficits that have been reported to occur even in the early stages of the disease and may precede conspicuous cognitive impairment. To date, the underlying causes of the visual deficits and whether they stem from retinal or cortical abnormalities remain poorly understood. The following studies aimed at establishing whether the pathological changes observed in the cerebrum are …
Oxygen Permeability (Dk) Of Silicone-Hydrogel Materials: Relationship With Water, Silicon, And Fluorine Contents, Terin E. Dupre
Oxygen Permeability (Dk) Of Silicone-Hydrogel Materials: Relationship With Water, Silicon, And Fluorine Contents, Terin E. Dupre
All ETDs from UAB
To more precisely determine the fundamental relationships between oxygen permeability (Dk), water content (WC), silicon (Si) content, and fluorine (F) content of clinically prescribed silicone-hydrogel (SiHy) materials, identical methodologies for 16 commercially available brands of SiHy materials were performed. Dk and WC were determined according to the ANSI and ISO standards and, with Si and F contents, on the same lot numbers of samples across a common range of available refractive powers. A negative linear relationship was found between Si content and water content. Lotrafilcon A, Lotrafilcon B, and the bulk polymer of Delefilcon A initially deviated from this relationship. …
Lipid Biomarkers And Pathway Identification For Contact Lens Related Discomfort, Shyam Panthi
Lipid Biomarkers And Pathway Identification For Contact Lens Related Discomfort, Shyam Panthi
All ETDs from UAB
The purpose of this investigation was to identify possible lipid biomarkers that are associated with contact lens related discomfort and determine whether inflammation as a result of lipid peroxidation or enzymatic arachidonic acid metabolism is associated with such discomfort. Ten microliters of tears were collected from each eye of fifteen subjects (11 non-contact lens wearers, 2 contact lens wearers with discomfort and 2 contact lens wearers without discomfort) and assayed using various chemical extraction methods and mass spectrometry based analytical approaches. This was done to determine whether lipid mediators of inflammation could be identified in low volume (10 l) of …