Medicine and Health Sciences Commons^™

Understanding Cardiovascular Dynamics: Insights From Data Driven Nonlinear Hyperelastic Wall Modeling In Pulmonary Arteries, Md Arifuzzaman, Mette S. Olufsen, Mansoor A. Haider

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stokes Flow Around Beating Microorganisms, Mckenna A. Witt

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Comparative Analysis Of Source Identification Algorithms, Pablo A. Curiel

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Immune Response To Sars-Cov-2, Hwayeon Ryu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Incorporating Awareness, Misinformation And Optimal Control In A Model Of Sars-Cov-2, Eric Numfor

Biology and Medicine Through Mathematics Conference

No abstract provided.

Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimizing Immunotherapies For Improved Cancer Treatment, Anne Talkington, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Topological Data Analysis Of Molecular Dynamics Simulations Of Monoclonal Antibodies, Melinda Kleczynski, Christina Bergonzo, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Stochastic Multi-Host Model For West Nile Virus: Determining The Probability Of Disease Extinction!, Suzanne Robertson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stochastic Immunology Model And Its Analysis, Rahnuma Islam, David Swigon

Biology and Medicine Through Mathematics Conference

No abstract provided.

Clustering Using Self Organizing Maps In Biology, Olcay Akman

Biology and Medicine Through Mathematics Conference

No abstract provided.

Decoding Immune Cell Navigation: Integrating Artificial Life Modeling With Tumor Microenvironment Dynamics, Sadegh Marzban

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary: Mathematics Of Malaria Transmission Dynamics: The Renewed Quest For Eradication, Abba Gumel

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary: Insights Into Depression: Mathematical Approaches, Janet Best

Biology and Medicine Through Mathematics Conference

No abstract provided.

Overexpression Of Wnt7a Enhances Radiosensitivity Of Non-Small Cell Lung Cancer Via The Wnt/Jnk Pathway, Loan Quynh Tran

VCU's Medical Journal Club: The Work of Future Health Professionals

Wnt7a serves an important role in slowing down the growth of non-small-cell lung cancer (NSCLC). However, little is known about the effect(s) of Wnt7a on the sensitivity of NSCLC to radiation. In the study, NSCLC cell proliferation and apoptosis in response to Wnt7a overexpression and/or radiation as one combination were determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tertazolium bromide (MTT) assay and flow cytometry, respectively. The western blot technique was used to further examine the activation of Wnt/cJun N-terminal kinase (JNK) and Wnt/b-catenin signaling pathways in NSCLC cell lines H1650 and A549.

The results indicate that the overexpression of Wnt7a, in combination with radiation inhibits …

The “Desegregation“ Of Mcv Hospitals, 1968 To 1971, Robert E. Petres

Publications from the Office of the Senior Vice President for Health Sciences

The “desegregation“ of MCV Hospitals, 1968 to 1971 Robert E. Petres

Retired OB/GYN physician recounts his experiences as resident at the Medical College of Virginia (MCV)’s St. Philip Hospital in Richmond, Va. in the late 1960s and early 1970s.

MCV declared the desegregation of its hospitals in 1965, but when Petres arrived in 1968, he observed something different. The obstetrical hospitals may have been racially integrated as a matter of policy, but in practice they were segregated. “Private Service" patients – most white women in Richmond – delivered their babies in the obstetrics unit of West Hospital, where there were …

Effect Of Psilocybin On Empathy And Moral Decision-Making, Sky Evans

VCU's Medical Journal Club: The Work of Future Health Professionals

Empathy is the ability for human beings, as well as all other mammals, to understand the mental state of another person on an emotional level. It allows us to feel compassion and promote the well-being of those around us. Impaired empathic abilities lead to severe negative social consequences and influence the development and treatment of several psychiatric disorders, specifically in disorders such as antisocial personality disorder. Furthermore, empathy has been shown to play a crucial role in moral and prosocial behavior. In neuroscience and psychiatry research, the serotonin system has been shown to be involved in modulating empathy and moral …

Expanded Forward Trial Demonstrates Continued Potential For Stem Cell-Derived Islet Cell Therapy To Eliminate Need For Insulin For People With T1d, Ananya Aengula

VCU's Medical Journal Club: The Work of Future Health Professionals

A clinical trial has released a potential new Stem-Cell Therapy, VX-880 that has been found to treat Type 1 Diabetes through hepatic portal vein infusion.

