Medicine and Health Sciences Commons^™

Evolution Of Influenza H3n2: A Random Walk In High Dimensions, James R. Moore

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Model For A Parameter Related To Free Virus Production From Infected Target Cells, Evan C. Haskell

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamic Modeling Of Problem Drinkers Undergoing Behavioral Treatment, Rebecca A. Everett

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Kinetics Of Type I Interferons During Influenza Virus Infection, Margaret A. Myers

Biology and Medicine Through Mathematics Conference

No abstract provided.

Rising Sea Surface Temperatures And Tipping Points For Seabird Colonies, Shandelle Henson, James Haywood, Jim Cushing

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamics Of Fluorescent Imaging In Glob-Driven Breakup, Lan Zhong, Christiaan Ketelaar, Richard J. Braun, Carolyn G. Begley, Peter Ewen King-Smith

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Hysteresis-Like Effect For Insect Control Strategies, Winfried Just

Biology and Medicine Through Mathematics Conference

No abstract provided.

Uncertainty Of 1-D Fluid Models In Patients With Pulmonary Hypertension, Mitchel J. Colebank

Biology and Medicine Through Mathematics Conference

No abstract provided.

Control Policies And Sensitivity Analysis In A Cutaneous Leishmaniasis Model: A Case Study In Cusco Region, Peru., Rocio M. Caja-Rivera, Ignacio Barradas

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stochastic Model Of Clogging In A Microfluidic Cell Sorter, Thomas G. Fai

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Exploits In Experimental Biology & Personalized Medicine, Gregory Forest

Biology and Medicine Through Mathematics Conference

No abstract provided.

Ability Of Critical Care Medics To Confirm Endotracheal Tube Placement By Ultrasound, Michael Joyce

Health Sciences Education Symposium

Point of care ultrasound is rapidly becoming the standard of care for many different clinical applications. The ACLS guidelines were recently updated to include ultrasound confirmation of endotracheal tube placement. While physicians sometimes utilize this in hospital, it is not commonly used in a pre-hospital setting. We proposed teaching this skill using a simulation approach including hands on teaching combined with simulation of pathology.

Use Of Management Pathways Or Algorithms In Children With Chronic Cough Chest Guideline And Expert Panel Report, Anne B. Chang, John J. Oppenheimer, Miles M. Weinberger, Bruce K. Rubin, Kelly Weir, Cameron C. Grant, Richard S. Irwin, Chest Expert Cough Panel

Pediatrics Publications

BACKGROUND: Using management algorithms or pathways potentially improves clinical outcomes. We undertook systematic reviews to examine various aspects in the generic approach (use of cough algorithms and tests) to the management of chronic cough in children (aged ≤ 14 years) based on key questions (KQs) using the Population, Intervention, Comparison, Outcome format.

METHODS: We used the CHEST Expert Cough Panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development and Evaluation framework. Data from the systematic reviews in conjunction with patients' values and preferences and the clinical context …

The Effect Of Variable Rest Intervals And Chronic Ankle Instability On Triplanar Ankle Motion During Performance Of The Star Excursion Balance Test, Yong Ung Kwon, D.S. Blaise Williams Iii

Physical Medicine and Rehabilitation Publications

Inadequate rest intervals may contribute to impaired performance during functional tests. However, the effect of different rest intervals on performance of the SEBT in individuals with and without CAI is not known. Our purposes were to determine whether different rest intervals impact ankle kinematics during the SEBT and whether there differences between those two populations. 24 controls and 24 CAI completed 3 trials in 3 reach directions (anteromedial; AM, medial; M, posteromedial; PM). The order of rest intervals and reach distance were randomized and counterbalanced. Three visits were required to complete the 3 rest interval conditions (10, 20, 40 s). …

The Association Between Childhood Adversities And Subsequent First Onset Of Psychotic Experiences: A Cross-National Analysis Of 23 998 Respondents From 17 Countries, J. J. Mcgrath, K. A. Mclaughlin, S. Saha, S. Aguilar-Gaxiola, A. Al-Hamzawi, J. Alonso, R. Bruffaerts, G. De Girolamo, P. De Jonge, O. Esan, S. Florescu, O. Gureje, J. M. Haro, C. Hu, E. G. Karam, V. Kovess-Masfety, S. Lee, J. P. Lepine, C. C. W. Lim, M. E. Medina-Mora, Z. Mneimneh, B. E. Pennell, M. Piazza, J. Posada-Villa, N. Sampson, M. C. Viana, M. Xavier, E. J. Bromet, K. S. Kendler, R. C. Kessler, Who World Mental Health Survey Collaborators

Psychiatry Publications

Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations.

