Medicine and Health Sciences Commons^™

Physician Role In Enhancing Patient Communication, Tamanna Sahni

Undergraduate Research Posters

Communication in the in-patient environment is crucial, and the relationship between a patient and physician enhances patient health and wellness. Patients should feel confident with their abilities to feel comfortable conversing with physicians, which would thus treat symptoms more effectively. This communication has decreased over time, hence patients are often are unable to obtain medical information from their healthcare providers. What is the relationship between psychological factors, such as self-esteem, and quality of patient-physician communication? And can physicians ensure increased patient comfort in the medical environment?

Various factors can affect the patients’ comfort with their physicians, and when addressed, these …

Design And Creation Of A Device To Induce Vergence Eye Movements, Jacob B. Jaminet, Paul A. Wetzel

Undergraduate Research Posters

Automated eye-tracking systems can detect and analyze eye movements as a means to accurately diagnose more than 20 neurological diseases including mild traumatic brain injury. Mild traumatic brain injury is an occurrence of injury to the head resulting from blunt trauma or from acceleration or deceleration forces. Eye movement refers to the voluntary or involuntary movement of the eyes, helping in acquiring, fixating and tracking visual stimuli. There are three types of voluntary eye movement to track objects: smooth pursuit, vergence shifts and saccades. Vergence shifts are eye movements where the eyes move in opposite directions: moving to the midline …

Combination Of Music And Aromatherapy To Improve The Efficiency Of Motor Functions And Speech In Patients Paralyzed From Stroke., Mounica Bevara

Undergraduate Research Posters

With the rapid development of medical technology, millions of dollars are being spent on discovering innovative methods of treating fatal diseases such as stroke that may also result in temporary paralysis. Physiotherapy treatments aimed at restoring brain function in patients paralyzed following a stroke is subjective to the patient and does not guarantee complete rehabilitation. While many practitioners have attempted to employ complementary and alternative methods of treatment such as massage therapy, acupuncture therapy, siddha, and marma therapy, none of them proved to be equally as effective as physiotherapy. However, prior studies support the notion that aromatherapy used in combination …

Ketamine, A Brighter Future For Those In Darkness, Matthew D. Gayhart

Undergraduate Research Posters

Millions of people around the world suffer from Major Depressive Disorder, and many of these people are given drugs to help treat this potentially devastating disease. For many, the first treatment is successful, and if not, certainly the second treatment gives them the relief they so desperately need. Others, however, are not so lucky, people with treatment resistant depression undergo numerous treatments, some of which are more aggressive than others, but still nothing helps alleviate their depression. Recently an older anesthetic, the drug Ketamine, has been making some news as a new depression treatment. This paper will compare Ketamine to …

Reducing Childhood Obesity In America Through National Legislation, Sailee A. Joshi

Undergraduate Research Posters

According to the Harvard T. H. Chan School of Public Health, the American childhood obesity rate has increased threefold within the past 25 years, a trend accompanied by increasing rates of hypertension, type 2 diabetes, cardiovascular disease, certain types of cancer, and even mortality. Obesity has grown so prevalent, in fact, that Centers for Disease Control estimate that one in three American children is obese. According to the Chan School of Public Health, unless legislation directly targeting America’s spiraling obesity rate is passed, the trend shows no signs of slowing or reversing.

Passing effective legislation requires a both an understanding …

Asthma-Related Anxiety And Quick-Relief Medication Use In Urban Children With Asthma, Sarah E. Astrab, Robin Everhart

Undergraduate Research Posters

Among children, asthma is the most common chronic illness. Although not curable, asthma is manageable with the use of both daily controller medication and quick relief or rescue medication. Anxiety has been found to increase asthma symptoms in children. Caregivers who are anxious about their child’s asthma symptoms may perceive their child’s asthma as more severe or doubt their ability to manage their child’s asthma, which can result in the misuse of asthma medication. This study focused on the association between asthma-related anxiety and the use of quick-relief asthma medications in a low-income, urban sample in Richmond, Virginia. Child participants …

