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Full-Text Articles in Medicine and Health Sciences
Amyloid Β Peptides Modify The Expression Of Antioxidant Repair Enzymes And A Potassium Channel In The Septohippocampal System, Jorge Duran-Gonzalez, Edna D. Michi, Brisa Elorza, Miriam G. Perez-Cordova, Luis F. Pacheco Otalora, Ahmed Touhami, Pamela Paulson, George Perry, Ian V. Murray, Luis V. Colom
Amyloid Β Peptides Modify The Expression Of Antioxidant Repair Enzymes And A Potassium Channel In The Septohippocampal System, Jorge Duran-Gonzalez, Edna D. Michi, Brisa Elorza, Miriam G. Perez-Cordova, Luis F. Pacheco Otalora, Ahmed Touhami, Pamela Paulson, George Perry, Ian V. Murray, Luis V. Colom
Health & Biomedical Sciences Faculty Publications and Presentations
Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder characterized by extracellular accumulations of amyloid β (Aβ) peptides, intracellular accumulation of abnormal proteins, and early loss of basal forebrain neurons. Recent studies have indicated that the conformation of Aβ is crucial for neuronal toxicity, with intermediate misfolded forms such as oligomers being more toxic than the final fibrillar forms. Our previous work shows that Aβ blocks the potassium (K(+)) currents IM and IA in septal neurons, increasing firing rates, diminishing rhythmicity and firing coherence. Evidence also suggests that oxidative stress (OS) plays a role in AD pathogenesis. Thus we wished …
Neurotrophin Signaling And Alzheimer's Disease Neurodegeneration - Focus On Bdnf/Trkb Signaling, Jenny Wong
Neurotrophin Signaling And Alzheimer's Disease Neurodegeneration - Focus On Bdnf/Trkb Signaling, Jenny Wong
Illawarra Health and Medical Research Institute
Neurotrophins are small proteins vital for neuronal growth, differentiation, survival, and plasticity. Members of the mammalian neurotrophin family include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin- 4/5 (NT-4/5). Their neurotrophic effects are mediated by the tropomyosin receptor kinase (Trk) receptors, membrane-bound receptor tyrosine kinases (NGF for TrkA, BDNF and NT4/5 for TrkB, and NT-3 for TrkC) which activate various cell signaling pathways linked to growth, differentiation, and survival. The importance of neurotrophin signaling in brain development is highlighted by findings showing that knockout mice for any one of the neurotrophins or their receptors are fatal …
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Faculty of Science, Medicine and Health - Papers: part A
ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate processing of amyloid precursor protein (APP) to generate the Alzheimer's disease (AD) amyloid-β (Aβ) peptide. Genome-wide association studies have indicated that ABCA7 single nucleotide polymorphisms confer increased risk for late-onset AD; however, the role that ABCA7 plays in the brain in the AD context is unknown. In the present study, we crossed ABCA7-deficient (A7-/-) mice with J20 amyloidogenic mice to address this issue. We show …
Brain Immune Interactions And Air Pollution: Macrophage Inhibitory Factor (Mif), Prion Cellular Protein (Prpc), Interleukin-6 (Il-6), Interleukin 1 Receptor Antagonist (Il-1ra), And Interleukin-2 (Il-2) In Cerebrospinal Fluid And Mif In Serum Differentiate Urban Children Exposed To Severe Vs. Low Air Pollution, Lilian Calderón-Garcidueñas, Janet V. Cross, Maricela Franco-Lira, Mariana Aragón-Flores, Michael Kavanaugh, Ricardo Torres-Jardon, Chih-Kai Chao, Charles Thompson, Jing Chang, Hongtu Zhu, Amedeo D'Angiulli
Brain Immune Interactions And Air Pollution: Macrophage Inhibitory Factor (Mif), Prion Cellular Protein (Prpc), Interleukin-6 (Il-6), Interleukin 1 Receptor Antagonist (Il-1ra), And Interleukin-2 (Il-2) In Cerebrospinal Fluid And Mif In Serum Differentiate Urban Children Exposed To Severe Vs. Low Air Pollution, Lilian Calderón-Garcidueñas, Janet V. Cross, Maricela Franco-Lira, Mariana Aragón-Flores, Michael Kavanaugh, Ricardo Torres-Jardon, Chih-Kai Chao, Charles Thompson, Jing Chang, Hongtu Zhu, Amedeo D'Angiulli
Biomedical and Pharmaceutical Sciences Faculty Publications
Mexico City Metropolitan Area children chronically exposed to high concentrations of air pollutants exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, innate and adaptive immune responses along with accumulation of misfolded proteins observed in the early stages of Alzheimer and Parkinson's diseases. A complex modulation of serum cytokines and chemokines influences children's brain structural and gray/white matter volumetric responses to air pollution. The search for biomarkers associating systemic and CNS inflammation to brain growth and cognitive deficits in the short term and neurodegeneration in the long-term is our principal aim. We explored and compared a profile …
Novel Behavioural Characteristics Of The Appswe/Ps1Δe9 Transgenic Mouse Model Of Alzheimer's Disease, David Cheng, Warren Logge, Jac Kee Low, Brett Garner, Tim Karl
Novel Behavioural Characteristics Of The Appswe/Ps1Δe9 Transgenic Mouse Model Of Alzheimer's Disease, David Cheng, Warren Logge, Jac Kee Low, Brett Garner, Tim Karl
Illawarra Health and Medical Research Institute
In order to better understand animal models of Alzheimer's disease, novel phenotyping strategies have been established for transgenic mouse models. In line with this, the current study characterised male APPxPS1 transgenic mice on mixed C57BL/6JxC3H/HeJ background for the first time for social recognition memory, sensorimotor gating, and spatial memory using the cheeseboard test as an alternative to the Morris water maze. Furthermore, locomotion, anxiety, and fear conditioning were evaluated in transgenic and wild type-like animals. APPxPS1 males displayed task-dependent hyperlocomotion and anxiety behaviours and exhibited social recognition memory impairments compared to wild type-like littermates. Spatial learning and memory, fear conditioning, …