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Articles 2641 - 2670 of 2904

Full-Text Articles in Medicine and Health Sciences

Mrnas Encoding Aquaporins Are Present During Murine Preimplantation Development., H Offenberg, L C Barcroft, A Caveney, D Viuff, P D Thomsen, A J Watson Dec 2000

Mrnas Encoding Aquaporins Are Present During Murine Preimplantation Development., H Offenberg, L C Barcroft, A Caveney, D Viuff, P D Thomsen, A J Watson

Obstetrics & Gynaecology Publications

The present study was conducted to investigate the mechanisms underlying fluid movement across the trophectoderm during blastocyst formation by determining whether aquaporins (AQPs) are expressed during early mammalian development. AQPs belong to a family of major intrinsic membrane proteins and function as molecular water channels that allow water to flow rapidly across plasma membranes in the direction of osmotic gradients. Ten different AQPs have been identified to date. Murine preimplantation stage embryos were flushed from the oviducts and uteri of superovulated CD1 mice. Reverse transcription-polymerase chain reaction (RT-PCR) methods employing primer sets designed to amplify conserved sequences of AQPs (1-9) …

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Canadian Medical Officers In The Royal Navy--World War Ii, Vivian Mcalister Dec 2000

Canadian Medical Officers In The Royal Navy--World War Ii, Vivian Mcalister

Data and Test Instruments

CANADIAN MEDICAL OFFICERS IN THE ROYAL NAVY - WORLD WAR II. Harry Stafford Morton. 112 pp. Must. Canadian Naval Memorial Trust, HMCS Sackville, PO Box 99000, Stn Forces, Halifax NS B3K 5X5. 2000. Can$18.00At the beginning of the Second World War, the Royal Canadian Navy offered 90 medical officers on loan to the Royal Navy. The author was among that group, which included leaders in Canadian surgery such as Surgeon Lieutenant McLachlin of London, Ont. The history of these medical officers has not been written because it fell between histories of the Royal Canadian Navy and the Royal Navy. Dr. …

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Drug Combo Winning War On Rejection: Qeii Doctors Getting Amazing Results With Fk506, Rapamycin, Ann Graham-Walker Sep 2000

Drug Combo Winning War On Rejection: Qeii Doctors Getting Amazing Results With Fk506, Rapamycin, Ann Graham-Walker

Data and Test Instruments

A Nova Scotia organ transplant unit is beating the odds on tissue rejection, with a dramatic new drug approach.

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Abdominal Fluid Collection After Laparoscopic Cholecystectomy, Vivian Mcalister Sep 2000

Abdominal Fluid Collection After Laparoscopic Cholecystectomy, Vivian Mcalister

Data and Test Instruments

A middle aged man who complains of abdominal pain and bloat for 3 days after a combined laparoscopic cholecystectomy and umbilical hernia repair develops a fistula through the umbilical wound. How should care proceed? Vivian McAlister of Halifax, Nova Scotia replies.

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Eye Position Signal Modulates A Human Parietal Pointing Region During Memory-Guided Movements., J F Desouza, S P Dukelow, J S Gati, R S Menon, R A Andersen, T Vilis Aug 2000

Eye Position Signal Modulates A Human Parietal Pointing Region During Memory-Guided Movements., J F Desouza, S P Dukelow, J S Gati, R S Menon, R A Andersen, T Vilis

Brain and Mind Institute Researchers' Publications

Using functional magnetic resonance imaging, we examined the signal in parietal regions that were selectively activated during delayed pointing to flashed visual targets and determined whether this signal was dependent on the fixation position of the eyes. Delayed pointing activated a bilateral parietal area in the intraparietal sulcus (rIPS), rostral/anterior to areas activated by saccades. During right-hand pointing to centrally located targets, the left rIPS region showed a significant increase in activation when the eye position was rightward compared with leftward. As expected, activation in motor cortex showed no modulation when only eye position changed. During pointing to retinotopically identical …

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Differential Involvement Of Na(+),K(+)-Atpase Isozymes In Preimplantation Development Of The Mouse., D J Macphee, D H Jones, K J Barr, D H Betts, A J Watson, G M Kidder Jun 2000

Differential Involvement Of Na(+),K(+)-Atpase Isozymes In Preimplantation Development Of The Mouse., D J Macphee, D H Jones, K J Barr, D H Betts, A J Watson, G M Kidder