Crispr-Cas9 Editing Of The Hbg1 And Hbg2 Promoters To Treat Sickle Cell Disease, Brooklyn Schofield

VCU's Medical Journal Club: The Work of Future Health Professionals

In order to protect against complications of Sickle Cell Disease, researchers used CRISPR-Cas9 gene editing to repeat CD34+ stem cells in an attempt to target and disrupt the HBG1 and HBG2 gene factors in sickle cell hemoglobin. Three participants were injected with OTQ923, the factored gene, and then monitored for F cell levels, hemoglobin levels, and fetal hemoglobin levels. Within 6-18 months, all 3 participants saw an increase in these factors from their original baseline.

Epds-Us (English), Sara W. Moyer, Patricia Kinser

School of Nursing Publications

How we talk about perinatal mental health matters, even in the minute details of words on screening forms. Any shifts towards removing barriers to screening, reducing stigma, encouraging disclosures, raising awareness related to symptom prevalence and the breadth symptom related experiences, and creating opportunities for connecting with support and care are essential.

In the EPDS-US, we have adapted the wording of the original Edinburgh Postnatal Depression Scale (EPDS), using a respectful care and trauma-informed approach with a focus on optimizing patient experiences and clinical utility while maintaining reliability and validity of the 10 item scale. Many individuals report feelings of …

Six-Month Pain And Function Outcome Expectations Were Established For Total Knee Arthroplasty Using The Smallest Worthwhile Effect, Daniel L. Riddle, Nancy Henderson

Physical Therapy Publications

Introduction: Interpretations of patient-reported outcome measures following knee arthroplasty lack context and typically do not account for costs, risks and benefits compared to an alternative treatment. The primary purpose of our paper is to estimate expectations patients have for pain and function destination outcome, six-months following surgery relative to the outcome expected if knee arthroplasty was not done. Secondary purposes were to determine if statistically significant changes in the smallest worthwhile six-month outcome occurred following an interactive discussion and to assess the construct validity of the expected six-month outcome obtained at baseline.

Methods: This was a secondary analysis …

Socioeconomic Status And Health Disparities Drive Differences In Accelerometer-Derived Physical Activity In Fatty Liver Disease And Significant Fibrosis, Lucia Tabacu, Sajag Swami, Mark Ledbetter, Mohamad S. Siddiqui, Ekaterina Smirnova

Internal Medicine Publications

Background and aims: The cornerstone of clinical management of patients with nonalcoholic fatty liver disease (NAFLD) are lifestyle changes such as increasing physical activity (PA) aimed at improving cardiometabolic risk. To inform NAFLD prevention and treatment guidelines we aimed to: (i) quantify the role of PA on lowering the risk for NAFLD and fibrosis; (ii) characterize NAFLD and fibrosis association with PA in the context of socioeconomic environment.

Methods: A sample of 2648 participants from the NHANES 2003–2006 was selected to develop survey weighted multivariable logistic regression models for predicting NAFLD and significant fibrosis, diagnosed non-invasively via fatty …

Alcohol Use And Alcohol Use Disorder Differ In Their Genetic Relationships With Ptsd: A Genomic Structural Equation Modelling Approach, Tulsi Patel

VCU's Medical Journal Club: The Work of Future Health Professionals

Posttraumatic stress disorder (PTSD) is associated with an increased alcohol use and increased risk of developing alcohol use disorder (AUD). Previous literature suggests that the genetic association between PTSD and alcohol use differs from that between PTSD and AUD. Researchers in this study used a genomic Structural Equation Modeling, genomicSEM, to analyze data from a larger genome-wide association studies (GWAS). Participants in the study were of European descent.

Researchers investigated the genetic association between PTSD, alcohol use, and AUD through these large scale statistical analyses. Researchers observed a significant improvement in model fit (p < .001). Genetic correlations (rG) between PTSD and AUD were positive (rG: .36, p < .001), while those between PTSD and alcohol use were negative (rG: -0.17, p < .001). Researchers observed that when specific variables for alcohol use and AUD were isolated, key differences resulted in genetic association with PTSD, which indicated that the genetic makeup of alcohol-related behaviors is different in individuals with PTSD.