Changes In Malaria Prevention And Incidence Due To Political Restructuring Of Mozambique And South Africa, Nirmala K. Shivakumar

Undergraduate Research Posters

The UN’s current Millennium Development Goal puts pressure on many countries to decrease malaria incidence by 2015, including Mozambique and South Africa. While Mozambique and South Africa have continually worked to decrease malaria incidence for the last five decades, neither country can claim elimination of disease by UN standards. This study analyzes the changes in political structure and the simultaneous changes in the malaria prevention programs of Mozambique and South Africa after the end of their respective civil wars in 1992 and 1994. This study analyzed public health, historical, and social science journal articles. This study examined political power distribution, …

Disproportion Of Women In General Surgery And Obstetrics-Gynecology Professions, Nidhi H. Patel

Undergraduate Research Posters

An increasingly number of women have been enrolling in U.S. medical schools recently and the field of obstetrics-gynecology has become predominantly female, but the profession of general surgery still remains largely unequal between the two genders. There is an observable pattern of gender inequality in both of these specialties, which is a result of several different factors which affect all women regardless of their profession. I studied how the stark difference in the percentages of female surgeons versus the percentages of female obstetricians-gynecologists compared to men has been created due to the prescribed gender roles of women in society. I …

The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier

Undergraduate Research Posters

Purpose: Abstract for poster submission to VCU Poster Symposium for

Undergraduate Research and Creativity

Title: The Metabolism of Alcohol: Risk and Protective Factors

Background: In 2002, it was reported by the National Institutes of Health that

60.3% of college aged students (18-22) drank alcohol in the past month of being

asked, as compared to 51.9% of those not in college. They also found that 20% of

college students met the criteria for at least one alcohol use disorder (AUDs)1.

Many genes have been linked to an increased risk for AUDs and how individuals

with various ethnic backgrounds respond to alcohol. …

Increasing Vaccination Rates In Children Of Vaccine-Hesitant Parents, Keegan G. Edgar

Undergraduate Research Posters

In recent years, the number of parents who have declining vaccinations or instituting altered immunization schedules for their children has risen. This has caused an increased number of outbreaks of vaccine-preventable diseases. It has also threatened herd immunity, which provides a measure of protection for those who are susceptible to disease given enough people are vaccinated, as this hinders the spread of the disease. To combat this threat to herd immunity, it is becoming increasingly necessary to find a solution to the problem of increasing personal belief exemption.

I took a cause and effect approach in the way I researched …

Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo

Undergraduate Research Posters

Cancer is the second leading cause of death in the U.S. and millions of novel cancer cases are being diagnosed each year. While chemotherapy and ionizing radiation are effective treatments against these malignant tumors, the adverse effects that accompany such treatments are devastating. In order to find alternative treatment methods with less side effects, we turn to Eastern herbal medicine. Recent scientific research has found that Tripterygium wilfordii, an herbal medicine traditionally used to treat inflammation in China, contains compounds (triptolide and celastrol) that prevent the growth of solid tumors, induce apoptosis, and prevent metastasis of developed tumors. Investigations …

Factors Involved In The Successful Transition To And Subsequent Use Of Electronic Health Records (Ehrs) Systems By Individual And Group-Practice Physicians, Naveen Chandra Kotha

Undergraduate Research Posters

The use of Electronic Health Records (EHRs) by healthcare professionals has been recommended as a way of improving healthcare quality, patient safety, and workflow efficiency, and lowering costs in the long run. While large hospital systems integrate EHRs into their services, individual and group practice-owning physicians, especially those of specialties and subspecialties, are often left wondering whether they should follow the trend and whether the transition from traditional, paper-chart systems or older EHRs to newer, commercial ones will truly benefit their patients and their practice as a whole. These physicians also often wonder whether benefits such as electronic-prescribing, clinical decision …

Developing A Neuroplasticity-Based Treatment Program For Psychopathy: Treatment Foci And Options, Mariah Villanueva