Obstetrics & Gynaecology Publications

Na(+),K(+)-ATPase plays an essential role in mammalian blastocoel formation (cavitation) by driving trans-epithelial sodium transport. Previously, the alpha1 and beta1 subunit isoforms of this enzyme were identified in preimplantation mouse embryos and were assumed to be responsible for this function. Here we show that mRNAs encoding an additional alpha subunit isoform (alpha3) and the remaining two beta subunit isoforms are also present in preimplantation embryos. Whereas alpha3 mRNA accumulates between the four-cell and the blastocyst stages and thus results from embryonic transcription, the same could not be demonstrated for beta2 and beta3 mRNAs. Immunoblot analyses confirmed that these subunits are …

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Could Humans Be Transfused With Pig And Cow Blood?, Donalee Moulton May 2000

Could Humans Be Transfused With Pig And Cow Blood?, Donalee Moulton

Data and Test Instruments

Today, hemophilia patients who have developed antibodies against human factor VIII use factor VIII derived from pigs' blood. "There is no evidence of disease being transferred," said Dr. [VivianMcAlister]. "However, great caution is required to make sure we know all the potential risks are controlled before transfusions of cells are attempted."

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Navigation-Related Structural Change In The Hippocampi Of Taxi Drivers, E A Maguire, D G Gadian, Ingrid Johnsrude, C D Good, J Ashburner, R S Frackowiak, C D Frith Apr 2000

Navigation-Related Structural Change In The Hippocampi Of Taxi Drivers, E A Maguire, D G Gadian, Ingrid Johnsrude, C D Good, J Ashburner, R S Frackowiak, C D Frith

Brain and Mind Institute Researchers' Publications

Structural MRIs of the brains of humans with extensive navigation experience, licensed London taxi drivers, were analyzed and compared with those of control subjects who did not drive taxis. The posterior hippocampi of taxi drivers were significantly larger relative to those of control subjects. A more anterior hippocampal region was larger in control subjects than in taxi drivers. Hippocampal volume correlated with the amount of time spent as a taxi driver (positively in the posterior and negatively in the anterior hippocampus). These data are in accordance with the idea that the posterior hippocampus stores a spatial representation of the environment …

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Impact Of Bovine Oocyte Maturation Media On Oocyte Transcript Levels, Blastocyst Development, Cell Number, And Apoptosis., A J Watson, P De Sousa, A Caveney, L C Barcroft, D Natale, J Urquhart, M E Westhusin Feb 2000

Impact Of Bovine Oocyte Maturation Media On Oocyte Transcript Levels, Blastocyst Development, Cell Number, And Apoptosis., A J Watson, P De Sousa, A Caveney, L C Barcroft, D Natale, J Urquhart, M E Westhusin

Obstetrics & Gynaecology Publications

The objectives were 1) to investigate the effects of oocyte maturation in serum-free and amino acid-supplemented defined media on oocyte transcript levels, blastocyst cell number, and apoptosis; 2) to investigate the influence of oocyte maturation culture atmosphere on blastocyst development, total cell number, and apoptosis; and 3) to examine the influence of epidermal growth factor (EGF) during oocyte maturation on blastocyst cell number and apoptosis. The results demonstrate that blastocysts derived from in vitro maturation, fertilization, and embryo culture protocols undergo apoptosis but that apoptotic levels are not greatly influenced by the oocyte maturation environment. Amino acid supplementation of oocyte …

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Clinical Equipoise And Rct Design, Charles Weijer Feb 2000

Clinical Equipoise And Rct Design, Charles Weijer

Philosophy Presentations

This presentation addresses these questions:
• “Upon what ethical grounds may the physician offer RCT enrollment to a patient?”
• Which is the preferred moral basis of the RCT?

