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- Antimicrobial stewadship; Mathematical modeling; Healthcare-associated infection; Nosocomial infection; Epidemiology; Antibiotic resistance (1)
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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Inhibiting Androgen Receptor Nuclear Entry In Castration-Resistant Prostate Cancer, Julie A. Pollock, Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, Scott A. Lawrence, James P. Stice, Ivan Spasojevic, Jennifer G. Baker, Sung Hoon Kim, Donald P. Mcdonnell, John A. Katzenellenbogen, John D. Norris
Inhibiting Androgen Receptor Nuclear Entry In Castration-Resistant Prostate Cancer, Julie A. Pollock, Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, Scott A. Lawrence, James P. Stice, Ivan Spasojevic, Jennifer G. Baker, Sung Hoon Kim, Donald P. Mcdonnell, John A. Katzenellenbogen, John D. Norris
Chemistry Faculty Publications
Clinical resistance to the second-generation antiandrogen enzalutamide in castration resistant prostate cancer (CRPC), despite persistent androgen receptor (AR) activity in tumors, highlights the unmet medical need for next generation antagonists. We have identified and characterized tetra-aryl cyclobutanes (CBs) as a new class of competitive AR antagonists that exhibit a unique mechanism of action. These CBs are structurally distinct from current antiandrogens (hydroxyflutamide, bicalutamide, and enzalutamide), and inhibit AR-mediated gene expression, cell proliferation, and tumor growth in several models of CRPC. Conformational profiling revealed that CBs stabilize an AR conformation resembling an unliganded receptor. Using a variety of techniques, it was …
Evaluating Treatments And Interventions: What Constitutes “Evidence-Based” Treatment?, Lisa Jobe-Shields, Amanda Costello, Carrie Jackson, Rochelle F. Hanson
Evaluating Treatments And Interventions: What Constitutes “Evidence-Based” Treatment?, Lisa Jobe-Shields, Amanda Costello, Carrie Jackson, Rochelle F. Hanson
Psychology Faculty Publications
This chapter provides an overview of the evidence-based treatment (EBT) paradigm, beginning with definitional issues, followed by a discussion on use of the iterative process and the importance of strong academic–practice partnerships to inform the development, selection, and implementation of EBTs. The discussion then turns to the importance of attaining, measuring, and sustaining fidelity to the treatment models; and identifying common barriers to sustained EBT use. Drawing from our expertise related to interventions for children and adolescents, a few dissemination/implementation models are highlighted as examples of current efforts to achieve sustained use of EBTs among practitioners, within agencies, and across …
Evaluating Infection Prevention Strategies In Out-Patient Dialysis Units Using Agent-Based Modeling, Joanna R. Wares, Barry Lawson, Douglas Shemin, Erika M. C. D'Agata
Evaluating Infection Prevention Strategies In Out-Patient Dialysis Units Using Agent-Based Modeling, Joanna R. Wares, Barry Lawson, Douglas Shemin, Erika M. C. D'Agata
Department of Math & Statistics Faculty Publications
Patients receiving chronic hemodialysis (CHD) are among the most vulnerable to infections caused by multidrug-resistant organisms (MDRO), which are associated with high rates of morbidity and mortality. Current guidelines to reduce transmission of MDRO in the out-patient dialysis unit are targeted at patients considered to be high-risk for transmitting these organisms: those with infected skin wounds not contained by a dressing, or those with fecal incontinence or uncontrolled diarrhea. Here, we hypothesize that targeting patients receiving antimicrobial treatment would more effectively reduce transmission and acquisition of MDRO. We also hypothesize that environmental contamination plays a role in the dissemination of …
The Role Of Mathematical Modeling In Designing And Evaluating Antimicrobial Stewardship Programs, Lester Caudill, Joanna R. Wares
The Role Of Mathematical Modeling In Designing And Evaluating Antimicrobial Stewardship Programs, Lester Caudill, Joanna R. Wares
Department of Math & Statistics Faculty Publications
Antimicrobial agent effectiveness continues to be threatened by the rise and spread of pathogen strains that exhibit drug resistance. This challenge is most acute in healthcare facilities where the well-established connection between resistance and suboptimal antimicrobial use has prompted the creation of antimicrobial stewardship programs (ASPs). Mathematical models offer tremendous potential for serving as an alternative to controlled human experimentation for assessing the effectiveness of ASPs. Models can simulate controlled randomized experiments between groups of virtual patients, some treated with the ASP measure under investigation, and some without. By removing the limitations inherent in human experimentation, including health risks, study …
The Role Of Mathematical Modeling In Designing And Evaluating Antimicrobial Stewardship Programs, Lester Caudill, Joanna R. Wares
The Role Of Mathematical Modeling In Designing And Evaluating Antimicrobial Stewardship Programs, Lester Caudill, Joanna R. Wares
Department of Math & Statistics Faculty Publications
Antimicrobial agent effectiveness continues to be threatened by the rise and spread of pathogen strains that exhibit drug resistance. This challenge is most acute in healthcare facilities where the well-established connection between resistance and sub-optimal antimicrobial use has prompted the creation of antimicrobial stewardship programs (ASPs). Mathematical models offer tremendous potential for serving as an alternative to controlled human experimentation for assessing the effectiveness of ASPs. Models can simulate controlled randomized experiments between groups of virtual patients, some treated with the ASP measure under investigation, and some without. By removing the limitations inherent in human experimentation, including health risks, study …
Column: From Plato To Ebola?: Introducing World History In A First Year Seminars On Epidemics, Carol Summers
Column: From Plato To Ebola?: Introducing World History In A First Year Seminars On Epidemics, Carol Summers
History Faculty Publications
How can world historians take advantage of interdisciplinary general education requirements to introduce new students to the methods and uses of history? When survey courses are not institutionalized, specialized courses that draw on individual faculty members’ expertise and fit into general education curricular niches may be the best option. This essay describes my efforts in a First Year Seminar on Epidemics and Empires to teach a broader range of students to how world historical approaches and methods both introduce them to a bigger, more complicated world, and provide tools to understand it.