Medicine and Health Sciences Commons^™

Purine And Pyrimidine Monophosphate Vs Polyphosphate Homeostasis In Human Retinal Endothelial Cells, Andrew Gregory, Jenna Hart, Thangal Yumnamcha, Mohamed Shawky, Shaimaa El Tanani, Ahmed Ibrahim

Medical Student Research Symposium

Introduction: A major cause of blindness is proliferative diabetic retinopathy (PDR), and there is limited data on the nucleic acid (NA) profiles in PDR. We characterized the profiles of NAs in human retinal endothelial cells (HRECs) subjected to high glucose (HG) and hypoxia (Hyp) - common risk factors associated with PDR.

Methods: HRECs were treated with osmotic control (Mannitol, 25 mM) or high glucose (HG, 25 mM) for 5 days, followed by normoxia or hypoxia (Hyp, 2% O2) for 24 hours. Pathway enrichment analysis from the significant metabolites in the Hyp+HG vs control comparison was subsequently performed.

Results: The precursors …

Kinship, Gift Exchange, And The Management Of Diabetes, Bryen Turco, Vito Agrusa, Laila Abdallah, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The authors examine the impact of kinship structures on the management poorly controlled type 2 diabetes

The Importance Of Stigma Theory For Clinical Decisions Related To Diabetic Foot Amputations, Rachael Garcia, Callie Bartkowiak, Alison Nesbitt Do

Clinical Research in Practice: The Journal of Team Hippocrates

The authors examine the unconsidered impact of social stigma theory on the shared clinical decision-making process for a patient with foot osteomyelitis and MRSA bacteremia facing the prospect of an amputation.

Chronic Illness Education 2022: Diabetes Mellitus Education For Adults In Southeast Michigan, Muhammad Ahmed, Ahmad Kofahi, Caleb Richard, Hadi El Ammar, Huda Warsame, Janice Gibbons, Jodene Takahashi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Wound Care Vigilance In Adult Diabetic Patients With Neuropathy, Gowri Chandrashekar, Allen Zhang, Daniel Domin, Karis Tutuska, Sarah Bassett, Varsha Kumar

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Developing A Hands-On Tool For Increased Accountability Amongst Diabetic Children, Kassandra Solrud, Bijan Sagman, Elena Carrillo, Gokturk Tepe, Itzick Nahmoud, Siena Snyder, William Crouch

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Diabetes Management In Adults In The Detroit Area, David Asebiode, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: A Recipe For Healthy Living, Awad Maria, Andrew Gregory, Andrew Rabah, Kia Sweeney, Laura Aravena, Nicholas Livingston, Tabassum Chowdhury

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Addressing Risk Of Body Image And Eating Disorders In Adolescents With Type I Diabetes, Ahmad El-Moussa, Dhruva Kadiyala, Kavitha Mohanarajan, Kevin Kim, Michael Brennan, Rajaa Shoukfeh, Ruth Amoakohene

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Type Ii Diabetes Management In Adults: Medications And Community Resources, Varag Abed, Camila Arellano, Carolyn Baldwin, Ethan Ervin, Haya Beydoun, Mahnoor Ayub, Yoshio Wagner

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson

Patient Education Projects

No abstract provided.

Metformin Monotherapy Is An Effective Alternative For Management Of Gestational Diabetes Mellitus In Patients Refusing Insulin Monotherapy, Tyler Russeth

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol. 2019;234(4):4695-4701. https://doi.org/10.1002/jcp.27238

for a patient with gestational diabetes mellitus (GDM) who does not wish to undergo insulin monotherapy.

Lifestyle Intervention Is Superior To Metformin In Prevention Of Microvascular Complications Of Diabetes In Women, But Socioeconomic Barriers May Lead To Use Of Combination, Katanya C. Alaga, Jesse Haddad

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using

Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: The Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015;3(11):866-875. https://doi.org/10.1016/S2213-8587(15)00291-0

for a patient with pre-diabetes who is concerned about the prevention of microvascular complications through lifestyle intervention while managing her busy schedule as a traveling house cleaner.