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The Feasibility Of Bovine Erythrocytes For The Purpose Of Cross-Species Transfusion To Human Recipients, James Johnstone Jan 2000

The Feasibility Of Bovine Erythrocytes For The Purpose Of Cross-Species Transfusion To Human Recipients, James Johnstone

Data and Test Instruments

Use of animal blood could overcome concerns of supply and disease transmission with human blood donation if immunological, microbiological and ethical barriers are overcome. Here we investigated the feasibility of using bovine red blood cells (RBC) because of possibly diminished cross-species immune reactivity and the relative ease of venous access in the cow. A group of 12 tagged Holstein cows were randomly selected from the NSAC herd for evaluation. Tests included hemagglutination, complement mediated lysis, osmotic fragility, conventional human crossmatch, an RBC absorbtion assay using ELISA, bovine blood type characterization, and human IgM and IgG (including subtypes) antibody binding. Each …

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Effects Of Superovulated Heifer Diet Type And Quantity On Relative Mrna Abundances And Pyruvate Metabolism In Recovered Embryos., C Wrenzycki, P De Sousa, E W Overström, R T Duby, D Herrmann, A J Watson, H Niemann, D O'Callaghan, M P Boland Jan 2000

Effects Of Superovulated Heifer Diet Type And Quantity On Relative Mrna Abundances And Pyruvate Metabolism In Recovered Embryos., C Wrenzycki, P De Sousa, E W Overström, R T Duby, D Herrmann, A J Watson, H Niemann, D O'Callaghan, M P Boland

Obstetrics & Gynaecology Publications

This study investigated the effects of quantity and type of diet fed to superovulated donor heifers on molecular and metabolic indices of embryonic development. These effects included the relative abundances of mRNAs for the alpha 1 subunit of Na/K-ATPase and the antioxidant enzyme Cu/Zn-SOD, as well as pyruvate utilization in bovine morulae and blastocysts developed in vivo. Heifers were fed a daily ration of either grass silage and a citrus-beet pulp-based concentrate or grass silage and a barley-based concentrate for 116 days, both at 3 kg per day or ad libitum. In embryos derived from heifers fed the pulp-based diets, …

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Uwomj Volume 70, Number 1, Spring 2000, Western University Jan 2000

Uwomj Volume 70, Number 1, Spring 2000, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

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The Critical Care Research Network: A Partnership In Community Based Research And Research Transfer, Sean Keenan, Jennifer Kossuth, William Sibbald, Claudio Martin, Jeannette Eberhard Jan 2000

The Critical Care Research Network: A Partnership In Community Based Research And Research Transfer, Sean Keenan, Jennifer Kossuth, William Sibbald, Claudio Martin, Jeannette Eberhard

Health Studies Publications

The objectives of this study were to present a short history of the Critical Care Research Network (CCR-Net), describe its approach to health ser- vices research and to summarize completed and current research projects. In doing this, we explored the question is this research network accom- plishing its goals? We reviewed the medical literature to identify studies on similar types of Networks and also the evidence supporting the metho- dology used by CCR-Net to conduct research using MEDLINE, HEALTHSTAR, CINAHL and the keywords network and health care or healthcare, benchmarking and health care or healthcare, and research transfer or research …

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Sirolimus-Tacrolimus Combination Immunosuppression., Vivian Mcalister, Zu-Hua Gao, Kevork Peltekian, Javier Domingues, Kamran Mahalati, Allan Macdonald Jan 2000

Sirolimus-Tacrolimus Combination Immunosuppression., Vivian Mcalister, Zu-Hua Gao, Kevork Peltekian, Javier Domingues, Kamran Mahalati, Allan Macdonald

Data and Test Instruments

A series of 32 recipients of liver, kidney, or pancreas transplants who were treated with sirolimus and low-dose tacrolimus experienced a low rate of rejection and excellent graft function without drug-related toxic effects.

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Canadian Medical Officers In The Royal Navy (Book Review), Vivian Mcalister Jan 2000

Canadian Medical Officers In The Royal Navy (Book Review), Vivian Mcalister

Data and Test Instruments

CANADIAN MEDICAL OFFICERS IN THE ROYAL NAVY -- WORLD WAR II. Harry Stafford Morton. 112 pp. Illust. Canadian Naval Memorial Trust, HMCS Sackville, PO Box 99000, Stn Forces, Halifax NS B3K 5X5. 2000. Can$18.00 At the beginning of the Second World War, the Royal Canadian Navy offered 90 medical officers on loan to the Royal Navy. The author was among that group, which included leaders in Canadian surgery such as Surgeon Lieutenant McLachlin of London, Ont. The history of these medical officers has not been written because it fell between histories of the Royal Canadian Navy and the Royal Navy. …

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Relational Autonomy, Self-Trust, And Health Care For Patients Who Are Oppressed, Carolyn Mcleod, Susan Sherwin Jan 2000

Relational Autonomy, Self-Trust, And Health Care For Patients Who Are Oppressed, Carolyn Mcleod, Susan Sherwin

Philosophy Publications

No abstract provided.

