Medicine and Health Sciences Commons^™

Effectiveness Of Financial Incentives In Improving Breast Cancer Screening Among Medicaid Recipients, James B. Sherwood

Theses and Dissertations

Breast cancer remains one of the leading causes of death among women. Roughly 2.4 million women are diagnosed annually with breast cancer throughout the world. Although breast cancer survival rates are favorable for the United States compared to other nations (90% 5-year survival for non-metastatic disease), it comes at a high cost. The United States spends an estimated $30 billion annually on breast cancer treatment. In addition, disparities in breast cancer survival rates also exist in the United States. Women Medicaid recipients, who are predominately minorities (60%), are more likely to die of breast cancer due to their high rates …

Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley

Theses and Dissertations

There is a continued need for new technology and strategies for tackling cancer and other diseases, and within the current century a novel therapeutic strategy has emerged in the realm of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifically targets and degrades disease-causing proteins via the ubiquitin-proteasome system, and has seen an explosion of research and intrigue in both academia and industry over the past two decades. The diversity of PROTAC classes based on the E3 ligase recruiting ligand and the target protein allows for a universal molecular structure that can be customized for a specific target and …

Analysis Of Referrals To Trauma Psychology And Subsequent Development And Proof-Of-Concept Study Of Provider Mental Health Training At A Level I Trauma Center, Samantha Mladen

Theses and Dissertations

Introduction: Millions of people are traumatically injured each year, with a significant portion going on to develop negative mental health sequelae. Many Level I trauma centers are integrating psychologists to provide acute assessment and intervention to patients at risk for poor outcomes. However, medical providers receive very limited training in how to best refer patients to mental health services and may benefit from such education.

Objective: To characterize current patterns of referral to trauma psychology at a Level I trauma center and to develop, refine, and test proof-of-concept for a new training for referring providers.

Method: One year of patient …

The Impact Of Patient Characteristics On Dysphagia Therapy Utilization And Feeding Outcomes For Premature Infants In The Neonatal Intensive Care Unit, Tiana Nguyen

Theses and Dissertations

Medical advances have significantly increased the survival rates of preterm infants at lower gestational ages. However, infants born at lower gestational ages have an increased risk for developmental disabilities and oral feeding difficulties. A stay in the neonatal intensive care unit (NICU) is very costly and inadequate oral feeding is the most common barrier to discharge for premature infants. Infants can receive dysphagia therapy services during their NICU stay that focuses on the development of oral feeding and swallowing skills. However, literature to this date has mainly focused on the impact of therapy services for premature infants after NICU discharge. …

The Presentation And Impact Of Compassion Fatigue And Compassion Satisfaction In Occupational And Physical Therapists Working With People Who Have Sustained Burn Injuries, Miranda L. Yelvington

Theses and Dissertations

Therapists who work with burn survivors are frequently exposed to patients who are undergoing or have undergone severe trauma and pain. This exposure places burn therapists at risk for the development of compassion fatigue and diminished professional quality of life. Alternatively, the sense of purpose and altruism experienced by these same therapists have the potential to foster compassion satisfaction. This dissertation explores the prevalence and presentation of compassion fatigue and compassion satisfaction in burn therapists in the United States. This three-paper design focuses on: 1) a scoping review of current literature, 2) a cross-sectional quantitative survey utilizing the Professional Quality …

Qvoices: Queer Voices In Oncology Igniting Change Through Empowered Stories Of Survivorship, Viktor Clark

Theses and Dissertations

Background: Each year in the United States there are roughly 2 million new cancer diagnoses, with over 600,000 deaths due to cancer. The National Cancer Institute developed a six-stage cancer control continuum framework ranging from etiology to survivorship to organize the cancer experience. Sexual and gender minorities (SGM) are comprised of multiple communities representing ~23.6 million adults in the US, SGM face disparities at each stage of the cancer control continuum. This study emphasizes three stages, prevention, detection, and treatment. Engagement in prevention can prevent or prolong cancer, early detection through engagement in cancer screening improves cancer trajectories and compliance …

Characterizing The Effects Of Antiandrogens And Senolytics To Enhance The Therapeutic Response To Castration-Resistant Prostate Cancer, Justin M. Silverman

Theses and Dissertations

Prostate cancer is the most frequently diagnosed cancer in males and the second most common cause of cancer deaths. Androgen deprivation therapy, whether through surgical or chemical castration, is the mainstay for treatment of advanced prostate cancer; however, despite an initial response, most patients eventually develop a progressive PSA rise, and castration- sensitive prostate cancer gives rise to castration-resistant prostate cancer. The standard of care therapy includes the antiandrogens such as enzalutamide and abiraterone acetate as well as the microtubule poison, docetaxel, and various immunotherapies; however, while prostate cancer research is progressing, there continues to be a compelling need for …

A Learning Health System For Radiation Oncology, Rishabh Kapoor

Theses and Dissertations

The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes.

