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Full-Text Articles in Medicine and Health Sciences
Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib
Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib
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Breast cancer stands out as a particularly challenging form of cancer to treat among various types. Traditional treatment methods have been longstanding approaches, yet their efficacy has diminished over time owing to heightened toxicity, adverse effects, and the emergence of multi-drug resistance. Nevertheless, a viable solution has emerged through the adoption of a complementary treatment strategy utilizing natural substances and the incorporation of intermittent fasting to enhance therapeutic outcomes. This study aimed to assess the anticancer activity of thymoquinone (TQ), intermittent fasting, and their combination using in vivo and in vitro methods. The anti-proliferative activity of TQ and fasting (glucose/serum …
Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara
Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara
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DNA methylation acts as a major epigenetic modification in mammals, characterized by the transfer of a methyl group to a cytosine. DNA methylation plays a pivotal role in regulating normal development, and misregulation in cells leads to an abnormal phenotype as is seen in several cancers. Any mutations or expression anomalies of genes encoding regulators of DNA methylation may lead to abnormal expression of critical molecules. A comprehensive genomic study encompassing all the genes related to DNA methylation regulation in relation to breast cancer is lacking. We used genomic and transcriptomic datasets from the Cancer Genome Atlas (TGCA) Pan-Cancer Atlas, …
Quality Of Life Of Emirati Women With Breast Cancer, Linda Smail, Ghufran Jassim, Sarah Khan, Syed Tirmazy, Mouza Al Ameri
Quality Of Life Of Emirati Women With Breast Cancer, Linda Smail, Ghufran Jassim, Sarah Khan, Syed Tirmazy, Mouza Al Ameri
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To examine the quality of life (QoL) of Emirati women with breast cancer (BC) and determine its relationships with their sociodemographic characteristics and clinical factors. The study will play a leading role in providing information about the QoL of Emirati women with BC and will help in recognizing the aspects of QoL in BC survivorship that requires special attention. A population-based cross-sectional study was conducted on 250 Emirati women using a multistage stratified clustered random sampling. The participants were interviewed face-to-face using a structured questionnaire composed of sociodemographic variables, reproductive characteristics, and the European Organization for Research and Treatment of …
How Do Healthy Women Perceive The Risk Of Breast Cancer? The Role Of Illness Perceptions And Compared Risk Between Portugal And The U.A.E, Maria J. Figueiras, David Dias Neto, Joao Marôco, Catarina Carmo
How Do Healthy Women Perceive The Risk Of Breast Cancer? The Role Of Illness Perceptions And Compared Risk Between Portugal And The U.A.E, Maria J. Figueiras, David Dias Neto, Joao Marôco, Catarina Carmo
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(1) Background: Breast cancer (BC) shows significant epidemiological differences between Eastern and Western countries. These may arise from socio-cultural factors influencing how healthy young women perceive this condition, their risk of getting cancer, and the implications for preventive screening behaviors. In this study, the illness perceptions, individual risk perception, compared risk, and beliefs about preventive behaviors for BC of female university students were compared using an anonymous online survey between a European country (Portugal) and the United Arab Emirates. (2) Method: A structural equation model (SEM) was developed to investigate the hypothetical relationship between illness perceptions and compared risk as …
Adherence To Mediterranean Diet And Nutritional Status In Women With Breast Cancer: What Is Their Impact On Disease Progression And Recurrence-Free Patients’ Survival?, Maria Mantzorou, Maria Tolia, Antigoni Poultsidi, Georgios K. Vasios, Dimitrios Papandreou, Stamatios Theocharis, Nikolaos Kavantzas, Andreas Y. Troumbis, Constantinos Giaginis
Adherence To Mediterranean Diet And Nutritional Status In Women With Breast Cancer: What Is Their Impact On Disease Progression And Recurrence-Free Patients’ Survival?, Maria Mantzorou, Maria Tolia, Antigoni Poultsidi, Georgios K. Vasios, Dimitrios Papandreou, Stamatios Theocharis, Nikolaos Kavantzas, Andreas Y. Troumbis, Constantinos Giaginis
