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Full-Text Articles in Medicine and Health Sciences
Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib
Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib
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Breast cancer stands out as a particularly challenging form of cancer to treat among various types. Traditional treatment methods have been longstanding approaches, yet their efficacy has diminished over time owing to heightened toxicity, adverse effects, and the emergence of multi-drug resistance. Nevertheless, a viable solution has emerged through the adoption of a complementary treatment strategy utilizing natural substances and the incorporation of intermittent fasting to enhance therapeutic outcomes. This study aimed to assess the anticancer activity of thymoquinone (TQ), intermittent fasting, and their combination using in vivo and in vitro methods. The anti-proliferative activity of TQ and fasting (glucose/serum …
Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara
Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara
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DNA methylation acts as a major epigenetic modification in mammals, characterized by the transfer of a methyl group to a cytosine. DNA methylation plays a pivotal role in regulating normal development, and misregulation in cells leads to an abnormal phenotype as is seen in several cancers. Any mutations or expression anomalies of genes encoding regulators of DNA methylation may lead to abnormal expression of critical molecules. A comprehensive genomic study encompassing all the genes related to DNA methylation regulation in relation to breast cancer is lacking. We used genomic and transcriptomic datasets from the Cancer Genome Atlas (TGCA) Pan-Cancer Atlas, …
Quality Of Life Of Emirati Women With Breast Cancer, Linda Smail, Ghufran Jassim, Sarah Khan, Syed Tirmazy, Mouza Al Ameri
Quality Of Life Of Emirati Women With Breast Cancer, Linda Smail, Ghufran Jassim, Sarah Khan, Syed Tirmazy, Mouza Al Ameri
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To examine the quality of life (QoL) of Emirati women with breast cancer (BC) and determine its relationships with their sociodemographic characteristics and clinical factors. The study will play a leading role in providing information about the QoL of Emirati women with BC and will help in recognizing the aspects of QoL in BC survivorship that requires special attention. A population-based cross-sectional study was conducted on 250 Emirati women using a multistage stratified clustered random sampling. The participants were interviewed face-to-face using a structured questionnaire composed of sociodemographic variables, reproductive characteristics, and the European Organization for Research and Treatment of …