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Full-Text Articles in Medicine and Health Sciences
Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells: Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju
Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells: Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to forty-two days for transfusion usage before being discarded. I am studying the effects of Ascorbic Acid (AA), N-acetylcysteine amide (AD4), and Serotonin or 5-hydroxytryptamine (5- HT) as additives in blood bank storage to find out if these additives can reduce storageinduced oxidative stress on red blood cells (RBCs), as well as to understand how potential blood storage additives can affect the shelf life …
Altered Axon Initial Segment Structure And Function In Inflammatory Disease, Kareem C. Clark
Altered Axon Initial Segment Structure And Function In Inflammatory Disease, Kareem C. Clark
Theses and Dissertations
Axonal pathology is a key contributor to long-term disability in multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), but the mechanisms that underlie axonal insults remain unclear. While most axonal pathologies characterized in MS are a direct consequence of myelin loss, we propose that axonal pathologies also occur independent of demyelination. In support of this idea, we recently reported that mice that develop experimental autoimmune encephalomyelitis (EAE), a model commonly used to mimic the pathogenesis of MS, exhibit a structural and functional disruption of the axon initial segment (AIS), a subdomain of the axon that …