Undergraduate Research Posters

Psychopathy is a neurodevelopmental disorder that is commonly misunderstood as the condition of criminals, and many people believe the best cure is simple confinement for those who ignore society’s laws. Psychopathy, though, is a genuine condition with a genetic basis that manifests itself through neurotransmitter system disruption and hormone imbalances. Psychopathy has a serious neurological impact on an individual, with impairments largely focused in the prefrontal cortex and amygdala, as well as overall negatively affecting the limbic system of the brain. Together, the total impact causes issues with that individual’s ability to empathize, to experience emotions normally, to develop a …

Exploring The Relationships Between Mindfulness And Biobehavioral Factors Associated With Cvd In Women, Susan Ghodrat, Jo Lynne W. Robins

Undergraduate Research Posters

Purpose: This study examined the relationship between mindfulness and specific biobehavioral factors associated with increased cardiovascular disease risk in women. Design: A secondary data analysis was conducted on baseline data collected in a larger study examining the effects of tai chi on cardiovascular disease risk in women. Subjects: 96 women aged 35-50 years with increased waist circumference and a family history of cardiovascular disease. Measures: Biological measures included: fasting glucose, insulin and lipids, as well as C-reactive protein and cytokines. Behavioral measures included: mindfulness, fatigue, perceived stress, depressive symptoms, social support, self-compassion and spiritual thoughts and behaviors. Results: Mindfulness was …

Creation Of An Annotated Library On Fda Approved Nanomedicines, Marley R. Hodson, Tanin Izadi, Nastassja Lewinski Ph.D, Bridget T. Mcinnes Ph.D

Undergraduate Research Posters

Nanomedicine is a type of nanotechnology used in the medical field to limit the dosage amount and target drug delivery to specific cells. Nanomedicines that are approved and used tend to be extremely successful; however despite over a decade of research, only a limited number of nanomedicines have advanced for clinical use. A possible reason for the numerous nanomedicine failures is lack of easily accessible information and research on previous nanomedicines. In this project, we have compiled nanomedicine labeling information from the Drugs@FDA website. We have extracted phrases/sentences from labels relating to keywords on nanomaterial properties and drug profile characteristics. …

Smoking Patterns Among Vcu Students, Jasmine Saini

Undergraduate Research Posters

For some individuals, college can be a high risk time for the development of problems associated with alcohol use and other substances. The purpose of this study is to examine these initiation and use patterns as they relate to nicotine use among college students 18 years of age and older enrolled in Spit for Science: The VCU Student Survey. The Spit for Science research project evaluates how genetic and environmental factors contribute to substance use and emotional health among college students at VCU. This study uses data from the Spit for Science 2011 cohort (n=2007) to investigate smoking patterns among …

Distress In Women With Ovarian Cancer, Judith Dellaripa

Theses and Dissertations

Clinicians and researchers know that women experience distress related to the diagnosis of and treatment for ovarian cancer. A review of the literature revealed that while there is interest in the topic, distress is inconsistently defined and measured. Women have been reported to have a variety of distress experiences including the challenges of late diagnosis and the treatment regimen, communication difficulties with healthcare providers, and concern about the effect of their diagnosis on their loved ones. Without information directly from women, assumptions predominate about what the experience is like and what they would find helpful from support persons. Women’s perceptions …

Mandibular Incisor Proclination Variability During Class Ii Correction, James Redford

Theses and Dissertations

Background: Lower incisor proclination has been shown to increase during Class II correction with appliances such as the Forsus. This lower incisor flaring shows great variability among patients. The purpose of this study was to evaluate the effects of Class II severity, mandibular growth, and occlusal plane rotation on lower incisor flaring in patients treated with the Forsus appliance. Materials and Methods: 121 records of Class II patients treated with the Forsus appliance were analyzed retrospectively. Cephalograms were traced at three time points. ANOVA was used to compare changes in cephalometric measurements over time. Pearson’s correlation was used to test …

The Reporting Of Supplement Use By Dental Patients On Their Medical History Questionnaire, Sarmad Bakuri

