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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts
Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts
2010-2019 OA Pubs
Vision is the primary sensory modality of birds, and its importance is evident in the sophistication of their visual systems. Coloured oil droplets in the cone photoreceptors represent an adaptation in the avian retina, acting as long-pass colour filters. However, we currently lack understanding of how the optical properties and morphology of component structures (e.g. oil droplet, mitochondrial ellipsoid and outer segment) of the cone photoreceptor influence the transmission of light into the outer segment and the ultimate effect they have on receptor sensitivity. In this study, we use data from microspectrophotometry, digital holographic microscopy and electron microscopy to inform …
Molecular Dynamics Simulations Of Kirbac1.1 Mutants Reveal Global Gating Changes Of Kir Channels, Tobias Linder, Shizhen Wang, Eva-Maria Zangerl-Plessl, Colin G Nichols, Anna Stary-Weinzinger
Molecular Dynamics Simulations Of Kirbac1.1 Mutants Reveal Global Gating Changes Of Kir Channels, Tobias Linder, Shizhen Wang, Eva-Maria Zangerl-Plessl, Colin G Nichols, Anna Stary-Weinzinger
2010-2019 OA Pubs
Prokaryotic inwardly rectifying (KirBac) potassium channels are homologous to mammalian Kir channels. Their activity is controlled by dynamical conformational changes that regulate ion flow through a central pore. Understanding the dynamical rearrangements of Kir channels during gating requires high-resolution structure information from channels crystallized in different conformations and insight into the transition steps, which are difficult to access experimentally. In this study, we use MD simulations on wild type KirBac1.1 and an activatory mutant to investigate activation gating of KirBac channels. Full atomistic MD simulations revealed that introducing glutamate in position 143 causes significant widening at the helix bundle crossing …