Pre-Mixed Insulin Has A Similar Efficacy To Basal-Bolus Insulin In Reducing Hba1c Levels In Type 2 Diabetics, Rujuta Patil

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Fulcher G, Roberts A, Sinha A, Proietto J. What happens when patients require intensification from basal insulin? A retrospective audit of clinical practice for the treatment of type 2 diabetes from four Australian centres. Diabetes Research and Clinical Practice, 2015;108(3):405–413. https://doi.org/10.1016/j.diabres.2015.03.004

for a patient with uncontrolled type 2 diabetes.

Starting Triple Oral Hypoglycemic Agent Therapy In Poorly Controlled Type 2 Diabetes Is A Suitable Therapeutic Strategy To Lower Hba1c When Insulin Therapy Is Not Desired, Mara A. Darian

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Søfteland E, Meier JJ, Vangen B, Toorawa R, Maldonado-Lutomirsky M, Broedl UC. Empagliflozin as Add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Linagliptin and Metformin: A 24-Week Randomized, Double-Blind, Parallel-Group Trial. Diabetes Care. 2016;40(2):201-209. https://doi.org/10.2337/dc16-1347

for a patient with uncontrolled type 2 diabetes on metformin and sitagliptin and hesitant to begin insulin therapy.

The Effect Of Nurse Case Coordination On Management Of Chronic Conditions, Aayush Mittal Ms-Hsm

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Ishani A, Greer N, Taylor BC, et al. Effect of nurse case management compared with usual care on controlling cardiovascular risk factors in patients with diabetes: a randomized controlled trial. Diabetes Care. 2011;34(8):1689-1694. https://doi.org/10.2337/dc10-2121

for a patient requiring care coordination for management of hypertension, diabetes, and hyperlipidemia.

Health Literacy, Social Support, And Diabetes Self Care Among Individuals Of Arab Descent, Abeer Aseeri

Wayne State University Dissertations

HEALTH LITERACY, SOCIAL SUPPORT, AND DIABETES SELF-CARE AMONG INDIVUDALS OF ARAB DESCENT

BY ABEER ASEERI

August 2020 Advisor: Dr. Joan Visger & Dr. Nancy Hauff

Major: Nursing

Degree: Doctor of Philosophy

Introduction/Objectives: Individuals of Arabic descent who live in the United States are at increased risk of diabetes because the Middle Eastern and North African regions have the second highest global rate of the disease which, is also projected to increase by over 95% by 2035. Diabetes self-care involves seven essential behaviors, including: (1) eating a healthy diet, (2) being physically active, (3) being compliant with medication, (4) monitoring blood …

Understanding Diabetes Through Pathway Analysis Evaluation, London Cavaletto

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

Metabolic disorders affect many people and identifying significantly perturbed biological processes in a metabolic disease can provide valuable insight into the disease’s mechanisms. Evaluating the proposed Metabolic Pathway Analysis Method (RAMP) will enable us to reliably use it to identify significantly perturbed metabolic pathways that could help identify disease mechanisms and potential therapy targets or disease bio-markers of a metabolic disorder.

Diabetes Interaction Study: Communicating Understanding And Social Support, Dana K. May

Wayne State University Dissertations

The current study evaluated a brief individualized feedback intervention developed to improve communication style of parents with an adolescent with type 1 diabetes. Seventy-nine parent-adolescent dyads (13-18 years) were randomized to receive a single session of brief feedback to target parental person-centered communication skills (n = 39) or to receive an educational comparison group (n = 40). Families were asked to discuss a diabetes related problem. A clinician concurrently rated the parent’s communication skills to identify communication strengths and weaknesses. Parents in the feedback group received feedback on their use of person-centered communication during the conversation using motivational interviewing techniques. …

Isolation And Characterization Of Natural Alpha-Glucosidase Inhibitors From Antioxidant Rich Red Wine Grapes (Vitis Vinifera), Hoda Chaouki Kadouh

Wayne State University Dissertations

Background: Diabetes is currently a global public health problem affecting people at all ages. Dietary antioxidants have been associated with a reduced risk of type 2 diabetes. Grape pomace contains considerable amounts of polyphenols and it has been reported to exhibit an inhibitory activity against alpha- glucosidases. Alpha-glucosidases, in turn, play a major role in controlling starch digestion and therefore postprandial blood glucose, a target for diabetes management.