Theses and Dissertations

The Reporting of Supplement Use by Dental Patients on Their Medical History Questionnaire Objectives: The goals of the study were three fold. Estimate the prevalence of supplement use by dental patients. Determine if the design of a medical history form influences the prevalence of supplement use reported. Determine whether or not patients are aware of supplement side effects and interactions with medications. Methods: Patients were randomly allocated to either a standard medical history form or the same form with additional questions about supplement use. After completing the initial forms, a survey containing questions about supplements was filled out by both …

The Fluoride Recharging Capability Of An Orthodontic Primer: An In Vitro Study, Samuel Allen

Theses and Dissertations

Objective: The purpose of this study was to determine the fluoride recharging capability of Opal Seal, a fluoride releasing orthodontic primer, as compared to Transbond XT, the control. Material and Methods: 1mm x 5mm disks of Opal Seal and Transbond were prepared according to the respective manufacturer’s instructions. Initially, the samples were stored in deionized water (DI) for 8 weeks. The samples were then randomly divided into one of two groups: Over-the-counter (OTC) fluoride mouthwash and prescription strength (PS) fluoride mouthwash. The OTC group samples were immersed in 5mL of 0.0219% sodium fluoride containing mouthwash for one minute every day …

The Role Of Cytoprotective And Non-Protective Autophagy In Radiation Sensitivity In Breast Tumor Cells, Jade Le

Theses and Dissertations

In general, ionizing radiation promotes cytoprotective autophagy in a majority of breast tumor cells. Previous studies from our laboratory indicated that radiation (5x2 Gy) induces cytoprotective autophagy in MCF-7 cells. In the current work, inhibition of autophagy by silencing of Beclin-1 in MCF-7 cells resulted in an increase in sensitivity to radiation based both on cell number and clonogenic survival; however, there was no increase in apoptosis and the basis for this sensitization is currently under investigation. Unexpectedly, enhancement of autophagy by silencing of Bcl-2 also led to an increase in sensitivity to radiation, possibly through the conversion of cytoprotective …

Relationship Of Mitochondrial Enzymes To Fatigue Intensity And Health-Related Quality Of Life In Men With Prostate Cancer Receiving External Beam Radiation Therapy, Kristin Filler

Theses and Dissertations

Introduction: Cancer-related fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after activity. Etiologic mechanisms underlying CRF are not well understood. Methods: A literature review was conducted to examine studies that had investigated the association of mitochondrial dysfunction with fatigue. The major conclusion from this review was that alterations in energy metabolism may contribute to fatigue. Therefore, the dissertation study focused on laboratory techniques for measuring mitochondrial oxidative phosphorylation enzymes (complexes I-V) and a mitochondrial-specific oxidative stress marker (superoxide dismutase 2 [SOD2]). The primary aim of the dissertation research …

Role Of Membrane Fusion Protein Ykt6 In Regulating Epithelial Cell-Cell And Cell-Matrix Adhesions., Supriya Joshi

Theses and Dissertations

Intercellular junctions and cell-matrix adhesions play important roles in the maintenance of epithelial integrity. Assembly and remodeling of the plasma membrane complexes are regulated by membrane trafficking and fusion. This thesis is aimed to elucidate the roles of an important membrane fusion protein, Ykt6, in the regulation of epithelial cell adhesion and migration. For the first time, we show that Ykt6 is essential for assembly of adherens junctions and tight junctions in human prostate epithelial cells. We also observed that Ykt6 negatively regulates both collective epithelial cell migration and cell invasion into Matrigel. The effects of YKT6 on epithelial junctions …

Factors Contributing To Infant Feeding Practices With Latina Mothers, Diana Cartagena

Theses and Dissertations

Background: An estimated 9.7% of U.S. infants and toddlers are considered overweight. Hispanic infants persistently show higher prevalence rates for being overweight compared to black and white infants. Little is known about factors promoting excessive infant weight gain in Latinos. Purpose: Primary aim of this study was to describe multidimensional factors and maternal feeding practices that may correlate with infant overfeeding in Latina mothers. A secondary aim was to determine whether there was an association between these factors and infant weight gain. Subjects: Sixty-two low-income immigrant Latina mothers and their infants ages 4-12 months receiving assistance through the Special Supplemental …