The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes …

Impact Of Portal Of Exit On The Prevalence Of Apical Periodontitis In Root Canal Treated Maxillary Molars With Missed Second Mesiobuccal Canals: A Cbct Study, Jing Ye

Theses and Dissertations

Objective: To evaluate the association of portal of exit (POE) of the second mesiobuccal (MB2) canal with the prevalence of apical periodontitis (AP) in previously treated maxillary molars

Methods: Cone beam computed tomography (CBCT) scans of 106 previously treated maxillary molars seen for either recall or retreatment in the past 3 years were included in the study. Scans were reviewed by one endodontic resident and one board-certified endodontist to determine the POE (separate versus common) of the missed MB2 canal and the presence or absence of a periapical hypo-dense area. Association between AP and portal of exit was assessed using …

Utilization Of Occupational Therapy Services For Patients With Cancer In Acute Care Settings, Christine Mcnichols

Theses and Dissertations

For patients with cancer diagnoses, effects from the disease or as a result of cancer treatments can cause profound impairments impeding patient functioning and independence. These assaults to the independent achievement of activities have far reaching implications and linkages to a patient’s length of stay and their likelihood of a hospital readmission. Unfortunately, occupational therapy services have frequently been found not to be ordered for patients with cancer, even when there have been demonstrated functional deficits and needs. Through the analysis of patient records from a National Cancer Institute hospital over 5 years, the current study investigated occupational therapy services …

Effect Of Apical Preparation Size On Endodontic Treatment Outcomes, Joseph Vaughn

Theses and Dissertations

Objective: Previous authors have attempted to identify the ideal apical preparation size needed to achieve endodontic treatment objectives. Despite vast literature on the topic, there exists a lack of consensus on ideal apical enlargement, with few studies discussing the effect of apical prep enlargement on clinical outcomes. The purpose of this retrospective study was to evaluate the effect of final apical preparation size on endodontic outcomes in maxillary and mandibular molars treated in both a graduate endodontic clinic and a private practice.

Methods: A chart review was conducted for patients seen at the VCU graduate endodontic clinic as well as …

Vulnerability And Adaptation Of Neocortical Neuron Subtypes In Models Of Concussive Traumatic Brain Injury And Multiple Sclerosis, Alan C. Harris Jr.

Theses and Dissertations

The pathognomonic sequela of traumatic brain injury is traumatic axonal injury, the

burden of which correlates with less favorable outcomes. Elucidation of

the intrinsic variables that endow delineated neuronal subgroups and microanatomical domains with outsized vulnerability to injury represents a critical domain of inquiry toward the successful translation of disease-modifying therapeutics. To this end, we studied mild traumatic brain injury (mTBI) within the central fluid percussion model to examine the consequences of mTBI on the morphology and functional integrity of the axon initial segment (AIS) and the relative contributions to network homeostasis mediated by distinct populations of inhibitory interneurons. One …

Grinding All My Life: Nipsey Hussle, Community Health, And Care Ethics, Pyar J. Seth, Carlton K. Harrison, Jasmyn Mackell

Journal of Hip Hop Studies

As John Legend said, “Nipsey was so gifted, so proud of his home, so invested in his community” (Martin, 2019). Though Nipsey Hussle certainly had a lyrical gift, the discourse after his murder remained largely focused on his work as a humanitarian and community activist. Hussle was a staunch advocate for gun control, police abolition, and education equity in Los Angeles and the State of California. Academic research has often neglected the very clear relationship between Hip Hop and health, particularly the underlying theme of improving community health. To our knowledge, Hussle never identified as a community health organizer. Still, …

Boxed Lunches, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes, Jemal Mohammed-Awel

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome, Justen Geddes

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion, Erin O. Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis, Choongseok Park, Sungwoo Ahn, Leonid Rubchinsky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Dynamics Of Usutu Virus Infection In Birds, Nora G. Heitzman-Breen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Epidemiological Assessment Of Wolbachia-Based Biocontrol For Reduction Of Dengue Morbidity, Olga Vasilieva, Oscar E. Escobar, Hector J. Martinez, Pierre-Alexandre Bliman, Yves Dumont

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mechanical Parameters Fitting For Layer-Reduced Umbilical Arteries Used For Grafting, Kun Gou

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Model Of Triple-Negative Breast Cancer In Response To Combination Chemotherapies, Angelica Davenport, Yun Lu, Carlos Gallegos, Adriana Massicano, Katherine Heinzman, Patrick Song, Anna Sorace, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Model Of Quarantine Implementation In An Animal Shelter For Canine Distemper Outbreak, Virginia Parkman, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break, Coffee Break

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary: Cardiovascular Models In Vascular Disease, Mette Olufsen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Biofilm-Phage Interactions In Mathematical Framework, Blessing Emerenini

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model For Biological Field Effect Tranistors, Ryan M. Evans, Seulki Cho, Arvind Ballijepalli, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimal Intervention Strategies To Minimize Spread Of Infectious Diseases And Economic Impact On A Dynamic Small-World Network, Malindi Whyte, Danielle Dasilva

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model Of Microtubule Assembly And Polarity In Dendrites, Anna Nelson

Biology and Medicine Through Mathematics Conference

No abstract provided.