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Self-Trust And Reproductive Autonomy, Carolyn Mcleod Aug 1999

Self-Trust And Reproductive Autonomy, Carolyn Mcleod

Philosophy Publications

In this thesis. I give a theory of the nature of self-trust and an explanation of its role in autonomous decision-making. We tend to think of trust as essentially interpersonal which casts doubt on the coherence of the concept of self-trust. Drawing on patients' experiences in reproductive medicine. I argue that self-trust is a meaningful as well as a useful concept. I provide autobiographical sketches of a number of women's experiences. supplemented by my own observations made while doing a clinical practicum in reproductive medicine, to illustrate that what many women feel toward themselves in a variety of reproductive health …

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Local And Global Stereopsis In The Horse., B Timney, K Keil May 1999

Local And Global Stereopsis In The Horse., B Timney, K Keil

Brain and Mind Institute Researchers' Publications

Although horses have laterally-placed eyes, there is substantial binocular overlap, allowing for the possibility that these animals have stereopsis. In the first experiment of the present study we measured local stereopsis by obtaining monocular and binocular depth thresholds for renal depth stimuli. On all measures, the horses' binocular performance was superior to their monocular. When depth thresholds were obtained, binocular thresholds were several times superior to those obtained monocularly, suggesting that the animals could use stereoscopic information when it was available. The binocular thresholds averaged about 15 min arc. In the second experiment we obtained evidence for the presence of …

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Perceptual-Mnemonic Functions Of The Perirhinal Cortex., Murray, Bussey Apr 1999

Perceptual-Mnemonic Functions Of The Perirhinal Cortex., Murray, Bussey

Brain and Mind Institute Researchers' Publications

It is widely acknowledged that the perirhinal cortex, located in the ventromedial aspect of the temporal lobe, is essential for certain types of memory in macaque monkeys. For example, removal of the perirhinal cortex yields severe impairments on tests of stimulus recognition and stimulus-stimulus association. There is considerable disagreement, however, about the most accurate way to characterize the function of the perirhinal cortex; some views emphasize a role in perception whereas others posit a role exclusively in declarative memory. In this article, we review recent findings from anatomical, physiological and ablation studies in monkeys, and discuss related findings obtained in …

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Igf Paracrine And Autocrine Interactions Between Conceptus And Oviduct., A J Watson, M E Westhusin, Q A Winger Jan 1999

Igf Paracrine And Autocrine Interactions Between Conceptus And Oviduct., A J Watson, M E Westhusin, Q A Winger

Obstetrics & Gynaecology Publications

Development in vitro is influenced by embryo density, serum, somatic cell co-culture and the production of 'embryotrophic' paracrine and autocrine factors. Research in our laboratory has focussed principally on the insulin-like growth factor (IGF) family. We have demonstrated that pre-attachment bovine and ovine embryos express mRNAs encoding a number of growth factor ligand and receptor genes including all members of the IGF ligand and receptor family throughout this developmental interval. In addition, early embryos express mRNAs encoding IGF-binding proteins (IGFBPs) 2-5 from the one-cell to the blastocyst stage and IGFBP5 mRNA at the blastocyst stage. Cultured bovine blastocysts release up …

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Uwomj Volume 69, No 2, Spring 1999, Western University Jan 1999

Uwomj Volume 69, No 2, Spring 1999, Western University

University of Western Ontario Medical Journal

An interdisciplinary medical science publication; established 1930.

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Uwomj Volume 60, No 3 April 1991, Western University Jan 1999

Uwomj Volume 60, No 3 April 1991, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Denistry

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Uwomj Volume 68, Number 1, Winter 1999, Western University Jan 1999

Uwomj Volume 68, Number 1, Winter 1999, Western University

University of Western Ontario Medical Journal

Schulich School of Medicine & Dentistry

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Functionally Dissociating Aspects Of Event Memory: The Effects Of Combined Perirhinal And Postrhinal Cortex Lesions On Object And Place Memory In The Rat., T J Bussey, J L Muir, J P Aggleton Jan 1999