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Introduction: Nutritional status impacts the survival of patients with cancer. There are few studies that investigate the role of nutritional status on breast cancer survival in women with breast cancer, and even fewer regarding the impact of adhering to the Mediterranean diet (MD). The present study aims to assess the nutritional status, MD adherence, physical activity levels and health-related quality of life (HRQOL) in women diagnosed with breast cancer and evaluate these parameters regarding recurrence-free survival. Methods: A total of 114 women, aged 35–87 years old, diagnosed with breast cancer in Larissa, Greece, participated in the study. Tumor histopathology was …
Comparing The Evidence From Observational Studies And Randomized Controlled Trials For Nonskeletal Health Effects Of Vitamin D, William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz
Comparing The Evidence From Observational Studies And Randomized Controlled Trials For Nonskeletal Health Effects Of Vitamin D, William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz
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Although observational studies of health outcomes generally suggest beneficial effects with, or following, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, randomized controlled trials (RCTs) have generally not supported those findings. Here we review results from observational studies and RCTs regarding how vitamin D status affects several nonskeletal health outcomes, including Alzheimer's disease and dementia, autoimmune diseases, cancers, cardiovascular disease, COVID-19, major depressive disorder, type 2 diabetes, arterial hypertension, all-cause mortality, respiratory tract infections, and pregnancy outcomes. We also consider relevant findings from ecological, Mendelian randomization, and mechanistic studies. Although clear discrepancies exist between findings of observational studies and RCTs on vitamin …
Understanding The Relationship Between Illness Perceptions Of Breast Cancer And Perceived Risk In A Sample Of U.A.E. Female University Students: The Role Of Comparative Risk, Maria J. Figueiras, David Dias Neto, João Marôco
Understanding The Relationship Between Illness Perceptions Of Breast Cancer And Perceived Risk In A Sample Of U.A.E. Female University Students: The Role Of Comparative Risk, Maria J. Figueiras, David Dias Neto, João Marôco
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BackgroundIn the Middle East region, the incidence of breast cancer (BC) has substantially increased in the last years. Despite a considerable body of research about BC in Arab countries, how illness perceptions of healthy women about BC may influence risk perception is unknown.MethodsA cross-sectional survey was conducted on a sample of 298 young Emirati women. The measures included demographic information, illness perceptions, and risk perception. Descriptive and correlational analyses were performed to assess illness perceptions about BC, perceived individual risk and comparative risk. A structural equation modelling (S.E.M.) was built to investigate the relationship between illness perceptions and perceived individual …
Sulforaphane Inhibits Growth Of Human Breast Cancer Cells And Augments The Therapeutic Index Of The Chemotherapeutic Drug, Gemcitabine, Arif Hussain, Javeria Mohsin, Sathyen Alwin Prabhu, Salema Begum, Qurrat El Ain Nusri, Geetganga Harish, Elham Javed, Munawwar Ali Khan, Chhavi Sharma
Sulforaphane Inhibits Growth Of Human Breast Cancer Cells And Augments The Therapeutic Index Of The Chemotherapeutic Drug, Gemcitabine, Arif Hussain, Javeria Mohsin, Sathyen Alwin Prabhu, Salema Begum, Qurrat El Ain Nusri, Geetganga Harish, Elham Javed, Munawwar Ali Khan, Chhavi Sharma
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Phytochemicals are among the natural chemopreventive agents with most potential for delaying, blocking or reversing the initiation and promotional events of carcinogenesis. They therefore offer cancer treatment strategies to reduce cancer related death. One such promising chemopreventive agent which has attracted considerable attention is sulforaphane (SFN), which exhibits anti-cancer, anti-diabetic, and anti-microbial properties. The present study was undertaken to assess effect of SFN alone and in combination with a chemotherapeutic agent, gemcitabine, on the proliferative potential of MCF-7 cells by cell viability assay and authenticated the results by nuclear morphological examination. Further we analyzed the modulation of expression of Bcl-2 …