Medicine and Health Sciences Commons^™

Amyloid Β Peptides Modify The Expression Of Antioxidant Repair Enzymes And A Potassium Channel In The Septohippocampal System, Jorge Duran-Gonzalez, Edna D. Michi, Brisa Elorza, Miriam G. Perez-Cordova, Luis F. Pacheco Otalora, Ahmed Touhami, Pamela Paulson, George Perry, Ian V. Murray, Luis V. Colom

Health & Biomedical Sciences Faculty Publications and Presentations

Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder characterized by extracellular accumulations of amyloid β (Aβ) peptides, intracellular accumulation of abnormal proteins, and early loss of basal forebrain neurons. Recent studies have indicated that the conformation of Aβ is crucial for neuronal toxicity, with intermediate misfolded forms such as oligomers being more toxic than the final fibrillar forms. Our previous work shows that Aβ blocks the potassium (K(+)) currents IM and IA in septal neurons, increasing firing rates, diminishing rhythmicity and firing coherence. Evidence also suggests that oxidative stress (OS) plays a role in AD pathogenesis. Thus we wished …