Functionally Dissociating Aspects Of Event Memory: The Effects Of Combined Perirhinal And Postrhinal Cortex Lesions On Object And Place Memory In The Rat., T J Bussey, J L Muir, J P Aggleton

Brain and Mind Institute Researchers' Publications

Reciprocal interactions between the hippocampus and the perirhinal and parahippocampal cortices form core components of a proposed temporal lobe memory system. For this reason, the involvement of the hippocampus in event memory is thought to depend on its connections with these cortical areas. Contrary to these predictions, we found that NMDA-induced lesions of the putative rat homologs of these cortical areas (perirhinal plus postrhinal cortices) did not impair performance on two allocentric spatial tasks highly sensitive to hippocampal dysfunction. Remarkably, for one of the tasks there was evidence of a facilitation of performance. The same cortical lesions did, however, disrupt …

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Education In Schizophrenia Support For Families, Amresh Srivastava Jan 1999

Education In Schizophrenia Support For Families, Amresh Srivastava

Data and Test Instruments

No abstract provided.

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Trudy Govier’S Dilemmas Of Trust, Carolyn Mcleod, S. Burns Jan 1999

Trudy Govier’S Dilemmas Of Trust, Carolyn Mcleod, S. Burns

Philosophy Publications

No abstract provided.

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How Pigs' Blood Could Save Lives: Canadian Study Could End Need For Human Donations, Allison Hanes, Randy Boswell Dec 1998

How Pigs' Blood Could Save Lives: Canadian Study Could End Need For Human Donations, Allison Hanes, Randy Boswell

Data and Test Instruments

Dr. [Vivian McAlister] agrees that the risk of inter-species infection remains a key obstacle to producing safe pigblood products for people: "The most important thing is that the safety of this sort of thing has to be thoroughly assessed before any implementation. We're dealing more with the immunological barriers, not the infectious disease," he says of his research. "However, if the infectious risks were overcome, or they were understood, an animal source for blood donation" could revolutionize blood-supply services around the world, he says. Currently mired in a depressed pork market that is threatening to put many producers out of …

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Trophectoderm Differentiation In The Bovine Embryo: Characterization Of A Polarized Epithelium., L C Barcroft, A Hay-Schmidt, A Caveney, E Gilfoyle, E W Overstrom, P Hyttel, A J Watson Nov 1998

Trophectoderm Differentiation In The Bovine Embryo: Characterization Of A Polarized Epithelium., L C Barcroft, A Hay-Schmidt, A Caveney, E Gilfoyle, E W Overstrom, P Hyttel, A J Watson

Obstetrics & Gynaecology Publications

Blastocytst formation is dependent on the differentiation of a transporting epithelium, the trophectoderm, which is coordinated by the embryonic expression and cell adhesive properties of E-cadherin. The trophectoderm shares differentiative characteristics with all epithelial tissues, including E-cadherin-mediated cell adhesion, tight junction formation, and polarized distribution of intramembrane proteins, including the Na-K ATPase. The present study was conducted to characterize the mRNA expression and distribution of polypeptides encoding E-cadherin, beta-catenin, and the tight junction associated protein, zonula occludens protein 1, in pre-attachment bovine embryos, in vitro. Immunocytochemistry and gene specific reverse transcription--polymerase chain reaction methods were used. Transcripts for E-cadherin and …

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Transient Expression Of A Translation Initiation Factor Is Conservatively Associated With Embryonic Gene Activation In Murine And Bovine Embryos., P A De Sousa, A J Watson, R M Schultz Oct 1998

Transient Expression Of A Translation Initiation Factor Is Conservatively Associated With Embryonic Gene Activation In Murine And Bovine Embryos., P A De Sousa, A J Watson, R M Schultz

Obstetrics & Gynaecology Publications

In the present study the abundance of mRNAs for eukaryotic translation initiation factors eIF-1A (formerly known as eIF-4C), -2alpha, -4A, -4E, and -5 was examined in in vivo-derived mouse embryos throughout preimplantation development using a semiquantitative reverse transcription-polymerase chain reaction assay. Although the mRNA profile for each gene is unique, only mRNA for eIF-1A transiently increases during embryonic gene activation (EGA) at the 2-cell stage, and this was confirmed by an independent hybridization-based assay. In in vitro-developed bovine embryos, mRNA for eIF-1A was transiently detected at the 8-cell stage, when the major activation of the genome occurs in this species. …

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