Effects Of Dextromethorphan On Mdma-Induced Serotonergic Aberration In The Brains Of Non-Human Primates Using [123i]-Adam/Spect, Sky Evans

VCU's Medical Journal Club: The Work of Future Health Professionals

MDMA, a widely used recreational drug belonging to the entactogen class, acts strongly on serotonin and dopamine receptors, potentially inducing neurotoxicity. In a study on primates, MDMA treatment resulted in reduced serotonin transporter levels, persisting for years. However, co-administration with dextromethorphan (DXM), an antitussive with anti-inflammatory properties, appeared to prevent this decrease, suggesting a protective effect against MDMA-induced serotonergic toxicity. The study employed SPECT scans with [123I]-ADAM radioligand to assess serotonin transporter levels in various brain regions, revealing significant differences between treatment groups.

The Clinical Inquiry Process Diagram (V. 5), Roy E. Brown

VCU Libraries Faculty and Staff Publications

This updated edition of The Clinical Inquiry Process Diagram improves on the 2023 version. It provides a depiction of the steps involved in the clinical inquiry process, covering research, performance improvement, and evidence-based practice. The revisions in this version emphasize the importance of alerting users to the iterative nature of clinical inquiry and the ongoing need to assess the situation or patient based on evolving evidence. It's crucial to recognize that the clinical inquiry process does not follow a linear, sequential progression. Instead, individuals may find themselves concurrently addressing different aspects of the process or revisiting prior steps as they …

The Clinical Inquiry Process Diagram Question Development Checklist, Roy E. Brown

VCU Libraries Faculty and Staff Publications

This updated handout, previously published in 2023, serves as a reference for those who are either in an EBP course or are practicing healthcare providers involved in questioning practices to improve patient care. The handout guides the user from identifying and developing a question to determining whether the clinical question, based on evidence, will be an evidence-based practice project/initiative, a performance improvement project, or a research project. It aligns with the fifth version of the Clinical Inquiry Process Diagram and now includes several different formats that can be used when trying to create a focused clinical question.

• Update of The …

Evidence-Based Decision Making At The Bedside Process, Roy E. Brown

VCU Libraries Faculty and Staff Publications

Evidence-based practice (EBP) is crucial in healthcare for improving care and organizational outcomes. However, there is a lack of consensus among various health professions regarding the definition and implementation of evidence-based practice in the clinical environment. This lack of consensus centers on whether EBP is project-based or if it occurs primarily at the bedside. This diagram illustrates how evidence is utilized to inform bedside decision-making. It demonstrates that the process is iterative and the intervention or decision made is contingent upon the evidence, one’s clinical experience, and the patient/situation.

The purpose of the diagram is to help those involved in …

Reverberations Of Medical Racism: Exploring The Legacy Of Vcu School Of Medicine Through The Emsw Project, Arya Hanjagi, Cynthia Lin, Olivia Washington

East Marshall Street Well Project Symposium Posters

Our work is centered on approaching research related to the East Marshall Street Well Project from a community-engaged perspective that integrates local actors throughout all levels of examination as a form of rectifying the harm that this historic exclusion has created. Given the nature of oral history as preservation of knowledge, we cannot draw conclusions about the significance of research unless we include the public. Our works seek to share our research through equitable and easily accessible means. Using oral histories as our main methodology, we can establish that recognizing this harm, and healing from it, requires fostering conversation among …

Connect: Community-Engaged, Community-Based Data Dissemination Framework, Maghboeba Mosavel

Division of Community Engagement Resources

This resource discusses community-engaged data dissemination processes. It provides information on being able to produce many scholarly outputs in addition to co-creating accessible outputs for the community. The framework describes how to continue partnerships that are mutually beneficial to both the institution and the community. The CONNECT framework addresses community frustrations by transforming data dissemination into a systematic, partnership-driven process that goes beyond data extraction. It enables researchers to align their work more closely with community needs, guiding the next steps in research design, focus, and methodology.

Small Airway-On-A-Chip Enables Analysis Of Human Lung Inflammation And Drug Responses In Vitro, Christina A. Fernandez

VCU's Medical Journal Club: The Work of Future Health Professionals

This presentation focuses on the development of the Small Airway-on-a-Chip, a microfluidic device meant to serve as a more accurate, human-relevant research model for lung inflammation-focused pharmaceutical testing, as described in Small Airway-on-a-Chip Enables Analysis of Human Lung Inflammation and Drug Responses in Vitro by Benam et al. Currently, there is no way to study organ-level complexities of human lung inflammation outside of the clinical setting. However, the human lung Small Airway-on-a-Chip demonstrated the ability to reconstitute a functional unit of the lung as well as model asthma, lung inflammation, and Chronic Obstructive Pulmonary Disease (COPD), suggesting that the device …