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A Lipidomic Analysis Of Placenta In Preeclampsia: Evidence For Lipid Storage, Simon H. J Brown, Samuel Eather, Dilys J. Freeman, Barbara J. Meyer, Todd W. Mitchell
A Lipidomic Analysis Of Placenta In Preeclampsia: Evidence For Lipid Storage, Simon H. J Brown, Samuel Eather, Dilys J. Freeman, Barbara J. Meyer, Todd W. Mitchell
Illawarra Health and Medical Research Institute
In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) …
An Automated Chromatography Procedure Optimized For Analysis Of Stable Cu Isotopes From Biological Materials, T. Gabriel Enge, M P. Field, Dianne F. Jolley, Heath Ecroyd, M H. Kim, Anthony Dosseto
An Automated Chromatography Procedure Optimized For Analysis Of Stable Cu Isotopes From Biological Materials, T. Gabriel Enge, M P. Field, Dianne F. Jolley, Heath Ecroyd, M H. Kim, Anthony Dosseto
Illawarra Health and Medical Research Institute
An automated ion-exchange chromatography method is developed for the separation of copper (Cu) from biological samples prior to stable, naturally occurring, isotope analysis. The technique does not require Cu to be fully oxidized/reduced into either Cu+ or Cu2+. Distribution coefficients of Cu and other cations to the Cu-specific anion exchange resin enable the effective purification and separation of Cu from complex matrixes using a single, reusable chromatographic column, with the potential to be modified for varying sample types. The automated chromatography system (prepFAST-MC™) can process up to 60 samples per run at a rate of 36 samples per day on …