Structural Alterations To The Axon Initial Segment Following Diffuse Axonal Injury As A Consequence Of Age, William Behl

Theses and Dissertations

An epidemiological shift towards the elderly population has occurred in traumatic brain injury (TBI). Age is believed to be one of the strongest prognostic indicators following TBI. Diffuse axonal injury (DAI), a prevalent feature of TBI, is believed to be the primary cause for much of the morbidity and mortality associated with TBI. The pathobiology associated with DAI is believed to occur in response to the primary injury in a progressive, secondary fashion. Though the injury mechanisms behind DAI have been shown to occur at numerous sites along the axon, recent work suggests that the axon initial segment (AIS) may …

Investigations Of Novel Mechanisms Of Action For Anti-Bacterial And Anti-Cancer Agent Development, Jenson Verghese

Theses and Dissertations

The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets that is quickly rendering our current arsenal of drugs ineffective for these therapies. Unless new drugs with novel mechanisms of action are identified and developed at a faster pace, we face a losing battle in managing these diseases. The first part of this work concerns with the natural product Simocyclinone D8 (SD8). Simocyclinone D8 is an angucyclinone …

A Retrospective Study Of Operating Room Utilization And Efficiency In A Pediatric Dental Residency Program, Brian Burke

Theses and Dissertations

Purpose: The purpose was to assess and understand operating room (OR) utilization and efficiency in a pediatric dental residency program. Methods: A retrospective study was performed using chart extraction from 778 patients completed by both pediatric dentistry faculty (n=7) and residents (n=17) in an ambulatory care setting over a 32 month period (between July 2010 and March 2013). Patterns in OR usage time were determined by documenting various timing metrics (start and stop times for anesthesia, start and stop times for the dental procedure, times for throat pack in and out), noting patient information (age and ASA patient classification status), …

Prevalence And Distribution Of Periapical Lesions Submitted For Histopathologic Analysis By Endodontists, Gerhard Claire Siegel

Theses and Dissertations

The current understanding of the distribution and frequency of periapical pathoses include biopsies submitted by all specialists and general dentists. As a result, they do not accurately reflect the distribution seen by endodontists. This retrospective chart review aims to determine the prevalence of periapical pathoses and associated demographics from biopsies submitted by endodontists over 30 years. All biopsy reports submitted to the Virginia Commonwealth University Oral Pathology Diagnostic Service from January 1, 1983 to December 31, 2012 were reviewed. Only reports submitted by verified endodontists and those with a periapical location were included. The following data was recorded from each …

Clinical And Radiographic Evaluation Of Mta Pulpotomies: A Retrospective Study, Claudia Colorado

Theses and Dissertations

Vital pulp therapy is the group of procedures indicated to maintain pulp vitality allowing for continued root development and apical closure in the presence of pulp exposure due to caries or trauma. Complete maturation results in stronger tooth structure that is more able to withstand occlusal forces. Historically, calcium hydroxide (Ca(OH)2) was the material of choice for a vital pulpotomy. Recently mineral trioxide aggregate (MTA) has been used as a pulp sealing material because of its biocompatibility and its ability to induce hard tissue barrier formation. The purpose of this retrospective study was to evaluate the clinical and radiographic outcome …

The Roles Of Krüppel-Like Transcription Factors Klf1 And Klf2 In Mouse Embryonic And Human Fetal Erythropoiesis, Divya Vinjamur

Theses and Dissertations

Hemoglobinopathies are some of the most common monogenic disorders in the world, affecting millions of people and representing a growing burden on health systems worldwide. Although the pathophysiology of sickle cell anemia and beta-thalassemia, two of the most common hemoglobinopathies, have been the focus of much research over the last century, patients affected by these diseases still lack a widely applicable and easily available cure. Sickle cell anemia and beta-thalassemia are caused by defects in the structure and production of the beta-globin chains that, along with the alpha-globin chains make up the heterotetrameric hemoglobin molecule. Studies geared towards re-expression of …