We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models.

Exposure to CAs was common, and those who experienced any CAs had increased odds of …

Symptoms Of Major Depression: Their Stability, Familiality, And Prediction By Genetic, Temperamental, And Childhood Environmental Risk Factors, Kenneth S. Kendler, Steven H. Aggen

Psychiatry Publications

Background: Psychiatry has long sought to develop biological diagnostic subtypes based on symptomatic differences. This effort assumes that symptoms reflect, with good fidelity, underlying etiological processes. We address this question for major depression (MD).

Methods: We examine, in twins from a population-based registry, similarity in symptom endorsement in individuals meeting criteria for last-year MD at separate interview waves and in concordant twin pairs. Among individuals with MD, we explore the impact of genetic-temperamental and child adversity risk factors on individual reported symptoms. Aggregated criteria do not separate insomnia from hypersomnia, weight gain from loss, etc. while disaggregated criteria do.

Results: …

Genomewide Association Study Of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors In Model Organisms, Amy E. Adkins, Laura M. Hack, Tim B. Bigdeli, Vernell S. Williamson, G. Omari Mcmichael, Mohammed Mamdani, Alexis C. Edwards, Fazil Aliev, Robin F. Chan, Poonam Bhandari, Richard C. Raabe, Joseph T. Alaimo, Ginamari G. Blackwell, Arden Moscati, Ryan S. Poland, Benjamin Rood, Diana G. Patterson, Dermot Walsh, Collaborative Study Of The Genetics Of Alcoholism Consortium, John B. Whitfield, Gu Zhu, Grant W. Montgomery, Anjali K. Henders, Nicholas G. Martin, Andrew C. Heath, Pamela A.F. Madden, Josef Frank, Monika Ridinger, Norbert Wodarz, Michael Soyka, Peter Zill, Marcus Ising, Markus M. Nöthen, Falk Kiefer, Marcella Rietschel, The German Study Of The Genetics Of Addiction Consortium, Joel Gelernter, Richard Sherva, Ryan Koesterer, Laura Almasy, Hongyu Zhao, Henry R. Kranzler, Lindsay A. Farrer, Brion S. Maher, Carol A. Prescott, Danielle M. Dick, Silviu A. Bacanu, Laura D. Mathies, Andrew G. Davies, Vladimir I. Vladimirov, Mike Grotewiel, M. Scott Bowers, Jill C. Bettinger, Bradley T. Webb, Michael F. Miles, Kenneth S. Kendler, Brien P. Riley

Psychiatry Publications

Background

Alcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified.

Methods

We conducted a genomewide association study in 706 related AD cases and 1,748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms (MOs) to assess the role of orthologous genes in ethanol (EtOH)-response behaviors. We tested 1 primate-specific gene for expression differences in case/control postmortem brain tissue.

Results

We detected significant association in COL6A3 and suggestive association in 2 previously implicated loci, KLF12 and RYR3. None of these signals are significant in replication. …

The Genetic And Environmental Sources Of Resemblance Between Normative Personality And Personality Disorder Traits, K. S. Kendler, S. H. Aggen, Nathan Gillespie, M. C. Neale, G. P. Knudsen, R. F. Krueger, Nikolai Czajkowski, Eivind Ystrom, T. Reichborn-Kjennerud

Psychiatry Publications

Recent work has suggested a high level of congruence between normative personality, most typically represented by the "big five" factors, and abnormal personality traits. In 2,293 Norwegian adult twins ascertained from a population-based registry, the authors evaluated the degree of sharing of genetic and environmental influences on normative personality, assessed by the Big Five Inventory (BFI), and personality disorder traits (PDTs), assessed by the Personality Inventory for DSM-S-Norwegian Brief Form (PID-5NBF). For four of the five BFI dimensions, the strongest genetic correlation was observed with the expected PID-5-NBF dimension (e.g., neuroticism with negative affectivity [+], conscientiousness with disinhibition [-]). However, …

Multiple Blood-Brain Barrier Transport Mechanisms Limit Bumetanide Accumulation, And Therapeutic Potential, In The Mammalian Brain, Kerstin Römermann, Maren Fedrowitz, Philip Hampel, Edith Kaczmarek, Kathrin Töllner, Thomas Erker, Douglas H. Sweet, Wolfgang Löscher