Objective: This study aims to investigate the anti-diabetes potential of a selection of six grape pomaces and prepare and purify active components in the active variety that specifically inhibit intestinal alpha-glucosidases. The …

Linking Environmental Toxicant Exposure To Diabetes Susceptibility, Jannifer Beth Tyrrell

Wayne State University Dissertations

An important and unresolved question in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity.

Previous studies suggested that dioxin exposure increased peripheral insulin resistance but did not appear to cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by the …

Type 2 Diabetes And Insomnia: Impact On Metabolic Control, Cheryl Lee Tannas

Wayne State University Dissertations

Diabetes is one of the most serious health challenges in the United States, affecting nearly 21 million Americans. The goal of diabetes management is to maintain the blood glucose close to normal to prevent diabetic complications and therefore extending life expectancy and improving quality of life. Research now indicates a relationship of the quantity and quality of sleep to glycemic control in type 2 diabetics. No research on the impact of insomnia on diabetes prevention and/or management was found in the literature. The purpose of this 11 week intervention study was to examine the effects of participation in Cognitive Behavioral …

Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis

Wayne State University Dissertations

MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN

ISCHEMIA

by

MONIQUE K. LEWIS

August 2011

Advisor: Dr. Donald DeGracia

Major: Physiology

Degree: Doctor of Philosophy

The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …

Effects Of Managed Care On The Health And Health-Care Of The Non-Elderly With Diabetes, Meihua Lu

Wayne State University Dissertations

This dissertation attempts to examine the quality effect of managed care plans (as compared with traditional fee-for-service plans, or FFS) on the health outcome and health care use of patients with diabetes. As the number of diabetics is growing rapidly with many of them are relying on managed care plans, knowing better the effects of different plans on health status and health care utilization is of great interest and significance to consumers, employers, and policymakers, especially at a time that universal health care is under being implemented.

Using up-to-date data from MEPS, a nationally representative survey, I compared 484 HMO …

Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh

Wayne State University Theses

Lipodystrophy caused by fat deficiency contributes to metabolic disease for which several treatment modalities have been implemented, with leptin therapy being the most effective to date. In addition to playing a role in energy homeostasis and metabolism, leptin was also shown to play a pro-thrombotic role in mice. This role was not examined in fatless mice, neither was thrombosis measured. The AZIP/F-1 (FVB) lipodystrophic mouse appeared to have a prolonged arterial occlusion time (p〈0.05) in a trial done in our lab, with clotting factors being normal. The present study was designed to observe the thrombotic and metabolic characteristics of fatless …

Prevalence And Risk Factors For Vaginal Candida Colonization In Women With Type 1 And Type 2 Diabetes, Ella M. De Leon, Scott J. Jacober, Jack D. Sobel, Betsy Foxman

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Diabetes mellitus increases the rate of vaginal colonization and infection with Candida species

Methods

We surveyed women with diabetes receiving care at either an urban or suburban diabetes clinic to examine the relationship between vaginal Candida colonization, diabetes type and duration, and HbA_1c level. 101 participants completed the self-administered questionnaire and self-collected a vaginal swab for Candida culture. Candida colonization was similar by age and race.

Results

Type 1 diabetics were three times as likely as type 2 diabetics to be colonized with any Candida species (OR = 3.4; 95% CI: 1.03, 11.41; p = 0.04); even …