Pharmacology and Toxicology Publications

There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but rather mediated by inhibition of the neuronal Na-K-C1 cotransporter isoform NKCC1. However, following systemic administration, brain levels of bumetanide are typically below those needed to inhibit NKCC1, which critically limits its clinical use for treating brain disorders. Recently, active efflux transport at the blood-brain barrier (BBB) has been suggested as a process involved in the low brain:plasma ratio of bumetanide, …

Can Real-Time Visual Feedback During Gait Retraining Reduce Metabolic Demand For Individuals With Transtibial Amputation?, Elizabeth R. Esposito, Harmony S. Choi, Benjamin J. Darter, Jason M. Wilken

Physical Therapy Publications

The metabolic demand of walking generally increases following lower extremity amputation. This study used real-time visual feedback to modify biomechanical factors linked to an elevated metabolic demand of walking in individuals with transtibial amputation. Eight persons with unilateral, traumatic transtibial amputation and 8 uninjured controls participated. Two separate bouts of real-time visual feedback were provided during a single session of gait retraining to reduce 1) center of mass sway and 2) thigh muscle activation magnitudes and duration. Baseline and post-intervention data were collected. Metabolic rate, heart rate, frontal plane center of mass sway, quadriceps and hamstrings muscle activity, and co-contraction …

Dynamical System Modeling To Simulate Donor T Cell Response To Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness In Alloreactivity Incidence Following Stem Cell Transplantation, Vishal Koparde, Badar Abdul Razzaq, Tara Suntum, Roy Sabo, Allison Scalora, Myrna Serrano, Max Jameson-Lee, Charles Hall, David Kobulnicky, Nihar Sheth, Juliana Feltz, Daniel Contaifer, Dayanjan Wijesinghe, Jason Reed, Catherine Roberts, Rehan Qayyum, Gregory Buck, Michael Neale, Amir Toor

Massey Comprehensive Cancer Center Data

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p

Genetic And Environmental Structure Of Dsm-Iv Criteria For Antisocial Personality Disorder: A Twin Study, Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A. Gillespie, Steven H. Aggen, Robert F. Krueger, Kenneth S. Kendler, Ted Reichborn-Kjennerud

Psychiatry Publications

Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level. Multivariate biometric models, including both independent and common pathways, were compared. A single phenotypic factor was found, and the best-fitting biometric …

Yap Functions Via Tead Mediated Transcriptional Activation In Hepatoblastoma Pathogenesis, Junyan Tao 8598903, Pin Liu, Jie Zhang, Sucha Singh, Xin Chen, Na Zhan, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

The Role Of Menin-Mll Interaction In The Dissociation Between Cholestatic Liver Diseases And Cholangiocarcinoma, Laurent Ehrlich 2085637, Chad Hall Dr., Tori Sheppard, Julie Venter, April O'Brien, Terry C. Lairmore Dr., Gianfranco Alpini Dr., Shannon Glaser Dr.

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Notch2 Controls Hepatocyte-Derived Cholangiocarcinoma Formation In Mice, Jingxiao Wang, Mingjie Dong, Xinhua Song, Kaiwen Hu, Xin Chen

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Survival Model Of Intrahepatic Cholangiocarcinoma; Sex As A Biological Variable, Mary A. Phillippi, Justin L. Mott, Cody J. Wehrkamp, Ying Xie, David Oupicky, Ashley M. Mohr, Bailey A. Stringham

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A Comprehensive Tcga Based Analysis Of Disruptions In Tgf-Β Pathway Across 33 Human Cancers, Sobia Zaidi

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Hepatocellular Cancer Genome And Transcriptome Analysis Validates Clinically Significant Mutational Signatures With The Tgf-𝛃 Pathway, Shuyun Rao, Jian Chen, Kazufumi Ohshiro, Shoujun Gu, Sobia Zaidi, Wilma S. Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Chuxia Deng, Bibhuti Mishra, Rehan Akbanni, The Tcga Cancer Network, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Alcoholic Liver Diseases, Stem Cell Disorder And Hepatocellular Carcinoma, Shoujun Gu, Shuyun Rao, Sobia Zaidi, Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Sjhulin Li, Chu-Xia Deng, Rehan Akbani, Bibhuti Mishra, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Transcriptional Reprograming That Persists After Clearance Of Oncogenic Hepatitis C Virus, Atsushi Ono, Francis J. Eng, Frank Juehling, Nourdine Hamdane, Naoto Fujiwara, Takaaki Higashi, Billie C. Bian, Hadassa Hirschfield, Vera Kim, Thomas F. Baumert, Andrea D. Branch, Yujin Hoshida

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.